# ModificationSet

Id: PSI-MOD
HomeUrl: http://www.psidev.info/MOD
ModificationUrl: http://www.ebi.ac.uk/ontology-lookup/browse.do?ontName=MOD&termId=MOD:{0:00000}
Description:
A concensus nomenclature that provides an ontology reconciling in a hierarchical representation the complementary descriptions of residue modifications.


Id: Unimod
HomeUrl: http://www.unimod.org/
ModificationUrl: http://www.unimod.org/modifications_view.php?editid1={0}
Description:
A community supported, comprehensive database of protein modifications for mass spectrometry applications.


# Modification

ModificationSetId: RESID
DiffFormula: C 0 Fe 3 H -7 N 0 Ni 1 O 3 S 3
Formula: C 28 Fe 3 H 34 N 9 Ni 1 O 14 S 7
Name:
tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide


ModificationSetId: RESID
DiffFormula: C 0 Fe 3 H -7 N 0 Ni 1 O 3 S 3
Formula: C 26 Fe 3 H 32 N 9 Ni 1 O 13 S 7
Name:
tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide


ModificationSetId: PSI-MOD
Name: protein modification
Definition:
Covalent modification of, or a change resulting in an alteration of the measured molecular mass of, a peptide or protein amino acid residue.


ModificationSetId: PSI-MOD
Name: N-glycosylated residue
Definition:
A protein modification that effectively replaces a residue hydrogen atom on a nitrogen with a carbohydrate-like group through a glycosidic bond.


ModificationSetId: PSI-MOD
Name: common
Definition:
Entry from UniMod representing one or more entries in RESID. OBSOLETE because organizational use is no longer required.


ModificationSetId: PSI-MOD
Name: natural residue
Definition:
A protein modification that removes a residue, or inserts or replaces a residue with a natural, standard or nonstandard, encoded residue.


ModificationSetId: PSI-MOD
SwissprotTerm: N-formylmethionine
Name: N-formyl-L-methionine residue
DiffFormula: C 0 H 0 N 0 O 0 S 0
Formula: C 6 H 10 N 1 O 2 S 1
AminoAcid: M
Definition:
A protein modification that effectively converts a source amino acid residue to an N-formyl-L-methionine, a natural pretranslational modification.


ModificationSetId: PSI-MOD
Name: L-selenocysteine residue
DiffFormula: C 0 H 0 N 0 O 0 Se 0
Formula: C 3 H 5 N 1 O 1 Se 1
AminoAcid: U
Definition:
A protein modification that effectively converts a source amino acid residue to an L-selenocysteine, a natural pretranslational modification.


ModificationSetId: PSI-MOD
Name: crosslinked residues
Definition: A protein modification that crosslinks two or more amino acid residues with covalent bonds.
Comment:
The covalent bond is formed directly between sidechain atoms. If non-aminoacid atoms are involved in connecting two or more peptide chain residues peptide chain, the connection is classified as a multivalent binding site.


ModificationSetId: PSI-MOD
Name: L-cystine (cross-link)
Definition: A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.
DiffFormula: C 0 H -2 N 0 O 0 S 0
Formula: C 6 H 8 N 2 O 2 S 2
Comment:
Cross-link 2; for formation of a disulfide bond between a peptide cysteine and a free cysteine, see MOD:00765.


ModificationSetId: PSI-MOD
SwissprotTerm: (3R)-3-hydroxyasparagine
Name: (2S,3R)-3-hydroxyasparagine
DiffFormula: C 0 H 0 N 0 O 1
Formula: C 4 H 6 N 2 O 3
AminoAcid: N
Definition:
A protein modification that effectively converts an L-asparagine residue to (2S,3R)-3-hydroxyasparagine.


ModificationSetId: PSI-MOD
SwissprotTerm: (3R)-3-hydroxyaspartate
Name: (2S,3R)-3-hydroxyaspartic acid
DiffFormula: C 0 H 0 N 0 O 1
Formula: C 4 H 5 N 1 O 4
AminoAcid: D
Definition:
A protein modification that effectively converts an L-aspartic acid residue to (2S,3R)-3-hydroxyaspartic acid.


ModificationSetId: PSI-MOD
Name: 5-hydroxy-L-lysine
DiffFormula: C 0 H 0 N 0 O 1
Formula: C 6 H 12 N 2 O 2
AminoAcid: K
Definition:
A protein modification that effectively converts an L-lysine  residue to one of the diastereomeric 5-hydroxy-L-lysine  residues.


ModificationSetId: PSI-MOD
SwissprotTerm: Pyrrolidone carboxylic acid
Name: 2-pyrrolidone-5-carboxylic acid (Gln)
Comment: DeltaMass gives a formula C 5 H 5 N 1 O 2 with mass 111.1
DiffFormula: C 0 H -3 N -1 O 0
Formula: C 5 H 6 N 1 O 2
AminoAcid: Q
Definition:
A protein modification that effectively converts an L-glutamine residue to 2-pyrrolidone-5-carboxylic acid.


ModificationSetId: PSI-MOD
SwissprotTerm: 4-carboxyglutamate
Name: L-gamma-carboxyglutamic acid
Comment: DeltaMass has an incorrect formula C 6 H 7 N 5 O 1 (N and O reversed) with mass 173.
DiffFormula: C 1 H 0 N 0 O 2
Formula: C 6 H 7 N 1 O 5
AminoAcid: E
Definition:
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.


ModificationSetId: PSI-MOD
SwissprotTerm: 4-aspartylphosphate
Name: L-aspartic 4-phosphoric anhydride
DiffFormula: C 0 H 1 N 0 O 3 P 1
Formula: C 4 H 6 N 1 O 6 P 1
AminoAcid: D
Definition:
A protein modification that effectively converts an L-aspartic acid residue to L-aspartic 4-phosphoric anhydride.


ModificationSetId: PSI-MOD
SwissprotTerm: Tele-phosphohistidine
Name: 1'-phospho-L-histidine
DiffFormula: C 0 H 1 N 0 O 3 P 1
Formula: C 6 H 8 N 3 O 4 P 1
AminoAcid: H
Definition:
A protein modification that effectively converts an L-histidine residue to tele-phospho-L-histidine (N-tau-phospho-L-histidine, 1'-phospho-L-histidine).


ModificationSetId: PSI-MOD
SwissprotTerm: Pros-phosphohistidine
Name: 3'-phospho-L-histidine
DiffFormula: C 0 H 1 N 0 O 3 P 1
Formula: C 6 H 8 N 3 O 4 P 1
AminoAcid: H
Definition:
A protein modification that effectively converts an L-histidine residue to pros-phospho-L-histidine (N-pi-phospho-L-histidine, 3'-phospho-L-histidine).


ModificationSetId: PSI-MOD
SwissprotTerm: N-acetylaspartate
Name: N-acetyl-L-aspartic acid
DiffFormula: C 2 H 2 N 0 O 1
Formula: C 6 H 8 N 1 O 4
AminoAcid: D
Definition:
A protein modification that effectively converts an L-aspartic acid residue to N-acetyl-L-aspartic acid.


ModificationSetId: PSI-MOD
SwissprotTerm: N-acetylglutamate
Name: N-acetyl-L-glutamic acid
DiffFormula: C 2 H 2 N 0 O 1
Formula: C 7 H 10 N 1 O 4
AminoAcid: E
Definition:
A protein modification that effectively converts an L-glutamic acid residue to N-acetyl-L-glutamic acid.


ModificationSetId: PSI-MOD
SwissprotTerm: N-methylalanine
Name: N-methyl-L-alanine
Definition: A protein modification that effectively converts an L-alanine residue to N-methyl-L-alanine.
DiffFormula: C 1 H 2 N 0 O 0
Formula: C 4 H 7 N 1 O 1
AminoAcid: A
Comment:
Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG].


ModificationSetId: PSI-MOD
Name: N-methylglycine
Definition: A protein modification that effectively converts a glycine residue to N-methylglycine.
DiffFormula: C 1 H 2 N 0 O 0
Formula: C 3 H 5 N 1 O 1
AminoAcid: G
Comment:
DeltaMass also has an entry for the free amino acid. Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG].


ModificationSetId: PSI-MOD
SwissprotTerm: N-methylphenylalanine
Name: N-methyl-L-phenylalanine
DiffFormula: C 1 H 2 N 0 O 0
Formula: C 10 H 11 N 1 O 1
AminoAcid: F
Definition:
A protein modification that effectively converts an L-phenylalanine residue to N-methyl-L-phenylalanine.

Comment:
Polypeptides with monomethylated amino terminals can undergo premature cleavage during the coupling step of an Edman degradation. This can result in "preview" with both a residue and the following residue being seen from the first step on through a sequence [JSG].


ModificationSetId: PSI-MOD
SwissprotTerm: Omega-N-methylated arginine
Name: symmetric dimethyl-L-arginine
DiffFormula: C 2 H 4 N 0 O 0
Formula: C 8 H 16 N 4 O 1
AminoAcid: R
Definition:
A protein modification that effectively converts an L-arginine residue to symmetric dimethylarginine, N(omega),N'(omega)-dimethyl-L-arginine.


ModificationSetId: PSI-MOD
SwissprotTerm: Asymmetric dimethylarginine
Name: asymmetric dimethyl-L-arginine
DiffFormula: C 2 H 4 N 0 O 0
Formula: C 8 H 16 N 4 O 1
AminoAcid: R
Definition:
A protein modification that effectively converts an L-arginine residue to asymmetric dimethylarginine, N(omega),N(omega)-dimethyl-L-arginine.


ModificationSetId: PSI-MOD
SwissprotTerm: Omega-N-methylarginine
Name: omega-N-methyl-L-arginine
DiffFormula: C 1 H 2 N 0 O 0
Formula: C 7 H 14 N 4 O 1
AminoAcid: R
Definition:
A protein modification that effectively converts an L-arginine residue to N(omega)-methyl-L-arginine.


ModificationSetId: PSI-MOD
SwissprotTerm: Glutamate methyl ester (Glu)
Name: L-glutamic acid 5-methyl ester (Glu)
DiffFormula: C 1 H 2 N 0 O 0
Formula: C 6 H 9 N 1 O 3
AminoAcid: E
Definition:
A protein modification that effectively converts an L-glutamic acid residue to L-glutamate 5-methyl ester.

Comment:
DeltaMass gives the formula "C 6 H 9 O 1 N 3" with mass 143 (formula incorrect, N and O reversed) [JSG].


ModificationSetId: PSI-MOD
SwissprotTerm: Pros-methylhistidine
Name: 3'-methyl-L-histidine
DiffFormula: C 1 H 2 N 0 O 0
Formula: C 7 H 9 N 3 O 1
AminoAcid: H
Definition:
A protein modification that effectively converts an L-histidine residue to pros-methyl-L-histidine (N-pi-methyl-L-histidine, 3'-methyl-L-histidine).


ModificationSetId: PSI-MOD
SwissprotTerm: N6,N6,N6-trimethyllysine
Name: N6,N6,N6-trimethyl-L-lysine
DiffFormula: C 3 H 7 N 0 O 0
Formula: C 9 H 19 N 2 O 1
AminoAcid: K
Definition:
A protein modification that effectively converts an L-lysine residue to N6,N6,N6-trimethyl-L-lysine.

Comment:
DeltaMass calculates the mass difference from protonated lysine rather than neutral lysine; for trimethylated lysine starting from protonated lysine see MOD:00855


ModificationSetId: PSI-MOD
SwissprotTerm: Aspartic acid 1-amide
Name: L-aspartic acid 1-amide
DiffFormula: C 0 H 1 N 1 O -1
Formula: C 4 H 7 N 2 O 3
AminoAcid: D
Definition:
A protein modification that effectively converts an L-aspartic acid residue to L-aspartic acid 1-amide.


ModificationSetId: PSI-MOD
SwissprotTerm: Glutamic acid 1-amide
Name: L-glutamic acid 1-amide
DiffFormula: C 0 H 1 N 1 O -1
Formula: C 5 H 9 N 2 O 3
AminoAcid: E
Definition:
A protein modification that effectively converts an L-glutamic acid residue to L-glutamic acid 1-amide.


ModificationSetId: PSI-MOD
SwissprotTerm: Phenylalanine amide
Name: L-phenylalanine amide
DiffFormula: C 0 H 1 N 1 O -1
Formula: C 9 H 11 N 2 O 1
AminoAcid: F
Definition:
A protein modification that effectively converts an L-phenylalanine residue to L-phenylalanine amide.


ModificationSetId: PSI-MOD
SwissprotTerm: Cysteine methyl disulfide
Name: L-cysteine methyl disulfide
DiffFormula: C 1 H 2 N 0 O 0 S 1
Formula: C 4 H 7 N 1 O 1 S 2
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to L-cysteine methyl disulfide.

Comment:
Produced artifactually by reaction of cysteine residues with methyl methanethiosulfonate (MMTS) [JSG].


ModificationSetId: PSI-MOD
Name: S-12-hydroxyfarnesyl-L-cysteine
DiffFormula: C 15 H 24 N 0 O 1 S 0
Formula: C 18 H 29 N 1 O 2 S 1
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to S-12-hydroxyfarnesyl-L-cysteine.


ModificationSetId: PSI-MOD
Name: S-geranylgeranyl-L-cysteine
Comment: DeltaMass calculates the mass with two double bonds rather than four
DiffFormula: C 20 H 32 N 0 O 0 S 0
Formula: C 23 H 37 N 1 O 1 S 1
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine.


ModificationSetId: PSI-MOD
Name: S-palmitoyl-L-cysteine
Definition: A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine.
DiffFormula: C 16 H 30 N 0 O 1 S 0
Formula: C 19 H 35 N 1 O 2 S 1
AminoAcid: C
Comment:
From DeltaMass: (name misspelled "S-palmityl Cystenyl" and formula incorrect, N and O reversed) Formula: C19H35O1N2S1 Monoisotopic Mass Change: 341.239 Average Mass Change: 341.556


ModificationSetId: PSI-MOD
Name: S-diacylglycerol-L-cysteine
Comment: Incidental to RESID:AA0060.
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to S-diacylglycerol-L-cysteine.


ModificationSetId: PSI-MOD
Name: S-(L-isoglutamyl)-L-cysteine
Comment: Cross-link 2; DeltaMass calculates the mass difference from glutamic acid rather than glutamine.
DiffFormula: C 0 H -3 N -1 O 0 S 0
Formula: C 8 H 10 N 2 O 3 S 1
Definition:
A protein modification that effectively crosslinks an L-cysteine residue and an L-glutamine residue by a thioester bond with the formation of S-(L-isoglutamyl)-L-cysteine and the release of ammonia.


ModificationSetId: PSI-MOD
Name: 2'-(S-L-cysteinyl)-L-histidine
Comment: Cross-link 2.
DiffFormula: C 0 H -2 N 0 O 0 S 0
Formula: C 9 H 10 N 4 O 2 S 1
Definition:
A protein modification that effectively cross-links an L-cysteine residue and an L-histidine residue by a thioether bond to form 2'-(S-L-cysteinyl)-L-histidine.


ModificationSetId: PSI-MOD
Name: L-lanthionine (Cys-Ser)
DiffFormula: C 0 H -2 N 0 O -1 S 0
Formula: C 6 H 8 N 2 O 2 S 1
Definition:
A protein modification that effectively cross-links an L-cysteine residue and an L-serine residue by a thioether bond to form L-lanthionine.

Comment:
Cross-link 2. The natural occurrence of this modification is rare. For the more common modification see MOD:00120 meso-lanthionine [JSG].


ModificationSetId: PSI-MOD
Name: meso-lanthionine
Comment: Cross-link 2.
DiffFormula: C 0 H -2 N 0 O -1 S 0
Formula: C 6 H 8 N 2 O 2 S 1
Definition:
A protein modification that effectively cross-links an L-cysteine residue and an L-serine residue by a thioether bond to form meso-lanthionine.


ModificationSetId: PSI-MOD
Name: (2S,3S,2'R)-3-methyllanthionine
Comment: Cross-link 2.
DiffFormula: C 0 H -2 N 0 O -1 S 0
Formula: C 7 H 10 N 2 O 2 S 1
Definition:
A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form (2S,3S,2'R)-3-methyllanthionine.


ModificationSetId: PSI-MOD
Name: 3'-(S-L-cysteinyl)-L-tyrosine
Comment: Cross-link 2.
DiffFormula: C 0 H -2 N 0 O 0 S 0
Formula: C 12 H 12 N 2 O 3 S 1
Definition:
A protein modification that effectively cross-links an L-cysteine residue and an L-tyrosine residue by a thioether bond to form 2-(S-L-cysteinyl)-L-tyrosine.


ModificationSetId: PSI-MOD
SwissprotTerm: Hypusine
Name: hypusine
Comment: This modification occurs uniquely in translation initiation factor eIF-5A [JSG].
DiffFormula: C 4 H 9 N 1 O 1
Formula: C 10 H 21 N 3 O 2
AminoAcid: K
Definition:
A protein modification that effectively converts an L-lysine residue to hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine.


ModificationSetId: PSI-MOD
SwissprotTerm: N6-biotinyllysine
Name: N6-biotinyl-L-lysine
Definition: A protein modification that effectively converts an L-lysine residue to N6-biotinyl-L-lysine.
DiffFormula: C 10 H 14 N 2 O 2 S 1
Formula: C 16 H 26 N 4 O 3 S 1
AminoAcid: K
Comment:
From DeltaMass: Average Mass: 354 Formula:C 16 H 26 O 4 N 3 S 1 (formula incorrect, N and O reversed) Monoisotopic Mass Change:354.172 Average Mass Change:354.471 References:PE Sciex.


ModificationSetId: PSI-MOD
SwissprotTerm: N6-(pyridoxal phosphate)lysine
Name: N6-pyridoxal phosphate-L-lysine
Comment: From DeltaMass: Average Mass: 231
DiffFormula: C 8 H 8 N 1 O 5 P 1
Formula: C 14 H 20 N 3 O 6 P 1
AminoAcid: K
Definition:
A protein modification that effectively converts an L-lysine residue to N6-pyridoxal phosphate-L-lysine.


ModificationSetId: PSI-MOD
SwissprotTerm: N6-(retinylidene)lysine
Name: N6-retinylidene-L-lysine
DiffFormula: C 20 H 26 N 0 O 0
Formula: C 26 H 38 N 2 O 1
AminoAcid: K
Definition:
A protein modification that effectively converts an L-lysine residue to N6-retinylidene-L-lysine, the adduct of retinal.


ModificationSetId: PSI-MOD
Name: L-2-aminoadipic acid
Definition: A protein modification that effectively converts an L-lysine residue to L-2-aminoadipic acid.
DiffFormula: C 0 H -3 N -1 O 2
Formula: C 6 H 9 N 1 O 3
AminoAcid: K
Comment:
From DeltaMass: References:Amici A, Levine, RL, Tsai, L, and Stadtman, ER: Conversion of amino acid residues in proteins and amino acid homopolymers to carbonyl derivatives by metal-catalyzed oxidation reactions. Journal of Biological Chemistry 264: 3341-3346 1989.Requena JR, Chao CC, Levine RL, and Stadtman ER: Glutamic and aminoadipic semialdehydes are the main carbonyl products of metal-catalyzed oxidation of proteins. Proceedings of the National Academy of Sciences USA 98: 69-74 2001. Notes:Expected reaction following oxidation of lysine to aminoadipic semialdehyde. Not proven experimentally but deduced by reference to the similar known reaction of oxidation of Arg to Glu via the semialdehyde. [This has been observed as a natural modification, see RESID:AA0122. JSG]


ModificationSetId: PSI-MOD
Name: L-lysinoalanine (Lys-Ser)
DiffFormula: C 0 H -2 N 0 O -1
Formula: C 9 H 15 N 3 O 2
Definition:
A protein modification that effectively crosslinks an L-serine residue and an L-lysine residue to release water and form 2-amino-6-(2-amino-2-carboxyethylamino)hexanoic acid.

Comment:
Cross-link 2. This entry is for the crosslink of peptidyl serine and peptidyl lysine. For the modification of peptidyl lysine by a free serine see MOD:01838. From DeltaMass: Average Mass: -34.


ModificationSetId: PSI-MOD
Name: N6-(L-isoglutamyl)-L-lysine (Gln)
Comment: Cross-link 2.
DiffFormula: C 0 H -3 N -1 O 0
Formula: C 11 H 17 N 3 O 3
Definition:
A protein modification that effectively crosslinks an L-glutamine residue and an L-lysine residue by an isopeptide bond with the formation of N6-(L-isoglutamyl)-L-lysine and the release of ammonia.


ModificationSetId: PSI-MOD
Name: N6-glycyl-L-lysine
DiffFormula: C 0 H -2 N 0 O -1
Formula: C 8 H 14 N 3 O 2
Definition:
A protein modification that effectively crosslinks an L-lysine residue and a glycine residue by an isopeptide bond to form N6-glycyl-L-lysine.

Comment:
Cross-link 2; this is the common crosslink structure formed by ubiquitin, SUMO, and similar proteins.


ModificationSetId: PSI-MOD
Name: N-(L-isoaspartyl)-glycine (Asn)
Comment: Cross-link 2.
DiffFormula: C 0 H -3 N -1 O 0
Formula: C 6 H 7 N 2 O 3
Definition:
A protein modification that effectively crosslinks an L-asparagine residue and a glycine residue by an isopeptide bond with formation of N-(L-isoaspartyl)glycine and the release of ammonia.


ModificationSetId: PSI-MOD
SwissprotTerm: 3-phenyllactic acid
Name: L-3-phenyllactic acid
DiffFormula: C 0 H -1 N -1 O 1
Formula: C 9 H 9 O 2
AminoAcid: F
Definition:
A protein modification that effectively converts an L-phenylalanine residue into L-3-phenyllactic acid.

Comment:
This modification is not the result of deamidation, instead the alpha amino group is replaced with an hydroxyl group.


ModificationSetId: PSI-MOD
SwissprotTerm: N2-succinyltryptophan
Name: N2-succinyl-L-tryptophan
DiffFormula: C 4 H 4 N 0 O 3
Formula: C 15 H 15 N 2 O 4
AminoAcid: W
Definition:
A protein modification that effectively converts an L-tryptophan residue to N2-succinyl-L-tryptophan.


ModificationSetId: PSI-MOD
Name: S-phycocyanobilin-L-cysteine
Comment: From DeltaMass: Average Mass: 587.
DiffFormula: C 33 H 38 N 4 O 6 S 0
Formula: C 36 H 43 N 5 O 7 S 1
AminoAcid: C
Definition:
A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound phycocyanobilin.


ModificationSetId: PSI-MOD
Name: S-phycoerythrobilin-L-cysteine
DiffFormula: C 33 H 40 N 4 O 6 S 0
Formula: C 36 H 45 N 5 O 7 S 1
AminoAcid: C
Definition:
A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound phycoerythrobilin.


ModificationSetId: PSI-MOD
Name: S-phytochromobilin-L-cysteine
DiffFormula: C 33 H 36 N 4 O 6 S 0
Formula: C 36 H 41 N 5 O 7 S 1
AminoAcid: C
Definition:
A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound phytochromobilin.


ModificationSetId: PSI-MOD
Name: heme-bis-L-cysteine
Comment: Cross-link 2.
DiffFormula: C 34 Fe 1 H 32 N 4 O 4 S 0
Formula: C 40 Fe 1 H 42 N 6 O 6 S 2
Definition:
A protein modification that effectively results from forming an adduct between two cysteine residues and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron.


ModificationSetId: PSI-MOD
Name: heme-L-cysteine
Comment: From DeltaMass: Average Mass: 617.
DiffFormula: C 34 Fe 1 H 32 N 4 O 4 S 0
Formula: C 37 Fe 1 H 37 N 5 O 5 S 1
AminoAcid: C
Definition:
A protein modification that effectively results from forming an adduct between a cysteine residue and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron.


ModificationSetId: PSI-MOD
Name: tetrakis-L-cysteinyl iron
Comment: Cross-link 4.
DiffFormula: C 0 Fe 1 H -4 N 0 O 0 S 0
Formula: C 12 Fe 1 H 16 N 4 O 4 S 4
Definition:
A protein modification that effectively converts four L-cysteine residues iron atom to tetrakis-L-cysteinyl iron.


ModificationSetId: PSI-MOD
Name: tetrakis-L-cysteinyl diiron disulfide
Comment: Cross-link 4.
DiffFormula: C 0 Fe 2 H -4 N 0 O 0 S 2
Formula: C 12 Fe 2 H 16 N 4 O 4 S 6
Definition:
A protein modification that effectively converts four L-cysteine residues and a two-iron two-sulfur cluster to tetrakis-L-cysteinyl diiron disulfide.


ModificationSetId: PSI-MOD
Name: hexakis-L-cysteinyl triiron trisulfide
Comment: Cross-link 6. This is a deprecated entry in RESID. It probably does not occur naturally [JSG].
DiffFormula: C 0 Fe 3 H -6 N 0 O 0 S 3
Formula: C 18 Fe 3 H 24 N 6 O 6 S 9
Definition:
A protein modification that effectively converts six L-cysteine residues and a three-iron three-sulfur cluster to hexakis-L-cysteinyl triiron trisulfide.


ModificationSetId: PSI-MOD
Name: tris-L-cysteinyl triiron tetrasulfide
Comment: Cross-link 3.
DiffFormula: C 0 Fe 3 H -3 N 0 O 0 S 4
Formula: C 9 Fe 3 H 12 N 3 O 3 S 7
Definition:
A protein modification that effectively converts three L-cysteine residues and a three-iron four-sulfur cluster to tris-L-cysteinyl triiron tetrasulfide.


ModificationSetId: PSI-MOD
Name: tetrakis-L-cysteinyl tetrairon tetrasulfide
Comment: Cross-link 4.
DiffFormula: C 0 Fe 4 H -4 N 0 O 0 S 4
Formula: C 12 Fe 4 H 16 N 4 O 4 S 8
Definition:
A protein modification that effectively converts four L-cysteine residues and a four-iron four-sulfur cluster to tetrakis-L-cysteinyl tetrairon tetrasulfide.


ModificationSetId: PSI-MOD
Name: L-cysteinyl-L-histidino-homocitryl molybdenum heptairon nonasulfide
Comment: Cross-link 2; incidental to RESID:AA0300.
DiffFormula: C 7 Fe 7 H 6 Mo 1 N 1 O 7 S 9
Formula: C 16 Fe 7 H 18 Mo 1 N 5 O 9 S 10
Definition:
A protein modification that effectively converts an L-cysteine residue, an L-histidine residue, homocitric acid and a one-molybdenum seven-iron nine-sulfur cluster to L-cysteinyl-L-histidino-homocitryl molybdenum heptairon nonasulfide.


ModificationSetId: PSI-MOD
Name: L-cysteinyl molybdopterin
DiffFormula: C 10 H 11 Mo 1 N 5 O 8 P 1 S 2
Formula: C 13 H 16 Mo 1 N 6 O 9 P 1 S 3
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to L-cysteinyl molybdopterin.


ModificationSetId: PSI-MOD
SwissprotTerm: S-8alpha-FAD cysteine
Name: S-(8alpha-FAD)-L-cysteine
DiffFormula: C 27 H 31 N 9 O 15 P 2 S 0
Formula: C 30 H 36 N 10 O 16 P 2 S 1
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to S'-(8alpha-FAD)-L-cystine.


ModificationSetId: PSI-MOD
SwissprotTerm: Pros-8alpha-FAD histidine
Name: 3'-(8alpha-FAD)-L-histidine
DiffFormula: C 27 H 31 N 9 O 15 P 2
Formula: C 33 H 38 N 12 O 16 P 2
AminoAcid: H
Definition:
A protein modification that effectively converts an L-histidine residue to 3'-(8alpha-FAD)-L-histidine.


ModificationSetId: PSI-MOD
SwissprotTerm: O-8alpha-FAD tyrosine
Name: O4'-(8alpha-FAD)-L-tyrosine
Comment: From DeltaMass: Average Mass: 783
DiffFormula: C 27 H 31 N 9 O 15 P 2
Formula: C 36 H 40 N 10 O 17 P 2
AminoAcid: Y
Definition:
A protein modification that effectively converts an L-tyrosine residue to O4'-(8alpha-FAD)-L-tyrosine.


ModificationSetId: PSI-MOD
SwissprotTerm: 3',4'-dihydroxyphenylalanine
Name: 3'-hydroxylation of L-tyrosine to L-3',4'-dihydroxyphenylalanine
Comment: incidental to RESID:AA0368 From DeltaMass: Average Mass: 16
DiffFormula: C 0 H 0 N 0 O 1
Formula: C 9 H 9 N 1 O 3
AminoAcid: Y
Definition:
A protein modification that effectively converts an L-tyrosine residue to L-3',4'-dihydroxyphenylalanine.


ModificationSetId: PSI-MOD
SwissprotTerm: 2',4',5'-topaquinone
Name: oxidation of tyrosine to L-2',4',5'-topaquinone
DiffFormula: C 0 H -2 N 0 O 2
Formula: C 9 H 7 N 1 O 4
AminoAcid: Y
Definition:
A protein modification that effectively converts an L-tyrosine residue to an L-2',4',5'-topaquinone.


ModificationSetId: PSI-MOD
SwissprotTerm: Tryptophylquinone
Name: oxidation of tryptophan to L-tryptophyl quinone
Comment: incidental to RESID:AA0149; incidental to RESID:AA0313; From DeltaMass: Average Mass: 30.
DiffFormula: C 0 H -2 N 0 O 2
Formula: C 11 H 8 N 2 O 3
AminoAcid: W
Definition:
A protein modification that effectively converts an L-tryptophan residue to an L-tryptophan quinone.


ModificationSetId: PSI-MOD
Name: 4'-(L-tryptophan)-L-tryptophyl quinone
Comment: Cross-link 2; secondary to RESID:AA0148; From DeltaMass: Average Mass: 28.
DiffFormula: C 0 H -4 N 0 O 2
Formula: C 22 H 16 N 4 O 4
Definition:
A protein modification that effectively cross-links two L-tryptophan residues by a carbon-carbon bond to form 4'-(L-tryptophan)-L-tryptophyl quinone.


ModificationSetId: PSI-MOD
SwissprotTerm: O-(pantetheine 4'-phosphoryl)serine
Name: O-phosphopantetheine-L-serine
Comment: UniMod has DiffFormula C 11 H 20 N 2 O 6 P 1 S 1 From DeltaMass: Average Mass: 339
DiffFormula: C 11 H 21 N 2 O 6 P 1 S 1
Formula: C 14 H 26 N 3 O 8 P 1 S 1
AminoAcid: S
Definition:
A protein modification that effectively converts an L-serine residue to O-phosphopantetheine-L-serine.


ModificationSetId: PSI-MOD
Name: N4-glycosyl-L-asparagine
AminoAcid: N
Definition:
A protein modification that effectively converts an L-asparagine residue to an N4-glycosyl-L-asparagine.


ModificationSetId: PSI-MOD
Name: S-glucosyl-L-cysteine
DiffFormula: C 6 H 10 N 0 O 5 S 0
Formula: C 9 H 15 N 1 O 6 S 1
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to S-glucosylated L-cysteine.


ModificationSetId: PSI-MOD
Name: O5-glucosylgalactosyl-L-hydroxylysine
Comment: Secondary to RESID:AA0028.
DiffFormula: C 12 H 20 N 0 O 11
Formula: C 18 H 32 N 2 O 12
AminoAcid: K
Definition:
A protein modification that effectively converts an L-lysine residue to O5-glucosylgalactosyl-L-hydroxylysine.


ModificationSetId: PSI-MOD
Name: O-(N-acetylamino)galactosyl-L-serine
DiffFormula: C 8 H 13 N 1 O 5
Formula: C 11 H 18 N 2 O 7
AminoAcid: S
Definition:
A protein modification that effectively converts an L-serine residue to O-(N-acetylaminogalactosyl)-L-serine.


ModificationSetId: PSI-MOD
Name: O-(N-acetylamino)galactosyl-L-threonine
DiffFormula: C 8 H 13 N 1 O 5
Formula: C 12 H 20 N 2 O 7
AminoAcid: T
Definition:
A protein modification that effectively converts an L-asparagine residue to O-(N-acetylaminogalactosyl)-L-threonine.


ModificationSetId: PSI-MOD
Name: 1'-mannosyl-L-tryptophan
DiffFormula: C 6 H 10 N 0 O 5
Formula: C 17 H 20 N 2 O 6
AminoAcid: W
Definition:
A protein modification that effectively converts an L-tryptophan residue to 1'-mannosyl-L-tryptophan.


ModificationSetId: PSI-MOD
Name: N-asparaginyl-glycosylphosphatidylinositolethanolamine
DiffFormula: C 2 H 6 N 1 O 3 P 1
Formula: C 6 H 13 N 3 O 6 P 1
AminoAcid: N
Definition:
A protein modification that effectively converts an L-asparagine residue to N-asparaginyl-glycosylphosphatidylinositolethanolamine.


ModificationSetId: PSI-MOD
Name: N-aspartyl-glycosylphosphatidylinositolethanolamine
DiffFormula: C 2 H 6 N 1 O 3 P 1
Formula: C 6 H 12 N 2 O 7 P 1
AminoAcid: D
Definition:
A protein modification that effectively converts an L-aspartic acid residue to N-(aspart-1-yl)-glycosylphosphatidylinositolethanolamine.


ModificationSetId: PSI-MOD
Name: N-cysteinyl-glycosylphosphatidylinositolethanolamine
DiffFormula: C 2 H 6 N 1 O 3 P 1 S 0
Formula: C 5 H 12 N 2 O 5 P 1 S 1
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to N-cysteinyl-glycosylphosphatidylinositolethanolamine.


ModificationSetId: PSI-MOD
Name: N-glycyl-glycosylphosphatidylinositolethanolamine
DiffFormula: C 2 H 6 N 1 O 3 P 1
Formula: C 4 H 10 N 2 O 5 P 1
AminoAcid: G
Definition:
A protein modification that effectively converts a glycine residue to N-glycyl-glycosylphosphatidylinositolethanolamine.


ModificationSetId: PSI-MOD
Name: N-seryl-glycosylphosphatidylinositolethanolamine
DiffFormula: C 2 H 6 N 1 O 3 P 1
Formula: C 5 H 12 N 2 O 6 P 1
AminoAcid: S
Definition:
A protein modification that effectively converts an L-serine residue to N-seryl-glycosylphosphatidylinositolethanolamine.


ModificationSetId: PSI-MOD
Name: N-alanyl-glycosylphosphatidylinositolethanolamine
DiffFormula: C 2 H 6 N 1 O 3 P 1
Formula: C 5 H 12 N 2 O 5 P 1
AminoAcid: A
Definition:
A protein modification that effectively converts an L-alanine residue to N-alanyl-glycosylphosphatidylinositolethanolamine.


ModificationSetId: PSI-MOD
Name: N-threonyl-glycosylphosphatidylinositolethanolamine
DiffFormula: C 2 H 6 N 1 O 3 P 1
Formula: C 6 H 14 N 2 O 6 P 1
AminoAcid: T
Definition:
A protein modification that effectively converts an L-threonine residue to N-threonyl-glycosylphosphatidylinositolethanolamine.


ModificationSetId: PSI-MOD
Name: N-glycyl-glycosylsphingolipidinositolethanolamine
DiffFormula: C 2 H 6 N 1 O 3 P 1
Formula: C 4 H 10 N 2 O 5 P 1
AminoAcid: G
Definition:
A protein modification that effectively converts a glycine residue to N-glycyl-glycosylsphingolipidinositolethanolamine.


ModificationSetId: PSI-MOD
Name: N-seryl-glycosylsphingolipidinositolethanolamine
DiffFormula: C 2 H 6 N 1 O 3 P 1
Formula: C 5 H 12 N 2 O 6 P 1
AminoAcid: S
Definition:
A protein modification that effectively converts an L-serine residue to N-seryl-glycosylsphingolipidinositolethanolamine.


ModificationSetId: PSI-MOD
SwissprotTerm: O-(phosphoribosyl dephospho-coenzyme A)serine
Name: O-(phosphoribosyl dephospho-coenzyme A)-L-serine
Comment: pRibodePcoA
DiffFormula: C 26 H 42 N 7 O 19 P 3 S 1
Formula: C 29 H 47 N 8 O 21 P 3 S 1
AminoAcid: S
Definition:
A protein modification that effectively converts an L-serine residue to O-(phosphoribosyl dephospho-coenzyme A)-L-serine.


ModificationSetId: PSI-MOD
SwissprotTerm: ADP-ribosylarginine
Name: omega-N-(ADP-ribosyl)-L-arginine
Comment: From DeltaMass: Average Mass: 541.
DiffFormula: C 15 H 21 N 5 O 13 P 2
Formula: C 21 H 33 N 9 O 14 P 2
AminoAcid: R
Definition:
A protein modification that effectively converts an L-argininine residue to omega-N-(ADP-ribosyl)-L-arginine.


ModificationSetId: PSI-MOD
SwissprotTerm: ADP-ribosylcysteine
Name: S-(ADP-ribosyl)-L-cysteine
Comment: From DeltaMass: Average Mass: 541.
DiffFormula: C 15 H 21 N 5 O 13 P 2 S 0
Formula: C 18 H 26 N 6 O 14 P 2 S 1
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to S-(ADP-ribosyl)-L-cysteine.


ModificationSetId: PSI-MOD
SwissprotTerm: 5-glutamyl glycerylphosphorylethanolamine
Name: L-glutamyl 5-glycerylphosphorylethanolamine
Comment: glycerylPE
DiffFormula: C 5 H 12 N 1 O 5 P 1
Formula: C 10 H 19 N 2 O 8 P 1
AminoAcid: E
Definition:
A protein modification that effectively converts an L-glutamic acid residue to L-glutamyl 5-glycerylphosphorylethanolamine.


ModificationSetId: PSI-MOD
Name: L-2'-bromophenylalanine
DiffFormula: Br 1 C 0 H -1 N 0 O 0
Formula: Br 1 C 9 H 8 N 1 O 1
AminoAcid: F
Definition:
A protein modification that effectively converts an L-phenylalanine residue to L-2'-bromophenylalanine.

Comment:
From DeltaMass: Average Mass: 78 Average Mass Change:78 References:Yoshino,K et.al. Biochemistry Vol. 30 pg 6203-9 (1991) Identifidation of a novel amino acid, o-bromo-L-phenylananine, in egg-associated peptides that activate spermatozoa.


ModificationSetId: PSI-MOD
Name: L-3'-bromophenylalanine
DiffFormula: Br 1 C 0 H -1 N 0 O 0
Formula: Br 1 C 9 H 8 N 1 O 1
AminoAcid: F
Definition:
A protein modification that effectively converts an L-phenylalanine residue to L-3'-bromophenylalanine.


ModificationSetId: PSI-MOD
Name: L-4'-bromophenylalanine
DiffFormula: Br 1 C 0 H -1 N 0 O 0
Formula: Br 1 C 9 H 8 N 1 O 1
AminoAcid: F
Definition:
A protein modification that effectively converts an L-phenylalanine residue to L-4'-bromophenylalanine.


ModificationSetId: PSI-MOD
SwissprotTerm: Triiodothyronine
Name: 3',3'',5'-triiodo-L-thyronine
Comment: From DeltaMass: Average Mass: 470.
DiffFormula: C 6 H 1 I 3 N 0 O 1
Formula: C 15 H 10 I 3 N 1 O 3
AminoAcid: Y
Definition:
A protein modification that effectively substitutes an L-tyrosine residue with 3',3'',5'-triiodo-L-thyronine.


ModificationSetId: PSI-MOD
SwissprotTerm: (Z)-2,3-didehydrotyrosine
Name: (Z)-2,3-didehydrotyrosine
Definition: A protein modification that effectively converts L-tyrosine to (Z)-2,3-didehydrotyrosine.
DiffFormula: C 0 H -2 N 0 O 0
Formula: C 9 H 7 N 1 O 2
AminoAcid: Y
Comment:
incidental to RESID:AA0184; incidental to RESID:AA0187; incidental to RESID:AA0188; incidental to RESID:AA0189; incidental to RESID:AA0378; incidental to RESID:AA0379; incidental to RESID:AA0380; incidental to RESID:AA0381


ModificationSetId: PSI-MOD
Name: L-serine 5-imidazolinone glycine
Comment: Cross-link 2; carboxamidine; incidental to RESID:AA0183; incidental to RESID:AA0365.
DiffFormula: C 0 H -2 N 0 O -1
Formula: C 5 H 6 N 2 O 2
Definition:
A protein modification that effectively crosslinks an L-serine residue and a glycine residue to form L-serine 5-imidazolinone glycine.


ModificationSetId: PSI-MOD
SwissprotTerm: Lactic acid
Name: lactic acid
DiffFormula: C 0 H -1 N -1 O 0
Formula: C 3 H 5 O 2
AminoAcid: S
Definition:
A protein modification that effectively converts an L-serine residue to an amino-terminal lactic acid.


ModificationSetId: PSI-MOD
Name: L-alanine 5-imidazolinone glycine
DiffFormula: C 0 H -2 N 0 O -1
Formula: C 5 H 6 N 2 O 1
Definition:
A protein modification that effectively crosslinks an L-alanine residue and a glycine residue to form L-alanine 5-imidazolinone glycine.

Comment:
Cross-link 2; carboxamidine; incidental to RESID:AA0181; incidental to RESID:AA0183; incidental to RESID:AA0365.


ModificationSetId: PSI-MOD
Name: L-cysteine 5-imidazolinone glycine
DiffFormula: C 0 H -2 N 0 O -1 S 0
Formula: C 5 H 6 N 2 O 1 S 1
Definition:
A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue to form L-cysteine 5-imidazolinone glycine.

Comment:
Cross-link 2; carboxamidine; incidental to RESID:AA0181; incidental to RESID:AA0183; incidental to RESID:AA0365.


ModificationSetId: PSI-MOD
Name: 2-imino-glutamine 5-imidazolinone glycine
Comment: Cross-link 2; carboxamidine; incidental to RESID:AA0183; incidental to RESID:AA0365.
DiffFormula: C 0 H -4 N 0 O -1
Formula: C 7 H 7 N 3 O 2
Definition:
A protein modification that effectively crosslinks an L-glutamine residue and a glycine residue to form 2-imino-glutamine 5-imidazolinone glycine.


ModificationSetId: PSI-MOD
SwissprotTerm: 5-glutamyl polyglycine
Name: L-isoglutamyl-polyglycine
DiffFormula: C 2 H 3 N 1 O 1
Formula: C 7 H 10 N 2 O 4
AminoAcid: E
Definition:
A protein modification that effectively converts an L-glutamic acid residue to L-isoglutamyl-polyglycine.


ModificationSetId: PSI-MOD
Name: L-isoglutamyl-polyglutamic acid
DiffFormula: C 5 H 7 N 1 O 3
Formula: C 10 H 14 N 2 O 6
AminoAcid: E
Definition:
A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl-polyglutamic acid, forming an isopeptide bond with a polyglutamic acid.


ModificationSetId: PSI-MOD
SwissprotTerm: O-AMP-tyrosine
Name: O4'-(phospho-5'-adenosine)-L-tyrosine
Comment: From DeltaMass: Average Mass: 329.
DiffFormula: C 10 H 12 N 5 O 6 P 1
Formula: C 19 H 21 N 6 O 8 P 1
AminoAcid: Y
Definition:
A protein modification that effectively crosslinks an L-tyrosine residue and 5'-phosphoadenosine through a phosphodiester bond to form O4'-(phospho-5'-adenosine)-L-tyrosine.


ModificationSetId: PSI-MOD
Name: S-(2-aminovinyl)-D-cysteine (Cys-Ser)
Comment: Cross-link 2.
DiffFormula: C -1 H -4 N 0 O -3 S 0
Formula: C 5 H 7 N 2 O 1 S 1
Definition:
A protein modification that effectively cross-links an L-cysteine residue and an L-serine residue by a thioether bond to form S-(2-aminovinyl)-D-cysteine.


ModificationSetId: PSI-MOD
SwissprotTerm: Cysteine sulfenic acid (-SOH)
Name: L-cysteine sulfenic acid
DiffFormula: C 0 H 0 N 0 O 1 S 0
Formula: C 3 H 5 N 1 O 2 S 1
AminoAcid: C
Definition:
A protein modification that effectively monooxygenates an L-cysteine residue to L-cysteine sulfenic acid.

Comment:
From DeltaMass: Average Mass: 16 Average Mass Change:16 Notes:Green et al. in J. B. C. 270, 18209-18211 (1995) quote Kim and Raines in Eur. J. Biochem. 224, 109-114 (1994). Kim and Raines using ESI-MS and sulfhydryl group titration found that bovine seminal ribonuclease contains a single oxidized sulfhydryl group, which cannot participate in a disulfide bond. This form of cysteine is called sulfenic acid (-SOH).


ModificationSetId: PSI-MOD
Name: S-(glycyl)-L-cysteine (Cys-Gly)
DiffFormula: C 0 H -2 N 0 O -1 S 0
Formula: C 5 H 7 N 2 O 2 S 1
Definition:
A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.

Comment:
Cross-link 2. For the modification of a C-terminal glycine by formation of a thioester bond with free L-cycteine see MOD:01777 [JSG].


ModificationSetId: PSI-MOD
SwissprotTerm: S-(4-hydroxycinnamyl)cysteine
Name: S-4-hydroxycinnamyl-L-cysteine
DiffFormula: C 9 H 6 N 0 O 2 S 0
Formula: C 12 H 11 N 1 O 3 S 1
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to S-4-hydroxycinnamyl-L-cysteine.


ModificationSetId: PSI-MOD
Name: chondroitin sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine
DiffFormula: C 0 H -1 N 0 O 0
Formula: C 3 H 4 N 1 O 2
AminoAcid: S
Definition:
A protein modification that effectively cross-links an L-serine residue to the polymer chondroitin sulfate by a D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl tetrasaccharide.


ModificationSetId: PSI-MOD
Name: dermatan 4-sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine
DiffFormula: C 0 H -1 N 0 O 0
Formula: C 3 H 4 N 1 O 2
AminoAcid: S
Definition:
A protein modification that effectively cross-links an L-serine residue to the polymer dermatan 4-sulfate by a D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl tetrasaccharide.


ModificationSetId: PSI-MOD
Name: heparan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine
DiffFormula: C 0 H -1 N 0 O 0
Formula: C 3 H 4 N 1 O 2
AminoAcid: S
Definition:
A protein modification that effectively cross-links an L-serine residue to the polymer heparan sulfate by a D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl tetrasaccharide.


ModificationSetId: PSI-MOD
Name: O4-arabinosyl-L-hydroxyproline
Comment: secondary to RESID:AA0030; From DeltaMass: Average Mass: 147.
DiffFormula: C 5 H 8 N 0 O 5
Formula: C 10 H 15 N 1 O 6
AminoAcid: P
Definition:
A protein modification that effectively converts an L-proline residue to O4-arabinosyl-L-hydroxyproline.


ModificationSetId: PSI-MOD
SwissprotTerm: O-(5'-phospho-RNA)-serine
Name: O-(phospho-5'-RNA)-L-serine
DiffFormula: C 0 H 0 N 0 O 3 P 1
Formula: C 3 H 5 N 1 O 5 P 1
AminoAcid: S
Definition:
A protein modification that effectively crosslinks an L-serine residue and the 5'-end of RNA through a phosphodiester to form O4'-(phospho-5'-RNA)-L-serine.


ModificationSetId: PSI-MOD
SwissprotTerm: Citrulline
Name: L-citrulline
Definition: A protein modification that effectively converts an L-arginine residue to L-citrulline.
DiffFormula: C 0 H -1 N -1 O 1
Formula: C 6 H 11 N 3 O 2
AminoAcid: R
Comment:
This modification is not the result of deamidation, instead the guanidino group is replaced with an ureido group.


ModificationSetId: PSI-MOD
Name: N-(L-isoaspartyl)-L-cysteine
Comment: Cross-link 2.
DiffFormula: C 0 H -3 N -1 O 0 S 0
Formula: C 7 H 9 N 2 O 3 S 1
Definition:
A protein modification that effectively crosslinks L-aspartic acid and L-cysteine residues via an isopeptide bond to form N-(L-isoaspartyl)-L-cysteine.


ModificationSetId: PSI-MOD
Name: 2'-alpha-mannosyl-L-tryptophan
DiffFormula: C 6 H 10 N 0 O 5
Formula: C 17 H 20 N 2 O 6
AminoAcid: W
Definition:
A protein modification that effectively converts an L-tryptophan residue to 2'-alpha-mannosyl-L-tryptophan.


ModificationSetId: PSI-MOD
SwissprotTerm: Aspartate 1-(chondroitin 4-sulfate)-ester
Name: 1-chondroitin sulfate-L-aspartic acid ester
DiffFormula: C 14 H 19 N 1 O 13 S 1
Formula: C 18 H 25 N 2 O 17 S 1
AminoAcid: D
Definition:
A protein modification that effectively converts an L-aspartic acid residue to 1-chondroitin sulfate-L-aspartic acid ester


ModificationSetId: PSI-MOD
SwissprotTerm: Tele-8alpha-FAD histidine
Name: 1'-(8alpha-FAD)-L-histidine
Comment: From DeltaMass: Average Mass: 784
DiffFormula: C 27 H 31 N 9 O 15 P 2
Formula: C 33 H 38 N 12 O 16 P 2
AminoAcid: H
Definition:
A protein modification that effectively converts an L-histidine residue to 1'-(8alpha-FAD)-L-histidine.


ModificationSetId: PSI-MOD
SwissprotTerm: Phosphoarginine
Name: omega-N-phospho-L-arginine
DiffFormula: C 0 H 1 N 0 O 3 P 1
Formula: C 6 H 13 N 4 O 4 P 1
AminoAcid: R
Definition:
A protein modification that effectively converts an L-arginine residue to omega-N-phospho-L-arginine.


ModificationSetId: PSI-MOD
Name: S-diphytanylglycerol diether-L-cysteine
Comment: incidental to RESID:AA0043.
DiffFormula: C 43 H 86 N 0 O 2 S 0
Formula: C 46 H 91 N 1 O 3 S 1
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to S-diphytanylglycerol diether-L-cysteine.


ModificationSetId: PSI-MOD
Name: alpha-1-microglobulin-Ig alpha complex chromophore
Comment: Cross-link 2.
DiffFormula: C 0 H -2 N 0 O 0 S 0
Formula: C 6 H 8 N 2 O 2 S 2
Definition:
A protein modification that effectively converts two L-cysteine residues to form alpha-1-microglobulin-Ig alpha complex chromophore.


ModificationSetId: PSI-MOD
Name: bis-L-cysteinyl bis-L-histidino diiron disulfide
Comment: Cross-link 4.
DiffFormula: C 0 Fe 2 H -4 N 0 O 0 S 2
Formula: C 18 Fe 2 H 20 N 8 O 4 S 4
Definition:
A protein modification that effectively converts two L-cysteine residues, two L-histidine residues and a two-iron two-sulfur cluster to bis-L-cysteinyl bis-L-histidino diiron disulfide.


ModificationSetId: PSI-MOD
Name: hexakis-L-cysteinyl hexairon hexasulfide
Comment: Cross-link 6. This is a deprecated entry in RESID. It probably does not occur naturally [JSG].
DiffFormula: C 0 Fe 6 H -6 N 0 O 0 S 6
Formula: C 18 Fe 6 H 24 N 6 O 6 S 12
Definition:
A protein modification that effectively converts six L-cysteine residues and a six-iron six-sulfur cluster to hexakis-L-cysteinyl hexairon hexasulfide.


ModificationSetId: PSI-MOD
Name: N6-(phospho-5'-adenosine)-L-lysine
DiffFormula: C 10 H 12 N 5 O 6 P 1
Formula: C 16 H 24 N 7 O 7 P 1
AminoAcid: K
Definition:
A protein modification that effectively crosslinks an L-lysine residue and 5'-phosphoadenosine through a phosphoramide ester bond to form N6-(phospho-5'-adenosine)-L-lysine.


ModificationSetId: PSI-MOD
Name: N6-(phospho-5'-guanosine)-L-lysine
DiffFormula: C 10 H 12 N 5 O 7 P 1
Formula: C 16 H 24 N 7 O 8 P 1
AminoAcid: K
Definition:
A protein modification that effectively crosslinks an L-lysine residue and 5'-phosphoguanosine through a phosphoramide ester bond to form N6-(phospho-5'-guanosine)-L-lysine.

Comment:
From DeltaMass: Average Mass: 345 Formula:C10H12O5N7P1 Monoisotopic Mass Change:345.047 Average Mass Change:345.209 References:PE Sciex


ModificationSetId: PSI-MOD
SwissprotTerm: S-glutathionyl cysteine
Name: L-cysteine glutathione disulfide
Comment: From DeltaMass: Average Mass: 305
DiffFormula: C 10 H 15 N 3 O 6 S 1
Formula: C 13 H 20 N 4 O 7 S 2
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to S-glutathionyl-L-cysteine.


ModificationSetId: PSI-MOD
SwissprotTerm: ADP-ribosylasparagine
Name: N4-(ADP-ribosyl)-L-asparagine
DiffFormula: C 15 H 21 N 5 O 13 P 2
Formula: C 19 H 27 N 7 O 15 P 2
AminoAcid: N
Definition:
A protein modification that effectively converts an L-asparagine residue to N4-(ADP-ribosyl)-L-asparagine.


ModificationSetId: PSI-MOD
SwissprotTerm: 3-methylthioaspartic acid
Name: L-beta-methylthioaspartic acid
DiffFormula: C 1 H 2 N 0 O 0 S 1
Formula: C 5 H 7 N 1 O 3 S 1
AminoAcid: D
Definition:
A protein modification that effectively converts an L-aspartic acid residue to L-beta-methylthioaspartic acid.


ModificationSetId: PSI-MOD
Name: 5'-(N6-L-lysine)-L-topaquinone
Comment: Cross-link 2; secondary to RESID:AA0147.
DiffFormula: C 0 H -4 N 0 O 1
Formula: C 15 H 17 N 3 O 4
Definition:
A protein modification that effectively cross-links an L-lysine residue and an L-tyrosine residue by a carbon-nitrogen bond to form 5'-(N6-L-lysine)-L-topaquinone.


ModificationSetId: PSI-MOD
Name: 4-hydroxy-L-lysine
Definition: A protein modification that effectively converts an L-lysine residue to 4-hydroxy-L-lysine.
DiffFormula: C 0 H 0 N 0 O 1
Formula: C 6 H 12 N 2 O 2
AminoAcid: K
Comment:
This modification was not structurally confirmed. Later 5-hydroxy-L-lysine was found at a homologous position in the same protein from closely related species. This is a deprecated entry in RESID. It probably does not occur naturally [JSG].


ModificationSetId: PSI-MOD
Name: N4-hydroxymethyl-L-asparagine
DiffFormula: C 1 H 2 N 0 O 1
Formula: C 5 H 8 N 2 O 3
AminoAcid: N
Definition:
A protein modification that effectively converts an L-asparagine residue to N4-hydroxymethyl-L-asparagine.

Comment:
N4-methyl-L-asparagine, see MOD:0079, was found at a homologous position of the same protein in a closely related species. Since the peptide containing this modification was obtained by enzymatic cleavage, not cyanogen bromide cleavage, it could have experienced oxidation of the following methionine residue, leading to the erroneous attribution of a mass of 29 for the modification rather than 14. comment: This is a deprecated entry in RESID. It probably does not occur naturally [JSG].


ModificationSetId: PSI-MOD
Name: L-cysteine oxazole-4-carboxylic acid
Comment: Cross-link 2.
DiffFormula: C 0 H -4 N 0 O -1 S 0
Formula: C 6 H 6 N 2 O 2 S 1
Definition:
A protein modification that effectively crosslinks an L-cysteine residue and an L-serine residue to form L-cysteine oxazole-4-carboxylic acid.


ModificationSetId: PSI-MOD
Name: L-cysteine oxazoline-4-carboxylic acid
Comment: Cross-link 2.
DiffFormula: C 0 H -2 N 0 O -1 S 0
Formula: C 6 H 8 N 2 O 2 S 1
Definition:
A protein modification that effectively crosslinks an L-cysteine residue and an L-serine residue to form L-cysteine oxazoline-4-carboxylic acid.


ModificationSetId: PSI-MOD
Name: glycine oxazole-4-carboxylic acid
Comment: Cross-link 2.
DiffFormula: C 0 H -4 N 0 O -1
Formula: C 5 H 4 N 2 O 2
Definition:
A protein modification that effectively crosslinks a glycine residue and an L-serine residue to form glycine oxazole-4-carboxylic acid.


ModificationSetId: PSI-MOD
Name: glycine thiazole-4-carboxylic acid
Comment: Cross-link 2.
DiffFormula: C 0 H -4 N 0 O -1 S 0
Formula: C 5 H 4 N 2 O 1 S 1
Definition:
A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue to form glycine thiazole-4-carboxylic acid.


ModificationSetId: PSI-MOD
Name: L-serine thiazole-4-carboxylic acid
Comment: Cross-link 2.
DiffFormula: C 0 H -4 N 0 O -1 S 0
Formula: C 6 H 6 N 2 O 2 S 1
Definition:
A protein modification that effectively crosslinks an L-cysteine residue and an L-serine residue to form L-serine thiazole-4-carboxylic acid.


ModificationSetId: PSI-MOD
Name: L-phenylalanine thiazole-4-carboxylic acid
Comment: Cross-link 2.
DiffFormula: C 0 H -4 N 0 O -1 S 0
Formula: C 12 H 10 N 2 O 1 S 1
Definition:
A protein modification that effectively crosslinks an L-cysteine residue and an L-phenylalanine residue to form L-phenylalanine thiazole-4-carboxylic acid.


ModificationSetId: PSI-MOD
Name: L-cysteine thiazole-4-carboxylic acid
Comment: Cross-link 2.
DiffFormula: C 0 H -4 N 0 O -1 S 0
Formula: C 6 H 6 N 2 O 1 S 2
Definition:
A protein modification that effectively crosslinks two L-cysteine residues to form L-cysteine thiazole-4-carboxylic acid.


ModificationSetId: PSI-MOD
Name: L-lysine thiazole-4-carboxylic acid
DiffFormula: C 0 H -4 N 0 O -1 S 0
Formula: C 9 H 13 N 3 O 1 S 1
Definition:
A protein modification that effectively crosslinks an L-cysteine residue and an L-lysine residue to form L-lysine thiazole-4-carboxylic acid.

Comment:
Cross-link 2. Lysine is now thought not to be encoded in the peptide sequence modified to produce GE2270. See RESID:AA0470. This is a deprecated entry in RESID. It probably does not occur naturally [JSG].


ModificationSetId: PSI-MOD
SwissprotTerm: O-(5'-phospho-DNA)-serine
Name: O-(phospho-5'-DNA)-L-serine
DiffFormula: C 0 H 0 N 0 O 3 P 1
Formula: C 3 H 5 N 1 O 5 P 1
AminoAcid: S
Definition:
A protein modification that effectively crosslinks an L-serine residue and the 5'-end of DNA through a phosphodiester bond to form O-(phospho-5'-DNA)-L-serine.


ModificationSetId: PSI-MOD
Name: keratan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-threonine
DiffFormula: C 0 H -1 N 0 O 0
Formula: C 4 H 6 N 1 O 2
AminoAcid: T
Definition:
A protein modification that effectively cross-links an L-threonine residue to the polymer keratan sulfate by a D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl tetrasaccharide.


ModificationSetId: PSI-MOD
Name: L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide) (Sec)
DiffFormula: C 40 H 47 Mo 1 N 20 O 26 P 4 S 4 Se 0
Formula: C 43 H 52 Mo 1 N 21 O 27 P 4 S 4 Se 1
AminoAcid: U
Definition:
A protein modification that effectively converts an L-selenocysteine residue to L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide).


ModificationSetId: PSI-MOD
SwissprotTerm: O-(5'-phospho-RNA)-tyrosine
Name: O4'-(phospho-5'-RNA)-L-tyrosine
DiffFormula: C 0 H 1 N 0 O 3 P 1
Formula: C 9 H 10 N 1 O 5 P 1
AminoAcid: Y
Definition:
A protein modification that effectively crosslinks an L-tyrosine residue and the 5'-end of RNA through a phosphodiester to form O4'-(phospho-5'-RNA)-L-tyrosine.


ModificationSetId: PSI-MOD
Name: 3-(3'-L-histidyl)-L-tyrosine
Comment: Cross-link 2.
DiffFormula: C 0 H -2 N 0 O 0
Formula: C 15 H 14 N 4 O 3
Definition:
A protein modification that effectively cross-links an L-histidine residue and an L-tyrosine residue by a carbon-nitrogen bond to form 3-(3'-L-histidyl)-L-tyrosine.


ModificationSetId: PSI-MOD
SwissprotTerm: S-(dipyrrolylmethanemethyl)cysteine
Name: dipyrrolylmethanemethyl-L-cysteine
DiffFormula: C 20 H 22 N 2 O 8 S 0
Formula: C 23 H 27 N 3 O 9 S 1
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to dipyrrolylmethanemethyl-L-cysteine.


ModificationSetId: PSI-MOD
Name: S-(2-aminovinyl)-3-methyl-D-cysteine
Comment: Cross-link 2.
DiffFormula: C -1 H -4 N 0 O -3 S 0
Formula: C 6 H 9 N 2 O 1 S 1
Definition:
A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form S-(2-aminovinyl)-3-methyl-D-cysteine.


ModificationSetId: PSI-MOD
SwissprotTerm: O-(5'-phospho-DNA)-tyrosine
Name: O4'-(phospho-5'-DNA)-L-tyrosine
DiffFormula: C 0 H 1 N 0 O 3 P 1
Formula: C 9 H 10 N 1 O 5 P 1
AminoAcid: Y
Definition:
A protein modification that effectively crosslinks an L-tyrosine residue and the 5'-end of DNA through a phosphodiester bond to form O4'-(phospho-5'-DNA)-L-tyrosine.


ModificationSetId: PSI-MOD
Name: O-(phospho-5'-DNA)-L-threonine
DiffFormula: C 0 H 0 N 0 O 3 P 1
Formula: C 4 H 7 N 1 O 5 P 1
AminoAcid: T
Definition:
A protein modification that effectively crosslinks an L-threonine residue and the 5'-end of DNA through a phosphodiester bond to form O-(phospho-5'-DNA)-L-threonine.


ModificationSetId: PSI-MOD
SwissprotTerm: O-UMP-tyrosine
Name: O4'-(phospho-5'-uridine)-L-tyrosine
Comment: From DeltaMass: Average Mass: 306.
DiffFormula: C 9 H 11 N 2 O 8 P 1
Formula: C 18 H 20 N 3 O 10 P 1
AminoAcid: Y
Definition:
A protein modification that effectively crosslinks an L-tyrosine residue and 5'-phosphouridine through a phosphodiester bond to form O4'-(phospho-5'-uridine)-L-tyrosine.


ModificationSetId: PSI-MOD
Name: N-(L-glutamyl)-L-tyrosine
Comment: Cross-link 2.
DiffFormula: C 0 H -1 N 0 O -1
Formula: C 14 H 16 N 2 O 5
Definition:
A protein modification that effectively forms a peptide bond between a C-terminal L-glutamic acid residue and a free L-tyrosine.


ModificationSetId: PSI-MOD
Name: S-phycoviolobilin-L-cysteine
DiffFormula: C 33 H 38 N 4 O 6 S 0
Formula: C 36 H 43 N 5 O 7 S 1
AminoAcid: C
Definition:
A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound phycoviolobilin.


ModificationSetId: PSI-MOD
Name: phycoerythrobilin-bis-L-cysteine
Comment: Cross-link 2.
DiffFormula: C 33 H 38 N 4 O 6 S 0
Formula: C 39 H 48 N 6 O 8 S 2
Definition:
A protein modification that effectively results from forming an adduct between two cysteine residues and the tetrapyrrole compound phycoerythrobilin.


ModificationSetId: PSI-MOD
Name: phycourobilin-bis-L-cysteine
Comment: Cross-link 2.
DiffFormula: C 33 H 38 N 4 O 6 S 0
Formula: C 39 H 48 N 6 O 8 S 2
Definition:
A protein modification that effectively results from forming an adduct between two cysteine residues and the tetrapyrrole compound phycourobilin.


ModificationSetId: PSI-MOD
Name: N-L-glutamyl-poly-L-glutamic acid
DiffFormula: C 0 H 0 N 0 O 0
Formula: C 10 H 15 N 2 O 7
AminoAcid: E
Definition:
A protein modification that effectively forms a peptide bond between a C-terminal L-glutamic acid residue and one or more free L-glutamic acid molecules to form N-(L-glutamyl)-poly-L-glutamic acid.


ModificationSetId: PSI-MOD
SwissprotTerm: Cysteine sulfinic acid (-SO2H)
Name: L-cysteine sulfinic acid
Comment: "Hyun Ae Woo, et. al., Science 300 (5619), 653-656"
DiffFormula: C 0 H 0 N 0 O 2 S 0
Formula: C 3 H 5 N 1 O 3 S 1
AminoAcid: C
Definition:
A protein modification that effectively dioxygenates an L-cysteine residue to L-cysteine sulfinic acid.


ModificationSetId: PSI-MOD
Name: L-3',4',5'-trihydroxyphenylalanine
Comment: From DeltaMass: Average Mass: 32
DiffFormula: C 0 H 0 N 0 O 2
Formula: C 9 H 9 N 1 O 4
AminoAcid: Y
Definition:
A protein modification that effectively converts an L-tyrosine residue to L-3',4',5'-trihydroxyphenylalanine.


ModificationSetId: PSI-MOD
SwissprotTerm: O-(sn-1-glycerophosphoryl)serine
Name: O-(sn-1-glycerophosphoryl)-L-serine
DiffFormula: C 3 H 7 N 0 O 5 P 1
Formula: C 6 H 12 N 1 O 7 P 1
AminoAcid: S
Definition:
A protein modification that effectively converts an L-serine residue to O-(sn-1-glycerophosphoryl)-L-serine.


ModificationSetId: PSI-MOD
SwissprotTerm: 1-thioglycine
Name: 1-thioglycine (internal)
Definition: A protein modification that effectively converts a glycine residue to an internal 1-thioglycine.
DiffFormula: C 0 H 0 N 0 O -1 S 1
Formula: C 2 H 3 N 1 S 1
AminoAcid: G
Comment:
This modification occurs naturally in two forms. At an interior peptide location it exists as aminoethanethionic acid (or aminoethanethioic O-acid). At the carboxyl-terminal it exists as aminoethanethiolic acid (or aminoethanethioic S-acid).


ModificationSetId: PSI-MOD
Name: heme P460-bis-L-cysteine-L-tyrosine
Comment: Cross-link 3.
DiffFormula: C 34 Fe 1 H 30 N 4 O 4 S 0
Formula: C 49 Fe 1 H 49 N 7 O 8 S 2
Definition:
A protein modification that effectively results from forming an adduct between two cysteine residues, the C-3' of a tyrosine residue, and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron.


ModificationSetId: PSI-MOD
SwissprotTerm: O-AMP-threonine
Name: O-(phospho-5'-adenosine)-L-threonine
DiffFormula: C 10 H 12 N 5 O 6 P 1
Formula: C 14 H 19 N 6 O 8 P 1
AminoAcid: T
Definition:
A protein modification that effectively crosslinks an L-threonine residue and 5'-phosphoadenosine through a phosphodiester bond to form O-(phospho-5'-adenosine)-L-threonine.


ModificationSetId: PSI-MOD
Name: tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino tetrairon disulfide trioxide
Comment: Cross-link 7; secondary to RESID:AA0269.
DiffFormula: C 0 Fe 4 H -7 N 0 O 3 S 3
Formula: C 28 Fe 4 H 34 N 9 O 14 S 7
Definition:
A protein modification that effectively converts four L-cysteine residues, two L-glutamic acid residues, an L-histidine residue and a four-iron three-sulfur three-oxygen cluster to tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino tetrairon disulfide trioxide.


ModificationSetId: PSI-MOD
SwissprotTerm: Cysteine persulfide
Name: L-cysteine persulfide
DiffFormula: C 0 H 0 N 0 O 0 S 1
Formula: C 3 H 5 N 1 O 1 S 2
AminoAcid: C
Definition:
A protein modification that effectively replaces the hydrogen atom of a cysteine sulfanyl group with a sulfanyl group, forming a disulfanyl group, and converting an L-cysteine residue to L-cysteine persulfide.


ModificationSetId: PSI-MOD
Name: 3'-(1'-L-histidyl)-L-tyrosine
Comment: Cross-link 2.
DiffFormula: C 0 H -2 N 0 O 0
Formula: C 15 H 14 N 4 O 3
Definition:
A protein modification that effectively cross-links an L-histidine residue and an L-tyrosine residue by a carbon-nitrogen bond to form 3'-(1'-L-histidyl)-L-tyrosine.


ModificationSetId: PSI-MOD
Name: heme P460-bis-L-cysteine-L-lysine
Comment: Cross-link 3.
DiffFormula: C 34 Fe 1 H 30 N 4 O 4 S 0
Formula: C 46 Fe 1 H 52 N 8 O 7 S 2
Definition:
A protein modification that effectively results from forming an adduct between two cysteine residues, a lysine residue, and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron.


ModificationSetId: PSI-MOD
SwissprotTerm: N-pyruvate 2-iminyl-cysteine
Name: N-pyruvic acid 2-iminyl-L-cysteine
DiffFormula: C 3 H 2 N 0 O 2 S 0
Formula: C 6 H 8 N 1 O 3 S 1
AminoAcid: C
Definition:
A protein modification that effectively converts an Lcysteline residue to N-pyruvic acid 2-iminyl-L-cysteine.


ModificationSetId: PSI-MOD
SwissprotTerm: N-pyruvate 2-iminyl-valine
Name: N-pyruvic acid 2-iminyl-L-valine
DiffFormula: C 3 H 2 N 0 O 2
Formula: C 8 H 12 N 1 O 3
AminoAcid: V
Definition:
A protein modification that effectively converts an L-valine residue to N-pyruvic acid 2-iminyl-L-valine.


ModificationSetId: PSI-MOD
Name: 3'-heme-L-histidine
DiffFormula: C 34 Fe 1 H 32 N 4 O 4
Formula: C 40 Fe 1 H 39 N 7 O 5
AminoAcid: H
Definition:
A protein modification that effectively results from forming an adduct between the pros nitrogen of a histidine residue and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron.


ModificationSetId: PSI-MOD
SwissprotTerm: N6-poly(methylaminopropyl)lysine
Name: N6-propylamino-poly(propylmethylamino)-propyldimethylamine-L-lysine
DiffFormula: C 24 H 54 N 6 O 0
Formula: C 30 H 66 N 8 O 1
AminoAcid: K
Definition:
A protein modification that effectively converts an L-lysine residue to an N6-propylamino-poly(propylmethylamino)-propyldimethylamine-L-lysine.


ModificationSetId: PSI-MOD
Name: dihydroxyheme-L-aspartate ester-L-glutamate ester
Comment: Cross-link 2.
DiffFormula: C 34 Fe 1 H 28 N 4 O 4
Formula: C 43 Fe 1 H 40 N 6 O 10
Definition:
A protein modification that effectively results from forming an adduct between an aspartic acid residue, a glutamic acid residue, and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron.


ModificationSetId: PSI-MOD
Name: dihydroxyheme-L-aspartate ester-L-glutamate ester-L-methionine sulfonium
Comment: Cross-link 3.
DiffFormula: C 34 Fe 1 H 29 N 4 O 4 S 0
Formula: C 48 Fe 1 H 50 N 7 O 11 S 1
Definition:
A protein modification that effectively results from forming an adduct between an aspartic acid residue, a glutamic acid residue, a methionine residue (forming a sulfonium ether), and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron.


ModificationSetId: PSI-MOD
Name: L-cysteinyl molybdenum bis(molybdopterin guanine dinucleotide)
DiffFormula: C 40 H 47 Mo 1 N 20 O 26 P 4 S 4
Formula: C 43 H 52 Mo 1 N 21 O 27 P 4 S 5
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to L-cysteinyl molybdenum bis(molybdopterin guanine dinucleotide).


ModificationSetId: PSI-MOD
SwissprotTerm: (3R,4S)-3,4-dihydroxyproline
Name: (2S,3R,4S)-3,4-dihydroxyproline
Comment: From DeltaMass: Average Mass: 32.
DiffFormula: C 0 H 0 N 0 O 2
Formula: C 5 H 7 N 1 O 3
AminoAcid: P
Definition:
A protein modification that effectively converts an L-proline residue to a (2S,3R,4S)-3,4-dihydroxyproline.


ModificationSetId: PSI-MOD
Name: pyrroloquinoline quinone
Comment: Cross-link 2.
DiffFormula: C 0 H -10 N 0 O 3
Formula: C 14 H 6 N 2 O 8
Definition:
A protein modification that effectively doubly cross-links an L-glutamic acid residue and an L-tyrosine residue with a carbon-carbon bond and a carbon-nitrogen bond to form pyrroloquinoline quinone.


ModificationSetId: PSI-MOD
Name: tris-L-cysteinyl L-N1'-histidino tetrairon tetrasulfide
Comment: Cross-link 4.
DiffFormula: C 0 Fe 4 H -4 N 0 O 0 S 4
Formula: C 15 Fe 4 H 18 N 6 O 4 S 7
Definition:
A protein modification that effectively converts three L-cysteine residues, an L-histidine residue and a four-iron four-sulfur cluster to tris-L-cysteinyl L-N1'-histidino tetrairon tetrasulfide.


ModificationSetId: PSI-MOD
Name: tris-L-cysteinyl L-N3'-histidino tetrairon tetrasulfide
Comment: Cross-link 4.
DiffFormula: C 0 Fe 4 H -4 N 0 O 0 S 4
Formula: C 15 Fe 4 H 18 N 6 O 4 S 7
Definition:
A protein modification that effectively converts three L-cysteine residues, an L-histidine residue and a four-iron four-sulfur cluster to tris-L-cysteinyl L-N3'-histidino tetrairon tetrasulfide.


ModificationSetId: PSI-MOD
Name: tris-L-cysteinyl L-aspartato tetrairon tetrasulfide
Comment: Cross-link 4.
DiffFormula: C 0 Fe 4 H -4 N 0 O 0 S 4
Formula: C 13 Fe 4 H 16 N 4 O 6 S 7
Definition:
A protein modification that effectively converts three L-cysteine residues, an L-aspartic acid residue and a four-iron four-sulfur cluster to tris-L-cysteinyl L-aspartato tetrairon tetrasulfide.


ModificationSetId: PSI-MOD
Name: N6-pyruvic acid 2-iminyl-L-lysine
DiffFormula: C 3 H 2 N 0 O 2
Formula: C 9 H 14 N 2 O 3
AminoAcid: K
Definition:
A protein modification that effectively converts an L-lysine residue to N6-pyruvic acid 2-iminyl-L-lysine.


ModificationSetId: PSI-MOD
Name: tris-L-cysteinyl L-serinyl tetrairon tetrasulfide
Comment: Cross-link 4.
DiffFormula: C 0 Fe 4 H -4 N 0 O 0 S 4
Formula: C 12 Fe 4 H 16 N 4 O 5 S 7
Definition:
A protein modification that effectively converts three L-cysteine residues, an L-serine residue and a four-iron four-sulfur cluster to tris-L-cysteinyl L-serinyl tetrairon tetrasulfide.


ModificationSetId: PSI-MOD
Name: bis-L-cysteinyl L-N3'-histidino L-serinyl tetrairon tetrasulfide
Comment: Cross-link 4.
DiffFormula: C 0 Fe 4 H -4 N 0 O 0 S 4
Formula: C 15 Fe 4 H 18 N 6 O 5 S 6
Definition:
A protein modification that effectively converts two L-cysteine residues, an L-histidine residues, an L-serine residue and a four-iron four-sulfur cluster to bis-L-cysteinyl L-N3'-histidino L-serinyl tetrairon tetrasulfide.


ModificationSetId: PSI-MOD
DiffFormula: C 0 Fe 3 H -7 N 0 Ni 1 O 3 S 3
Formula: C 28 Fe 3 H 34 N 9 Ni 1 O 14 S 7
Name:
tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide

Definition:
A protein modification that effectively converts four L-cysteine residues, two L-glutamic acid residues, an L-histidine residue and a three-iron three-sulfur three-oxygen cluster to tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide.

Comment:
Cross-link 7; secondary to RESID:AA0269. This is a deprecated entry in RESID. It probably does not occur naturally [JSG].


ModificationSetId: PSI-MOD
DiffFormula: C 0 Fe 3 H -7 N 0 Ni 1 O 3 S 3
Formula: C 26 Fe 3 H 32 N 9 Ni 1 O 13 S 7
Name:
tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide

Definition:
A protein modification that effectively converts four L-cysteine residues, an L-glutamic acid residue, an L-histidine residue, an L-serine residue and a one-nickel three-iron three-sulfur three-oxygen cluster to tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide.

Comment:
Cross-link 7; secondary to RESID:AA0269. This is a deprecated entry in RESID. It probably does not occur naturally [JSG].


ModificationSetId: PSI-MOD
Name: N6-(L-isoaspartyl)-L-lysine (Asn)
Comment: Cross-link 2.
DiffFormula: C 0 H -3 N -1 O 0
Formula: C 10 H 15 N 3 O 3
Definition:
A protein modification that effectively crosslinks an L-asparagine residue and an L-lysine residue by an isopeptide bond with the formation of N6-(L-isoaspartyl)-L-lysine and the release of ammonia.


ModificationSetId: PSI-MOD
SwissprotTerm: PolyADP-ribosyl glutamic acid
Name: L-glutamyl-5-poly(ADP-ribose)
DiffFormula: C 15 H 21 N 5 O 13 P 2
Formula: C 20 H 28 N 6 O 16 P 2
AminoAcid: E
Definition:
A protein modification that effectively converts an L-glutamic acid residue to L-glutamyl-5-poly(ADP-ribose).


ModificationSetId: PSI-MOD
Name: O-(N-acetylglucosamine-1-phosphoryl)-L-serine
DiffFormula: C 8 H 14 N 1 O 8 P 1
Formula: C 11 H 19 N 2 O 10 P 1
AminoAcid: S
Definition:
A protein modification that effectively converts an L-serine residue to O-(N-acetylglucosamine-1-phosphoryl)-L-serine.


ModificationSetId: PSI-MOD
Name: O-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine
DiffFormula: C 6 H 11 N 0 O 8 P 1
Formula: C 9 H 16 N 1 O 10 P 1
AminoAcid: S
Definition:
A protein modification that effectively converts an L-serine residue to O-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine.


ModificationSetId: PSI-MOD
Name: heptakis-L-histidino tetracopper mu4-sulfide hydroxide
Comment: Cross-link 7.
DiffFormula: C 0 Cu 4 H -6 N 0 O 1 S 1
Formula: C 42 Cu 4 H 43 N 21 O 8 S 1
Definition:
A protein modification that effectively converts seven L-histidinine residues and a four-copper one-sulfur one-hydroxide cluster to heptakis-L-histidino tetracopper mu4-sulfide hydroxide.


ModificationSetId: PSI-MOD
Name: hexakis-L-cysteinyl L-serinyl octairon heptasulfide
Comment: Cross-link 7; incidental to RESID:AA0141.
DiffFormula: C 0 Fe 8 H -8 N 0 O 0 S 7
Formula: C 21 Fe 8 H 27 N 7 O 8 S 13
Definition:
A protein modification that effectively converts six L-cysteine residues, an L-serine residue and a eight-iron seven-sulfur cluster to hexakis-L-cysteinyl L-serinyl octairon heptasulfide.


ModificationSetId: PSI-MOD
Name: L-aspartimide
DiffFormula: C 0 H -2 N 0 O -1
Formula: C 4 H 5 N 2 O 2
AminoAcid: N
Definition:
A protein modification that effectively cyclizes an L-asparagine residue to form a carboxyl-terminal L-aspartimide.

Comment:
From DeltaMass: Average Mass: -17 Average Mass Change:-17 References:Clarke, S., Lability of Aspargine and Aspartic Acid Residues in Protein and Peptides, in: Stability of Protein Pharmaceuticals : Chemical and Physical Paths of Protein Degradation, Part A (T.J. Ahern and M.C. Manning, eds.), 1992,Plenum Press, New York, pp.1-29Xie, M.; Vander Velde, D.; Morton, M.; Borchardt, R.T.; Schowen,R.L.: pH-Induced Change in the Rate-Determining Step for the Hydrolysis of the Asp/Asn-Derived Cyclic-Imide Intermediate in Protein Degradation. (1996) J. Am. Chem. Soc. 118: 8955-8956.


ModificationSetId: PSI-MOD
Name: L-glutamimide
DiffFormula: C 0 H -2 N 0 O -1
Formula: C 5 H 7 N 2 O 2
AminoAcid: Q
Definition:
A protein modification that effectively cyclizes an L-glutamine residue to form a carboxyl-terminal L-glutamimide.


ModificationSetId: PSI-MOD
Name: L-beta-carboxyaspartic acid
Comment: References to this modification as a gamma-carboxylation are in error [JSG].
DiffFormula: C 1 H 0 N 0 O 2
Formula: C 5 H 5 N 1 O 5
AminoAcid: D
Definition:
A protein modification that effectively converts an L-aspartic acid residue to L-beta-carboxyaspartic acid.


ModificationSetId: PSI-MOD
Name: L-cysteine coenzyme A disulfide
Comment: DeltaMass gives no formula with mass as 454.
DiffFormula: C 21 H 34 N 7 O 16 P 3 S 1
Formula: C 24 H 39 N 8 O 17 P 3 S 2
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to L-cysteine coenzyme A disulfide.


ModificationSetId: PSI-MOD
Name: pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide
Comment: Cross-link 6.
DiffFormula: C 0 Fe 4 H -6 N 0 Ni 1 O 0 S 5
Formula: C 21 Fe 4 H 26 N 8 Ni 1 O 6 S 10
Definition:
A protein modification that effectively converts five L-cysteine residues, an L-histidine residue and a one-nickel four-iron five-sulfur cluster to pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide.


ModificationSetId: PSI-MOD
SwissprotTerm: N4,N4-dimethylasparagine
Name: N4,N4-dimethyl-L-asparagine
DiffFormula: C 2 H 4 N 0 O 0
Formula: C 6 H 10 N 2 O 2
AminoAcid: N
Definition:
A protein modification that effectively converts an L-asparagine residue to N4,N4-dimethyl-L-asparagine.


ModificationSetId: PSI-MOD
Name: N6-3,4-didehydroretinylidene-L-lysine
DiffFormula: C 20 H 24 N 0 O 0
Formula: C 26 H 36 N 2 O 1
AminoAcid: K
Definition:
A protein modification that effectively converts an L-lysine residue to N6-3,4-didehydroretinylidene-L-lysine.


ModificationSetId: PSI-MOD
Name: 4'-(S-L-cysteinyl)-L-tryptophyl quinone
Comment: Cross-link 2; secondary to RESID:AA0148.
DiffFormula: C 0 H -4 N 0 O 2 S 0
Formula: C 14 H 11 N 3 O 4 S 1
Definition:
A protein modification that effectively cross-links an L-cysteine residue and an L-tryptophan residue by a thioether bond to form 4'-(S-L-cysteinyl)-L-tryptophyl quinone.


ModificationSetId: PSI-MOD
Name: 3-(S-L-cysteinyl)-L-aspartic acid
Comment: Cross-link 2.
DiffFormula: C 0 H -2 N 0 O 0 S 0
Formula: C 7 H 8 N 2 O 4 S 1
Definition:
A protein modification that effectively cross-links an L-cysteine residue and an L-aspartic acid residue by a thioether bond to form 2-(S-L-cysteinyl)-L-aspartic acid.


ModificationSetId: PSI-MOD
Name: 4-(S-L-cysteinyl)-L-glutamic acid
Comment: Cross-link 2.
DiffFormula: C 0 H -2 N 0 O 0 S 0
Formula: C 8 H 10 N 2 O 4 S 1
Definition:
A protein modification that effectively cross-links an L-cysteine residue and an L-glutamic acid residue by a thioether bond to form 4-(S-L-cysteinyl)-L-glutamic acid.


ModificationSetId: PSI-MOD
Name: cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid L-aspartate ester
DiffFormula: C 17 H 26 N 0 O 4
Formula: C 21 H 31 N 1 O 7
AminoAcid: D
Definition:
A protein modification that effectively converts an L-aspartic acid residue to cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid L-aspartate ester.


ModificationSetId: PSI-MOD
Name: L-serinyl molybdenum bis(molybdopterin guanine dinucleotide)
DiffFormula: C 40 H 47 Mo 1 N 20 O 27 P 4 S 4
Formula: C 43 H 52 Mo 1 N 21 O 29 P 4 S 4
AminoAcid: S
Definition:
A protein modification that effectively converts an L-serine residue to L-serinyl molybdenum bis(molybdopterin guanine dinucleotide).


ModificationSetId: PSI-MOD
Name: L-beta-methylthioasparagine
DiffFormula: C 1 H 2 N 0 O 0 S 1
Formula: C 5 H 8 N 2 O 2 S 1
AminoAcid: N
Definition:
A protein modification that effectively converts an L-asparagine residue to L-beta-methylthioasparagine.

Comment:
This modification was predicted for ribosomal protein S12 in Bacillus subtilis when the sequence in the original version of the genome was reported to have asparagine rather than aspartic acid at the position of the methylthioaspartic acid modification (see MOD:00237). Two groups independently confirmed that the genome sequence was incorrect. The sequence in the revised genome has aspartic acid at that position. This is a deprecated entry in RESID. It probably does not occur naturally [JSG].


ModificationSetId: PSI-MOD
Name: L-pyrrolysine (Lys)
DiffFormula: C 6 H 7 N 1 O 1
Formula: C 12 H 19 N 3 O 2
AminoAcid: K
Definition:
A protein modification that effectively converts an L-lysine residue to L-pyrrolysine (not known as a natural, post-translational modification process).

Comment:
This entry is for the artifactual formation of L-pyrrolysine from lysine. For encoded L-pyrrolysine, use MOD:01187 [JSG].


ModificationSetId: PSI-MOD
SwissprotTerm: 3-hydroxytryptophan
Name: 3-hydroxy-L-tryptophan
DiffFormula: C 0 H 0 N 0 O 1
Formula: C 11 H 10 N 2 O 2
AminoAcid: W
Definition:
A protein modification that effectively converts an L-tryptophan residue to a 3-hydroxy-L-tryptophan.


ModificationSetId: PSI-MOD
Name: O4'-(phospho-3'-DNA)-L-tyrosine
DiffFormula: C 0 H 1 N 0 O 3 P 1
Formula: C 9 H 10 N 1 O 5 P 1
AminoAcid: Y
Definition:
A protein modification that effectively crosslinks an L-tyrosine residue and the 3'-end of DNA through a phosphodiester bond to form O4'-(phospho-3'-DNA)-L-tyrosine.


ModificationSetId: PSI-MOD
Name: hydroxyheme-L-glutamate ester
DiffFormula: C 34 Fe 1 H 30 N 4 O 4
Formula: C 39 Fe 1 H 37 N 5 O 7
AminoAcid: E
Definition:
A protein modification that effectively results from forming an adduct between a glutamic acid residue and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron.


ModificationSetId: PSI-MOD
Name: (phospho-5'-guanosine)-L-histidine
DiffFormula: C 10 H 12 N 5 O 7 P 1
Formula: C 16 H 19 N 8 O 8 P 1
AminoAcid: H
Definition:
A protein modification that effectively converts an L-histidine residue to a (phospho-5'-guanosine)-L-histidine.


ModificationSetId: PSI-MOD
Name: tetrakis-L-cysteinyl triiron tetrasulfide
Comment: Cross-link 4.
DiffFormula: C 0 Fe 3 H -4 N 0 O 0 S 4
Formula: C 12 Fe 3 H 16 N 4 O 4 S 8
Definition:
A protein modification that effectively converts four L-cysteine residues and a three-iron four-sulfur cluster to tetrakis-L-cysteinyl triiron tetrasulfide.


ModificationSetId: PSI-MOD
SwissprotTerm: Aspartic acid 1-[(3-aminopropyl)(5'-adenosyl)phosphono]amide
Name: (3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine
Comment: UniMod origin shown as C-term [JSG].
DiffFormula: C 13 H 19 N 6 O 6 P 1
Formula: C 17 H 26 N 8 O 9 P 1
AminoAcid: N
Definition:
A protein modification that effectively converts an L-asparagine residue to (3-aminopropyl)(L-aspartyl-1-amino)phosphoryl-5'-adenosine.


ModificationSetId: PSI-MOD
Name: 1'-heme-L-histidine
DiffFormula: C 34 Fe 1 H 32 N 4 O 4
Formula: C 40 Fe 1 H 39 N 7 O 5
AminoAcid: H
Definition:
A protein modification that effectively results from forming an adduct between the tele nitrogen of a histidine residue and the porphyrin compound heme b, (7,12-diethenyl-3,8,13,17-tetramethylporphyrin-2,18-dipropanoato)iron.


ModificationSetId: PSI-MOD
Name: (2S,3S,2'R)-3-methyllanthionine sulfoxide
Comment: Cross-link 2.
DiffFormula: C 0 H -2 N 0 O 0 S 0
Formula: C 7 H 10 N 2 O 3 S 1
Definition:
A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form (2S,3S,2'R)-3-methyllanthionine sulfoxide.


ModificationSetId: PSI-MOD
Name: tris-L-cysteinyl L-aspartato diiron disulfide
Comment: Cross-link 4.
DiffFormula: C 0 Fe 2 H -4 N 0 O 0 S 2
Formula: C 13 Fe 2 H 16 N 4 O 6 S 5
Definition:
A protein modification that effectively converts three L-cysteine residues, an L-aspartic acid residue and a two-iron two-sulfur cluster to tris-L-cysteinyl L-aspartato diiron disulfide.


ModificationSetId: PSI-MOD
Name: L-cysteinyl hydrogenase diiron subcluster
Comment: incidental to RESID:AA0140.
DiffFormula: C 5 Fe 2 H -1 N 2 O 5 S 2
Formula: C 8 Fe 2 H 4 N 3 O 6 S 3
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to L-cysteinyl hydrogenase diiron subcluster.


ModificationSetId: PSI-MOD
Name: 2-(S-L-cysteinyl)-L-phenylalanine
Comment: Cross-link 2.
DiffFormula: C 0 H -2 N 0 O 0 S 0
Formula: C 12 H 12 N 2 O 2 S 1
Definition:
A protein modification that effectively cross-links an L-cysteine residue and an L-phenylalanine residue by a thioether bond to form 2-(S-L-cysteinyl)-L-phenylalanine.


ModificationSetId: PSI-MOD
Name: 2-(S-L-cysteinyl)-D-phenylalanine
Comment: Cross-link 2.
DiffFormula: C 0 H -2 N 0 O 0 S 0
Formula: C 12 H 12 N 2 O 2 S 1
Definition:
A protein modification that effectively cross-links an L-cysteine residue and an L-phenylalanine residue by a thioether bond to form 2-(S-L-cysteinyl)-D-phenylalanine.


ModificationSetId: PSI-MOD
Name: 2-(S-L-cysteinyl)-D-allo-threonine
Comment: Cross-link 2.
DiffFormula: C 0 H -2 N 0 O 0 S 0
Formula: C 7 H 10 N 2 O 3 S 1
Definition:
A protein modification that effectively cross-links an L-cysteine residue and an L-threonine residue by a thioether bond to form 2-(S-L-cysteinyl)-D-allo-threonine.


ModificationSetId: PSI-MOD
Name: 4-amino-3-isothiazolidinone-L-serine
Comment: Cross-link 2.
DiffFormula: C 0 H -2 N 0 O 0 S 0
Formula: C 6 H 8 N 2 O 3 S 1
Definition:
A protein modification that effectively crosslinks an L-cysteine residue and an L-serine residue to form 4-amino-3-isothiazolidinone-L-serine.


ModificationSetId: PSI-MOD
SwissprotTerm: Pentaglycyl murein peptidoglycan amidated threonine
Name: L-threonyl-pentaglycyl-murein peptidoglycan
DiffFormula: C 10 H 14 N 5 O 4
Formula: C 14 H 22 N 6 O 7
AminoAcid: T
Definition:
A protein modification that effectively attaches an L-threonine residue to murein peptidoglycan by a pentaglycine linker peptide.


ModificationSetId: PSI-MOD
Name: N-glycyl-1-(phosphatidyl)ethanolamine
DiffFormula: C 39 H 74 N 1 O 7 P 1
Formula: C 41 H 78 N 2 O 9 P 1
AminoAcid: G
Definition:
A protein modification that effectively converts a glycine residue to N-glycyl-1-(phosphatidyl)ethanolamine.


ModificationSetId: PSI-MOD
Name: L-glutamyl 5-omega-hydroxyceramide ester
DiffFormula: C 50 H 96 N 0 O 4
Formula: C 55 H 104 N 2 O 6
AminoAcid: Q
Definition:
A protein modification that effectively converts an L-glutamic acid residue to L-glutamyl 5-omega-hydroxyceramide ester.


ModificationSetId: PSI-MOD
Name: S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium
Comment: Cross-link 3.
DiffFormula: C 0 H -3 N 0 O 0 S 0
Formula: C 25 H 25 N 4 O 4 S 1
Definition:
A protein modification that effectively cross-links an L-tryptophan residue with an L-tyrosine residue by a carbon-carbon bond, and cross-links the L-tyrosine residue to an L-methionine residue by a thioether bond to form S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium.


ModificationSetId: PSI-MOD
SwissprotTerm: FMN phosphoryl threonine
Name: O-(riboflavin phosphoryl)-L-threonine
DiffFormula: C 17 H 19 N 4 O 8 P 1
Formula: C 21 H 26 N 5 O 10 P 1
AminoAcid: T
Definition:
A protein modification that effectively converts an L-threonine residue to O-(riboflavin phosphoryl)-L-threonine.


ModificationSetId: PSI-MOD
SwissprotTerm: FMN phosphoryl serine
Name: O-(riboflavin phosphoryl)-L-serine
DiffFormula: C 17 H 19 N 4 O 8 P 1
Formula: C 20 H 24 N 5 O 10 P 1
AminoAcid: S
Definition:
A protein modification that effectively converts an L-serine residue to O-(riboflavin phosphoryl)-L-serine.


ModificationSetId: PSI-MOD
SwissprotTerm: Tele-8alpha-FMN histidine
Name: 1'-(8alpha-FMN)-L-histidine
DiffFormula: C 17 H 19 N 4 O 9 P 1
Formula: C 23 H 26 N 7 O 10 P 1
AminoAcid: H
Definition:
A protein modification that effectively converts an L-histidine residue to 1'-(8alpha-FMN)-L-histidine.


ModificationSetId: PSI-MOD
Name: 3'-(8alpha-FMN)-L-histidine
DiffFormula: C 17 H 19 N 4 O 9 P 1
Formula: C 23 H 26 N 7 O 10 P 1
AminoAcid: H
Definition:
A protein modification that effectively converts an L-histidine residue to 3'-(8alpha-FMN)-L-histidine.

Comment:
In a later publication, PubMed:19438211, the authors changed the enzyme activity, the connection from a histidine nitrogen to a cysteine sulfur, and the identity of the flavin from FMN to FAD. They now believe the modification is S-(8alpha-FAD)-L-cysteine, see MOD:00152. This is a deprecated entry in RESID. It probably does not occur naturally [JSG].


ModificationSetId: PSI-MOD
Name: L-cysteinyl copper sulfido molybdopterin cytosine dinuncleotide
DiffFormula: C 19 Cu 1 H 24 Mo 1 N 8 O 15 P 2 S 3
Formula: C 22 Cu 1 H 29 Mo 1 N 9 O 16 P 2 S 4
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to L-cysteinyl copper sulfido molybdopterin cytosine dinuncleotide.


ModificationSetId: PSI-MOD
Name: tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide
Comment: Cross-link 3.
DiffFormula: C 15 Fe 4 H 19 N 6 O 5 S 5
Formula: C 24 Fe 4 H 34 N 9 O 8 S 8
Definition:
A protein modification that effectively converts three L-cysteine residues, an S-adenosylmethionine and a four-iron four-sulfur cluster to tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide.


ModificationSetId: PSI-MOD
Name: tris-L-cysteinyl L-arginyl diiron disulfide
Comment: Cross-link 4.
DiffFormula: C 0 Fe 2 H -3 N 0 O 0 S 2
Formula: C 15 Fe 2 H 24 N 7 O 4 S 5
Definition:
A protein modification that effectively converts three L-cysteine residues, an L-arginine residue and a two-iron two-sulfur cluster to tris-L-cysteinyl L-arginyl diiron disulfide.


ModificationSetId: PSI-MOD
Name: L-cysteinyl-L-selenocysteine (Cys-Sec)
Comment: Cross-link 2.
DiffFormula: C 0 H -2 N 0 O 0 S 0 Se 0
Formula: C 6 H 8 N 2 O 2 S 1 Se 1
Definition:
A protein modification that effectively cross-links an L-cysteine residue and an L-selenocysteine residues to form L-cysteinyl-L-selenocystine.


ModificationSetId: PSI-MOD
SwissprotTerm: N6,N6,N6-trimethyl-5-hydroxylysine
Name: 5-hydroxy-N6,N6,N6-trimethyl-L-lysine
Comment: Incidental to RESID:AA0278; secondary to RESID:AA0028; secondary to RESID:AA0074.
DiffFormula: C 3 H 7 N 0 O 1
Formula: C 9 H 19 N 2 O 2
AminoAcid: K
Definition:
A protein modification that effectively converts an L-lysine residue to 5-hydroxy-N6,N6,N6-trimethyl-L-lysine.


ModificationSetId: PSI-MOD
Name: N-(L-isoglutamyl)-glycine
Comment: Cross-link 2.
DiffFormula: C 0 H -2 N 0 O -1
Formula: C 7 H 9 N 2 O 3
Definition:
A protein modification that effectively crosslinks an L-glutamic acid residue and a glycine residue by an isopeptide bond to form N-(L-isoglutamyl)-glycine.


ModificationSetId: PSI-MOD
Name: N-carboxy-L-methionine
Definition: A protein modification that effectively converts an L-methionine residue to N-carboxy-L-methionine.
DiffFormula: C 1 H 0 N 0 O 2 S 0
Formula: C 6 H 10 N 1 O 3 S 1
AminoAcid: M
Comment:
At least three protein crystallographic structures have been reported with this modification. However, no chemical evidence for this modification is provided, there were no reports of this modification before these crystallographic reports, and there is no metabolic explanation for the conversion of a formyl group to a carboxy group. There is confusion in its description, and misnaming is common. This modification is probably a misidentification of N-(dihydroxymethyl)methionine, the hydrated form of N-formylmethionine. See MOD:01446 [JSG].


ModificationSetId: PSI-MOD
SwissprotTerm: (E)-2,3-didehydrotyrosine
Name: (E)-2,3-didehydrotyrosine
DiffFormula: C 0 H -2 N 0 O 0
Formula: C 9 H 7 N 1 O 2
AminoAcid: Y
Definition:
A protein modification that effectively converts an L-tyrosine residue to (E)-2,3-didehydrotyrosine.

Comment:
incidental to RESID:AA0184; incidental to RESID:AA0187; incidental to RESID:AA0188; incidental to RESID:AA0189; incidental to RESID:AA0378; incidental to RESID:AA0379; incidental to RESID:AA0380; incidental to RESID:AA0381


ModificationSetId: PSI-MOD
Name: bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide
Comment: Cross-link 6.
DiffFormula: C 0 Ca 1 H -6 Mn 4 N 0 O 4
Formula: C 29 Ca 1 H 32 Mn 4 N 8 O 20
Definition:
A protein modification that effectively converts two L-aspartic acid residues, three L-glutamic acid residues, an L-histidine residue, and a one-calcium, four-iron, four-oxygen cluster to bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide.


ModificationSetId: PSI-MOD
Name: 3'-(3'-L-tyrosinyl)-L-tyrosine
Comment: Cross-link 2; From DeltaMass: Average Mass: -2.
DiffFormula: C 0 H -2 N 0 O 0
Formula: C 18 H 16 N 2 O 4
Definition:
A protein modification that effectively cross-links two L-tyrosine residues with a carbon-carbon bond to form 3'-(3'-L-tyrosinyl)-L-tyrosine.


ModificationSetId: PSI-MOD
Name: 3'-(O4'-L-tyrosinyl)-L-tyrosine
Comment: Cross-link 2; secondary to RESID:AA0146; From DeltaMass: Average Mass: -2.
DiffFormula: C 0 H -2 N 0 O 0
Formula: C 18 H 16 N 2 O 4
Definition:
A protein modification that effectively cross-links L-tyrosine residues with an ether bond to form 3'-(O4'-L-tyrosinyl)-L-tyrosine.


ModificationSetId: PSI-MOD
Name: 1'-(phospho-5'-adenosine)-L-histidine
DiffFormula: C 10 H 12 N 5 O 6 P 1
Formula: C 16 H 19 N 8 O 7 P 1
AminoAcid: H
Definition:
A protein modification that effectively crosslinks an L-histidine residue and 5'-phosphoadenosine through a phosphoramide ester bond to form 1'-(phospho-5'-adenosine)-L-histidine.


ModificationSetId: PSI-MOD
Name: 1'-(phospho-5'-uridine)-L-histidine
DiffFormula: C 9 H 11 N 2 O 8 P 1
Formula: C 15 H 18 N 5 O 9 P 1
AminoAcid: H
Definition:
A protein modification that effectively crosslinks an L-histidine residue and 5'-phosphouridine through a phosphoramide ester bond to form 1'-(phospho-5'-uridine)-L-histidine.


ModificationSetId: PSI-MOD
SwissprotTerm: Aspartyl aldehyde
Name: L-aspartyl semialdehyde
DiffFormula: C 0 H 0 N 0 O -1
Formula: C 4 H 5 N 1 O 2
AminoAcid: D
Definition:
A protein modification that effectively converts an L-aspartic acid residue to L-aspartyl semialdehyde.


ModificationSetId: PSI-MOD
SwissprotTerm: Serine microcin E492 siderophore ester
Name: L-serine microcin E492 siderophore ester
Comment: UniMod origin corrected [JSG].
DiffFormula: C 36 H 37 N 3 O 20
Formula: C 39 H 43 N 4 O 23
AminoAcid: S
Definition:
A protein modification that effectively converts an L-serine residue to L-serine microcin E492 siderophore ester.


ModificationSetId: PSI-MOD
Name: L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide)
DiffFormula: C 40 H 47 Mo 1 N 20 O 26 P 4 S 4
Formula: C 44 H 52 Mo 1 N 21 O 29 P 4 S 4
AminoAcid: D
Definition:
A protein modification that effectively converts an L-aspartic acid residue to L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide).


ModificationSetId: PSI-MOD
Name: L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide) (Sec)
DiffFormula: C 40 H 47 N 20 O 26 P 4 S 5 Se 0 W 1
Formula: C 43 H 52 N 21 O 27 P 4 S 5 Se 1 W 1
AminoAcid: U
Definition:
A protein modification that effectively converts an L-selenocysteine residue to L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide).


ModificationSetId: PSI-MOD
Name: 3-(2-methylthio)ethyl-6-(4-hydroxybenzylidene)-5-iminopiperazin-2-one
DiffFormula: C 0 H -4 N 0 O -1 S 0
Formula: C 14 H 15 N 2 O 2 S 1
Definition:
A protein modification that effectively crosslinks an L-methionyl-L-tyrosine dipeptide to form 3-(2-methylthio)ethyl-6-(4-hydroxybenzylidene)-5-iminopiperazin-2-one.

Comment:
carboxamidine; cross-link 1. This is a deprecated entry in RESID. It probably does not occur naturally [JSG].


ModificationSetId: PSI-MOD
Name: 2-imino-glutamic acid 5-imidazolinone glycine
Comment: Cross-link 2; carboxamidine; cross-link 1; incidental to RESID:AA0183; incidental to RESID:AA0365.
DiffFormula: C 0 H -4 N 0 O -1
Formula: C 7 H 6 N 2 O 3
Definition:
A protein modification that effectively crosslinks an L-glutamic acid residue and a glycine residue to form 2-imino-glutamic acid 5-imidazolinone glycine.


ModificationSetId: PSI-MOD
Name: 2-imino-methionine 5-imidazolinone glycine
Comment: Cross-link 2; carboxamidine; cross-link 1; incidental to RESID:AA0183; incidental to RESID:AA0365.
DiffFormula: C 0 H -4 N 0 O -1 S 0
Formula: C 7 H 8 N 2 O 1 S 1
Definition:
A protein modification that effectively crosslinks an L-methionine residue and a glycine residue to form 2-imino-methionine 5-imidazolinone glycine.


ModificationSetId: PSI-MOD
Name: L-asparagine 5-imidazolinone glycine
Comment: Cross-link 2; carboxamidine; incidental to RESID:AA0183; incidental to RESID:AA0365.
DiffFormula: C 0 H -2 N 0 O -1
Formula: C 6 H 7 N 3 O 2
Definition:
A protein modification that effectively crosslinks an L-asparagine residue and a glycine residue to form L-asparagine 5-imidazolinone glycine.


ModificationSetId: PSI-MOD
Name: L-lysine 5-imidazolinone glycine
Comment: Cross-link 2; carboxamidine; incidental to RESID:AA0183; incidental to RESID:AA0365.
DiffFormula: C 0 H -2 N 0 O -1
Formula: C 8 H 13 N 3 O 1
Definition:
A protein modification that effectively crosslinks an L-lysine residue and a glycine residue to form L-lysine 5-imidazolinone glycine.


ModificationSetId: PSI-MOD
Name: 2-tetrahydropyridinyl-5-imidazolinone glycine
Comment: Cross-link 2; carboxamidine; incidental to RESID:AA0183; incidental to RESID:AA0365.
DiffFormula: C 0 H -7 N -1 O -1
Formula: C 8 H 9 N 2 O 1
Definition:
A protein modification that effectively crosslinks an L-lysine residue and a glycine residue to form 2-tetrahydropyridinyl-5-imidazolinone glycine.


ModificationSetId: PSI-MOD
SwissprotTerm: Pentaglycyl murein peptidoglycan amidated alanine
Name: L-alanyl-pentaglycyl-murein peptidoglycan
DiffFormula: C 10 H 14 N 5 O 4
Formula: C 13 H 20 N 6 O 6
AminoAcid: A
Definition:
A protein modification that effectively attaches an L-alanine residue to murein peptidoglycan by a pentaglycine linker peptide.


ModificationSetId: PSI-MOD
Name: N-formyl-L-proline
Definition: A protein modification that effectively converts an L-proline residue to N-formyl-L-proline.
DiffFormula: C 1 H 0 N 0 O 1
Formula: C 6 H 8 N 1 O 2
AminoAcid: P
Comment:
CAUTION - observations of this modification can be attributed to unintended artifactual production, or to spurious peptide MS identification. This modification is probably not a natural post-translational modification [JSG].


ModificationSetId: PSI-MOD
Name: O-methylated residue
Definition:
A protein modification that effectively replaces a hydroxyl group hydrogen with a methyl group to produce either an ether from an alcohol or an ester from an acid.


ModificationSetId: PSI-MOD
Name: acetylated residue
Definition: A protein modification that effectively replaces a hydrogen atom with an acetyl group.
DiffFormula: C 2 H 2 O 1
Formula: none
Comment:
Amino hydrogens are replaced to produce amides; hydroxyl hydrogens are replaced to produce esters; and hydrosulfanyl (thiol) hydrogens are replaced to produce sulfanyl esters (thiol esters). From DeltaMass: Average Mass: 42


ModificationSetId: PSI-MOD
Name: thioester crosslinked residues
Definition:
A protein modification that crosslinks two residues by formation of a thioester bond between a cysteine thiol and either an alpha-carbonyl, as in S-(L-methionyl-L-cysteine), or a sidechain carbonyl, as in S-(L-isoglutamyl)-L-cysteine.


ModificationSetId: PSI-MOD
Name: O-glycosylated residue
Definition:
A protein modification that effectively replaces a residue hydrogen atom on an oxygen with a carbohydrate-like group through a glycosidic bond.


ModificationSetId: PSI-MOD
Name: iodoacetamide derivatized residue
DiffFormula: C 2 H 3 N 1 O 1
Formula: none
Definition:
A protein modification that is produced by reaction with iodoacetamide, usually replacement of a reactive hydrogen with a methylcarboxamido group.


ModificationSetId: PSI-MOD
Name: carbamoylated residue
DiffFormula: C 1 H 1 N 1 O 1
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom with a carbamoyl (carboxamido) group. Replacement of an amino hydrogen produces a ureido group.

Comment:
This modification can be produced by hydrogen cyanate, either used as a reagent or as released by urea degradation in solution [JSG].


ModificationSetId: PSI-MOD
Name: iodoacetic acid derivatized residue
DiffFormula: C 2 H 2 O 2
Formula: none
Definition:
A protein modification that is produced by reaction with iodoacetic acid, usually replacement of a reactive hydrogen with a methylcarboxy group.

Comment:
From DeltaMass: Average Mass: 58 Abbreviation:CmC Average Mass Change:58 Notes:Cysteine reacts with iodoacetic acid to produce carboxymethyl cysteine.


ModificationSetId: PSI-MOD
Name: deamidated residue
Comment: From DeltaMass: References:Vish Katta.
DiffFormula: H -1 N -1 O 1
Formula: none
Definition:
A protein modification that effectively replaces a carboxamido group with a carboxyl group, with both a gain of oxygen and loss of a nitrogen and a hydrogen.


ModificationSetId: PSI-MOD
Name: Gygi ICAT(TM) d0 modified cysteine
DiffFormula: C 22 H 38 N 4 O 6 S 1
Formula: C 25 H 43 N 5 O 7 S 2
AminoAcid: C
Definition:
A protein modification that is produced by formation of an adduct of a cysteine residue with the Gygi isotope-coded affinity tag d0 reagent.


ModificationSetId: PSI-MOD
Name: Gygi ICAT(TM) d8 modified cysteine
DiffFormula: C 22 (1)H 30 (2)H 8 N 4 O 6 S 1
Formula: C 25 (1)H 35 (2)H 8 N 5 O 7 S 2
AminoAcid: C
Definition:
A protein modification that is produced by formation of an adduct of a cysteine residue with the Gygi isotope-coded affinity tag d8 reagent.


ModificationSetId: PSI-MOD
Name: homoserine
Definition: A protein modification that effectively converts an L-methionine residue to homoserine.
DiffFormula: C -1 H -2 O 1 S -1
Formula: C 4 H 7 N 1 O 2
AminoAcid: M
Comment:
Usually formed from methionine by reaction with cyanogen bromide, CNBr, which cleaves the peptide at the methionine carboxyl group and the following residue amino group.


ModificationSetId: PSI-MOD
Name: homoserine lactone
Definition: A protein modification that effectively converts an L-methionine residue to homoserine lactone.
DiffFormula: C -1 H -4 S -1
Formula: C 4 H 5 N 1 O 1
AminoAcid: M
Comment:
Usually formed from methionine by reaction with cyanogen bromide, CNBr, which cleaves the peptide at the methionine carboxyl group. Under acid conditions the homoserine dehydrates to form the cyclic lactone.


ModificationSetId: PSI-MOD
Name: Applied Biosystems original ICAT(TM) d8 modified cysteine
DiffFormula: C 20 (1)H 26 (2)H 8 N 4 O 5 S 1
Formula: C 23 (1)H 31 (2)H 8 N 5 O 6 S 2
AminoAcid: C
Definition:
A protein modification that is produced by formation of an adduct of a cysteine residue with the Applied Biosystems original isotope-coded affinity tag d8 reagent.


ModificationSetId: PSI-MOD
Name: Applied Biosystems original ICAT(TM) d0 modified cysteine
DiffFormula: C 20 (1)H 34 N 4 O 5 S 1
Formula: C 23 (1)H 39 N 5 O 6 S 2
AminoAcid: C
Definition:
A protein modification that is produced by formation of an adduct of a cysteine residue with the Applied Biosystems original isotope-coded affinity tag d0 reagent.


ModificationSetId: PSI-MOD
Name: residue methyl ester
DiffFormula: C 1 H 2
Formula: none
Definition:
A protein modification that effectively replaces a carboxyl group with a carboxy methyl ester group. OBSOLETE because UniMod:14 merged with entry 34, remap to MOD:00599.


ModificationSetId: PSI-MOD
Name: N-acetylated residue
DiffFormula: C 2 H 2 O 1
Formula: none
Definition:
A protein modification that effectively replaces a residue amino or imino hydrogen with an acetyl group.


ModificationSetId: PSI-MOD
Name: S-(N-isopropylcarboxamidomethyl)-L-cysteine
DiffFormula: C 5 H 9 N 1 O 1 S 0
Formula: C 8 H 14 N 2 O 2 S 1
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to S-(N-isopropylcarboxamidomethyl)-L-cysteine.


ModificationSetId: PSI-MOD
Name: O18 label
Comment: A modification from UniMod:18
DiffFormula: (16)O -1 (18)O 1
Formula: none
Definition:
modification from UniMod Isotopic label. OBSOLETE because UniMod:18 is now merged with entry 258 remap to MOD:00581 'single 018 label'


ModificationSetId: PSI-MOD
Name: oxidation
DiffFormula: O 1
Formula: none
Definition:
modification from UniMod artifact. OBSOLETE because UniMod entry 19 is now merged with UniMod 35 remap to MOD:00425 'monohydroxylated residue'.


ModificationSetId: PSI-MOD
Name: biotinyl-iodoacetamidyl-3,6-dioxaoctanediamine derivatized cysteine
DiffFormula: C 18 H 30 N 4 O 5 S 1
Formula: C 21 H 35 N 5 O 6 S 2
AminoAcid: C
Definition:
A protein modification that is produced by reaction of a cysteine residue with biotinyl-iodoacetamidyl-3,6-dioxaoctanediamine.


ModificationSetId: PSI-MOD
Name: monomethylated L-arginine
Comment: From DeltaMass: formula incorrect, N and O reversed
DiffFormula: C 1 H 2 N 0 O 0
Formula: C 7 H 14 N 4 O 1
AminoAcid: R
Definition:
A protein modification that effectively replaces one hydrogen atom of an L-arginine residue with one methyl group.


ModificationSetId: PSI-MOD
Name: phosphorylation without neutral loss
DiffFormula: H 1 O 3 P 1
Formula: none
Definition:
modification from UniMod - OBSOLETE because UniMod entry 22 is now merged with entry 21 remap to MOD:00696 'phosphorylated residue'.


ModificationSetId: PSI-MOD
Name: phosphorylation of an hydroxyl amino acid with prompt loss of phosphate
DiffFormula: H -2 O -1
Formula: none
Definition:
A change resulting in an alteration of the measured molecular mass of a peptide or protein hydroxyl amino acid phosphorylated promptly followed by secondary loss of a neutral trihydrogen phosphate molecular fragment.

Comment:
O4-phosphotyrosine does not lose phosphate by this mechanism. UniMod does not provide a citation for this particular modification [JSG].


ModificationSetId: PSI-MOD
Name: S-carboxamidoethyl-L-cysteine
DiffFormula: C 3 H 5 N 1 O 1 S 0
Formula: C 6 H 10 N 2 O 2 S 1
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to S-carboxamidoethyl-L-cysteine.

Comment:
From DeltaMass: References: Anal. Biochem. Vol 216 No. 1 p131 (citation not found) Notes: Residual acrylamide in SDS gels can label free cysteines to produce propionamido-Cys (also known as PAM-Cys)


ModificationSetId: PSI-MOD
Name: pyridylacetylated residue
Comment: Produced by reaction with N-[(pyrid-3-yl)acetyl]oxy-succinimide [JSG].
DiffFormula: C 7 H 5 N 1 O 1
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom with an (pyridin-3-yl)acetyl group.


ModificationSetId: PSI-MOD
Name: (R)-5-oxo-1,4-tetrahydrothiazine-3-carboxylic acid
DiffFormula: C 2 H 0 N 0 O 1 S 0
Formula: C 5 H 6 N 1 O 2 S 1
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to (R)-5-oxo-1,4-tetrahydrothiazine-3-carboxylic acid.

Comment:
From DeltaMass: A secondary modification affecting peptides with S-carbamoylmethyl-L-cysteine (CamC) at the N-terminus. These exist in enzymatic digests of proteins that have been S-alkylated with iodoacetamide. Cyclization of N-terminal CamC gives a residue of (R)-5-oxoperhydro-1,4-thiazine-3-carboxylic acid. Peptides in which this has occurred become more hydrophobic, and lose 17 Da from the N-terminal residue.


ModificationSetId: PSI-MOD
SwissprotTerm: Pyrrolidone carboxylic acid (Glu)
Name: 2-pyrrolidone-5-carboxylic acid (Glu)
DiffFormula: C 0 H -2 N 0 O -1
Formula: C 5 H 6 N 1 O 2
AminoAcid: E
Definition:
A protein modification that effectively converts an L-glutamic acid residue to 2-pyrrolidone-5-carboxylic acid.

Comment:
From DeltaMass: References: The conversion of glutamic acid to pyroglutamic was reported for the beta-amyloid protein. Miller et al. Arch. Biochem. Biophy. (1993) 301, 41-52 [DeltaMass]. The modification in amyloid protein is probably an artifact of treatment with strong acid under anhydrous conditions. Peptides with N-terminal glutamic acid isolated from single cells of Aplysia neurons show partial conversion to pyroglutamic acid, possibly dependent on a temperature sensitive factor [JSG].


ModificationSetId: PSI-MOD
Name: C-glycosylated residue
Definition:
A protein modification that effectively replaces a residue hydrogen atom on a carbon with a carbohydrate-like group through a glycosidic bond.


ModificationSetId: PSI-MOD
Name: alpha-amino morpholine-2-acetylated residue
DiffFormula: C 6 H 9 N 1 O 2
Formula: none
Definition:
A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a morpholine-2-acetyl group.

Comment:
The UniMod name "N-Succinimidyl-3-morpholine acetate" appears to have been a typographical error [JSG].


ModificationSetId: PSI-MOD
Name: S-pyridylethyl-L-cysteine
DiffFormula: C 7 H 7 N 1
Formula: C 10 H 12 N 2 O 1 S 1
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to S-pyridylethyl-L-cysteine.

Comment:
From DeltaMass: Formula:C10H12O2N1S1 (formula incorrect, N and O reversed) Monoisotopic Mass Change:208.067 Average Mass Change:208.286 (mass incorrect, aggregate not delta) References:PE Sciex


ModificationSetId: PSI-MOD
Name: S-glycosylated residue
Definition:
A protein modification that effectively replaces a residue hydrogen atom on a sulfur with a carbohydrate-like group through a glycosidic bond.


ModificationSetId: PSI-MOD
Name: methylated residue
Definition: A protein modification that effectively replaces a hydrogen atom with a methyl group.
Comment:
From DeltaMass: Average Mass: 14 Average Mass Change:14 References:Methylation of Asparagine (found in phycobiliproteins) Klotz and Glazer (1987) J. Biol. Chem. 262; 17350-17355


ModificationSetId: PSI-MOD
Name: dimethylated residue
Definition: A protein modification that effectively replaces two hydrogen atoms with two methyl groups.
DiffFormula: C 2 H 4
Formula: none
Comment:
For amino-terminal proline residues, dimethylation can effectively only be accomplished with a protonated imino group. This process accounts only for dimethylation and not protonation. The alternative Me2+Res process accounts for both protonation and dimethylation [JSG].


ModificationSetId: PSI-MOD
Name: trimethylated residue
Definition: A protein modification that effectively replaces three hydrogen atoms with three methyl groups.
DiffFormula: C 3 H 6
Formula: none
Comment:
For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative Me3+Res process accounts for both protonation and trimethylation.


ModificationSetId: PSI-MOD
Name: modified residue with a secondary neutral loss
Definition:
Covalent modification of, or a change resulting in an alteration of the measured molecular mass of, a peptide or protein amino acid residue with a secondary loss of a neutral molecular fragment.


ModificationSetId: PSI-MOD
Name: modified residue with neutral loss of phosphate
Definition:
Covalent modification of, or a change resulting in an alteration of the measured molecular mass of, a peptide or protein amino acid residue with a secondary loss of a neutral trihydrogen phosphate molecular fragment.


ModificationSetId: PSI-MOD
Name: glucosylated residue
DiffFormula: C 6 H 10 N 0 O 5
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom with an glucose group through a glycosidic bond.


ModificationSetId: PSI-MOD
Name: hexosylated residue
DiffFormula: none
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a hexose sugar group through a glycosidic bond.

Comment:
From DeltaMass: Average Mass: 162 Formula:C6 H10 05 Monoisotopic Mass Change:162.053 Average Mass Change:162.143 References:PE Sciex.


ModificationSetId: PSI-MOD
Name: O-phospho-L-serine with neutral loss of phosphate
DiffFormula: C 0 H -3 N 0 O -4 P -1
Formula: C 3 H 3 N 1 O 1
Definition:
Covalent modification of a peptide or protein amino acid phosphorylated serine with a secondary loss of a neutral trihydrogen phosphate molecular fragment.


ModificationSetId: PSI-MOD
Name: N-acetylhexosaminylated
DiffFormula: C 8 H 13 N 1 O 5
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with an N-acetylhexosamine group through a glycosidic bond.


ModificationSetId: PSI-MOD
Name: O-phospho-L-threonine with neutral loss of phosphate
DiffFormula: C 0 H -3 N 0 O -4 P -1
Formula: C 4 H 5 N 1 O 1
Definition:
Covalent modification of a peptide or protein amino acid phosphorylated threonine with a secondary loss of a neutral trihydrogen phosphate molecular fragment.


ModificationSetId: PSI-MOD
DiffFormula: C 1 H 2 N 2 O 0
Formula: C 7 H 14 N 2 O 1
AminoAcid: R
Name:
protonated omega-N,omega-N'-dimethylated L-arginine with secondary neutral loss of N,N'-carbodiimide

Definition:
Covalent modification of a peptide or protein L-arginine residue to protonated omega-N,omega-N'-dimethylated L-arginine with secondary loss of an N,N'-carbodiimide molecular fragment.


ModificationSetId: PSI-MOD
Name: protonated omega-N,omega-N-dimethlyated L-arginine with secondary neutral loss of N,N-dimethylamine
DiffFormula: C 2 H 7 N 2
Formula: C 6 H 10 N 3 O 1
AminoAcid: R
Definition:
Covalent modification of a peptide or protein L-arginine residue to protonated omega-N,omega-N-dimethlyated L-arginine with secondary neutral loss of an N,N-dimethylamine molecular fragment.


ModificationSetId: PSI-MOD
Name: N-palmitoyl-S-(sn-1-2,3-dipalmitoyl-glycerol)cysteine
DiffFormula: C 51 H 96 O 5
Formula: C 54 H 101 N 1 O 6 S 1
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to N-palmitoyl-S-(sn-1-2,3-dipalmitoyl-glycerol)cysteine.


ModificationSetId: PSI-MOD
Name: L-homoarginine
DiffFormula: C 1 H 2 N 2
Formula: C 7 H 14 N 4 O 1
AminoAcid: K
Definition:
A protein modification that effectively converts an L-lysine residue to L-homoarginine, such as reaction with O-methylisourea.


ModificationSetId: PSI-MOD
Name: 4-hydroxynonenal adduct
Definition: A protein modification produced by formation of an adduct of a residue with 4-hydroxynonenal.
DiffFormula: C 9 H 16 O 2
Formula: none
Comment:
4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG].


ModificationSetId: PSI-MOD
Name: N-glucuronylated residue
DiffFormula: C 6 H 8 O 6
Formula: none
Definition:
A protein modification that effectively results from forming an adduct with a glucuronic acid either through a carboxyl group amide or ester bond, or through C1-glycosylation.


ModificationSetId: PSI-MOD
Name: N-acetylaminoglucosylated residue
DiffFormula: C 8 H 13 N 1 O 5
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom with an N-acetylaminoglucose group through a glycosidic bond.


ModificationSetId: PSI-MOD
Name: alpha-amino propanoylated residue
DiffFormula: C 3 H 4 O 1
Formula: none
Definition:
A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a propanoyl group.


ModificationSetId: PSI-MOD
Name: alpha-amino 3x(13)C-labeled propanoylated residue
DiffFormula: (13)C 3 H 4 O 1
Formula: (12)C 6 (13)C 3 H 16 N 2 O 2
AminoAcid: K
Definition:
A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a 3x(13)C-labeled propanoyl group.


ModificationSetId: PSI-MOD
Name: quaternary amine labeling reagent light form (N-term & K)
DiffFormula: C 7 H 13 N 1 O 1
Formula: none
Definition:
A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a quaternary amine reagent light form group.


ModificationSetId: PSI-MOD
Name: quaternary amine labeling reagent heavy form (+3amu) (N-term & K)
DiffFormula: C 7 (1)H 10 (2)H 3 N 1 O 1
Formula: C 13 (1)H 22 (2)H 3 N 3 O 2
Definition:
A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a quaternary amine reagent heavy (+3amu) form group.


ModificationSetId: PSI-MOD
Name: quaternary amine labeling reagent heavy form (+6amu) (N-term & K)
DiffFormula: C 7 H 7 (2)H 6 N 1 O 1
Formula: none
Definition:
A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a quaternary amine reagent heavy (+6amu) form group.


ModificationSetId: PSI-MOD
Name: quaternary amine labeling reagent heavy form (+9amu) (N-term & K)
DiffFormula: C 7 (1)H 4 (2)H 9 N 1 O 1
Formula: C 13 (1)H 16 (2)H 9 N 3 O 2
Definition:
A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a quaternary amine reagent heavy (+9amu) form group.


ModificationSetId: PSI-MOD
Name: alpha-amino succinylated residue
DiffFormula: (12)C 4 (1)H 4 O 3
Formula: none
Definition:
A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a succinyl group.


ModificationSetId: PSI-MOD
Name: 4x(2)H labeled alpha-amino succinylated residue
DiffFormula: C 4 (2)H 4 O 3
Formula: none
Definition:
A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a 4x(2)H labeled succinyl group.


ModificationSetId: PSI-MOD
Name: 4x(13)C labeled alpha-amino succinylated residue
DiffFormula: (13)C 4 H 4 O 3
Formula: none
Definition:
A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a 4x(13)C labeled succinyl group.


ModificationSetId: PSI-MOD
Name: L-cysteic acid (L-cysteine sulfonic acid)
DiffFormula: C 0 H 0 N 0 O 3 S 0
Formula: C 3 H 5 N 1 O 4 S 1
AminoAcid: C
Definition:
A protein modification that effectively trioxygenates an L-cysteine residue to L-cysteine sulfonic acid.

Comment:
From DeltaMass: Notes:Treatment of cysteine by strongly oxidising reagents such as performic acid results in the complete oxidation of the sulphur atom. Such treatment is often carried out prior to amino acid analysis as the resulting cysteic acid is then resistant to acid degradation during the hydrolysis procedure.


ModificationSetId: PSI-MOD
Name: 3'-hydroxy-L-kynurenine
DiffFormula: C -1 O 2
Formula: C 10 H 10 N 2 O 3
AminoAcid: W
Definition:
A protein modification that effectively converts an L-tryptophan residue to 3'-hydroxy-L-kynurenine.


ModificationSetId: PSI-MOD
Name: N'-formyl-L-kynurenine
Definition: A protein modification that effectively converts an L-tryptophan residue to N'-formyl-L-kynurenine.
DiffFormula: O 2
Formula: C 11 H 10 N 2 O 3
AminoAcid: W
Comment:
From DeltaMass: References:Willy V. Bienvenut, Catherine Déon, Carla Pasquarello, Jennifer M. Campbell, Jean-Charles Sanchez, Marvin L. Vestal, Denis F. Hochstrasser Matrix-assisted laser desorption/ionization-tandemmass spectrometry with high resolution andsensitivity for identification and characterizationof proteins. Proteomics 2002, 2, 868-876 Notes: A double oxidation of tryptophan for which the N-formylkynurenine (+32) structure can be proposed. Many minor peaks accompanying the main peak might also be attributed to other oxidation products of the tryptophan such as kynurenine (+4), an unknown by-product found in all oxidized tryptophan patterns (+13), hydroxytryptophan (+16), 3-hydroxykynurenine (+20) and hydroxy-N-formylkynurenine (+48). See proposed structures at http://www.abrf.org/images/misc/dmass32.jpg.


ModificationSetId: PSI-MOD
Name: dihydroxyphenylalanine (Phe)
DiffFormula: O 2
Formula: C 9 H 9 N 1 O 3
AminoAcid: F
Definition:
A protein modification that effectively converts an L-phenylalanine residue to a dihydroxyphenylalanine.

Comment:
Dihydroxyphenyalanines with a 4'-hydroxyl orginate naturally by a monohydroxylation of tyrosine, and not by dihydroxylation of phenylalanine [JSG].


ModificationSetId: PSI-MOD
Name: glycosylsphingolipidinositolated residue
Definition:
A protein modification that effectively converts a residue to a glycosylsphingolipidinositolethanolamidated.


ModificationSetId: PSI-MOD
Name: S-([1,1,2-(2)H3]-carboxamidoethyl)-L-cysteine
DiffFormula: C 3 (1)H 2 (2)H 3 N 1 O 1
Formula: C 6 (1)H 7 (2)H 3 N 2 O 2 S 1
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to S-(1,1,2-(2)H3)-propanamide-L-cysteine.


ModificationSetId: PSI-MOD
Name: galactosylated residue
Definition:
A protein modification that effectively replaces a hydrogen atom with an galactose group through a glycosidic bond.


ModificationSetId: PSI-MOD
Name: 2-pyrrolidone
DiffFormula: C -1 H -1 N 0 O 0
Formula: C 4 H 6 N 1 O 1
AminoAcid: P
Definition:
A protein modification that effectively converts, by oxidative decarboxylation, an L-proline residue to 2-pyrrolidone with breakage of the peptide chain.

Comment:
The oxidative decarboxylation of a proline residue results in breaking of the peptide chain, leaving a peptidyl-2-pyrrolidone at the C-terminus. The difference formula, derived from the result in the original citation, has been corrected from the UniMod entry.


ModificationSetId: PSI-MOD
Name: glutamyl semialdehyde (Arg)
Definition: A protein modification that effectively converts an L-arginine residue to L-glutamyl semialdehyde.
DiffFormula: C -1 H -5 N -3 O 1
Formula: C 5 H 7 N 1 O 2
AminoAcid: R
Comment:
From DeltaMass: Average Mass: -27 Monoisotopic Mass Change:-27.06 Average Mass Change:-27.07 References:Amici A, Levine, RL, Tsai, L, and Stadtman, ER: Conversion of amino acid residues in proteins and amino acid homopolymers to carbonyl derivatives by metal-catalyzed oxidation reactions. Journal of Biological Chemistry 264: 3341-3346 1989.Requena JR, Chao CC, Levine RL, and Stadtman ER: Glutamic and aminoadipic semialdehydes are the main carbonyl products of metal-catalyzed oxidation of proteins. Proceedings of the National Academy of Sciences USA 98: 69-74 2001.


ModificationSetId: PSI-MOD
SwissprotTerm: N-formylmethionine
Name: N-formyl-L-methionine (Met)
DiffFormula: C 1 H 0 N 0 O 1 S 0
Formula: C 6 H 10 N 1 O 2 S 1
AminoAcid: M
Definition:
A protein modification that effectively converts an L-methionine residue to N-formyl-L-methionine (not known as a natural, post-translational modification process).

Comment:
This entry is for the artifactual formation of N-formyl-L-methionine from methionine. For encoded N-formyl-L-methionine, use MOD:00030 [JSG].


ModificationSetId: PSI-MOD
Name: ubiquitination signature dipeptidyl lysine
DiffFormula: C 4 H 6 N 2 O 2
Formula: C 10 H 18 N 4 O 3
AminoAcid: K
Definition:
A protein modification that crosslinks the N6-amino of a peptidyl lysine with the carboxyl of glycylglycine, the two glycine residues left after tryptic digestion of ubiquitin.


ModificationSetId: PSI-MOD
Name: monoiodinated residue
Comment: From DeltaMass: Average Mass: 126
DiffFormula: H -1 I 1
Formula: none
Definition:
A protein modification that effectively substitutes one hydrogen atom of a residue with one iodine atom.


ModificationSetId: PSI-MOD
Name: diiodinated residue
Comment: From DeltaMass: Average Mass: 252
DiffFormula: H -2 I 2
Formula: none
Definition:
A protein modification that effectively substitutes two hydrogen atoms of a residue with two iodine atoms.


ModificationSetId: PSI-MOD
Name: triiodinated residue
DiffFormula: H -3 I 3
Formula: none
Definition:
A protein modification that effectively substitutes three hydrogen atoms of a residue with three iodine atoms.

Comment:
From UniMod. In PubMed:2026710, mono- and diiodination of tyrosine are discussed, but triiodination of tyrosine is not mentioned. In PubMed:15627961, triiodothyronine (see MOD:00186) is discussed, but triiodotyrosine is not mentioned. This modification probably does not exist, and may be a confusion of "tyrosine" for "thyronine", a common error [JSG].


ModificationSetId: PSI-MOD
Name: N-(cis-delta 5)-tetradecaenoylglycine
DiffFormula: C 14 H 24 N 0 O 1
Formula: C 16 H 27 N 1 O 2
AminoAcid: G
Definition:
A protein modification that effectively converts a glycine residue to N-(cis-delta 5)-tetradecaenoylglycine.


ModificationSetId: PSI-MOD
Name: N-(cis,cis-delta 5,delta 8)-tetradecadienoylglycine
DiffFormula: C 14 H 22 O 1
Formula: C 16 H 25 N 1 O 2
AminoAcid: G
Definition:
A protein modification that effectively converts a glycine residue to N-(cis,cis-delta 5,delta 8)-tetradecadienoylglycine.


ModificationSetId: PSI-MOD
Name: ISD a-series (C-Term)
Definition: modification from UniMod Other
DiffFormula: C -1 H -1 O -1
Formula: none
Comment:
Virtual Modification for MS/MS of a-type ions, by decarboxylation of C-terminus as reaction inside the mass spectrometer.


ModificationSetId: PSI-MOD
Name: Hex1HexNAc1NeuAc1 glycosylated residue
Comment: From DeltaMass: Average Mass: 657
DiffFormula: C 25 H 41 N 2 O 18
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a carbohydrate-like group composed of Hex1HexNAc1NeuAc1 linked through a glycosidic bond.


ModificationSetId: PSI-MOD
Name: Hex1HexNAc1NeuAc2 glycosylated residue
DiffFormula: C 36 H 57 N 3 O 26
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a carbohydrate-like group composed of Hex1HexNAc1NeuAc2 linked through a glycosidic bond.


ModificationSetId: PSI-MOD
Name: (18)O labeled deglycosylated asparagine
DiffFormula: H -1 N -1 (18)O 1
Formula: C 4 H 5 N 1 (16)O 2 (18)O 1
AminoAcid: N
Definition:
A protein modification that effectively converts an L-asparagine residue to L-aspartic acid with one (18)O as the result of having been deglycosylated in (18)O water.


ModificationSetId: PSI-MOD
Name: phosphorylation to amine thiol
Definition: modification from UniMod Chemical derivative
DiffFormula: C 4 H 9 N 1 O -1 S 1
Formula: none
Comment:
DAET = 2-(dimethylamino)ethanethiol. The phosphorylation to amine is the beta elimination of phosphate and Michael addition of 2-(dimethylamino)ethanethiol to the site.


ModificationSetId: PSI-MOD
Name: L-serine to L-alanine replacement
DiffFormula: O -1
Formula: none
AminoAcid: S
Definition:
OBSOLETE because UniMod 179 merged wth UniMod 447 remap to ??? a protein modification that replaces an L-serine residue with an L-alanine residue


ModificationSetId: PSI-MOD
Name: threonine reduced to aminobutynate
DiffFormula: H -1 O -1
Formula: none
AminoAcid: T
Definition:
OBSOLETE because UniMod 179 merged wth UniMod 447 remap to ??? modification from UniMod O-linked glycosylation


ModificationSetId: PSI-MOD
Name: 9x(13)C labeled residue
DiffFormula: (12)C -9 (13)C 9
Formula: none
Definition:
A protein modification that effectively converts a residue containing common isotopes to a 9x(13)C labeled residue.


ModificationSetId: PSI-MOD
Name: 9x(13)C labeled L-phosphotyrosine
DiffFormula: (12)C -9 (13)C 9 H 1 O 3 P 1
Formula: (13)C 9 H 10 N 1 O 5 P 1
AminoAcid: Y
Definition:
A protein modification that effectively converts an L-tyrosine residue to 9x(13)C labeled L-phosphotyrosine.


ModificationSetId: PSI-MOD
Name: 6x(13)C labeled residue
DiffFormula: (12)C -6 (13)C 6
Formula: none
Definition:
A protein modification that effectively converts a residue containing common isotopes to a 6x(13)C labeled residue.


ModificationSetId: PSI-MOD
Name: (18)O label at both C-terminal oxygens
DiffFormula: (16)O -2 (18)O 2
Formula: none
Definition:
A protein modification that effectively substitutes two (18)O atom for the two (16)O atoms of an alpha-carboxyl (1-carboxyl) group.


ModificationSetId: PSI-MOD
Name: APTA d3
Definition: modification from UniMod Isotopic label
DiffFormula: C 9 (1)H 16 (2)H 3 N 2 O 1
Formula: C 12 (1)H 21 (2)H 3 N 3 O 2 S 1
AminoAcid: C
Comment:
Derivatization of cysteine with 3-acrylamidopropyl)trimethylammonium chloride (difference formula correct) [JSG].


ModificationSetId: PSI-MOD
Name: 4x(2)H labeled dimethylated residue
Comment: Supposed to be alpha-amino and Lys-N6 derivatized by C(2)H2O and reduction.
DiffFormula: C 2 (2)H 4
Formula: none
Definition:
A protein modification that effectively converts a residue containing common isotopes to a 4x(2)H labeled dimethylated residue.


ModificationSetId: PSI-MOD
Name: 1,2-ethanedithiol modified residue
Comment: From DeltaMass: Average Mass: 93; supposed to be derivatization of serine and threonine.
DiffFormula: C 2 H 4 O -1 S 2
Formula: none
Definition:
A protein modification that effectively substitutes a (2-sulfanylethyl)sulfanyl (or thioethylthiol) group for a hydroxy group.


ModificationSetId: PSI-MOD
Name: APTA-d0 with no neutral loss
DiffFormula: C 9 H 18 N 2 O 1
Formula: none
AminoAcid: C
Definition:
OBSOLETE because UniMod entry 202 was merged with entry 195, remap to MOD:00548. modification from UniMod Chemical derivative


ModificationSetId: PSI-MOD
Name: N-acetylaminogalactosylated residue
DiffFormula: C 8 H 13 N 1 O 5
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom with an N-acetylaminogalactose group through a glycosidic bond.


ModificationSetId: PSI-MOD
Name: Applied Biosystems iTRAQ(TM) multiplexed quantitation chemistry
DiffFormula: (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 O 1
Formula: none
Definition:
Modification from UniMod Isotopic label. The UniMod term was extracted when it had not been approved. OBSOLETE because redundant to MOD:01505. Remap to MOD:01505, or one of the child terms MOD:01493 or MOD:01497.


ModificationSetId: PSI-MOD
Name: deglycosylated asparagine
Definition: modification from UniMod N-linked glycosylation
DiffFormula: H -1 N -1 O 1
Formula: C 4 H 5 N 1 O 3
AminoAcid: N
Comment:
Conversion of glycosylated asparagine residues upon deglycosylation with PGNase F in H2O. CAUTION - the difference formula appears to be based on a partial structure [JSG].


ModificationSetId: PSI-MOD
Name: 2-pyrrolidone-5-carboxylic acid (Pro)
DiffFormula: H -2 O 1
Formula: C 5 H 6 N 1 O 2
AminoAcid: P
Definition:
A modification that effectively oxygenates C5 of an L-proline residue to form a 2-pyrrolidone-5-carboxylic acid, pyroglutamic acid.

Comment:
The review article PubMed:9252331 does not provide an original citation for this modification [JSG].


ModificationSetId: PSI-MOD
Name: 6x(13)C,2x(15)N labeled L-lysine
DiffFormula: (12)C -6 (13)C 6 (14)N -2 (15)N 2
Formula: (13)C 6 H 12 (15)N 2 O 1
AminoAcid: K
Definition:
A protein modification that effectively converts an L-lysine residue to 6x(13)C,2x(15)N labeled L-lysine.


ModificationSetId: PSI-MOD
Name: thiophosphorylated residue
DiffFormula: H 1 O 2 P 1 S 1
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom with a thiophosphono group (H2PO2S, 'thiophosphate').


ModificationSetId: PSI-MOD
Name: deuterium trisubstituted residue
DiffFormula: (1)H -3 (2)H 3
Formula: none
Definition:
A protein modification that effectively substitutes three (2)H deuterium atoms for three (1)H protium atoms.


ModificationSetId: PSI-MOD
Name: 6x(13)C,4x(15)N labeled L-arginine
DiffFormula: (12)C -6 (13)C 6 (14)N -4 (15)N 4
Formula: (13)C 6 H 12 (15)N 4 O 1
AminoAcid: R
Definition:
A protein modification that effectively converts an L-arginine residue to 6x(13)C, 4x(15)N labeled L-arginine.


ModificationSetId: PSI-MOD
Name: 5x(13)C,1x(15)N labeled L-valine
DiffFormula: (12)C -5 (13)C 5 (14)N -1 (15)N 1
Formula: (13)C 5 H 9 (15)N 1 O 1
AminoAcid: V
Definition:
A protein modification that effectively converts an L-valine residue to 5x(13)C,1x(15)N labeled L-valine.


ModificationSetId: PSI-MOD
Name: 1x(13)C,1x(15)N labeled L-phenylalanine
DiffFormula: (12)C -9 (13)C 9 (14)N -1 (15)N 1
Formula: (13)C 9 H 9 (15)N 1 O 1
AminoAcid: F
Definition:
A protein modification that effectively converts an L-phenylalanine residue to (13)C,(15)N labeled L-phenylalanine.


ModificationSetId: PSI-MOD
Name: mannosylated residue
DiffFormula: C 6 H 10 N 0 O 5
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom with an manose group through a glycosidic bond


ModificationSetId: PSI-MOD
Name: 4-(2-aminoethyl)benzenesulfonyl fluoride derivatized residue
DiffFormula: C 8 H 9 N 1 O 2 S 1
Formula: none
Definition:
A protein modification that is produced by formation of an adduct with 4-(2-aminoethyl)benzenesulfonyl fluoride, AEBS.

Comment:
From DeltaMass: Average Mass: 183 Average Mass Change:183 References:We have found that AEBSF modifies many proteins by covalent attachment, preferentially on Tyr, and to a lesser extent on Lys, His, and the amino-terminus. These modifications were identified by electrospray MS of the proteins (adds 183 Da per AEBS-group) and by peptide mapping and MS/MS. All the proteins we examined were modified after 24 hrs. at 4 C with 1 mM AEBSF in TRIS, pH 8.0. The reaction is 10-20x slower at pH 7; however AEBSF is quite stable in aqueous solution and the extent of to which the protein is modified continues to increase for several days. We have seen the addition of 10 or more AEBS-groups to proteins after prolonged storage. We found no equivalent modification from PMSF, probably because it degrades so quickly. We no longer use AEBSF, and urge caution to those who do. To address the problem, Boehringer Mannheim (now Roche Molecular Biochemicals) introduced Pefabloc PLUS which includes an additional component to compete for these side reactions. In our limited experience with Pefabloc PLUS, it reduces the +183 modifications, but does not always eliminate them. As a result, we prefer PMSF, despite its own set of drawbacks. We have never found PMSF-induced modification of proteins (except trypsin), probably due to its short half-life in aqeous solution.


ModificationSetId: PSI-MOD
Name: S-(2-hydroxyethyl)cysteine
Comment: This modification of cysteine is produced by the reagent iodoethanol with triethylphosphine [JSG].
DiffFormula: C 2 H 4 O 1
Formula: C 5 H 9 N 1 O 2 S 1
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to S-(2-hydroxyethyl)cysteine


ModificationSetId: PSI-MOD
Name: L-glutamic acid 5-ethyl ester
DiffFormula: C 2 H 4
Formula: C 7 H 11 N 1 O 3
AminoAcid: E
Definition:
A protein modification that effectively converts an L-glutamic acid residue to L-glutamate 5-ethyl ester.

Comment:
From DeltaMass: Average Mass: 28 with no citation. The UniMod citation refers to the formation of glutamate ethyl ester and not to either lysine or N-terminal alkylation. For dimethylated residues, see MOD:00429 and its children [JSG].


ModificationSetId: PSI-MOD
Name: cyclized residue
Definition:
A protein modification that effectively produces an heterocyclic amino acid with a covalent bond between the side chain and either its alpha amino or 1-carboxyl group, possibly breaking the peptide chain.


ModificationSetId: PSI-MOD
Name: N-methylated residue
Definition:
A protein modification that effectively replaces a hydrogen atom of a residue amino or imino group with an methyl group.


ModificationSetId: PSI-MOD
Name: 2x(2)H monomethylated L-lysine
DiffFormula: C 1 (2)H 2
Formula: C 7 (1)H 12 (2)H 2 N 2 O 1
AminoAcid: K
Definition:
A protein modification that effectively converts an L-lysine residue to 2x(2)H labeled monomethylated L-lysine.


ModificationSetId: PSI-MOD
Name: dioxoindolealanine lactone
Definition: modification from UniMod Chemical derivative
DiffFormula: H -1 O 2
Formula: C 11 H 9 N 2 O 3
AminoAcid: W
Comment:
UniMod name, formula, and terminal specification corrected. Formula corresponded to uncleaved intermediate [JSG].


ModificationSetId: PSI-MOD
Name: iodouridine monophosphate derivatized residue
DiffFormula: C 9 H 11 N 2 O 9 P 1
Formula: none
Definition:
A protein modification that is produced by reaction of iodouridine monophosphate, or a polynucleotide containing iodouridine, with a residue.


ModificationSetId: PSI-MOD
Name: 3-(carboxamidomethylthio)propanoylated residue
DiffFormula: C 5 H 7 N 1 O 2 S 1
Formula: none
Definition:
A protein modification that is produced by derivatization of a residue with 3,3-dithiobis[sulfosuccinimidyl propanoate], DTSSP, or with Pierce EZ-Link Sulfo-NHS-SS-Biotin reagent, sulfosuccinimidyl 3-[(2-[biotinamido]ethyl)disulfanyl]propanoate, followed by reduction with dithiothreitol and then reaction with iodoacetamide.


ModificationSetId: PSI-MOD
Name: fucosylated
DiffFormula: C 6 H 10 O 4
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a fucose (6-deoxy-D-galactose) group through a glycosidic bond.


ModificationSetId: PSI-MOD
Name: 3x(2)H residue methyl ester
DiffFormula: C 1 (1)H -1 (2)H 3
Formula: none
Definition:
A protein modification that effectively converts a residue containing common isotopes to a 3x(2)H labeled residue methyl ester.


ModificationSetId: PSI-MOD
Name: Hex2
DiffFormula: C 12 H 20 O 10
Formula: none
Definition:
a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with two hexose sugar groups through glycosidic bonds


ModificationSetId: PSI-MOD
Name: MDA adduct +62
Definition: modification from UniMod Chemical derivative
DiffFormula: C 5 H 2
Formula: C 11 H 14 N 2 O 1
AminoAcid: K
Comment:
Usually major adduct formed from malondialdehyde (MDA) with the amino group of lysine residues [UniProt].


ModificationSetId: PSI-MOD
Name: C3-H2-O adduct (+54 amu) of malondialdehyde with lysine or methylglyoxal with arginine.
Definition: modification from UniMod Chemical derivative
DiffFormula: C 3 H 2 O 1
Formula: none
Comment:
This is not a legitimate ontological entry and will become obsolete when the children are reassigned [JSG]


ModificationSetId: PSI-MOD
Name: bis-N-I-sulfonerahodamine
Definition: modification from UniMod Chemical derivative
DiffFormula: C 31 H 30 I 1 N 4 O 6 S 1
Formula: C 34 H 35 I 1 N 5 O 7 S 2
AminoAcid: C
Comment:
Invitrogen B-10621, a red fluorescent cross-linking reagent (only link to Cys is indicated) [UniMod].


ModificationSetId: PSI-MOD
Name: S-ethylcysteine (Ser)
Definition: A protein modification that effectively converts an L-serine residue to S-ethylcysteine.
DiffFormula: C 2 H 4 O -1 S 1
Formula: C 5 H 9 N 1 O 1 S 1
AminoAcid: S
Comment:
Modification from UniMod. Phosphoserine is converted to dehydroalanine then by Michael addition of ethanethiol to S-ethylcysteine. Needs parent and sibling for S-ethyl-cysteine.


ModificationSetId: PSI-MOD
Name: 1x(13)C,3x(2)H labeled monomethylated L-arginine
DiffFormula: (13)C 1 (1)H -1 (2)H 3
Formula: (12)C 6 (13)C 1 (1)H 11 (2)H 3 N 4 O 1
AminoAcid: R
Definition:
A protein modification that effectively replaces one hydrogen atom of an L-arginine residue with a (13)C,3x(2)H labeled methyl group to form a 1x(13)C,3x(2)H labeled monomethylated L-arginine.


ModificationSetId: PSI-MOD
Name: 2x(13)C,6x(2)H labeled dimethylated L-arginine
DiffFormula: (13)C 2 (1)H -2 (2)H 6
Formula: (12)C 6 (13)C 2 (1)H 10 (2)H 6 N 4 O 1
AminoAcid: R
Definition:
A protein modification that effectively replaces two hydrogen atoms of an L-arginine residue with two (13)C,3x(2)H labeled methyl groups to form a 2x(13)C,6x(2)H labeled dimethylated L-arginine.


ModificationSetId: PSI-MOD
Name: reduced 4-hydroxynonenal adduct
DiffFormula: C 9 H 18 O 2
Formula: none
Definition:
A protein modification produced by formation of an adduct of a residue with 4-hydroxynonenal artificially reduced by a reagent such as NaBH4.

Comment:
4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG].


ModificationSetId: PSI-MOD
Name: S-acetylated residue
DiffFormula: C 2 H 2 O 1 S 0
Formula: none
Definition:
A protein modification that effectively replaces a residue sulfanyl group with an acetylsulfanyl group.


ModificationSetId: PSI-MOD
Name: acetylated L-cysteine
DiffFormula: C 2 H 2 N 0 O 1 S 0
Formula: C 5 H 7 N 1 O 2 S 1
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to either N-acetyl-L-cysteine or S-acetyl-L-cysteine.


ModificationSetId: PSI-MOD
Name: acetylated L-serine
DiffFormula: C 2 H 2 N 0 O 1
Formula: none
AminoAcid: S
Definition:
A protein modification that effectively converts an L-serine residue to either N-acetyl-L-serine, O-acetyl-L-serine, or N,O-diacetyl-L-serine.


ModificationSetId: PSI-MOD
Name: O-palmitoylated residue
DiffFormula: C 16 H 30 O 1
Formula: none
Definition:
A protein modification that effectively replaces a residue hydroxyl group with a palmitoyloxy group.


ModificationSetId: PSI-MOD
Name: S-palmitoylated residue
DiffFormula: C 16 H 30 O 1 S 0
Formula: none
Definition:
A protein modification that effectively replaces a residue sulfanyl group with an palmitoylsulfanyl group.


ModificationSetId: PSI-MOD
Name: S-myristoylated residue
DiffFormula: C 14 H 26 O 1 S 0
Formula: none
Definition:
A protein modification that effectively replaces a residue sulfanyl group with an myristoylsulfanyl group.


ModificationSetId: PSI-MOD
Name: C-methylated residue
Definition:
A protein modification that effectively replaces a residue hydrocarbyl hydrogen with an methyl group.


ModificationSetId: PSI-MOD
SwissprotTerm: Glutamate methyl ester (Gln)
Name: L-glutamic acid 5-methyl ester (Gln)
Comment: This is known to be a natural modification of glutamine in prokaryotes.
DiffFormula: C 1 H 1 N -1 O 1
Formula: C 6 H 9 N 1 O 3
AminoAcid: Q
Definition:
A protein modification that effectively converts an L-glutamine residue to L-glutamate 5-methyl ester.


ModificationSetId: PSI-MOD
Name: methylated arginine
AminoAcid: R
Definition:
A protein modification that effectively converts an L-arginine residue to a methylated arginine, either 5-methylargine, N5-methylarginine, or an omega-N-methylated L-arginine.


ModificationSetId: PSI-MOD
Name: methylated glutamine
AminoAcid: Q
Definition:
A protein modification that effectively converts an L-glutamine residue to a methylated glutamine, either 2-methylated glutamine, N5-methylated glutamine, or methyl esterified deamidated glutamine.


ModificationSetId: PSI-MOD
Name: methylated cysteine
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to a methylated cysteine, either S-methylcysteine, or cysteine methyl ester.


ModificationSetId: PSI-MOD
Name: methylated histidine
AminoAcid: H
Definition:
A protein modification that effectively converts an L-histidine residue to a methylated histidine, such as pros-methylhistidine, or tele-methylhistidine.


ModificationSetId: PSI-MOD
Name: methylated leucine
AminoAcid: L
Definition:
A protein modification that effectively converts an L-leucine residue to a methylated leucine, either N-methylleucine, or leucine methyl ester.


ModificationSetId: PSI-MOD
Name: stereoisomerized residue
Definition:
A protein modification that effectively replaces a residue L-enantiomer (stereoisomer) with a D-enantiomer or with a different diastereomeric isomer.


ModificationSetId: PSI-MOD
Name: methylated alanine
AminoAcid: A
Definition:
A protein modification that effectively converts an L-alanine residue to a methylated alanine, such as N-methylalanine, N,N-dimethylalanine, or N,N,N-trimethylalanine.


ModificationSetId: PSI-MOD
Name: N-acylated residue
Definition:
A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an acyl group.


ModificationSetId: PSI-MOD
Name: S-acylated residue
Definition:
A protein modification that effectively replaces a residue sulfanyl group with an acylsulfanyl group.


ModificationSetId: PSI-MOD
Name: methylated asparagine
AminoAcid: N
Definition:
A protein modification that effectively converts an L-asparagine residue to a methylated asparagine, such as N4-methyl-L-asparagine, or N4,N4-dimethyl-L-asparagine.


ModificationSetId: PSI-MOD
Name: oxidized residue
Definition:
A protein modification that effectively either removes neutral hydrogen atoms (proton and electron), or adds oxygen atoms to a residue with or without the removal of hydrogen atoms.


ModificationSetId: PSI-MOD
Name: oxygenated residue
Definition:
A protein modification that effectively adds oxygen atoms to a residue with or without the removal of hydrogen atoms.


ModificationSetId: PSI-MOD
Name: carbon oxygenated residue
Definition:
A protein modification that effectively adds oxygen atoms to a carbon atom of a residue and removes hydrogen atoms.


ModificationSetId: PSI-MOD
Name: sulfur oxygenated residue
Definition:
A protein modification that effectively adds oxygen atoms to a sulfur atom of a residue without removing hydrogen atoms.


ModificationSetId: PSI-MOD
Name: hydroxylated arginine
AminoAcid: R
Definition:
A protein modification that effectively converts an L-arginine residue to a hydroxylated L-arginine.


ModificationSetId: PSI-MOD
Name: dehydrogenated residue
Definition:
A protein modification that effectively removes neutral hydrogen atoms (proton and electron) from a residue.


ModificationSetId: PSI-MOD
Name: L-selenocysteine (Cys)
DiffFormula: C 0 H 0 N 0 O 0 S -1 Se 1
Formula: C 3 H 5 N 1 O 1 Se 1
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to L-selenocysteine (not known as a natural, post-translational modification process).

Comment:
This entry is for the artifactual formation of L-selenocysteine from cysteine. For encoded L-selenocysteine, use MOD:00031 [JSG].


ModificationSetId: PSI-MOD
Name: thioether crosslinked residues
Definition:
A protein modification that crosslinks two residues by formation of a thioether bond between a cysteine thiol and either an alkyl C as in lanthionine, or an aryl C as 2'-(S-cysteinyl)-L-histidine.


ModificationSetId: PSI-MOD
Name: isopeptide crosslinked residues
Definition:
A protein modification that crosslinks two residues with an amide bond where either the donor amino or carboxyl is not an alpha group.


ModificationSetId: PSI-MOD
Name: glycosylated residue
Definition:
A protein modification that effectively replaces a hydrogen atom with an carbohydrate-like group through a glycosidic bond.


ModificationSetId: PSI-MOD
Name: sulfated residue
Comment: From DeltaMass: Average Mass: 80.
DiffFormula: O 3 S 1
Formula: none
Definition:
A protein modification that effectively substitutes a sulfonyl group for the hydrogen atom of a hydroxyl or sulfanyl group.


ModificationSetId: PSI-MOD
Name: phosphorylated residue
Comment: From DeltaMass: Average Mass: 80.
DiffFormula: H 1 O 3 P 1
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom with a phosphono group (H2PO3 or 'phosphate').


ModificationSetId: PSI-MOD
Name: flavin modified residue
DiffFormula: C 27 H 31 N 9 O 15 P 2 S 0
Formula: none
Definition:
A protein modification that effectively results from forming an adduct with a compound containing a flavin group.


ModificationSetId: PSI-MOD
Name: metal or metal cluster containing modified residue
Definition:
A protein modification that effectively substitutes a metal atom or a metal cluster for hydrogen atoms, or coordinates a metal ion.


ModificationSetId: PSI-MOD
Name: porphyrin modified residue
Definition:
A protein modification that effectively results from forming an adduct with a compound containing a porphyrin group.


ModificationSetId: PSI-MOD
Name: tetrapyrrole modified residue
Definition:
A protein modification that effectively results from forming an adduct with a compound containing a tetrapyrrole group.


ModificationSetId: PSI-MOD
Name: nucleotide or nucleic acid modified residue
Definition:
A protein modification that effectively results from forming an adduct with a compound containing a nucleotide or a polynucleotide through formation of either a phosphodiester bond, a phosphoramide ester bond, or a glycosidic bond.


ModificationSetId: PSI-MOD
Name: isotope labeled residue
Definition:
A protein modification that effectively substitutes atoms of particular common isotopes with atoms or groups containing isotopes that are not the most common.

Comment:
In SILAC (stable isotope labelling of amino acids in cell culture), the label may be introduced either through labeling of an incorporated residue or labeling of the substrates in a metabolic modification. For isotope labeling introduced through a modification reagent see MOD:01426.


ModificationSetId: PSI-MOD
Name: isoprenylated residue
Definition:
A protein modification that effectively replaces a hydrogen atom with a group derived from an isoprene polymer, such as a geranyl (C10), farnesyl (C15) or geranylgeranyl (C20) group.


ModificationSetId: PSI-MOD
Name: dehydrated residue
DiffFormula: C 0 H -2 N 0 O -1
Formula: none
Definition:
A protein modification that effectively forms a double bond by removing a molecule of water from a residue.


ModificationSetId: PSI-MOD
Name: hydroxylated tyrosine
AminoAcid: Y
Definition:
a protein modification that effectively converts an L-tyrosine residue to a multihydroxylated L-phenylalanine


ModificationSetId: PSI-MOD
Name: sulfur oxygenated L-cysteine
AminoAcid: C
Definition:
A protein modification that effectively adds oxygen atoms to a sulfur atom of L-cysteine residue without removing hydrogen atoms.


ModificationSetId: PSI-MOD
Name: sulfur oxygenated L-methionine
AminoAcid: M
Definition:
A protein modification that effectively adds oxygen atoms to a sulfur atom of L-methionine residue without removing hydrogen atoms.


ModificationSetId: PSI-MOD
Name: protonated-dimethylated residue
Definition:
A protein modification that effectively adds a proton and replaces two hydrogen atoms with two methyl groups.

Comment:
For N-terminal proline residues, dimethylation can effectively only be accomplished with a protonated imino group. This process accounts for both protonation and dimethylation. The alternative Me2Res process accounts only for dimethylation and not protonation.


ModificationSetId: PSI-MOD
Name: trimethylated protonated-residue
DiffFormula: C 3 H 7 N 0 O 0 S 0
Formula: none
Definition:
A protein modification that effectively replaces three hydrogen atoms with three methyl groups, after a proton has been added to form an aminium group.

Comment:
For amino acids residues, amine trimethylation can effectively only be accomplished with a protonated primary amino group. This process accounts for both protonation and trimethylation. The alternative Me3Res process accounts only for trimethylation and not protonation.


ModificationSetId: PSI-MOD
Name: methylated proline
AminoAcid: P
Definition:
A protein modification that effectively converts an L-proline residue to a methylated proline, such as N,N-dimethylproline.


ModificationSetId: PSI-MOD
Name: methylated glutamic acid
Definition:
A protein modification that effectively converts an L-glutamic acid residue to a methylated glutamic acid, such as L-glutamate 5-methyl ester.


ModificationSetId: PSI-MOD
Name: methylated glycine
AminoAcid: G
Definition:
A protein modification that effectively converts a glycine residue to a methylated glycine, such as N-methylglycine.


ModificationSetId: PSI-MOD
Name: methylated isoleucine
AminoAcid: I
Definition:
A protein modification that effectively converts an L-isoleucine residue to a methylated isoleucine residue, such as N-methyl-L-isoleucine.


ModificationSetId: PSI-MOD
Name: methylated methionine
AminoAcid: M
Definition:
A protein modification that effectively converts an L-methionine residue to a methylated methionine, such as N-methyl-L-methionine.


ModificationSetId: PSI-MOD
Name: methylated phenylalanine
AminoAcid: F
Definition:
A protein modification that effectively converts an L-phenylalanine residue to a methylated phenylalanine, such as N-methyl-L-phenylalanine.


ModificationSetId: PSI-MOD
Name: methylated tyrosine
AminoAcid: Y
Definition:
A protein modification that effectively converts an L-tyrosine residue to a methylated tyrosine, such as N-methyl-L-tyrosine.


ModificationSetId: PSI-MOD
SwissprotTerm: Methionine (R)-sulfoxide
Name: L-methionine sulfoxide
DiffFormula: C 0 H 0 N 0 O 1 S 0
Formula: C 5 H 9 N 1 O 2 S 1
AminoAcid: M
Definition:
A protein modification that oxygenates an L-methionine residue to one of the diastereomeric L-methionine sulfoxide residues.

Comment:
From DeltaMass: Average Mass: 147 Formula:C5H9O1N2S Monoisotopic Mass Change:147.035 Average Mass Change:147.195 (formula incorrect, N and O reversed) References:PE Sciex.


ModificationSetId: PSI-MOD
SwissprotTerm: Methionine (R)-sulfoxide
Name: L-methionine (R)-sulfoxide
DiffFormula: C 0 H 0 N 0 O 1 S 0
Formula: C 5 H 9 N 1 O 2 S 1
AminoAcid: M
Definition:
A protein modification that effectively oxygenates an L-methionine residue to L-methionine sulfoxide R-diastereomer.


ModificationSetId: PSI-MOD
Name: L-methionine (S)-sulfoxide
DiffFormula: C 0 H 0 N 0 O 1 S 0
Formula: C 5 H 9 N 1 O 2 S 1
AminoAcid: M
Definition:
A protein modification that effectively oxygenates an L-methionine residue to L-methionine sulfoxide S-diastereomer.


ModificationSetId: PSI-MOD
Name: monomethylated L-glutamine
DiffFormula: C 1 H 2 N 0 O 0
Formula: C 6 H 10 N 2 O 2
AminoAcid: Q
Definition:
A protein modification that effectively replaces one hydrogen atom of an L-glutamine residue with one methyl group.


ModificationSetId: PSI-MOD
Name: N-acetylated L-lysine
DiffFormula: C 2 H 2 N 0 O 1
Formula: C 8 H 15 N 2 O 2
AminoAcid: K
Definition:
A protein modification that effectively converts an L-lysine residue to either N2-acetyl-L-lysine, or N6-acetyl-L-lysine.


ModificationSetId: PSI-MOD
Name: N-methylated L-histidine
DiffFormula: C 1 H 2 N 0 O 0
Formula: C 7 H 9 N 3 O 1
AminoAcid: H
Definition:
A protein modification that effectively replaces one hydrogen atom on a nitrogen of an L-histidine residue with one methyl group.


ModificationSetId: PSI-MOD
Name: complex glycosylation
Definition:
A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a carbohydrate-like group linked through a glycosidic bond.


ModificationSetId: PSI-MOD
Name: glucosylated
DiffFormula: C 6 H 10 O 5
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a glucose group through a glycosidic bond.


ModificationSetId: PSI-MOD
Name: mannosylated
DiffFormula: C 6 H 10 O 5
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a mannose group through a glycosidic bond,


ModificationSetId: PSI-MOD
Name: galactosylated
DiffFormula: C 6 H 10 O 5
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a galactose group through a glycosidic bond.


ModificationSetId: PSI-MOD
Name: pentosylated residue
DiffFormula: C 5 H 8 O 4
Formula: none
Definition:
a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a pentose sugar group through a glycosidic bond

Comment:
for Pentoses DeltaMass gives mass 132, for Pentosyl DeltaMass gives formula C 6 H 10 N4 with mass 146


ModificationSetId: PSI-MOD
Name: arabinosylated
DiffFormula: C 5 H 8 O 4
Formula: none
Definition:
a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a arabinose sugar group through a glycosidic bond


ModificationSetId: PSI-MOD
Name: ribosylated
DiffFormula: C 5 H 8 O 4
Formula: none
Definition:
a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a ribose sugar group through a glycosidic bond


ModificationSetId: PSI-MOD
Name: xylosylated
DiffFormula: C 5 H 8 O 4
Formula: none
Definition:
a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a xylose sugar group through a glycosidic bond


ModificationSetId: PSI-MOD
Name: N-acetylaminoglucosylated
DiffFormula: C 8 H 13 N 1 O 5
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with an N-acetylglucosamine group through a glycosidic bond.


ModificationSetId: PSI-MOD
Name: N-acetylaminogalactosylated
DiffFormula: C 8 H 13 N 1 O 5
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with an N-acetylgalactosamine group through a glycosidic bond.

Comment:
From DeltaMass: Average Mass: 203 Formula:C8H13O5N1 Monoisotopic Mass Change:203.079 Average Mass Change:203.196 References:PE Sciex


ModificationSetId: PSI-MOD
Name: hexosuronylated
DiffFormula: C 6 H 8 O 6
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a hexosuronic acid group through a glycosidic bond.


ModificationSetId: PSI-MOD
Name: deoxyhexosylated
Comment: From DeltaMass: Average Mass: 146
DiffFormula: C 6 H 10 O 4
Formula: none
Definition:
a protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a deoxyhexose group through a glycosidic bond


ModificationSetId: PSI-MOD
Name: N-acetylneuraminylated
Comment: From DeltaMass: Average Mass: 291
DiffFormula: C 11 H 17 N 1 O 8
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with an N-acetylneuraminic acid (sialic acid) group through a glycosidic bond.


ModificationSetId: PSI-MOD
Name: iron containing modified residue
Definition:
A protein modification that effectively substitutes an iron atom or a cluster containing iron for hydrogen atoms, or that coordinates an iron ion.


ModificationSetId: PSI-MOD
Name: iron-sulfur cluster containing modification
Definition:
A protein modification that effectively substitutes a cluster of iron and sulfur atoms for hydrogen atoms.


ModificationSetId: PSI-MOD
Name: manganese containing modified residue
Definition:
A protein modification that effectively substitutes a manganese atom or a cluster containing manganese for hydrogen atoms, or that coordinates a manganese ion.


ModificationSetId: PSI-MOD
Name: nickel containing modified residue
Definition:
A protein modification that effectively substitutes a nickel atom or a cluster containing nickel for hydrogen atoms, or that coordinates a nickel ion.


ModificationSetId: PSI-MOD
Name: copper containing modified residue
Definition:
A protein modification that effectively substitutes a copper atom or a cluster containing copper for hydrogen atoms, or that coordinates a copper ion.


ModificationSetId: PSI-MOD
Name: molybdenum containing modified residue
Definition:
A protein modification that effectively substitutes a molybdenum atom or a cluster containing molybdenum for hydrogen atoms, or that coordinates a molybdenum ion.


ModificationSetId: PSI-MOD
Name: selenium containing residue
Definition:
A protein modification that effectively substitutes a selenium atom or a cluster containing selenium for hydrogen atoms.


ModificationSetId: PSI-MOD
Name: tungsten containing modified residue
Definition:
A protein modification that effectively substitutes a tungsten atom or a cluster containing tungsten for hydrogen atoms, or that coordinates a tungsten ion.


ModificationSetId: PSI-MOD
Name: pterin modified residue
Definition:
A protein modification that effectively results from forming an adduct with a compound containing a pterin group.


ModificationSetId: PSI-MOD
Name: deoxyribonucleic acid linked residue
Definition:
A protein modification that effectively crosslinks an amino acid residue and the 3'- or 5'-end of DNA through a phosphodiester bond.


ModificationSetId: PSI-MOD
Name: adenosine diphosphoribosyl (ADP-ribosyl) modified residue
Comment: From DeltaMass: Average Mass: 541.
DiffFormula: C 15 H 21 N 5 O 13 P 2
Formula: none
Definition:
A protein modification that effectively results from forming an adduct with ADP-ribose through formation of a glycosidic bond.


ModificationSetId: PSI-MOD
Name: iodinated residue
Definition:
A protein modification that effectively substitutes an iodine atom of a residue for a hydrogen atom.


ModificationSetId: PSI-MOD
Name: O4-galactosyl-L-hydroxyproline
Comment: secondary to RESID:AA0030
DiffFormula: C 6 H 10 N 0 O 6
Formula: C 11 H 17 N 1 O 7
AminoAcid: P
Definition:
A protein modification that effectively converts an L-proline residue to O4-galactosyl-L-hydroxyproline.


ModificationSetId: PSI-MOD
Name: O4-(N-acetylamino)glucosyl-L-hydroxyproline
Comment: secondary to RESID:AA0030
DiffFormula: C 8 H 13 N 1 O 6
Formula: C 13 H 20 N 2 O 7
AminoAcid: P
Definition:
A protein modification that effectively converts an L-proline residue to O4-(N-acetylamino)glucosyl-L-hydroxyproline.


ModificationSetId: PSI-MOD
Name: monohexosylated (Hex1)
DiffFormula: C 6 H 10 O 5
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with one hexose sugar group through a glycosidic bond.


ModificationSetId: PSI-MOD
Name: glycoconjugated residue
Definition:
A protein modification that effectively results from forming an adduct with a carbohydrate-like group either through enzymatic formation of a glycosidic bond, or through non-enzymatic glycation formation of a Schiff-base or an Amadori ketosamine residue adduct.


ModificationSetId: PSI-MOD
SwissprotTerm: S-cysteinyl cysteine
Name: cysteinylation (disulfide with free L-cysteine)
DiffFormula: C 3 H 5 N 1 O 2 S 1
Formula: C 6 H 10 N 2 O 3 S 2
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to S-(L-cysteinyl)-L-cysteine, forming a disulfide bond with free cysteine.

Comment:
This entry is for formation of a disulfide bond between a peptide cysteine and a free cysteine. For the cystine cross-link, see MOD:00234. From DeltaMass: (name misspelled and formula incorrect, N and O reversed) Formula: C6H10O2N3S2 Monoisotopic Mass Change: 222.013 Average Mass Change: 222.283


ModificationSetId: PSI-MOD
Name: glycated residue
Definition:
A modification produced in a non-enzymatic reaction between a carbohydrate carbonyl group (C1 of aldohexose or C2 of fructose) and a protein amino group to form a Schiff-base or an Amadori ketosamine residue adduct.


ModificationSetId: PSI-MOD
Name: vanadium containing modified residue
Definition:
A protein modification that effectively substitutes a vanadium atom or a cluster containing vanadium for hydrogen atoms, or that coordinates a vanadium ion.


ModificationSetId: PSI-MOD
Name: L-asparagine (His)
DiffFormula: C -2 H -1 N -1 O 1
Formula: C 4 H 6 N 2 O 2
AminoAcid: H
Definition:
An artifactual protein modification that converts an L-histidine residue to L-asparagine by oxidative degradation.


ModificationSetId: PSI-MOD
Name: L-aspartic acid (His)
DiffFormula: C -2 H -2 N -2 O 2
Formula: C 4 H 5 N 1 O 3
AminoAcid: H
Definition:
An artifactual protein modification that converts an L-histidine residue to L-aspartic acid by oxidative degradation.

Comment:
From OMSSA: desc="oxidation of H to D" monomass= -23.015984 (this is the same mass difference as OMSSA:54, his2asnh) [JSG].


ModificationSetId: PSI-MOD
Name: lysine oxidation to aminoadipic semialdehyde
Definition: OBSOLETE because redundant with MOD:00130. Remap to MOD:00130.
DiffFormula: H -3 N -1 O 1
Formula: none
AminoAcid: K
Comment:
From DeltaMass: Average Mass: -1 Average Mass Change:-1 References:Amici A, Levine, RL, Tsai, L, and Stadtman, ER: Conversion of amino acid residues in proteins and amino acid homopolymers to carbonyl derivatives by metal-catalyzed oxidation reactions. Journal of Biological Chemistry 264: 3341-3346 1989.Requena JR, Chao CC, Levine RL, and Stadtman ER: Glutamic and aminoadipic semialdehydes are the main carbonyl products of metal-catalyzed oxidation of proteins. Proceedings of the National Academy of Sciences USA 98: 69-74 2001.


ModificationSetId: PSI-MOD
Name: dimethylated L-arginine
DiffFormula: C 2 H 4 N 0 O 0
Formula: C 8 H 16 N 4 O 1
AminoAcid: R
Definition:
A protein modification that effectively replaces two hydrogen atoms of an L-arginine residue with two methyl groups.


ModificationSetId: PSI-MOD
Name: N-acetyl-L-phenylalanine
Comment: This modification has not been observed to occur naturally.
DiffFormula: C 2 H 2 N 0 O 1
Formula: C 11 H 11 N 1 O 2
AminoAcid: F
Definition:
A protein modification that effectively converts an L-phenylalanine residue to N-acetyl-L-phenylalanine.


ModificationSetId: PSI-MOD
Name: deuterium substituted residue
Definition:
A protein modification that effectively substitutes one or more (2)H deuterium atoms for (1)H protium atoms.


ModificationSetId: PSI-MOD
Name: diisopropylphosphoserine
DiffFormula: C 6 H 13 O 3 P 1
Formula: C 9 H 18 N 1 O 5 P 1
AminoAcid: S
Definition:
modification from UniMod - label for the active site serine of the serine esterase/protease family also shown to label tyrosine in serum albumin


ModificationSetId: PSI-MOD
Name: Bruker Daltonics SERVA-ICPL(TM) quantification chemistry, heavy form
DiffFormula: (13)C 6 H 3 N 1 O 1
Formula: none
Definition:
modification from UniMod - isotopic label ICPL method - The paper describes an H/D labeling strategy whereas the commercial product follows a C/13C labeling strategy. The digest is typically applied AFTER ICPL_light/heavy labeling, only Protein N-term labeling and Lys-specific labeling is applied.


ModificationSetId: PSI-MOD
Name: 1x(18)O labeled deamidated L-glutamine
DiffFormula: H -1 N -1 (18)O 1
Formula: C 5 H 7 N 1 (16)O 2 (18)O 1
AminoAcid: Q
Definition:
A protein modification that effectively converts an L-glutamine residue to L-glutamic acid with one (18)O.


ModificationSetId: PSI-MOD
Name: deuterium monosubstituted residue
Definition:
A protein modification that effectively substitutes one (2)H deuterium atom for one (1)H protium atom.


ModificationSetId: PSI-MOD
SwissprotTerm: 2,3-didehydroalanine (Cys)
Name: dehydroalanine (Cys)
Definition: A protein modification that effectively converts an L-cysteine residue to dehydroalanine.
DiffFormula: C 0 H -2 N 0 O 0 S -1
Formula: C 3 H 3 N 1 O 1
AminoAcid: C
Comment:
From DeltaMass: In an attempt to clarfiy the difference between the modification of cysteine to lanthionine and cysteine to dehydroalanine, the following contributions from the ABRF email forum are presented:Structurally speaking lanthionine is like cystine but lacks one S atom. I imagine one can think of it as a condensation of cysteine and dehydroalanine but I do not know how it is made biologically. Dehydroalanine could be derived from either serine or cysteine. If I recall Biochem 101 correctly lanthionine was first found in wool.-Lowell Ericsson (ERICSSONLH@U.WASHINGTON.EDU)As far as I know, the structure of lanthionine is two Ala's joined by a single sulphur with the loss of two hydrogens from the methyl group of the Ala.Stephen Bayne (sbay@novo.dk)Regarding the structure of lanthionine and dehydroalanine: dehydroalanine is formed by the loss of one sulfur atom and two hydrogen atoms from ONE cysteine residue. lanthionine is formed from TWO cysteines, is a thioether, and contains one sulfur atom less than the amino acid cystine. Dan McCormick (MCCORMICK@rcf.mayo.edu) [DeltaMass]. Most bacterially produced lanthionine crosslinks are made by dehydration of L-serine to dehydroalanine, and then reaction with L-cysteine so as to produce chiral inversion at the alpha-carbon of the original L-serine; the lanthionine is a meso-diastereomer with L-configuration of the original cysteine alpha-carbon and D-configuration of the original L-serine alpha-carbon. In cypemycin dehydroalanine has been shown to be produced by loss of hydrogen sulfide from cysteine. Beta-elimination of hydrogen sulfide does occur during treatment with performic acid [JSG].


ModificationSetId: PSI-MOD
Name: pyrrolidone from proline
Definition: OBSOLETE because redundant and identical to MOD:00477. Remap to MOD:00477.
DiffFormula: C -1 O -1
Formula: C 4 H 7 N 1 O 0
AminoAcid: P
Comment:
This UniMod entry appears to have come from the same description in PubMed:9252331 as UniMod:360. This entry was not annotated as being approved. Neither difference formula corresponds to the result described in the original citation PubMed:2161657.


ModificationSetId: PSI-MOD
SwissprotTerm: 2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Name: 2-(S-L-cysteinyl)pyruvic acid O-phosphothioketal
DiffFormula: C 3 H 5 N 0 O 6 P 1 S 0
Formula: C 6 H 10 N 1 O 7 P 1 S 1
AminoAcid: C
Definition:
a protein modification that effectively converts an L-cysteine residue to the PEP adduct, 2-(S-L-cysteinyl)pyruvic acid O-phosphothioketal


ModificationSetId: PSI-MOD
Name: half cystine
DiffFormula: C 0 H -1 N 0 O 0 S 0
Formula: C 3 H 4 N 1 O 1 S 1
AminoAcid: C
Definition:
A protein modification that can be regarded as effectively either one half of a cystine cross-link, or a cysteine residue with one hydrogen atom or proton removed.


ModificationSetId: PSI-MOD
Name: S-galactosyl-L-cysteine
Definition: A protein modification that effectively converts an L-cysteine residue to S-galactosyl-L-cysteine.
DiffFormula: C 6 H 10 N 0 O 5 S 0
Formula: C 9 H 15 N 1 O 6 S 1
AminoAcid: C
Comment:
The reported peptide has not been isolated or characterized in subsequent work, and the peptide sequence has not been found in the human proteome. This is a deprecated entry in RESID. It probably does not occur naturally [JSG].


ModificationSetId: PSI-MOD
Name: L-cysteinyl-L-histidino-homocitryl vanadium heptairon nonasulfide
Comment: Cross-link 2; incidental to RESID:AA0300.
DiffFormula: C 7 Fe 7 H 6 N 0 O 7 S 9 V 1
Formula: C 16 Fe 7 H 18 N 4 O 9 S 10 V 1
Definition:
A protein modification that effectively converts an L-cysteine residue, an L-histidine residue, homocitric acid and a one-vanadium seven-iron nine-sulfur cluster to L-cysteinyl-L-histidino-homocitryl vanadium heptairon nonasulfide.


ModificationSetId: PSI-MOD
Name: L-cysteinyl-L-histidino-homocitryl octairon nonasulfide
Comment: Cross-link 2; incidental to RESID:AA0300.
DiffFormula: C 7 Fe 8 H 6 N 0 O 7 S 9
Formula: C 16 Fe 8 H 18 N 4 O 9 S 10
Definition:
A protein modification that effectively converts an L-cysteine residue, an L-histidine residue, homocitric acid and an eight-iron nine-sulfur cluster to L-cysteinyl-L-histidino-homocitryl octairon nonasulfide.


ModificationSetId: PSI-MOD
Name: L-histidino vanadium tetraoxide
DiffFormula: C 0 H 2 N 0 O 4 V 1
Formula: C 6 H 9 N 3 O 5 V 1
AminoAcid: H
Definition:
a protein modification that effectively converts an L-histidine residue to L-histidino vanadium tetraoxide


ModificationSetId: PSI-MOD
Name: 3-(S-L-cysteinyl)-L-tyrosine
Comment: Cross-link 2.
DiffFormula: C 0 H -2 N 0 O 0 S 0
Formula: C 12 H 12 N 2 O 3 S 1
Definition:
A protein modification that effectively cross-links an L-cysteine residue and an L-tyrosine residue by a thioether bond to form 3-(S-L-cysteinyl)-L-tyrosine.


ModificationSetId: PSI-MOD
Name: O-glucosyl-L-serine
DiffFormula: C 6 H 10 N 0 O 5
Formula: C 9 H 15 N 1 O 7
AminoAcid: S
Definition:
A protein modification that effectively converts an L-serine residue to O3-beta-glucosylated L-serine.


ModificationSetId: PSI-MOD
Name: O-(N-acetylamino)glucosyl-L-serine
DiffFormula: C 8 H 13 N 1 O 5
Formula: C 11 H 18 N 2 O 7
AminoAcid: S
Definition:
A protein modification that effectively converts an L-serine residue to O3-(N-acetylaminoglucosyl)-L-serine.


ModificationSetId: PSI-MOD
Name: O-(N-acetylamino)glucosyl-L-threonine
DiffFormula: C 8 H 13 N 1 O 5
Formula: C 12 H 20 N 2 O 7
AminoAcid: T
Definition:
A protein modification that effectively converts an L-threonine residue to O3-(N-acetylaminoglucosyl)-L-threonine.


ModificationSetId: PSI-MOD
Name: O-xylosyl-L-serine
Definition: A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
DiffFormula: C 5 H 8 N 0 O 4
Formula: C 8 H 13 N 1 O 6
AminoAcid: S
Comment:
One glycosylated serine with weak electron density was modeled as O3-alpha-xylosylserine, while O3-alpha-mannosyl serine and threonine were modeled at ten other positions. The authors do not discuss this exception or provide chemical evidence for it. Since an O3-xylosyl serine modification has not been reported in any other fungal proteins, the modification is probably also an O3-alpha-mannosyl serine, see MOD:00810 [JSG].


ModificationSetId: PSI-MOD
Name: 3'-geranyl-2',3'-dihydro-2',N2-cyclo-L-tryptophan
DiffFormula: C 10 H 16 N 0 O 0
Formula: C 21 H 26 N 2 O 1
AminoAcid: W
Definition:
A protein modification that effectively converts an L-tryptophan residue to 3'-geranyl-2',3'-dihydro-2',N2-cyclo-L-tryptophan.


ModificationSetId: PSI-MOD
Name: glycosylphosphatidylinositolated residue
DiffFormula: C 2 H 6 N 1 O 3 P 1
Formula: none
Definition:
A protein modification that effectively converts a residue to a glycosylphosphatidylinositolethanolamidated.


ModificationSetId: PSI-MOD
Name: L-2-aminobutanoic acid (Glu)
DiffFormula: C -1 H 0 N 0 O -2
Formula: C 4 H 7 N 1 O 1
AminoAcid: E
Definition:
A protein modification that effectively converts an L-glutamic acid residue to L-2-aminobutanoic acid.


ModificationSetId: PSI-MOD
Name: 2-imino-alanine 5-imidazolinone glycine
Comment: Cross-link 2; carboxamidine.
DiffFormula: C -1 H -4 N 0 O -3
Formula: C 5 H 4 N 2 O 1
Definition:
A protein modification that effectively crosslinks an L-aspartic acid residue and a glycine residue to form 2-imino-alanine 5-imidazolinone glycine.


ModificationSetId: PSI-MOD
Name: S-(L-alanyl)-L-cysteine
Comment: Cross-link 2.
DiffFormula: C 0 H -2 N 0 O -1 S 0
Formula: C 6 H 9 N 2 O 2 S 1
Definition:
A protein modification that effectively crosslinks an L-alanine residue and an L-cysteine residue by a thioester bond to form S-(L-alanyl)-L-cysteine.


ModificationSetId: PSI-MOD
Name: S-(L-leucyl)-L-cysteine
Comment: Cross-link 2.
DiffFormula: C 0 H -2 N 0 O -1 S 0
Formula: C 9 H 15 N 2 O 2 S 1
Definition:
A protein modification that effectively crosslinks an L-leucine residue and an L-cysteine residue by a thioester bond to form S-(L-leucyl)-L-cysteine.


ModificationSetId: PSI-MOD
Name: S-(L-methionyl)-L-cysteine
Comment: Cross-link 2.
DiffFormula: C 0 H -2 N 0 O -1 S 0
Formula: C 8 H 13 N 2 O 2 S 2
Definition:
A protein modification that effectively crosslinks an L-methionine residue and an L-cysteine residue by a thioester bond to form S-(L-methionyl)-L-cysteine.


ModificationSetId: PSI-MOD
Name: S-(L-phenylalanyl)-L-cysteine
Comment: Cross-link 2.
DiffFormula: C 0 H -2 N 0 O -1 S 0
Formula: C 12 H 13 N 2 O 2 S 1
Definition:
A protein modification that effectively crosslinks an L-phenylalanine residue and an L-cysteine residue by a thioester bond to form S-(L-phenylalaninyl)-L-cysteine.


ModificationSetId: PSI-MOD
Name: S-(L-threonyl)-L-cysteine
Comment: Cross-link 2.
DiffFormula: C 0 H -2 N 0 O -1 S 0
Formula: C 7 H 11 N 2 O 3 S 1
Definition:
A protein modification that effectively crosslinks an L-threonine residue and an L-cysteine residue by a thioester bond to form S-(L-threonyl)-L-cysteine.


ModificationSetId: PSI-MOD
Name: S-(L-tyrosyl)-L-cysteine
Comment: Cross-link 2.
DiffFormula: C 0 H -2 N 0 O -1 S 0
Formula: C 12 H 13 N 2 O 3 S 1
Definition:
A protein modification that effectively crosslinks an L-tyrosine residue and an L-cysteine residue by a thioester bond to form S-(L-tyrosyl)-L-cysteine.


ModificationSetId: PSI-MOD
Name: S-(L-tryptophanyl)-L-cysteine
Comment: Cross-link 2.
DiffFormula: C 0 H -2 N 0 O -1 S 0
Formula: C 14 H 14 N 3 O 2 S 1
Definition:
A protein modification that effectively crosslinks an L-tryptophan residue and an L-cysteine residue by a thioester bond to form S-(L-tryptophanyl)-L-cysteine.


ModificationSetId: PSI-MOD
Name: O-(L-phenylalanyl)-L-serine
Comment: Cross-link 2.
DiffFormula: C 0 H -2 N 0 O -1 S 0
Formula: C 12 H 13 N 2 O 3
Definition:
A protein modification that effectively crosslinks an L-phenylalanine residue and an L-serine residue by an ester bond to form S-(L-phenylalaninyl)-L-serine.


ModificationSetId: PSI-MOD
Name: N4-(N-acetylamino)glucosyl-L-asparagine
DiffFormula: C 8 H 13 N 1 O 5
Formula: C 12 H 19 N 3 O 7
AminoAcid: N
Definition:
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.


ModificationSetId: PSI-MOD
Name: N4-(N-acetylamino)galactosyl-L-asparagine
DiffFormula: C 8 H 13 N 1 O 5
Formula: C 12 H 19 N 3 O 7
AminoAcid: N
Definition:
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetaminogalactosyl)-L-asparagine.


ModificationSetId: PSI-MOD
Name: O-(N-acetylamino)fucosyl-L-serine
DiffFormula: C 8 H 13 N 1 O 4
Formula: C 11 H 18 N 2 O 6
AminoAcid: S
Definition:
A protein modification that effectively converts an L-serine residue to O3-(N-acetamino)fucosylserine.


ModificationSetId: PSI-MOD
Name: deuterium disubstituted residue
Definition:
A protein modification that effectively substitutes two (2)H deuterium atoms for two (1)H protium atoms.


ModificationSetId: PSI-MOD
Name: deuterium tetrasubstituted residue
Definition:
A protein modification that effectively substitutes four (2)H deuterium atoms for four (1)H protium atoms.


ModificationSetId: PSI-MOD
Name: 3x(2)H labeled L-leucine
DiffFormula: (1)H -3 (2)H 3
Formula: C 6 (1)H 8 (2)H 3 N 1 O 1
AminoAcid: L
Definition:
A protein modification that effectively substitutes three (1)H protium atoms with three (2)H deuterium atoms to produce 3x(2)H labeled L-leucine.


ModificationSetId: PSI-MOD
Name: (2)H deuterium labeled residue
Definition:
A protein modification that effectively substitutes atoms of particular common isotopes with atoms of or groups containing deuteriumm, (2)H.


ModificationSetId: PSI-MOD
Name: (13)C labeled residue
Definition:
A protein modification that effectively substitutes atoms of particular common isotopes with atoms of or groups containing (13)C.


ModificationSetId: PSI-MOD
Name: (15)N labeled residue
Definition:
A protein modification that effectively substitutes atoms of particular common isotopes with atoms of or groups containing (15)N.


ModificationSetId: PSI-MOD
Name: (18)O labeled residue
Definition:
A protein modification that effectively substitutes atoms of particular common isotopes with atoms of or groups containing (18)O.


ModificationSetId: PSI-MOD
Name: reagent derivatized residue
Definition:
A protein modification that is produced by formation of an adduct with a particular compound used as a reagent.


ModificationSetId: PSI-MOD
Name: unnatural residue
Definition:
A protein modification that inserts or replaces a residue with an unnatural residue that is not considered to be derived from a natural residue by some chemical process.


ModificationSetId: PSI-MOD
Name: (18)O labeled deamidated residue
Definition:
A protein modification that effectively replaces a carboxamido group with a carboxyl group labeled with (18)O.


ModificationSetId: PSI-MOD
Name: 1x(18)O labeled deamidated residue
DiffFormula: H -1 N -1 (18)O 1
Formula: none
Definition:
A protein modification that effectively replaces a carboxamido group with a carboxyl group labeled with one (18)O.


ModificationSetId: PSI-MOD
Name: 2x(18)O labeled deamidated residue
DiffFormula: H -1 N -1 (16)O -1 (18)O 2
Formula: none
Definition:
A protein modification that effectively replaces a carboxamido group with a carboxyl group labeled with two (18)O.


ModificationSetId: PSI-MOD
Name: protonated L-lysine (L-lysinium) residue
Definition: A protein modification that effectively converts an L-lysine to L-lysinium (protonated L-lysine).
DiffFormula: C 0 H 1 N 0 O 0
Formula: C 6 H 13 N 2 O 1
AminoAcid: K
Comment:
Some sources compute the difference formula for charged, quatenary modified lysine based on protonated lysine rather than neutral lysine residue. In such cases, a comparable difference formula can be calculated based on this derivative.


ModificationSetId: PSI-MOD
Name: N6,N6,N6-trimethyl-L-lysine (from L-lysinium residue)
DiffFormula: C 3 H 6 N 0 O 0
Formula: C 9 H 19 N 2 O 1
Definition:
A protein modification that effectively converts an L-lysinium (N6-protonated L-lysine) residue to an N6,N6,N6-trimethyl-L-lysine.

Comment:
For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative N6Me3+Lys process (MOD:00083) accounts for both protonation and trimethylation.


ModificationSetId: PSI-MOD
Name: protonated L-alanine (L-alaninium) residue
DiffFormula: C 0 H 1 N 0 O 0
Formula: C 3 H 7 N 1 O 1
AminoAcid: A
Definition:
A protein modification that effectively converts an L-alanine residue to an L-alaninium (protonated L-alanine).


ModificationSetId: PSI-MOD
Name: N,N,N-trimethyl-L-alanine (from L-alaninium)
DiffFormula: C 3 H 6 N 0 O 0
Formula: C 6 H 13 N 1 O 1
Definition:
A protein modification that effectively converts an L-alaninium (protonated L-alanine) residue to an N,N,N-trimethyl-L-alanine.

Comment:
For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative N2Me3+Ala process (MOD:00071) accounts for both protonation and trimethylation.


ModificationSetId: PSI-MOD
Name: modified residue that can arise from different natural residues
Definition:
A protein modification that can be derived from different natural residues by different chemical processes.


ModificationSetId: PSI-MOD
Name: tris-L-cysteinyl L-histidino diiron disulfide
Comment: Cross-link 4.
DiffFormula: C 0 Fe 2 H -4 N 0 O 0 S 2
Formula: C 15 Fe 2 H 18 N 6 O 4 S 5
Definition:
A protein modification that effectively converts three L-cysteine residues, an L-histidine residue and a two-iron two-sulfur cluster to tris-L-cysteinyl L-histidino diiron disulfide.


ModificationSetId: PSI-MOD
Name: N-aspartyl-glycosylsphingolipidinositolethanolamine
DiffFormula: C 2 H 6 N 1 O 3 P 1
Formula: C 6 H 12 N 2 O 7 P 1
AminoAcid: D
Definition:
A protein modification that effectively converts an L-aspartic acid residue to N-aspartyl-glycosylsphingolipidinositolethanolamine.


ModificationSetId: PSI-MOD
Name: dihydroxylated proline
DiffFormula: C 0 H 0 N 0 O 2
Formula: C 5 H 7 N 1 O 3
AminoAcid: P
Definition:
A protein modification that effectively converts an L-proline residue to one of several dihydroxylated proline residues, such as (2S,3R,4R)-3,4-dihydroxyproline or (2S,3R,4S)-3,4-dihydroxyproline.


ModificationSetId: PSI-MOD
Name: L-cysteinyl-L-selenocysteine (Cys-Cys)
Comment: Cross-link 2.
DiffFormula: C 0 H -2 N 0 O 0 S -1 Se 1
Formula: C 6 H 8 N 2 O 2 S 1 Se 1
Definition:
A protein modification that effectively cross-links an L-cysteine residue and an L-cysteine converted to an L-selenocysteine residue to form L-cysteinyl-L-selenocystine.


ModificationSetId: PSI-MOD
Name: natural, non-standard encoded residue
Definition:
A protein modification that inserts or replaces a residue with a natural, non-standard encoded residue, such as N-formyl-L-methionine, L-selenocysteine, or L-pyrrolysine.

Comment:
These are produced exclusively by modification of amino acids acylated to special tRNA before incorporation by ribosomes into proteins. For this reason, they have also been referred to as pre-translational modifications.


ModificationSetId: PSI-MOD
Name: L-isoglutamyl diglutamic acid
DiffFormula: C 10 H 14 N 2 O 6
Formula: C 15 H 21 N 3 O 9
AminoAcid: E
Definition:
A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl glutamyl-glutamic acid, forming an isopeptide bond with a diglutamic acid.


ModificationSetId: PSI-MOD
Name: L-isoglutamyl triglutamic acid
Comment: From DeltaMass: Average Mass: 388.
DiffFormula: C 15 H 21 N 3 O 9
Formula: C 20 H 28 N 4 O 12
AminoAcid: E
Definition:
A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl glutamyl-glutamyl-glutamic acid, forming an isopeptide bond with a triglutamic acid.


ModificationSetId: PSI-MOD
Name: L-isoglutamyl tetraglutamic acid
DiffFormula: C 20 H 28 N 4 O 12
Formula: C 25 H 35 N 5 O 15
AminoAcid: E
Definition:
A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl glutamyl-glutamyl-glutamyl-glutamic acid, forming an isopeptide bond with a tetraglutamic acid.


ModificationSetId: PSI-MOD
Name: hexosaminylated residue
DiffFormula: C 6 H 11 N 1 O 4
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a hexosamine sugar group through a glycosidic bond.


ModificationSetId: PSI-MOD
Name: imidoester crosslink dimethyl pimelimidate doubly attached
DiffFormula: C 7 H 10 N 2
Formula: none
Definition:
dimethyl pimelimidate modification from UniMod - Mechanism of the reaction of imidoesters with amines


ModificationSetId: PSI-MOD
Name: 6x(13)C labeled 4-sulfophenyl isothiocyanate derivatized residue
DiffFormula: (12)C 1 (13)C 6 H 5 N 1 O 3 S 2
Formula: none
Definition:
A protein modification produced by formation of an adduct with 6x(13)C labeled 4-sulfophenyl isothiocyanate.


ModificationSetId: PSI-MOD
Name: S-(2-aminoethyl)cysteine (Ser)
Definition: A protein modification that effectively converts an L-serine residue to S-(2-aminoethyl)cysteine.
DiffFormula: C 2 H 5 N 1 O -1 S 1
Formula: C 5 H 10 N 2 O 1 S 1
AminoAcid: S
Comment:
From DeltaMass: Average Mass: 146 Abbreviation:-AECys_ Formula:C5H10O2N1S1 Monoisotopic Mass Change:146.051 Average Mass Change:146.214 References:PE Sciex.


ModificationSetId: PSI-MOD
Name: C1-amidated residue
DiffFormula: C 0 H 1 N 1 O -1
Formula: none
Definition:
A protein modification that effectively replaces a 1-carboxyl group (usually referred to as the alpha-carboxyl) with a carboxamido group.

Comment:
The normal biological process involves formation of an amide of an amino acid residue in a peptide sequence where it is followed by a glycine and two basic residues, either arginine or lysine, although in some taxa only one basic residue is required. The peptide is cleaved after the basic residues, glycine is oxidized to hydroxyglycine, which decomposes to release a carboxamide C-terminal [JSG].


ModificationSetId: PSI-MOD
Name: S-aminoethylcysteine (Cys)
Definition: A protein modification that effectively converts an L-cysteine residue to S-2-aminoethylcysteine.
DiffFormula: C 2 H 5 N 1 O 0 S 0
Formula: C 5 H 10 N 2 O 1 S 1
AminoAcid: C
Comment:
This modified residue is a chemical isolog of L-lysine for trypsin hydolysis produced from L-cysteine by aziridine.


ModificationSetId: PSI-MOD
SwissprotTerm: 6'-chlorotryptophan
Name: 6'-chloro-L-tryptophan
Definition: A protein modification that effectively converts an L-tryptophan residue to 6'-chloro-L-tryptophan.
DiffFormula: C 0 Cl 1 H -1 N 0 O 0
Formula: C 11 Cl 1 H 9 N 2 O 1
AminoAcid: W
Comment:
The UniMod:340 cross-reference to RESID:AA0180 is incorrect. RESID:AA0180 should be cross-referenced by UniMod:936 [JSG].


ModificationSetId: PSI-MOD
Name: methylated aspartic acid
Definition:
A protein modification that effectively converts an L-aspartic acid residue to a methylated aspartic acid, such as aspartic acid 4-methyl ester.


ModificationSetId: PSI-MOD
Name: protonated L-proline (L-prolinium) residue
DiffFormula: C 0 H 1 N 0 O 0
Formula: C 5 H 9 N 1 O 1
AminoAcid: P
Definition:
A protein modification that effectively converts an L-proline to an L-prolinium (protonated L-proline).


ModificationSetId: PSI-MOD
Name: N,N-dimethyl-L-proline (from L-prolinium)
DiffFormula: C 2 H 4 N 0 O 0
Formula: C 7 H 13 N 1 O 1
Definition:
A protein modification that effectively converts an L-prolinium (charged L-proline) residue to N,N-dimethyl-L-proline.


ModificationSetId: PSI-MOD
Name: phosphorylated L-histidine
DiffFormula: C 0 H 1 N 0 O 3 P 1
Formula: C 6 H 8 N 3 O 4 P 1
AminoAcid: H
Definition:
A protein modification that effectively converts an L-histidine residue to a phosphorylated L-histidine, such as pros-phosphohistidine, or tele-phosphohistidine.


ModificationSetId: PSI-MOD
Name: FAD modified residue
Definition:
A protein modification that effectively results from forming an adduct with a compound containing a flavin adenine dinucleotide (FAD) group.


ModificationSetId: PSI-MOD
Name: FMN modified residue
Definition:
A protein modification that effectively results from forming an adduct with a compound containing a riboflavin phosphate (flavin mononucleotide, FMN) group.


ModificationSetId: PSI-MOD
Name: N-acetyl-S-archeol-cysteine
DiffFormula: C 45 H 88 N 0 O 3 S 0
Formula: C 48 H 93 N 1 O 4 S 1
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to N-acetyl-S-archeol-L-cysteine.


ModificationSetId: PSI-MOD
Name: S-(sn-1-2-oleoyl-3-palmitoyl-glycerol)cysteine
Comment: Incidental to RESID:AA0060.
DiffFormula: C 37 H 68 N 0 O 4 S 0
Formula: C 40 H 73 N 1 O 5 S 1
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to S-(sn-1-2-oleoyl-3-palmitoyl-glycerol)cysteine.


ModificationSetId: PSI-MOD
Name: N-palmitoyl-S-diacylglycerol-L-cysteine
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to N-palmitoyl-S-diacylglycerol-L-cysteine.


ModificationSetId: PSI-MOD
Name: N-palmitoyl-S-(sn-1-2-oleoyl-3-palmitoyl-glycerol)cysteine
DiffFormula: C 53 H 98 N 0 O 5 S 0
Formula: C 56 H 103 N 1 O 6 S 1
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to N-palmitoyl-S-(sn-1-2-oleoyl-3-palmitoyl-glycerol)cysteine.


ModificationSetId: PSI-MOD
Name: N6-(L-threonyl)-L-lysine
Comment: Cross-link 2.
DiffFormula: C 0 H -2 N 0 O -1
Formula: C 10 H 18 N 3 O 3
Definition:
A protein modification that effectively crosslinks an L-lysine residue and an L-threonine residue by an isopeptide bond to form N6-(L-threonyl)-L-lysine.


ModificationSetId: PSI-MOD
Name: heptosylated residue
Comment: From UniMod with no citation [JSG].
DiffFormula: C 7 H 12 O 6
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of an amino acid residue or of a modifying group with a heptose sugar group through a glycosidic bond.


ModificationSetId: PSI-MOD
Name: Bisphenol A diglycidyl ether derivative
DiffFormula: C 21 H 24 O 4
Formula: none
Definition:
Modification from UniMod Non-standard residue. OBSOLETE because not an amino acid modification. From UniMod not an approved entry.


ModificationSetId: PSI-MOD
Name: 2x(13)C,4x(2)H labeled dimethylated residue
DiffFormula: (13)C 2 (2)H 4
Formula: none
Definition:
A protein modification that effectively replaces two hydrogen atoms of a residue containing common isotopes with two (13)C,3x(2)H labeled methyl groups to form a 2x(13)C,6x(2)H labeled dimethylated residue.


ModificationSetId: PSI-MOD
Name: lactose glycated lysine
Comment: The term lactosylation used with this meaning is a misnomer [JSG].
DiffFormula: C 12 H 22 O 11
Formula: C 18 H 34 N 2 O 12
AminoAcid: K
Definition:
A modification produced in a non-enzymatic reaction between a lactose carbonyl group and an L-lysine to form a Schiff-base or an Amadori ketosamine lysine adduct.


ModificationSetId: PSI-MOD
Name: propyl-NAG tyrosine adduct
DiffFormula: C 9 H 14 N 1 O 4 S 1
Formula: C 18 H 23 N 2 O 6 S 1
AminoAcid: Y
Definition:
tyrosine adduct with substrate analog inhibitor 1,2-dideoxy-2'-methyl-alpha-D-glucopyranoso-[2,1-d]-Delta2'-thiazoline.


ModificationSetId: PSI-MOD
Name: Michael addition of t-butyl hydroxylated BHT (BHTOH) to C, H or K
DiffFormula: C 15 H 22 O 2
Formula: none
Definition:
modification from UniMod Other - BHTOH is formed upon metabolism of BHT with P450 enzymes. The BHTOH is further metabolized to its quinone methide (electrophile) which reacts with -SH and -NH2 groups


ModificationSetId: PSI-MOD
Name: methylglyoxal arginine adduct (+54 amu)
DiffFormula: C 3 H 2 O 1
Formula: C 9 H 14 N 4 O 2
AminoAcid: R
Definition:
modification from UniMod Chemical derivative - 5-hydro-5-methylimidazol-4-one, arginine methylglyoxal arginine adduct (+54 amu)

Comment:
Ref. Uchida K, Sakai K, Itakura K, Osawa T, Toyokuni S. 1977. Protein modification by lipid peroxidation products: formation of malondialdehyde-derived N(epsilon)-(2-propenol)lysine in proteins. Arch Biochem Biophys. 346(1):45-52.


ModificationSetId: PSI-MOD
Name: (4,4,5,5-(2)H4)-L-lysine
Comment: For SILAC experiments.
DiffFormula: (1)H -4 (2)H 4
Formula: C 6 (1)H 8 (2)H 4 N 2 O 1
AminoAcid: K
Definition:
A protein modification that effectively substitutes four (1)H protium atoms with four (2)H deuterium atoms to produce (4,4,5,5-(2)H4)-L-lysine.


ModificationSetId: PSI-MOD
Name: decomposed carboxymethylated methionine
Definition: modification from DeltaMass
DiffFormula: none
Formula: none
AminoAcid: M
Comment:
From DeltaMass: Average Mass: -48 Average Mass Change:-48 References:Anal. Biochem. Vol 216 No.1 p141


ModificationSetId: PSI-MOD
Name: L-gamma-carboxyglutamic acid with neutral loss of carbon dioxide
DiffFormula: C -1 H 0 N 0 O -2
Formula: C 5 H 7 N 1 O 3
AminoAcid: E
Definition:
Covalent modification of a peptide or protein L-glutamic acid residue to gamma-carboxyglutamic acid with secondary loss of a neutral carbon dioxide molecular fragment.

Comment:
From DeltaMass: Average Mass: -44 Formula:CO2 Average Mass Change:-44 References:Nakamura T, Yu Z, Fainzilber M, Burlingame AL. Protein Sci (1996) 5, 524-530 Mass spectrometric-based revision of the structure of a cysteine-rich peptide toxin with gamma-carboxyglutamic acid, TxVIIA, from the sea snail, Conus textile. Notes: The elimination of CO2 will regenerate glutamate as if there was no modification. However, peaks appearing with an interval of 44 is quite characteristic. It would be noteworthy to remind that loss of 44 from a gamma-carboxyglutamate-containing peptide may be observed not only as a result of spontaneous decarboxylation but also as an artifact under some ionization conditions such as negative ion mode MALDI.


ModificationSetId: PSI-MOD
Name: (2-aminosuccinimidyl)acetic acid (Asp)
DiffFormula: C 0 H -2 N 0 O -1
Formula: C 6 H 6 N 2 O 3
Definition:
A protein modification that crosslinks an aspartic acid and the following glycine residue with the formation of (2-aminosuccinimidyl)acetic acid and the loss of a water molecule.

Comment:
Cross-link 2; this cross-link is formed by the condensation of an aspartic acid residue with the alpha-amido of the following residue.


ModificationSetId: PSI-MOD
Name: O-(L-isoglutamyl)-L-serine (Glu-Ser)
Comment: Cross-link 2; From DeltaMass: with no citation.
DiffFormula: C 0 H -2 N 0 O -1
Formula: C 8 H 10 N 2 O 4
Definition:
A protein modification that effectively crosslinks an L-glutamic acid residue and an L-serine residue by an ester bond and releasing water to form O-(L-isoglutamyl)-L-serine.


ModificationSetId: PSI-MOD
Name: alaninohistidine (serine crosslinked to tele or pros nitrogen of histidine)
DiffFormula: C 0 H -2 N 0 O -1
Formula: C 9 H 10 N 4 O 2
Definition:
A protein modification that effectively crosslinks an L-serine residue and an L-histidine residue to release water and form tele- or pros-(2-amino-2-carboxyethyl)histidine.

Comment:
Cross-link 2; From DeltaMass with no citation or formula: Average Mass: -18. The DeltaMass description "Serine crosslinked to theta or pi carbon of Histidine" is incorrect. The histidine ring nitrogens (not carbons) are designated tele or N-tau (not theta), and pros or N-pi [JSG].


ModificationSetId: PSI-MOD
Name: misincorporation of norleucine for methionine
Definition: modification from DeltaMass
DiffFormula: C 1 H 2 N 0 O 0 S -1
Formula: C 6 H 11 N 1 O 1
AminoAcid: M
Comment:
From DeltaMass: Average Mass: -18 Average Mass Change:-18 Notes: It has the same mass as leucine or isoleucine and can be charged on the methionyl t-RNA. This often happens in minimal media-prepared fermentations that are not supplemented with enough free methionine. It gives a mass change of -18 and can often be confused with dehydration.


ModificationSetId: PSI-MOD
Name: modified residue with neutral loss of carbon dioxide
DiffFormula: C -1 H 0 N 0 O -2
Formula: none
Definition:
Covalent modification of, or a change resulting in an alteration of the measured molecular mass of, a peptide or protein amino acid residue with a secondary loss of a neutral carbon dioxide molecular fragment.


ModificationSetId: PSI-MOD
Name: reduction of disulfide crosslink in cystine to two cysteines
DiffFormula: C 0 H 2 N 0 O 0 S 0
Formula: C 6 H 10 N 2 O 2 S 2
Definition:
A protein modification that effectively reduces the disulfide bond of cystine to form two cysteine residues.

Comment:
Cross-link 2; this modification destroys the cross-link. From DeltaMass: Treatment of cystine (cys-cys) by reducing agents such as dithiothreitol (DTT) or triscarboxyethylphosphine (TCEP) results in cleavage of the disulphide bond and reduction of the sulphur atom of each molecule to create cysteine.


ModificationSetId: PSI-MOD
Name: 2',3'-dihydrotryptophan
DiffFormula: C 0 H 2 N 0 O 0 S 0
Formula: C 11 H 12 N 2 O 1
AminoAcid: W
Definition:
A protein modification that by reducing the indole ring system of tryptophan to indoline effectively converts an L-tryptophan residue to 2',3'-dihydrotryptophan.

Comment:
From DeltaMass: References:1. Pearson,D.A., Blanchette,M., Baker,M.L. and Guindon,C.A. (1989) Trialkylsilanes as scavengers for the trifluoroacetic acid deblocking ofprotecting groups in peptide synthesis. Tetrahedron Lett., 30(21), 2739-2742 Notes: Reduction of indole double bond of Trp which occurs when triethylsilane (TES) is used as a scavenger and Trp is incorporated without protection of indole nitrogen [1]. This side reaction is likely to be accompanied by oxidation of indoline ring with formation of intensively colored peptide by-products. Triisopropylsilane (TIPS) does not give this side reaction. See structure at http://www.abrf.org/images/misc/dmass2.gif. [However, the pictured indoline structure is incorrect - JSG].


ModificationSetId: PSI-MOD
Name: Oxidation of Trp to kynurenine
DiffFormula: none
Formula: none
AminoAcid: W
Definition:
Modification from DeltaMass. OBSOLETE because redundant and identical to MOD:00462. Remap to MOD:00462.

Comment:
From DeltaMass: Average Mass: 4 Monoisotopic Mass Change:3.995 Average Mass Change:3.989 References:Ruoppolo M, Amoresano A, Pucci P, Pascarella S, Polticelli F, Trovato M,Menegatti E, Ascenzi P.Characterization of five new low-molecular-mass trypsin inhibitors fromwhite mustard (Sinapis alba L.) seed.Eur J Biochem. 2000 267:6486-92. Notes: See structure at http://www.abrf.org/images/misc/dmass32.jpg.


ModificationSetId: PSI-MOD
Name: lysine epsilon amino to imine + 12 amu
Definition: modification from DeltaMass
DiffFormula: C 1 H 0 N 0 O 0
Formula: C 7 H 12 N 2 O 1
AminoAcid: K
Comment:
From DeltaMass: Average Mass: 12 Average Mass Change: 12 References: Mathews, W. Rodney; Runge, Thomas A.; Haroldsen, Peter E.; Gaskell, Simon J. (1989) Characterization of impurities in a synthetic renin substrate peptide by fast-atom bombardment mass spectrometry and hybrid tandem mass spectrometry. Rapid Commun. Mass Spectrom. 3(9), 314-19 Notes: Fast-atom bombardment mass spectrometry of a synthetic renin substrate decapeptide (Pro-His-Pro-Phe-His-Leu-Val-Ile-His-D-Lys) indicated the presence of several side products, including a component 12 Da higher in mass. Low-energy collisionally activated ***decompn*** analyses were performed using a hybrid tandem instrument and demonstrated that the heavier side product had two components, in which the structural modification was either at the N- or the C-terminus. Addnl. analyses of the N-acetyl deriv. indicated that for each component the structural modification blocked a site of N-acetylation. It is suggested that the formation of these side products is attributable to the generation of formaldehyde, during removal of the histidine protecting group (benzyloxymethyl), which reacts with the N-terminus of the peptide to give an imidazolidinone structure or with the D- ***lysine***.epsilon.-amine group to yield an ***imine*** . While the precise genesis of the side-products remains speculative, it is clear that the combined strategy of derivatization and tandem mass spectrometry has allowed structural conclusions concerning individual components of an isobaric mixt.


ModificationSetId: PSI-MOD
Name: 4-thiazolidinecarboxylic acid
DiffFormula: C 1 H 0 N 0 O 0 S 0
Formula: C 4 H 6 N 1 O 1 S 1
AminoAcid: C
Definition:
A protein modification that effectively converts an N-terminal L-cysteine residue by a formadehyde adduct to 4-thiazolidinecarboxylic acid.

Comment:
From DeltaMass: References: Mitchell, M.A., Runge, T.A., Mathews, W.R., Ichhpurani, A.K., Harn, N.K., Dobrowolski, P.J. and Eckenrrrode, F.M. Problems associated with use of the benzylozymethyl protecting group for histidines. Formaldehyde adducts formed during cleavage by hydrogen fluoride. Int. J. Pept. Protein Res. 1990, 36(4), 350-355. Gesquiere, J.-C., Diesis, E. and Tartar, A. Conversion of N-terminal cysteine to thiazolidine carboxylic acid during hydrogen fluoride deprotection of peptides containing pi-N-Bom protected histidine. J. Chem. Soc. Chem. Commun. 1990, (20), 1402-1403. Kumagaye, K.Y., Inui, T., Nakajima, K., Kimura,T. and Sakakibara, S. Suppression of a side reaction associated with Nim-benzyloxymethyl group during synthesis of peptides containing cysteinyl residue at the N-terminus. Pept. Res. 1991, 4(2), 84-87. Colombo, R., Colombo, F. and Jones, J.H. Acid-labile histidine side-chain protection. The N(pi)-t-butoxymethyl group. J. Chem. Soc. Chem. Commun. 1984, (5), 292-293. Notes: Conversion of N-term Cys to thiazolidine during HF deprotection of His(Bom)-containing peptides [1-3]. See structure at http://www.abrf.org/images/misc/dmass12b.gif; modification in red. This modification cannot be excluded during final deprotection/cleavage in Fmoc-chemistry in cases when His(Bum) was employed [4]. For formation of free imino acid see PubMed:1527501.


ModificationSetId: PSI-MOD
Name: 1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid
DiffFormula: C 1 H 0 N 0 O 0 S 0
Formula: C 12 H 10 N 2 O 1
AminoAcid: W
Definition:
A protein modification that effectively converts an N-terminal L-tryptophan residue by a formadehyde adduct to 1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid.

Comment:
From DeltaMass: Average Mass: 12 Average Mass Change: 12 References: Lippke, K. P., W. G. Schunack, W. Wenning, W. E. Mueller. 1983..beta.-Carbolines as benzodiazepine receptor ligands. 1. Synthesis andbenzodiazepine receptor interaction of esters of.beta.-carboline-3-carboxylic acid. J. Med. Chem.26: 499-503 Cain, M., R. W. Weber, F. Guzman, J. M. Cook, S. A. Barker, K. C.Rice, J. N. Crawley, S. M. Paul, P. Skolnick. 1982. .beta.-Carbolines:synthesis and neurochemical and pharmacological actions on brainbenzodiazepine receptors.J. Med. Chem. 25: 1081-91 Notes: +12 Da modification corresponds to formaldehyde adduct of Trp having beta-carboline structure (methylene bridge links carbon-2 of indole ring and alfa-N. See structure at http://www.abrf.org/images/misc/dmass12a.gif; modification in red.


ModificationSetId: PSI-MOD
Name: syndesine
Comment: Cross-link 2; From DeltaMass: Average Mass: 13 Average Mass Change: 13 (incorrect) [JSG].
DiffFormula: C 0 H -3 N -2 O 3
Formula: C 12 H 21 N 2 O 5
Definition:
A protein modification that effectively cross-links two L-lysine residues to form syndesine, hydroxylysinohydroxynorleucine.


ModificationSetId: PSI-MOD
Name: CM-Cys vs PAM-Cys
Definition: modification from DeltaMass
DiffFormula: none
Formula: none
AminoAcid: C
Comment:
From DeltaMass: Average Mass: 13 Formula:C2H2O2 vs C3H5ON Monoisotopic Mass Change:13.03 Average Mass Change:13.05 Notes:Residual acrylamide in SDS gels can partly label cysteine residues in proteins (propionamido-Cys, PAM-Cys, DeltaMass +71Da; see entry). Subsequent alkylation of protein bands with iodoacetic acid e.g. in preparation for proteomic analysis, will convert remaining free cysteines into carboxymethyl-Cys (CM-Cys, DeltaMass +58Da; see entry). Peptide mass fingerprinting may therefore potentially reveal the same cysteine-containing peptide in two forms, differing in mass by 13Da. The relative ratios of the peaks will depend on the initial degree of labelling with acrylamide. Use of high quality, deionised acrylamide in the SDS gel will minimise modification of cysteine through this route. Where it remains a problem, deliberate alkylation using acrylamide instead of iodoacetamide will ensure chemical homogeneity of the final product.


ModificationSetId: PSI-MOD
Name: CAM-Cys vs PAM-Cys
Definition: modification from DeltaMass
DiffFormula: none
Formula: none
AminoAcid: C
Comment:
From DeltaMass: Average Mass: 14 Formula:CH2 Monoisotopic Mass Change:14.016 Average Mass Change:14.027 Notes: Residual acrylamide in SDS gels can partly label cysteine residues in proteins (propionamido-Cys, PAM-Cys, DeltaMass +71Da; see entry). Subsequent alkylation of protein bands with iodoacetamide e.g. in preparation for proteomic analysis, will convert remaining free cysteines into carboxamidomethyl-Cys (CAM-Cys, DeltaMass +57Da; see entry). Peptide mass fingerprinting may therefore potentially reveal the same cysteine-containing peptide in two forms, differing in mass by 14Da. The relative ratios of the peaks will depend on the initial degree of labelling with acrylamide. Use of high quality, deionised acrylamide in the SDS gel will minimise modification of cysteine through this route. Where it remains a problem, deliberate alkylation using acrylamide instead of iodoacetamide will ensure chemical homogeneity of the final product.


ModificationSetId: PSI-MOD
Name: delta-hydroxy-allysine (Lys)
Definition: modification from DeltaMass
DiffFormula: none
Formula: none
AminoAcid: K
Comment:
From DeltaMass: Average Mass: 15 Average Mass Change:15 Notes:In going from Lys to hydroxy-allysine, two separate reactions are involved:1. the oxidative deamination converting Lys to allysine (-CH2NH2 being converted to -CHO) with a net mass change of -1;2.conversion of allysine to delta-hydroxy-allysine (-CH2-CHO being converted to -CH(OH)-CHO) with a mass change of +16. The net change from Lys to hydroxyallysine thus is +15.


ModificationSetId: PSI-MOD
Name: Oxohistidine (from histidine)
Definition: modification from DeltaMass
DiffFormula: none
Formula: none
AminoAcid: H
Comment:
From DeltaMass: Average Mass: 16 Average Mass Change:16 References:Lewisch, S. A. and Levine, R. L. (1995) Anal. Biochem. 231, 440-446. Determination of 2-oxo-histidine by amino acid analysis Notes:Rod LevineNIHBldg 3, Room 106 MSC 0320Bethesda, MD 20892-0320email: rlevine@nih.govvoice: 1 (301) 496-2310fax: 1 (301) 496-0599


ModificationSetId: PSI-MOD
Name: monobrominated L-phenylalanine
DiffFormula: Br 1 C 0 H -1 N 0 O 0
Formula: Br 1 C 9 H 8 N 1 O 1
AminoAcid: F
Definition:
A protein modification that effectively converts an L-phenylalanine residue to a monobrominated L-phenylalanine, such as L-2'-bromophenylalanine.

Comment:
From DeltaMass: Average Mass: 78 Average Mass Change:78 References:Yoshino,K et.al. Biochemistry Vol. 30 pg 6203-9 (1991) Identifidation of a novel amino acid, o-bromo-L-phenylananine, in egg-associated peptides that activate spermatozoa


ModificationSetId: PSI-MOD
Name: Oxidation of proline (to glutamic acid)
Definition: modification from DeltaMass
DiffFormula: none
Formula: none
AminoAcid: P
Comment:
From DeltaMass: Average Mass: 32 Monoisotopic Mass Change:31.99 Average Mass Change:32 References:Amici A, Levine, RL, Tsai, L, and Stadtman, ER: Conversion of amino acid residues in proteins and amino acid homopolymers to carbonyl derivatives by metal-catalyzed oxidation reactions. Journal of Biological Chemistry 264: 3341-3346 1989.Rod Levine (unpublished)


ModificationSetId: PSI-MOD
Name: potassium salt
Comment: From DeltaMass: Average Mass: 38
DiffFormula: H -1 K 1
Formula: none
Definition:
modification from DeltaMass - OBSOLETE because redundant and identical to MOD:01072. Remap to MOD:01072.


ModificationSetId: PSI-MOD
Name: piperidine adduct to C-terminal Cys
Definition: modification from DeltaMass
DiffFormula: none
Formula: none
AminoAcid: C
Comment:
From DeltaMass: Average Mass: 51 Average Mass Change: 51 References:Lukszo, Patterson, Albericio, and Kates, Letters in Peptide Science 3, 157-166(1996) Notes:The side reaction can be very significant, and the level to which it occurs depends on how the C-terminal Cys is anchored and what the side-chain protecting group is. The mechanism involves piperidine-mediated beta-elimination of sulfur (with the protecting group on), followed by addition of piperidine across the C-terminaldehydroalanine. Since this last-mentioned step creates a chiral center, a mixture of diastereomers is formed which in special cases can be separatedby HPLC. Another problem with C-terminal Cys is racemization; some references in the review article by Andreu, Albericio, Sole, Munson, Ferrer, and Barany in Pennington-Dunn Peptide Synthesis and Purification Protocols, vol 35, 1994, pp. 91-169.


ModificationSetId: PSI-MOD
Name: Carboxamidomethyl (on Cysteine)
DiffFormula: none
Formula: none
AminoAcid: C
Definition:
modification from DeltaMass - OBSOLETE because redundant, the difference component of MOD:01060. Remap to MOD:01060.

Comment:
From DeltaMass: Average Mass: 57 Abbreviation:CamCys Formula:C2H3NO Monoisotopic Mass Change:57.021 Average Mass Change:57.051 Notes:Cysteine reacts with iodoacetamide to produce carboxamidomethyl cysteine. Alternative names are often used, such as amidocarboxymethylcysteine and carbamoylmethylcysteine


ModificationSetId: PSI-MOD
Name: L-selenocysteine (Ser)
DiffFormula: C 0 H 0 N 0 O -1 Se 1
Formula: C 3 H 5 N 1 O 1 Se 1
AminoAcid: S
Definition:
A protein modification that effectively converts an L-serine residue to L-selenocysteine (not known as a natural post-translational modification process).

Comment:
[From DeltaMass: Average Mass: 64.] Although selenocysteine-charged tRNA(Sec) is biosynthesized from serine-charged tRNA(Sec), in peptide work selenocysteine is usually considered as either a natural residue or as a modified cysteine residue. This entry is for the artifactual formation of L-selenocysteine from serine. For encoded L-selenocysteine, use MOD:00031 [JSG].


ModificationSetId: PSI-MOD
Name: Asp transamidation with piperidine
Definition: modification from DeltaMass
DiffFormula: none
Formula: none
AminoAcid: D
Comment:
From DeltaMass: Average Mass: 67 Average Mass Change:67 References:http://www.abrf.org/archives/hmail/0008/0007.html Notes:1.) Get rid of the DBU. It can cause piperidine amides at Asp residues. The tbu ester side chain comes off during synthesis and the residue is trans-amidated with piperidine (+67Da by MS). If you haven't yet seen this, you will. Even "normal" 20% pip/DMF (NMP) will cause this, but less frequently. Literature exists for this; I don't remember the exact reference. David H. Singleton Scientist Pfizer Central Research PO Box 8118-101 Eastern Point Road Groton, CT 06340 (860)441-4404.


ModificationSetId: PSI-MOD
Name: halogenated tyrosine
AminoAcid: Y
Definition:
A protein modification that effectively substitutes a hydrogen atom of an L-tyrosine residue with a halogen atom.


ModificationSetId: PSI-MOD
Name: chlorinated tyrosine
AminoAcid: Y
Definition:
A protein modification that effectively substitutes a hydrogen atom of an L-tyrosine residue with a chlorine atom.


ModificationSetId: PSI-MOD
Name: brominated tyrosine
AminoAcid: Y
Definition:
A protein modification that effectively substitutes a hydrogen atom of an L-tyrosine residue with a bromine atom.


ModificationSetId: PSI-MOD
Name: glutamate 5-glycerol ester
Definition: modification from DeltaMass
DiffFormula: C 3 H 6 O 2
Formula: C 8 H 13 N 1 O 5
AminoAcid: E
Comment:
From DeltaMass: Average Mass: 74 Average Mass Change: 74 References: Anal. Biochem. 1993 Vol 208 No. 2 382-386, PubMed:8452236. [DeltaMass] This article only suggests this as a possible modification and does no characterization. Isolation and stuctural evidence for artifactual modification are found in PubMed:18767873 [JSG].


ModificationSetId: PSI-MOD
Name: (81)Br labeled 2'-bromophenylalanine
Comment: From DeltaMass: Average Mass: 80
DiffFormula: (81)Br 1 H -1
Formula: (81)Br 1 C 9 H 8 N 1 O 1
AminoAcid: F
Definition:
A protein modification that effectively converts an L-phenylalanine residue to (81)Br-L-2'-bromophenylalanine.


ModificationSetId: PSI-MOD
Name: iodinated tyrosine
AminoAcid: Y
Definition:
A protein modification that effectively substitutes a hydrogen atom of an L-tyrosine residue with an iodine atom.


ModificationSetId: PSI-MOD
Name: homoseryl lactone
Definition: OBSOLETE because redundant and identical to MOD:00404. Remap to MOD:00404.
DiffFormula: none
Formula: none
AminoAcid: M
Comment:
From DeltaMass: Average Mass: 83 Formula:C4H5O1N1 Monoisotopic Mass Change:83.037 Average Mass Change:83.09


ModificationSetId: PSI-MOD
Name: monobrominated tyrosine
AminoAcid: Y
Definition:
A protein modification that effectively substitutes one hydrogen atom of an L-tyrosine residue with one bromine atom.


ModificationSetId: PSI-MOD
Name: gamma-aminobutyryl
Definition: modification from DeltaMass
DiffFormula: C 4 H 7 N 1 O 1
Formula: none
Comment:
From DeltaMass: Average Mass: 85 Formula: C 4 H 7 O 1 N 1 Monoisotopic Mass Change: 85.053 Average Mass Change: 85.106


ModificationSetId: PSI-MOD
Name: diaminopropionyl
Definition: modification from DeltaMass
DiffFormula: C 3 H 6 N 2 O 1
Formula: none
Comment:
From DeltaMass: Average Mass: 86 Formula: C 3 H 6 O 2 N 1 Monoisotopic Mass Change: 86.048 Average Mass Change: 86.094


ModificationSetId: PSI-MOD
Name: dibrominated tyrosine
DiffFormula: Br 2 C 0 H -2 N 0 O 0
Formula: Br 2 C 9 H 7 N 1 O 2
AminoAcid: Y
Definition:
A protein modification that effectively substitutes two hydrogen atoms of an L-tyrosine residue with two bromine atoms.


ModificationSetId: PSI-MOD
Name: anisyl modified residue
Comment: From DeltaMass with no citation or formula: Average Mass: 90.
DiffFormula: C 7 H 6
Formula: none
Definition:
A protein modification that effectively substitutes an anisyl (methoxyphenyl) group for a hydroxyl group, typically at the 4 or para position.


ModificationSetId: PSI-MOD
Name: benzyl (Bzl) and benzyl ester (OBzl) modified residue
Comment: From DeltaMass with no citation or formula: Average Mass: 90
DiffFormula: C 7 H 6
Formula: none
Definition:
A protein modification that effectively substitutes a benzyl (phenylmethyl) group for a hydrogen atom.


ModificationSetId: PSI-MOD
Name: oxidation of disulfide crosslink in cystine to two cysteic acids
DiffFormula: C 0 H 2 N 0 O 6 S 0
Formula: C 6 H 10 N 2 O 8 S 2
Definition:
A protein modification that effectively oxidizes the disulfide bond of a cystine crosslink to form two cysteic acid residues.

Comment:
Cross-link 2. This modification destroys a cross-link. From DeltaMass: Average Mass: 98 Abbreviation: Cya Average Mass Change: 98 Notes: Treatment of cystine by strongly oxidising reagents such as performic acid results in the breakage of the disulphide bond and complete oxidation of the sulphur atoms on each molecule. Such treatment is often carried out prior to amino acid analysis as the resulting cysteic acid is then resistant to acid degradation during the hydrolysis procedure.


ModificationSetId: PSI-MOD
Name: phosphate/sulphate adduct of proteins
Definition: modification from DeltaMass
DiffFormula: none
Formula: none
Comment:
From DeltaMass: Average Mass: 98 Formula:H3PO4 or H2SO4 Monoisotopic Mass Change:97.97 Average Mass Change:98 Notes:Proteins may pick up non-covalent salt adducts during purification. Phosphate and sulphate salts are commonly used and may be observed as +98 amu adducts (or multiples thereof) forming ion pairs with basic residues. Monoisotopic masses H2SO4 97.967, H3PO4 97.977


ModificationSetId: PSI-MOD
Name: homoseryl (-Hse-)
Definition: OBSOLETE because redundant and identical to MOD:00403. Remap to MOD:00403.
DiffFormula: none
Formula: none
AminoAcid: M
Comment:
From DeltaMass: Average Mass: 101 Abbreviation:-Hse- Formula:C4H7O2N Monoisotopic Mass Change:101.048 Average Mass Change:101.105


ModificationSetId: PSI-MOD
Name: 2-piperidinecarboxylic acid
DiffFormula: C 0 H -3 N -1 O 0
Formula: C 6 H 9 N 1 O 1
AminoAcid: K
Definition:
A protein modification that effectively converts an L-lysine residue to 2-piperidinecarboxylic acid.


ModificationSetId: PSI-MOD
Name: monohydroxylated proline
Comment: From DeltaMass: Average Mass: 131. This is the mass of the free amino acid [JSG].
DiffFormula: C 0 H 0 N 0 O 1
Formula: C 5 H 7 N 1 O 2
AminoAcid: P
Definition:
A protein modification that effectively converts an L-proline residue to one of several monohydroxylated proline residues, including 3-hydroxy-L-proline and 4-hydroxy-L-proline.


ModificationSetId: PSI-MOD
Name: monochlorinated L-tyrosine
DiffFormula: C 0 Cl 1 H -1 N 0 O 0
Formula: C 9 Cl 1 H 8 N 1 O 2
AminoAcid: Y
Definition:
A protein modification that effectively substitutes one hydrogen atom of an L-tyrosine residue with one chlorine atom.


ModificationSetId: PSI-MOD
Name: succinylated residue
Comment: From DeltaMass with no citation or formula, Average Mass: 117 [JSG].
DiffFormula: C 4 H 4 O 3
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom with a succinyl group linked through a carbonyl carbon.


ModificationSetId: PSI-MOD
Name: O-methyl aspartyl
Definition: OBSOLETE because redundant and identical to MOD:01181. Remap to MOD:01181.
DiffFormula: none
Formula: C 5 H 7 N 1 O 3
AminoAcid: D
Comment:
From DeltaMass:148 (name misspelled "aspartamyl", and formula incorrect, N and O reversed) Average Mass: 129 Formula: C5H7O1N3 Monoisotopic Mass Change: 129.042 Average Mass Change: 129.116


ModificationSetId: PSI-MOD
Name: dichlorinated tyrosine
DiffFormula: C 0 Cl 2 H -2 N 0 O 0
Formula: C 9 Cl 2 H 7 N 1 O 2
AminoAcid: Y
Definition:
A protein modification that effectively substitutes two hydrogen atoms of an L-tyrosine residue with two chlorine atoms.


ModificationSetId: PSI-MOD
Name: hydroxy aspartyl
Definition: OBSOLETE because redundant and identical to MOD:00036. Remap to MOD:00036.
DiffFormula: none
Formula: C 4 H 5 N 1 O 4
AminoAcid: D
Comment:
From DeltaMass:152 (name misspelled "aspartamyl", and formula incorrect, N and O reversed) Average Mass: 131 Formula:C4H5O1N4 Monoisotopic Mass Change:131.022 Average Mass Change:131.088


ModificationSetId: PSI-MOD
Name: p-nitrobenzyl ester modified residue
DiffFormula: C 7 H 5 N 1 O 2
Formula: none
Definition:
A protein modification that effectively substitutes a p-nitrobenzyl group for the hydrogen atom of a carboxyl group.


ModificationSetId: PSI-MOD
Name: N-methyl glutamyl
Definition: OBSOLETE because redundant and identical to MOD:00080. Remap to MOD:00080.
DiffFormula: none
Formula: none
AminoAcid: Q
Comment:
From DeltaMass with no citation. Formula:C6H10O2N2 (name misspelled, formula for N5-methylglutaminyl, rather than N2-methylglutamyl)


ModificationSetId: PSI-MOD
Name: 3',5'-dichloro-L-tyrosine
DiffFormula: C 0 Cl 2 H -2 N 0 O 0
Formula: C 9 Cl 2 H 7 N 1 O 2
AminoAcid: Y
Definition:
A protein modification that effectively converts an L-tyrosine residue to 3',5'-dichloro-L-tyrosine.


ModificationSetId: PSI-MOD
Name: monohydroxylated lysine
Definition: A protein modification that effectively converts an L-lysine residue to a monohydroxylated lysine.
DiffFormula: C 0 H 0 N 0 O 1
Formula: C 6 H 12 N 2 O 2
AminoAcid: K
Comment:
From DeltaMass: Average Mass: 144 Abbreviation:-Hyl- Formula:C6H12N2O2 Monoisotopic Mass Change:144.09 Average Mass Change:144.174.


ModificationSetId: PSI-MOD
Name: 2-pyrrolidone-5-carboxylic acid
DiffFormula: none
Formula: C 5 H 6 N 1 O 2
Definition:
A protein modification that effectively converts a source amino acid residue to 2-pyrrolidone-5-carboxylic acid.

Comment:
From DeltaMass: Average Mass: -18 Average Mass Change: -18.01 References:The conversion of glutamic acid to pyroglutamic was reported for the beta-amiloid protein. Miller et al. Arch. Biochem. Biophy. (1993) 301, 41-52.


ModificationSetId: PSI-MOD
Name: halogenated histidine
AminoAcid: H
Definition:
A protein modification that effectively substitutes a hydrogen atom of an L-histidine residue with a halogen atom.


ModificationSetId: PSI-MOD
Name: pyridyl alanyl
Definition: modification from DeltaMass
DiffFormula: none
Formula: none
AminoAcid: A
Comment:
From DeltaMass: Average Mass: 148 Formula:C8H8O2N1 Monoisotopic Mass Change:148.064 Average Mass Change:148.165


ModificationSetId: PSI-MOD
Name: S-carboxamidomethyl-L-cysteine
Comment: From DeltaMass: (name misspelled "Carboxyamidomethyl Cystenyl") [JSG].
DiffFormula: C 2 H 3 N 1 O 1 S 0
Formula: C 5 H 8 N 2 O 2 S 1
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to S-carboxamidomethyl-L-cysteine.


ModificationSetId: PSI-MOD
Name: S-carboxymethyl-L-cysteine
DiffFormula: C 2 H 2 N 0 O 2 S 0
Formula: C 5 H 7 N 1 O 3 S 1
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to S-carboxymethyl-L-cysteine.

Comment:
From DeltaMass with no citation, name misspelled "Carboxymethyl Cystenyl", and formula incorrect, N and O reversed: Average Mass: 161 Abbreviation: -Cmc- Formula: C5H7O1N3S1 Monoisotopic Mass Change: 161.015 Average Mass Change: 161.179 [JSG].


ModificationSetId: PSI-MOD
Name: carboxymethyl cysteinyl
Definition: OBSOLETE because duplicate and redundant with MOD:01061. Remap to MOD:01061
DiffFormula: none
Formula: C 5 H 7 N 3 O 1 S 1
AminoAcid: C
Comment:
From DeltaMass:197 (Name misspelled "cystenyl", and formula incorrect, N and O reversed) Abbreviation:-Cmc- Formula:C5H7O1N3S1 Monoisotopic Mass Change:161.015 Average Mass Change:161.179


ModificationSetId: PSI-MOD
Name: monomethylated phenylalanine
DiffFormula: C 1 H 2 N 0 O 0
Formula: C 10 H 11 N 1 O 1
AminoAcid: F
Definition:
A protein modification that effectively converts an L-phenylalanine residue to a monomethylated phenylalanine.

Comment:
From DeltaMass: Average Mass: 161 Formula: C10H11O1N1 Monoisotopic Mass Change: 161.084 Average Mass Change: 161.205. No citation provided. It is not obvious whether the DeltaMass entry is supposed to represent N-methylphenylalanine, alpha-methylphenylalanine, 2'-, 3'-, or 4'-methylphenylalanine [JSG].


ModificationSetId: PSI-MOD
Name: hexose glycated N-terminal
Comment: From DeltaMass: Average Mass: 162
DiffFormula: C 6 H 10 O 5
Formula: none
Definition:
A modification produced in a non-enzymatic reaction between a carbohydrate carbonyl group (C1 of aldohexose or C2 of fructose) and a protein N-terminal amino group to form a Schiff-base or an Amadori ketosamine  (or aminoketose) residue adduct.


ModificationSetId: PSI-MOD
Name: halogenated phenylalanine
AminoAcid: F
Definition:
A protein modification that effectively substitutes a hydrogen atom of an L-phenylalanine residue with a halogen atom.


ModificationSetId: PSI-MOD
Name: linker attached to peptide in Fmoc peptide synthesis
Definition: modification from DeltaMass
DiffFormula: none
Formula: none
Comment:
From DeltaMass: Average Mass: 162 Average Mass Change:162 Notes: (from the ABRF discussion list archive) There may be ... things in the reagent K that would allow cleavage of the peptide to occur at the wrong place...in this case it removes the dimethoxybenzyl group first inactivating that site for cleavage, and it goes after tne next amide bond closer to the resin. Try the TFA/TIS/water/EDT cocktail...TFA = 92%, TIS =3%, and water is at 5%. .. had this issue on longer peptides.. and by increasing the amount of water a little bit... able to elminate this problem.


ModificationSetId: PSI-MOD
Name: halogenated tryptophan
AminoAcid: W
Definition:
A protein modification that effectively substitutes a hydrogen atom of an L-tryptophan residue with a halogen atom.


ModificationSetId: PSI-MOD
Name: 2-chlorobenzyloxycarbonyl modified residue
DiffFormula: C 8 Cl 1 H 6 O 2
Formula: none
Definition:
A protein modification that effectively substitutes a 2-chlorobenzyloxycarbonyl group for a hydrogen atom.


ModificationSetId: PSI-MOD
Name: mercury containing modified residue
Definition:
A protein modification that effectively substitutes a mercury atom or a cluster containing mercury for hydrogen atoms, or that coordinates a mercury ion.


ModificationSetId: PSI-MOD
Name: N-methyl arginyl
DiffFormula: none
Formula: C 7 H 14 N 4 O 1
AminoAcid: R
Definition:
modification from DeltaMass - OBSOLETE because redundant and identical to MOD:00414. Remap to MOD:00414.

Comment:
From DeltaMass: Average Mass: 170 Formula:C7H14O4N1 Monoisotopic Mass Change:170.117 Average Mass Change:170.215


ModificationSetId: PSI-MOD
Name: ethanedithiol/TFA cyclic adduct
Definition: modification from DeltaMass
DiffFormula: none
Formula: none
Comment:
From DeltaMass: Average Mass: 172 Average Mass Change:172 References:[1]. Sieber,P.(1987) Modification of tryptophan residues during acidolysis of4-methoxy-2,3,6-trimethylbenzenesulfonyl groups. Effects of scavengers. Tetrahedron Lett., 28(15),1637-1640. Notes: TFA-cyclic dithioketal by-product is formed when Trp-containing peptide is subjected to prolonged TFA/EDT treatment [1]. See structure at http://www.abrf.org/images/misc/dmass172.gif. Additional discussion of this adduct, and how to avoid it, can befound in Methods in Enzymology 289, 67 (1997)


ModificationSetId: PSI-MOD
Name: S-(2-aminoethyl)-3-methylcysteine (Thr)
DiffFormula: C 2 H 5 N 1 O -1 S 1
Formula: C 6 H 12 N 2 O 1 S 1
AminoAcid: T
Definition:
A protein modification that effectively converts an L-threonine residue to S-(2-aminoethyl)-3-methylcysteine.

Comment:
From DeltaMass: Average Mass: 146 Abbreviation:-AECys_ Formula:C5H10O2N1S1 Monoisotopic Mass Change:146.051 Average Mass Change:146.214 References:PE Sciex.


ModificationSetId: PSI-MOD
Name: S-(acetylamino)methyl-L-cysteine
DiffFormula: C 3 H 5 N 1 O 1 S 0
Formula: C 6 H 10 N 2 O 2 S 1
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to S-[(acetylamino)methyl]-L-cysteine.

Comment:
From DeltaMass: (name misspelled "Acetamidomethyl Cystenyl") Average Mass: 174 Formula: C 6 H 10 O 2 N 2 S 1 Monoisotopic Mass Change: 174.046 Average Mass Change: 174.221. [These are aggregate masses, not delta masses.] See Organic Syntheses, Coll. Vol. 6, p.5 (1988); Vol. 59, p.190 (1979); http://www.orgsyn.org/orgsyn/orgsyn/prepContent.asp?prep=cv6p0005 [JSG].


ModificationSetId: PSI-MOD
Name: acrylamidyl cysteinyl
Definition: modification from DeltaMass
DiffFormula: none
Formula: C 6 H 10 N 2 O 2 S 1
AminoAcid: C
Comment:
From DeltaMass: (name misspelled "Acrylamidyl Cystenyl") Average Mass: 174 Formula: C6H10O2N2S1 Monoisotopic Mass Change: 174.046 Average Mass Change: 174.221


ModificationSetId: PSI-MOD
Name: 4-glycosyloxy- (hexosyl, C6) (of proline)
Definition: modification from DeltaMass
DiffFormula: C 6 H 10 O 6
Formula: C 11 H 17 N 1 O 6
AminoAcid: P
Comment:
From DeltaMass: Average Mass: 177. Caution: Formula does not match mass. The natural glycosylating sugar of hydroxyproline is galactose.


ModificationSetId: PSI-MOD
Name: iodoacetic acid derivatized amino-terminal residue
DiffFormula: C 2 H 2 O 2
Formula: none
Definition:
A protein modification that by reaction of iodoacetic acid effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a carboxymethyl group.


ModificationSetId: PSI-MOD
Name: alpha-N-gluconoylation (His Tagged proteins)
Definition: modification from DeltaMass
DiffFormula: none
Formula: none
Comment:
From DeltaMass: Average Mass: 178 Formula: C6H10O6 Monoisotopic Mass Change: 178.05 Average Mass Change: 178.14 References: Geoghegan, K. F., H. B. Dixon, et al. (1999). Spontaneous alpha-N-6-phosphogluconoylation of a His tag in Escherichia coli: the cause of extra mass of 258 or 178 Da in fusion proteins. Anal Biochem 267(1): 169-84.


ModificationSetId: PSI-MOD
Name: 2,4,5-trichlorophenyl modified residue
DiffFormula: C 6 Cl 3 H 1
Formula: none
Definition:
A protein modification that effectively substitutes a 2,4,5-trichlorophenyl group for a hydrogen atom.


ModificationSetId: PSI-MOD
Name: 2,4,6-trimethyloxybenzyl modified residue
DiffFormula: C 10 H 12 O 3
Formula: none
Definition:
A protein modification that effectively substitutes a 2,4,6-trimethyloxybenzyl group for a hydrogen atom.


ModificationSetId: PSI-MOD
Name: iodoacetamide derivatized amino-terminal residue
DiffFormula: C 2 H 3 N 1 O 1
Formula: none
Definition:
A protein modification that by reaction of iodoacetamide effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a carboxamidomethyl group.


ModificationSetId: PSI-MOD
Name: monochlorinated L-phenylalanine
DiffFormula: C 0 Cl 1 H -1 N 0 O 0
Formula: C 9 Cl 1 H 8 N 1 O 1
AminoAcid: F
Definition:
A protein modification that effectively substitutes one hydrogen atom of an L-phenylalanine residue with one chlorine atom.

Comment:
From DeltaMass: Average Mass: 182 Formula:C9H8O1N1Cl1 Monoisotopic Mass Change:181.029 Average Mass Change:181.623


ModificationSetId: PSI-MOD
Name: isopropyl lysyl
Definition: modification from DeltaMass
DiffFormula: none
Formula: C 9 H 16 N 2 O 2
AminoAcid: K
Comment:
From DeltaMass: Average Mass: 184 Formula: C9H16O2N2 Monoisotopic Mass Change: 184.12 Average Mass Change: 184.24 with no citation.


ModificationSetId: PSI-MOD
Name: N6-carboxymethyl-L-lysine
Definition: A protein modification that effectively converts an L-lysine residue to N6-carboxymethyl-L-lysine.
DiffFormula: C 2 H 2 O 2
Formula: C 8 H 14 N 2 O 3
AminoAcid: K
Comment:
From DeltaMass:237 (with no citation, formula incorrect, N and O reversed) Average Mass: 186 Formula: C8H14O2N3 Monoisotopic Mass Change: 186.1 Average Mass Change: 186.211 [JSG].


ModificationSetId: PSI-MOD
Name: Matrix alpha cyano MH+
Definition: Modification from DeltaMass. OBSOLETE because not an amino acid modification.
DiffFormula: none
Formula: C 10 H 8 N 1 O 3
Comment:
From DeltaMass with no citation, formula incorrect, N and O reversed: Formula: C10H8O1N3 Monoisotopic Mass Change: 190.05 Average Mass Change: 190.18.


ModificationSetId: PSI-MOD
Name: naphthylalanine residue
Definition: A protein modification that inserts or replaces a residue with a naphthylalanine.
DiffFormula: none
Formula: C 13 H 11 N 1 O 1
Comment:
From DeltaMass: Average Mass: 197 Formula: C13H11O1N1 Monoisotopic Mass Change: 197.084 Average Mass Change: 197.238. No citation provided. It is not obvious which isomer of naphthylalanine this DeltaMass entry is supposed to represent [JSG].


ModificationSetId: PSI-MOD
Name: succinyl beta-aspartyl anhydride
DiffFormula: C 4 H 2 N 0 O 2
Formula: C 8 H 8 N 1 O 5
AminoAcid: D
Definition:
A protein modification that effectively converts an L-aspartic acid residue to succinyl beta-aspartyl anhydride.

Comment:
From DeltaMass with no citation (name misspelled "aspartamyl", and formula incorrect, N and O reversed) Average Mass: 198 Formula: C8H8O1N5 Monoisotopic Mass Change: 198.04 Average Mass Change: 198.156 [JSG].


ModificationSetId: PSI-MOD
Name: S-Farnesyl-
Definition: OBSOLETE because erroneous and apparently redundant to MOD:00111. Remap to MOD:00111.
DiffFormula: none
Formula: none
Comment:
Modification from DeltaMass: Average Mass: 206. This entry with no other information available appears to be the same as the entry at 204 for "Farnesylation" but with an incorrect mass.


ModificationSetId: PSI-MOD
Name: myristoylation-4H (two double bonds)
Definition: OBSOLETE because redundant and identical to MOD:00504. Remap to MOD:00504.
DiffFormula: none
Formula: none
Comment:
From DeltaMass: Average Mass: 206 Formula: C14 H22 O1 Monoisotopic Mass Change: 206.167 Average Mass Change: 206.324 References: Neubert TA, Johnson RS, Hurley JB, Walsh KA (1992). The rod transducin alpha subunit amino terminus is heterogeneously fatty acylated. J Biol Chem. 267(26), 18274-7. Notes: Modification of protein N-terminus with (cis,cis-delta 5, delta 8)-tetradecadienoyl group (myristoylation with 2 double bonds)


ModificationSetId: PSI-MOD
Name: N-formyl-L-tryptophan
Definition: A protein modification that effectively converts an L-tryptophan residue to N-formyl-L-tryptophan.
DiffFormula: C 1 H 0 N 0 O 1
Formula: C 12 H 10 N 2 O 2
AminoAcid: W
Comment:
From DeltaMass with no citation or formula: Average Mass: 214. It is not clear what this is supposed to represent. The mass corresponds to an N-formyl tryptophan (either N2 or N1'), but neither of these modifications has been reported as commonly encountered. It may have been confused with N'-formyl-L-kynurenine, see MOD:00464 [JSG]


ModificationSetId: PSI-MOD
Name: O5-benzyl-L-glutamate
DiffFormula: C 7 H 6
Formula: C 12 H 13 N 1 O 3
AminoAcid: E
Definition:
A protein modification that effectively converts an L-glutamic acid residue to O5-benzyl-L-glutamate.

Comment:
From DeltaMass with no citation: (formula incorrect, N and O reversed; mass incorrect, aggregate not delta) Average Mass: 219 Formula: C12H13O1N3 Monoisotopic Mass Change: 219.241 Average Mass Change: 219.09 [JSG].


ModificationSetId: PSI-MOD
Name: 2-amino-5-(4-methoxyphenyl)-5-oxopentanoic acid (Glu)
DiffFormula: C 7 H 6
Formula: C 12 H 13 N 1 O 3
AminoAcid: E
Definition:
A protein modification that effectively converts an L-glutamic acid residue to 2-amino-5-(4-methoxyphenyl)-5-oxopentanoic acid, glutamtic acid anisole adduct.

Comment:
From DeltaMass with no citation: (formula incorrect, N and O reversed; mass incorrect, aggregate not delta) Average Mass: 219 Formula: C12H13O1N3 Monoisotopic Mass Change: 219.241 Average Mass Change: 219.09 [JSG].


ModificationSetId: PSI-MOD
Name: isoprenylated cysteine
DiffFormula: none
Formula: none
AminoAcid: C
Definition:
A protein modification that effectively replaces a hydrogen atom of an L-cysteine residue with a group derived from an isoprene polymer, such as a geranyl (C10), farnesyl (C15) or geranylgeranyl (C20).


ModificationSetId: PSI-MOD
Name: dimethoxybenzhydryl modified residue
DiffFormula: C 15 H 14 O 2
Formula: none
Definition:
A protein modification that effectively substitutes a dimethoxybenzhydryl group for a hydrogen atom.

Comment:
From DeltaMass: Average Mass: 226 with no citation. A reagent, typically 4,4'-dimethoxybenzhydryl chloride, used as a protecting group for the carboxamido group of asparagine and glutamine during chemical peptide synthesis [JSG].


ModificationSetId: PSI-MOD
Name: nicotinoyl lysine
Definition: modification from DeltaMass
DiffFormula: C 6 H 3 N 1 O 1
Formula: C 12 H 15 N 3 O 2
AminoAcid: K
Comment:
From DeltaMass: (name misspelled "nicotinyl"; formula incorrect, N and O reversed; mass incorrect, aggregate not delta) Average Mass: 233 Formula: C12H15O3N2 Monoisotopic Mass Change: 233.116 Average Mass Change: 233.271


ModificationSetId: PSI-MOD
Name: triphenylmethyl
Definition: modification from DeltaMass
DiffFormula: C 19 H 14
Formula: none
Comment:
From DeltaMass: Average Mass: 242 Average Mass Change: 242.3 Notes: blocking group used in peptide synthesis for C,H,Q,N


ModificationSetId: PSI-MOD
Name: isoprenylated tryptophan
DiffFormula: none
Formula: none
AminoAcid: W
Definition:
A protein modification that effectively replaces a hydrogen atom of an L-tryptophan residue with a group derived from an isoprene polymer, such as a geranyl (C10), farnesyl (C15) or geranylgeranyl (C20).


ModificationSetId: PSI-MOD
Name: S-farnesyl-L-cysteine methyl ester
DiffFormula: C 16 H 26 N 0 O 0 S 0
Formula: C 19 H 32 N 1 O 2 S 1
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to S-farnesyl-L-cysteine methyl ester.


ModificationSetId: PSI-MOD
Name: alpha-N-6-phosphogluconoylation (His Tagged proteins)
Definition: modification from DeltaMass
DiffFormula: none
Formula: none
Comment:
From DeltaMass: Average Mass: 258 Formula: C6H10O6HPO3 Monoisotopic Mass Change: 258.01 Average Mass Change: 258.12 References: Geoghegan, K. F., H. B. Dixon, et al. (1999). Spontaneous alpha-N-6-phosphogluconoylation of a His tag in Escherichia coli: the cause of extra mass of 258 or 178 Da in fusion proteins. Anal Biochem 267(1): 169-84.


ModificationSetId: PSI-MOD
Name: S-geranylgeranyl-L-cysteine methyl ester
DiffFormula: C 21 H 34 N 0 O 0 S 0
Formula: C 24 H 40 N 1 O 2 S 1
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine methyl ester.


ModificationSetId: PSI-MOD
Name: 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride derivatized residue
DiffFormula: C 14 H 18 O 3 S 1
Formula: none
Definition:
A protein modification that is produced by formation of an adduct with 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride, Pmc chloride.

Comment:
From DeltaMass: Average Mass: 266 Notes: blocking group for Arg in peptide synthesis. CAS:112160-39-1 [JSG].


ModificationSetId: PSI-MOD
Name: aldohexosyl lysyl
Definition: modification from DeltaMass
DiffFormula: C 6 H 10 N 0 O 5
Formula: C 12 H 22 N 2 O 6
AminoAcid: K
Comment:
From DeltaMass: (formula incorrect, N and O reversed; mass incorrect, aggregate not delta) Average Mass: 290 Formula: C12H22O2N6 Monoisotopic Mass Change: 290.148 Average Mass Change: 290.317


ModificationSetId: PSI-MOD
Name: 5'phos Uridinyl
Definition: OBSOLETE because redundant and identical to MOD:01166. Remap to MOD:01166.
DiffFormula: none
Formula: none
Comment:
From DeltaMass: Average Mass: 306 Formula: C9H11O2N8P1 Monoisotopic Mass Change: 306.025 Average Mass Change: 306.17


ModificationSetId: PSI-MOD
Name: 5'phos dAdenosyl
Definition: modification from DeltaMass
DiffFormula: none
Formula: none
Comment:
From DeltaMass: Average Mass: 313 Formula: C10H12O5N5P1 Monoisotopic Mass Change: 313.058 Average Mass Change: 313.211


ModificationSetId: PSI-MOD
Name: SucPhencarb Lysyl
Definition: modification from DeltaMass
DiffFormula: none
Formula: none
Comment:
From DeltaMass: Average Mass: 327 Formula: C17H17O3N4 Monoisotopic Mass Change: 327.122 Average Mass Change: 327.342


ModificationSetId: PSI-MOD
Name: S-12-hydroxyfarnesyl-L-cysteine methyl ester
DiffFormula: C 16 H 26 N 0 O 1 S 0
Formula: C 19 H 32 N 1 O 3 S 1
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to S-12-hydroxyfarnesyl-L-cysteine methyl ester.


ModificationSetId: PSI-MOD
Name: fluorescein labelling of peptide N-terminal using NHS ester
Definition: modification from DeltaMass
DiffFormula: none
Formula: none
Comment:
From DeltaMass: Average Mass: 359 Formula: C21H11O6 Monoisotopic Mass Change: 359.055 Average Mass Change: 359.315 Notes: Using the DHB matrix at low pH the carboxyl group and one of the oxygens on the flurorescein molecule are protinated so the delta mass is 2Da higher than most text book illustrations would indicate. See Bioconjugate Techniques by Greg Hermanson, Academic Press, page 305, figure 204. Text books of course just show the coupling reaction at neutral or basic pH.


ModificationSetId: PSI-MOD
Name: dioctyl phthalate
Definition: modification from DeltaMass
DiffFormula: none
Formula: none
Comment:
From DeltaMass: Average Mass: 391 Average Mass Change: 391 Notes: A common plasticizer, and, unfortunaltely, a common contaminate. A sodium adduct is often associated with this peak at 413.


ModificationSetId: PSI-MOD
Name: N6-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)-L-lysine
DiffFormula: C 14 H 18 O 3 S 1
Formula: C 20 H 30 N 2 O 4 S 1
AminoAcid: K
Definition:
A protein modification that is produced by reaction of a lysine residue with 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride, Pmc chloride, to form N6-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)-L-lysine.

Comment:
From DeltaMass: Average Mass: Formula: C20H30O2N4S1 Monoisotopic Mass Change: 394.192 Average Mass Change: 394.534


ModificationSetId: PSI-MOD
Name: Aedans Cystenyl
Definition: modification from DeltaMass
DiffFormula: none
Formula: none
AminoAcid: C
Comment:
[probably aminoethyldansyl, JSG] From DeltaMass: (name misspelled "Aedans Cystenyl", and formula incorrect, N and O reversed) Average Mass: 409 Abbreviation: Aedans-Cys Formula: C17H19O3N5S2 Monoisotopic Mass Change: 409.077 Average Mass Change: 409.482


ModificationSetId: PSI-MOD
Name: dioctyl phthalate sodium adduct
Definition: modification from DeltaMass
DiffFormula: none
Formula: none
Comment:
From DeltaMass: Mass: Average Mass Change: 413 Notes: A common plasticizer, and, unfortunaltely, a common contaminate. A sodium adduct is often associated with this peak at 413.


ModificationSetId: PSI-MOD
Name: diiodinated tyrosine
DiffFormula: C 0 H -2 I 2 N 0 O 0
Formula: C 9 H 7 I 2 N 1 O 2
AminoAcid: Y
Definition:
A protein modification that effectively substitutes two hydrogen atoms of an L-tyrosine residue with two iodine atoms.


ModificationSetId: PSI-MOD
Name: omega-N-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)-L-arginine
DiffFormula: C 14 H 18 O 3 S 1
Formula: C 20 H 30 N 4 O 4 S 1
AminoAcid: R
Definition:
A protein modification that is produced by reaction with 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride, Pmc chloride, to form omega-N-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)-L-arginine.

Comment:
From DeltaMass: Average Mass: Formula: C20H30O4N4S1 Monoisotopic Mass Change: 422.199 Average Mass Change: 422.547


ModificationSetId: PSI-MOD
Name: S-15,16-dihydrobiliverdin-L-cysteine
DiffFormula: C 33 H 36 N 4 O 6 S 0
Formula: C 36 H 41 N 5 O 7 S 1
AminoAcid: C
Definition:
A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound 15,16-dihydrobiliverdin.


ModificationSetId: PSI-MOD
Name: 15,16-dihydrobiliverdin-bis-L-cysteine
Comment: Cross-link 2.
DiffFormula: C 33 H 36 N 4 O 6 S 0
Formula: C 39 H 46 N 6 O 8 S 2
Definition:
A protein modification that effectively results from forming an adduct between two cysteine residues and the tetrapyrrole compound 15,16-dihydrobiliverdin.


ModificationSetId: PSI-MOD
Name: S-(sn-1-2,3-dipalmitoylglycerol)-L-cysteine
Comment: From DeltaMass: Average Mass: 524
DiffFormula: C 35 H 66 N 0 O 4 S 0
Formula: C 38 H 71 N 1 O 5 S 1
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to S-(sn-1-2,3-dipalmitoyl-glycerol)cysteine.


ModificationSetId: PSI-MOD
Name: N-tau-(ADP-ribosyl)diphthamide
DiffFormula: C 22 H 36 N 7 O 14 P 2
Formula: C 28 H 43 N 10 O 15 P 2
AminoAcid: H
Definition:
A protein modification that effectively converts an L-histidine residue to N-tau-(ADP-ribosyl)diphthamide.

Comment:
From DeltaMass: (name misspelled "N theta -(ADP-ribosyl) diphthamide (of Histidine)") Average Mass: 648


ModificationSetId: PSI-MOD
Name: ubiquitinylated lysine
AminoAcid: K
Definition:
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.


ModificationSetId: PSI-MOD
Name: sumoylated lysine
AminoAcid: K
Definition:
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.


ModificationSetId: PSI-MOD
Name: neddylated lysine
AminoAcid: K
Definition:
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a nedd8 protein.


ModificationSetId: PSI-MOD
Name: phosphorylated residue with neutral loss of phosphate
DiffFormula: C 0 H -3 N 0 O -4 P -1
Formula: none
Definition:
Covalent modification of, or a change resulting in an alteration of the measured molecular mass of, a peptide or protein amino acid phosphorylated residue with a secondary loss of a neutral trihydrogen phosphate molecular fragment.


ModificationSetId: PSI-MOD
Name: methylthiolated residue
DiffFormula: C 1 H 2 N 0 O 0 S 1
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom with an methylsulfanyl group (thiomethyl group).


ModificationSetId: PSI-MOD
Name: lipoconjugated residue
Definition:
A protein modification that effectively results from forming an adduct with a compound containing a lipid-like group either through acylation, alkylation, or amidation.


ModificationSetId: PSI-MOD
Name: protein modification categorized by chemical process
Definition:
Modified amino acid residue derived from a natural amino acid by a real or hypothetical chemical process.


ModificationSetId: PSI-MOD
Name: protein modification categorized by amino acid modified
Definition:
A protein modification considered either as modified amino acid residues derived from natural amino acids, as a replacement by another natural amino acid, or as a replacement by an unnatural amino acid.


ModificationSetId: PSI-MOD
Name: peptidoglycanated residue
Definition:
A protein modification that effectively attaches a residue to murein peptidoglycan by either a pentaglycine linker peptide or a peptide-like L-alanyl-D-glutamyl-2,6-diaminopimelic acid linkage.


ModificationSetId: PSI-MOD
Name: deaminated residue
DiffFormula: C 0 H -3 N -1 O 0
Formula: none
Definition:
A protein modification that effectively results in the loss of an ammonia, usually by a process of vicinal dehydration, rearrangement, and rehydration with release of ammonia, resulting in a loss of nitrogen with no gain of oxygen.


ModificationSetId: PSI-MOD
Name: deoxygenated residue
DiffFormula: C 0 H 0 N 0 O -1
Formula: none
Definition:
A protein modification that effectively removes oxygen atoms from a residue without the removal of hydrogen atoms.


ModificationSetId: PSI-MOD
Name: guanylated residue
DiffFormula: C 10 H 12 N 5 O 7 P 1
Formula: none
Definition:
A protein modification that effectively crosslinks an amino acid residue and 5'-phosphoguanosine through either a phosphodiester or a phosphoramide bond.

Comment:
From DeltaMass: (formula incorrect, N and O reversed) Average Mass: 345 Formula: C10H12O5N7P1 Monoisotopic Mass Change: 345.047 Average Mass Change: 345.209.


ModificationSetId: PSI-MOD
Name: riboflavin-phosphoryl
DiffFormula: C 17 H 19 N 4 O 8 P 1
Formula: none
Definition:
A protein modification that effectively results from forming an adduct with a compound containing a riboflavin phosphate (flavin mononucleotide, FMN) group through a phosphodiester bond.


ModificationSetId: PSI-MOD
Name: adenylated residue
Comment: From DeltaMass: (name misspelled "5'phos adenosinyl") Average Mass: 329
DiffFormula: C 10 H 12 N 5 O 6 P 1
Formula: none
Definition:
A protein modification that effectively crosslinks an amino acid residue and 5'-phosphoadenosine through either a phosphodiester or a phosphoramide bond.


ModificationSetId: PSI-MOD
Name: uridylated residue
DiffFormula: C 9 H 11 N 2 O 8 P 1
Formula: none
Definition:
A protein modification that effectively crosslinks an amino acid residue and 5'-phosphouridine through either a phosphodiester or a phosphoramide bond.

Comment:
From DeltaMass: (name misspelled "5'phos Uridinyl" and formula incorrect, N and O reversed) Average Mass: 306 Formula: C9H11O2N8P1 Monoisotopic Mass Change: 306.025 Average Mass Change: 306.17


ModificationSetId: PSI-MOD
Name: pyruvic acid iminylated residue
DiffFormula: C 3 H 2 N 0 O 2
Formula: none
Definition:
A protein modification that effectively forms a 2-ketoimine of pyruvicacid with a residue amino group.


ModificationSetId: PSI-MOD
Name: N-alanyl-glycosylsphingolipidinositolethanolamine
DiffFormula: C 2 H 6 N 1 O 3 P 1
Formula: C 5 H 12 N 2 O 5 P 1
AminoAcid: A
Definition:
A protein modification that effectively converts an L-alanine residue to N-alanyl-glycosylsphingolipidinositolethanolamine.


ModificationSetId: PSI-MOD
Name: N-asparaginyl-glycosylsphingolipidinositolethanolamine
DiffFormula: C 2 H 6 N 1 O 3 P 1
Formula: C 6 H 13 N 3 O 6 P 1
AminoAcid: N
Definition:
A protein modification that effectively converts an L-asparagine residue to N-asparaginyl-glycosylsphingolipidinositolethanolamine.


ModificationSetId: PSI-MOD
Name: S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)-L-cysteine
DiffFormula: C 20 H 28 N 0 O 3 S 0
Formula: C 23 H 33 N 1 O 4 S 1
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)-L-cysteine.


ModificationSetId: PSI-MOD
Name: S-phycourobilin-L-cysteine
DiffFormula: C 33 H 38 N 4 O 6 S 0
Formula: C 36 H 43 N 5 O 7 S 1
AminoAcid: C
Definition:
A protein modification that effectively results from forming an adduct between a cysteine residue and the tetrapyrrole compound phycourobilin.


ModificationSetId: PSI-MOD
Name: L-dehydrolysinonorleucine
Comment: Cross-link 2.
DiffFormula: C 0 H -5 N -1 O 0
Formula: C 12 H 19 N 3 O 2
Definition:
A protein modification that effectively cross-links an L-lysine residue and an L-lysine residue converted to allysine with a carbon-nitrogen bond to form L-dehydrolysinonorleucine.


ModificationSetId: PSI-MOD
SwissprotTerm: Tele-(1,2,3-trihydroxypropan-2-yl)histidine
Name: 1'-(1,2,3-trihydroxyprop-2-yl)-L-histidine
DiffFormula: C 3 H 6 N 0 O 3
Formula: C 9 H 13 N 3 O 4
AminoAcid: H
Definition:
A protein modification that effectively converts an L-histidine residue to 1'-(1,2,3-trihydroxyprop-2-yl)-L-histidine.


ModificationSetId: PSI-MOD
Name: S-(aspart-4-yloxy) thiocarbonate
DiffFormula: C 1 H 0 N 0 O 2 S 1
Formula: C 5 H 5 N 1 O 5 S 1
AminoAcid: D
Definition:
A protein modification that effectively converts an L-aspartic acid residue to S-(aspart-4-yloxy) thiocarbonate.

Comment:
This modification was originally observed in an Entamoeba histolytica enzyme expressed in Escherichia coli. It was not chemically confirmed or characterized. It did not appear in a later model at higher resolution by the same group. This is a deprecated entry in RESID. It probably does not occur naturally [JSG].


ModificationSetId: PSI-MOD
Name: 2-hydroxyglycine observational artifact
Definition: A protein modification that effectively converts a glycine residue to 2-hydroxyglycine.
DiffFormula: C 0 H 0 N 0 O 1
Formula: C 2 H 3 N 1 O 2
AminoAcid: G
Comment:
CAUTION - peptides of 2-hydroxyglycine are known to be unstable, decaying to break the peptide backbone or to form peptidyl amides [see J. Am. Chem. Soc. 111, 1933-1934, 1989, and J. Org. Chem. 57, 3916-3921, 1992]. If computer analysis of tandem mass-spectrometric results predicts this modification, then it is most probable that there are multiple isobaric peptides differing in the location of multiple hydroxylation modifications [JSG].


ModificationSetId: PSI-MOD
Name: L-aspartic acid 4-methyl ester
DiffFormula: C 1 H 2 N 0 O 0
Formula: C 5 H 7 N 1 O 3
AminoAcid: D
Definition:
A protein modification that effectively converts an L-aspartic acid residue to L-aspartate 4-methyl ester.

Comment:
CAUTION - observations of this modifation are attributable to artifacts produced in preparation. It is extremely unlikely that eukaryotes produce this modification, because an enzyme acting to form the methyl ester of L-aspartyl peptides would interfere with the D-aspartyl peptide repair mechanism [JSG].


ModificationSetId: PSI-MOD
Name: 6-(S-L-cysteinyl)-8alpha-(-3'-L-histidino)-FAD
Comment: Cross-link 2.
DiffFormula: C 27 H 29 N 9 O 15 P 2 S 0
Formula: C 36 H 41 N 13 O 17 P 2 S 1
Definition:
A protein modification that crosslinks a cysteine and a histidine residue by forming the adduct 6-(S-L-cysteinyl)-8alpha-(-3'-L-histidino)-FAD.


ModificationSetId: PSI-MOD
Name: L-selenocystine (oxidized selenocysteine) (Sec-Sec)
DiffFormula: C 0 H -2 N 0 O 0 Se 0
Formula: C 6 H 8 N 2 O 2 Se 2
Definition:
A protein modification that effectively cross-links two L-selenocysteine residues to form L-selenocystine,

Comment:
Cross-link 2; for formation of the same modification by substitution of 2 selenium for 2 sulfur atoms in L-cystine, see MOD:01184.


ModificationSetId: PSI-MOD
Name: L-selenocystine (selenium disubstituted L-cystine)
DiffFormula: C 0 H -2 N 0 O 0 S -2 Se 2
Formula: C 6 H 8 N 2 O 2 Se 2
Definition:
A protein modification that effectively substitutes two selenium atoms for two sulfur atoms in L-cystine to form L-selenocystine.

Comment:
Cross-link 2; for formation of the same modification by oxidation of two L-selenocysteine residues, see MOD:01183.


ModificationSetId: PSI-MOD
Name: acetylated L-threonine
DiffFormula: C 2 H 2 N 0 O 1
Formula: none
AminoAcid: T
Definition:
A protein modification that effectively converts an L-threonine residue to either N-acetyl-L-threonne, or O-acetyl-Lthreonine.


ModificationSetId: PSI-MOD
Name: L-pyrrolysine residue
DiffFormula: C 0 H 0 N 0 O 0
Formula: C 12 H 19 N 3 O 2
AminoAcid: O
Definition:
A protein modification that inserts or replaces a residue with an L-pyrrolysine residue, a natural pretranslational modification.


ModificationSetId: PSI-MOD
Name: dibromo
DiffFormula: Br 2 H -2
Formula: none
AminoAcid: Y
Definition:
Modification from UniMod Chemical derivative. OBSOLETE because duplicate and redundant with MOD:01006. Remap to MOD:01006.


ModificationSetId: PSI-MOD
Name: N-heptosyl-L-asparagine
Comment: From UniMod with no citation [JSG].
DiffFormula: C 7 H 12 O 6
Formula: C 11 H 18 N 2 O 8
AminoAcid: N
Definition:
A protein modification that effectively converts an L-asparagine residue to N-heptosyl-L-asparagine.


ModificationSetId: PSI-MOD
Name: N6-(pyridylacetyl)lysine
Comment: Produced by reaction with N-[(pyrid-3-yl)acetyl]oxy-succinimide [JSG].
DiffFormula: C 7 H 5 N 1 O 1
Formula: C 13 H 17 N 3 O 2
AminoAcid: K
Definition:
A protein modification that effectively converts an L-lysine residue to N6-[(pyrid-3-yl)acetyl]lysine.


ModificationSetId: PSI-MOD
Name: Hex1HexNAc1NeuAc2 O-glycosylated serine
DiffFormula: C 36 H 57 N 3 O 26
Formula: C 39 H 62 N 4 O 28
AminoAcid: S
Definition:
A protein modification that effectively replaces an O3 hydrogen atom of a serine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc2 linked through a glycosidic bond.


ModificationSetId: PSI-MOD
Name: Hex1HexNAc1NeuAc2 O-glycosylated threonine
DiffFormula: C 36 H 57 N 3 O 26
Formula: C 40 H 64 N 4 O 28
AminoAcid: T
Definition:
A protein modification that effectively replaces an O3 hydrogen atom of a threonine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc2 linked through a glycosidic bond.


ModificationSetId: PSI-MOD
Name: Hex1HexNAc1NeuAc2 N4-glycosylated asparagine
DiffFormula: C 36 H 57 N 3 O 26
Formula: C 40 H 63 N 5 O 28
AminoAcid: N
Definition:
A protein modification that effectively replaces an N4 hydrogen atom of an asparagine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc2 linked through a glycosidic bond.


ModificationSetId: PSI-MOD
Name: copper(1+) carboxylate C-terminal residue
DiffFormula: Cu 1 H -1
Formula: none
Definition:
A protein modification that effectively converts a C-terminal residue to the copper(1+) carboxylate salt.


ModificationSetId: PSI-MOD
Name: copper(1+) L-aspartate
DiffFormula: Cu 1 H -1
Formula: C 4 Cu 1 H 4 N 1 O 3
AminoAcid: D
Definition:
A protein modification that effectively converts an L-aspartic acid residue to the copper(1+) aspartate salt.


ModificationSetId: PSI-MOD
Name: copper(1+) L-glutamate
DiffFormula: Cu 1 H -1
Formula: C 5 Cu 1 H 6 N 1 O 3
AminoAcid: E
Definition:
A protein modification that effectively converts an L-glutamic acid residue to the copper(1+) glutamate salt.


ModificationSetId: PSI-MOD
Name: N6-(morpholine-2-acetyl)-lysine
DiffFormula: C 6 H 9 N 1 O 2
Formula: C 12 H 21 N 3 O 3
AminoAcid: K
Definition:
A protein modification that effectively converts an L-lysine residue to N6-(morpholine-2-acetyl)-lysine.

Comment:
The UniMod name "N-Succinimidyl-3-morpholine acetate" appears to have been a typographical error [JSG].


ModificationSetId: PSI-MOD
Name: iodoacetamide N6-derivatized lysine
DiffFormula: C 2 H 3 N 1 O 1
Formula: C 8 H 15 N 3 O 2
AminoAcid: K
Definition:
A protein modification that effectively converts an L-lysine residue to N6-(carboxamidomethyl)lysine.


ModificationSetId: PSI-MOD
Name: iodoacetamide derivatized histidine
DiffFormula: C 2 H 3 N 1 O 1
Formula: C 8 H 10 N 4 O 2
AminoAcid: H
Definition:
A protein modification that effectively converts an L-histidine residue to an iodoacetamide derivatized histidine, either 1'- or 3'-(carboxamidolmethyl)histidine.


ModificationSetId: PSI-MOD
Name: iodoacetamide - site C
DiffFormula: C 2 H 3 N 1 O 1
Formula: none
AminoAcid: C
Definition:
modification from UniMod Chemical derivative - OBSOLETE because redundant, the difference component of MOD:01060. Remap to MOD:01060.


ModificationSetId: PSI-MOD
Name: iodoacetamide derivatized aspartic acid
DiffFormula: C 2 H 3 N 1 O 1
Formula: C 6 H 8 N 2 O 4
AminoAcid: D
Definition:
A protein modification that effectively converts an L-aspartic acid residue to O4-(carboxamidomethyl)aspartate.


ModificationSetId: PSI-MOD
Name: iodoacetamide derivatized glutamic acid
DiffFormula: C 2 H 3 N 1 O 1
Formula: C 7 H 10 N 2 O 4
AminoAcid: E
Definition:
A protein modification that effectively converts an L-glutamic acid residue to O5-(carboxamidomethyl)glutamate.


ModificationSetId: PSI-MOD
Name: monofluorinated L-phenylalanine
DiffFormula: C 0 F 1 H -1 N 0 O 0
Formula: C 9 F 1 H 8 N 1 O 1
AminoAcid: F
Definition:
A protein modification that effectively converts an L-phenylalanine residue to an L-fluorophenylalanine.

Comment:
From UniMod: the citation appears to be correct, but the PMID is not and has been corrected. From DeltaMass: (element abbreviation in formula incorrect, mass incorrect, and aggregate not delta) Average Mass: 149 Formula: C9H8O1N1Fl1 Average Mass Change: 149 References:PE Sciex with no citation [JSG].


ModificationSetId: PSI-MOD
Name: monoiodinated tyrosine
Comment: From DeltaMass: Average Mass: 289 [name misspelled "monoiodated" - JSG].
DiffFormula: H -1 I 1
Formula: C 9 H 8 I 1 N 1 O 2
AminoAcid: Y
Definition:
A protein modification that effectively substitutes one hydrogen atom of an L-tyrosine residue with one iodine atom.


ModificationSetId: PSI-MOD
Name: 3x(13)C labeled N6-propanoyl-L-lysine
DiffFormula: (13)C 3 H 4 O 1
Formula: (12)C 6 (13)C 3 H 16 N 2 O 2
AminoAcid: K
Definition:
A protein modification that effectively converts an L-lysine residue to 3x(13)C labeled N6-propanoyl-L-lysine.


ModificationSetId: PSI-MOD
Name: 3x(12)C labeled N6-propanoyl-L-lysine
DiffFormula: (12)C 3 H 4 O 1
Formula: (12)C 9 H 16 N 2 O 2
AminoAcid: K
Definition:
A protein modification that effectively converts an L-lysine residue to 3x(12)C labeled N6-propanoyl-L-lysine.


ModificationSetId: PSI-MOD
Name: 3x(2)H labeled N6-acetyl-L-lysine
DiffFormula: C 2 (1)H -1 (2)H 3 O 1
Formula: C 8 (1)H 11 (2)H 3 N 2 O 2
AminoAcid: K
Definition:
A protein modification that effectively converts an L-lysine residue to 3x(2)H labeled N6-acetyl-L-lysine.


ModificationSetId: PSI-MOD
Name: cysteine 4-hydroxynonenal adduct
DiffFormula: C 9 H 16 O 2
Formula: C 12 H 21 N 1 O 3 S 1
AminoAcid: C
Definition:
A protein modification produced by formation of an adduct of an L-cysteine residue with 4-hydroxynonenal.

Comment:
4-hydroxynonenal, a toxic lipid aldehyde, is a product of the hydroperoxide beta-cleavage degradation of omega-6 polyunsaturated fatty acids, such as arachidonic and linoleic acids [JSG].


ModificationSetId: PSI-MOD
Name: lysine 4-hydroxynonenal adduct
DiffFormula: C 9 H 16 O 2
Formula: C 15 H 28 N 2 O 3
AminoAcid: K
Definition:
A protein modification produced by formation of an adduct of an L-lysine residue with 4-hydroxynonenal.


ModificationSetId: PSI-MOD
Name: histidine 4-hydroxynonenal adduct
DiffFormula: C 9 H 16 O 2
Formula: C 15 H 23 N 3 O 3
AminoAcid: H
Definition:
A protein modification produced by formation of an adduct of an L-histidine residue with 4-hydroxynonenal.


ModificationSetId: PSI-MOD
Name: ubiquitination signature tetrapeptidyl lysine
DiffFormula: C 16 H 29 N 7 O 4
Formula: C 22 H 41 N 9 O 5
AminoAcid: K
Definition:
A protein modification that crosslinks the N6-amino of a peptidyl lysine with the carboxyl of leucyl-arginyl-glycyl-glycine, the C-terminal tetrapeptide of ubiquitin.


ModificationSetId: PSI-MOD
Name: 3x(2)H labeled L-aspartic acid 4-methyl ester
DiffFormula: C 1 (1)H -1 (2)H 3
Formula: C 5 (1)H 4 (2)H 3 N 1 O 3
AminoAcid: D
Definition:
A protein modification that effectively converts an L-lysine residue to 3x(2)H labeled L-aspartic acid 4-methyl ester.


ModificationSetId: PSI-MOD
Name: 3x(2)H labeled L-glutamic acid 5-methyl ester
DiffFormula: C 1 (1)H -1 (2)H 3
Formula: C 6 (1)H 6 (2)H 3 N 1 O 3
AminoAcid: E
Definition:
A protein modification that effectively converts an L-lysine residue to 3x(2)H labeled L-glutamic acid 5-methyl ester.


ModificationSetId: PSI-MOD
Name: potassium carboxylate C-terminal residue
DiffFormula: H -1 K 1
Formula: none
Definition:
A protein modification that effectively converts a C-terminal residue to the potassium carboxylate salt.


ModificationSetId: PSI-MOD
Name: potassium L-glutamate
DiffFormula: H -1 K 1
Formula: C 5 H 6 K 1 N 1 O 3
AminoAcid: E
Definition:
A protein modification that effectively converts an L-glutamioc acid residue to the potassium glutamate salt.


ModificationSetId: PSI-MOD
Name: potassium L-aspartate
DiffFormula: H -1 K 1
Formula: C 4 H 4 K 1 N 1 O 3
AminoAcid: D
Definition:
A protein modification that effectively converts an L-aspartic acid residue to the potassium aspartate salt.


ModificationSetId: PSI-MOD
Name: iodouridine monophosphate derivatized tyrosine
Comment: This has an ether linkage and not a phosphodiester linkage with UMP.
DiffFormula: C 9 H 11 N 2 O 9 P 1
Formula: C 18 H 20 N 3 O 11 P 1
AminoAcid: Y
Definition:
A protein modification that is produced by reaction of iodouridine monophosphate, or a polynucleotide containing iodouridine, with an L-tyrosine residue to form an ether linkage.


ModificationSetId: PSI-MOD
Name: iodouridine monophosphate derivatized tryptophan
Comment: This has a carbon-nitrogen linkage and not a phosphodiester linkage with UMP.
DiffFormula: C 9 H 11 N 2 O 9 P 1
Formula: C 20 H 21 N 4 O 10 P 1
AminoAcid: W
Definition:
A protein modification that is produced by reaction of iodouridine monophosphate, or a polynucleotide containing iodouridine, with an L-tryptophan residue.


ModificationSetId: PSI-MOD
Name: iodouridine monophosphate derivatized phenylalanine
Comment: This has a carbon-carbon linkage and not a phosphodiester linkage with UMP.
DiffFormula: C 9 H 11 N 2 O 9 P 1
Formula: C 18 H 20 N 3 O 10 P 1
AminoAcid: F
Definition:
A protein modification that is produced by reaction of iodouridine monophosphate, or a polynucleotide containing iodouridine, with an L-phenylalanine residue.


ModificationSetId: PSI-MOD
Name: N6-[3-(carboxamidomethylthio)propanoyl]lysine
DiffFormula: C 5 H 7 N 1 O 2 S 1
Formula: C 11 H 19 N 3 O 3 S 1
AminoAcid: K
Definition:
A protein modification that effectively converts an L-lysine residue to N6-[3-(carboxamidomethylthio)propanoyl]lysine.


ModificationSetId: PSI-MOD
Name: 4x(2)H labeled dimethylated L-lysine
DiffFormula: C 2 (2)H 4
Formula: C 8 H 12 (2)H 4 N 2 O 1
AminoAcid: K
Definition:
A protein modification that effectively converts an L-lysine residue to 4x(2)H labeled dimethylated L-lysine.


ModificationSetId: PSI-MOD
Name: S-(2-sulfanylethyl)cysteine (Ser)
DiffFormula: C 2 H 4 O -1 S 2
Formula: C 5 H 9 N 1 O 1 S 2
AminoAcid: S
Definition:
A protein modification that effectively converts an L-serine residue to S-(2-sulfanylethyl)cysteine.


ModificationSetId: PSI-MOD
Name: 3-methyl-S-(2-sulfanylethyl)cysteine (Thr)
DiffFormula: C 2 H 4 O -1 S 2
Formula: C 6 H 11 N 1 O 1 S 2
AminoAcid: T
Definition:
A protein modification that effectively converts an L-threonine residue to 3-methyl-S-(2-sulfanylethyl)cysteine.


ModificationSetId: PSI-MOD
Name: O-[4-(2-aminoethyl)benzenesulfonyl] serine
DiffFormula: C 8 H 9 N 1 O 2 S 1
Formula: C 11 H 14 N 2 O 4 S 1
AminoAcid: S
Definition:
A protein modification that is produced by formation of an adduct with 4-(2-aminoethyl)benzenesulfonyl fluoride, AEBS, and an L-serine residue.


ModificationSetId: PSI-MOD
Name: N'-[4-(2-aminoethyl)benzenesulfonyl] derivatized histidine
DiffFormula: C 8 H 9 N 1 O 2 S 1
Formula: C 14 H 16 N 4 O 3 S 1
AminoAcid: H
Definition:
A protein modification that is produced by formation of an adduct with 4-(2-aminoethyl)benzenesulfonyl fluoride, AEBS, and an L-histidine residue.


ModificationSetId: PSI-MOD
Name: N6-[4-(2-aminoethyl)benzenesulfonyl]lysine
DiffFormula: C 8 H 9 N 1 O 2 S 1
Formula: C 14 H 21 N 3 O 3 S 1
AminoAcid: K
Definition:
A protein modification that is produced by formation of an adduct with 4-(2-aminoethyl)benzenesulfonyl fluoride, AEBS, and an L-lysine residue.


ModificationSetId: PSI-MOD
Name: O4'-[4-(2-aminoethyl)benzenesulfonyl]tyrosine
DiffFormula: C 8 H 9 N 1 O 2 S 1
Formula: C 17 H 18 N 2 O 4 S 1
AminoAcid: Y
Definition:
A protein modification that is produced by formation of an adduct with 4-(2-aminoethyl)benzenesulfonyl fluoride, AEBS, and an L-tyrosine residue.


ModificationSetId: PSI-MOD
Name: 6x(13)C,1x(15)N labeled L-leucine
DiffFormula: (12)C -6 (13)C 6 (14)N -1 (15)N 1
Formula: (13)C 6 H 11 (15)N 1 O 1
AminoAcid: L
Definition:
A protein modification that effectively converts an L-leucine residue to 6x(13)C,1x(15)N isotope labeled L-leucine.


ModificationSetId: PSI-MOD
Name: 6x(13)C,1x(15)N labeled L-isoleucine
DiffFormula: (12)C -6 (13)C 6 (14)N -1 (15)N 1
Formula: (13)C 6 H 11 (15)N 1 O 1
AminoAcid: I
Definition:
A protein modification that effectively converts an L-isoleucine residue to 6x(13)C,1x(15)N isotope labeled L-isoleucine.


ModificationSetId: PSI-MOD
Name: 1x(18)O labeled deamidated L-asparagine
DiffFormula: H -1 N -1 (18)O 1
Formula: C 4 H 5 N 1 (16)O 2 (18)O 1
AminoAcid: N
Definition:
A protein modification that effectively converts an L-asparagine residue to L-aspartic acid with one (18)O.


ModificationSetId: PSI-MOD
Name: monosodium L-aspartate
DiffFormula: H -1 Na 1
Formula: C 4 H 4 N 1 Na 1 O 3
AminoAcid: D
Definition:
A protein modification that effectively converts an L-aspartic acid residue to monosodium L-aspartate.


ModificationSetId: PSI-MOD
Name: monosodium L-glutamate
DiffFormula: H -1 Na 1
Formula: C 5 H 6 N 1 Na 1 O 3
AminoAcid: E
Definition:
A protein modification that effectively converts an L-glutamic acid residue to monosodium L-glutamate.


ModificationSetId: PSI-MOD
Name: 5x(13)C labeled L-proline
Definition: A protein modification that effectively converts an L-proline residue to 5x(13)C labeled L-proline.
DiffFormula: (12)C -5 (13)C 5
Formula: (13)C 5 H 7 N 1 O 1
AminoAcid: P
Comment:
In PubMed:12716131, fully (13)C labeled proline apparently resulted from the catabolic conversion of (13)C labeled L-arginine during SILAC.


ModificationSetId: PSI-MOD
Name: reduced cysteine 4-hydroxynonenal adduct
DiffFormula: C 9 H 18 O 2
Formula: C 12 H 23 N 1 O 3 S 1
AminoAcid: C
Definition:
A protein modification produced by formation of an adduct of an L-cysteine residue with 4-hydroxynonenal artificially reduced by a reagent such as NaBH4.


ModificationSetId: PSI-MOD
Name: reduced lysine 4-hydroxynonenal adduct
DiffFormula: C 9 H 18 O 2
Formula: C 15 H 30 N 2 O 3
AminoAcid: K
Definition:
A protein modification produced by formation of an adduct of an L-histidine residue with 4-hydroxynonenal artificially reduced by a reagent such as NaBH4.


ModificationSetId: PSI-MOD
Name: methylamine Michael addition derivatized threonine
DiffFormula: C 1 H 3 N 1 O -1
Formula: C 5 H 10 N 2 O 1
AminoAcid: T
Definition:
A protein modification that effectively converts an L-threonine residue to 2-amino-3-(methylamino)butanoic acid.

Comment:
In PubMed:11743741 phosphothreonine is converted to dehydrobutyrine in base, then by Michael addition of methylamine to 2-amino-3-(methylamino)butanoic acid.


ModificationSetId: PSI-MOD
Name: methylamine Michael addition derivatized serine
DiffFormula: C 1 H 3 N 1 O -1
Formula: C 4 H 8 N 2 O 1
AminoAcid: S
Definition:
A protein modification that effectively converts an L-serine residue to 2-amino-3-(methylamino)propanoic acid.

Comment:
In PubMed:11743741 phosphoserine is converted to dehydroalanine in base, then by Michael addition of methylamine to 2-amino-3-(methylamino)propanoic acid.


ModificationSetId: PSI-MOD
Name: N4-hexosaminylated asparagine
DiffFormula: C 6 H 11 N 1 O 4
Formula: C 10 H 17 N 3 O 6
AminoAcid: N
Definition:
A protein modification that effectively converts an L-asparagine residue to an N4-hexosaminyl-L-asparagine.

Comment:
The natural modifications are N4-(N-acetylamino)galactosyl-L-asparagine (MOD:00832) or N4-(N-acetylamino)glucosyl-L-asparagine (MOD:00831) [JSG].


ModificationSetId: PSI-MOD
Name: N6-hexosaminylated lysine
DiffFormula: C 6 H 11 N 1 O 4
Formula: C 12 H 23 N 3 O 5
AminoAcid: K
Definition:
A protein modification that effectively converts an L-lysine residue to an N4-hexosaminyl-L-lysine, as a synthetic peptide protectting group.


ModificationSetId: PSI-MOD
Name: N1'-hexosaminylated tryptophan
Comment: The natural modification is N1'-mannosyl-L-tryptophan (MOD:00165) [JSG].
DiffFormula: C 6 H 11 N 1 O 4
Formula: C 17 H 21 N 3 O 5
AminoAcid: W
Definition:
A protein modification that effectively converts an L-tryptophan residue to N1'-hexosaminyl-L-tryptophan.


ModificationSetId: PSI-MOD
Name: O-hexosaminylated threonine
DiffFormula: C 6 H 11 N 1 O 4
Formula: C 10 H 18 N 2 O 6
AminoAcid: T
Definition:
A protein modification that effectively converts an L-threonine residue to O-hexosaminyl-L-threonine.

Comment:
The natural modifications are O-(N-acetylaminogalactosyl)-L-threonine (MOD:00164) or O-(N-acetylaminoglucosyl)-L-threonine (MOD:00806) [JSG].


ModificationSetId: PSI-MOD
Name: quaternary amine labeling reagent light form N6-L-lysine
DiffFormula: C 3 (1)H 9 N 1
Formula: C 9 (1)H 21 N 3 O 1
AminoAcid: K
Definition:
A protein modification that effectively replaces a lysine N6-hydrogen with a quaternary amine reagent light form group.


ModificationSetId: PSI-MOD
Name: quaternary amine labeling reagent heavy form (+3amu) N6-L-lysine
DiffFormula: C 3 (1)H 6 (2)H 3 N 1
Formula: C 9 (1)H 18 (2)H 3 N 3 O 1
AminoAcid: K
Definition:
A protein modification that effectively replaces a lysine N6-hydrogen with a quaternary amine reagent heavy (+3amu) form group.


ModificationSetId: PSI-MOD
Name: quaternary amine labeling reagent heavy form (+6amu) N6-L-lysine
Comment: Apparently incorrect parent [JSG].
DiffFormula: C 3 (1)H 3 (2)H 6 N 1
Formula: C 9 (1)H 15 (2)H 6 N 3 O 1
AminoAcid: K
Definition:
A protein modification that effectively replaces a lysine N6-hydrogen with a quaternary amine reagent heavy (+6amu) form group.


ModificationSetId: PSI-MOD
Name: quaternary amine labeling reagent heavy form (+9amu) N6-L-lysine
DiffFormula: C 3 (2)H 9 N 1
Formula: C 9 (1)H 12 (2)H 9 N 3 O 1
AminoAcid: K
Definition:
A protein modification that effectively replaces a lysine N6-hydrogen with a quaternary amine reagent heavy (+9amu) form group.


ModificationSetId: PSI-MOD
Name: 4x(1)H,4x(12)C-labeled N6-succinyl-L-lysine
DiffFormula: (12)C 4 (1)H 4 O 3
Formula: (12)C 10 H 16 N 2 O 4
AminoAcid: K
Definition:
A protein modification that effectively converts an L-lysine residue to 4x(1)H,4x(12)C-labeled N6-succinyl-L-lysine.


ModificationSetId: PSI-MOD
Name: 4x(2)H labeled N6-succinyl-L-lysine
DiffFormula: C 4 (2)H 4 O 3
Formula: C 10 (1)H 12 (2)H 4 N 2 O 4
AminoAcid: K
Definition:
A protein modification that effectively converts an L-lysine residue to 4x(2)H-labeled N6-succinyl-L-lysine.


ModificationSetId: PSI-MOD
Name: 4x(13)C labeled N6-succinyl-L-lysine
DiffFormula: (13)C 4 H 4 O 3
Formula: (12)C 6 (13)C 4 H 16 N 2 O 4
AminoAcid: K
Definition:
A protein modification that effectively converts an L-lysine residue to 4x(13)C labeled N6-succinyl-L-lysine.


ModificationSetId: PSI-MOD
Name: 9x(13)C labeled L-tyrosine
DiffFormula: (12)C -9 (13)C 9
Formula: (13)C 9 H 9 N 1 O 2
AminoAcid: Y
Definition:
A protein modification that effectively converts an L-tyrosine residue to 9x(13)C labeled L-tyrosine.


ModificationSetId: PSI-MOD
Name: 9x(13)C labeled L-phenylalanine
DiffFormula: (12)C -9 (13)C 9
Formula: (13)C 9 H 9 N 1 O 1
AminoAcid: F
Definition:
A protein modification that effectively converts an L-phenylalanine residue to 9x(13)C labeled L-phenylalanine.


ModificationSetId: PSI-MOD
Name: iodoacetic acid - site W
Definition: modification from UniMod Chemical derivative - hydroxylethanone
DiffFormula: C 2 H 2 O 2
Formula: C 13 H 12 N 2 O 3
AminoAcid: W
Comment:
There is no citation for this UniMod entry. Iodoacetic acid derivatization of tryptophan is not mentioned in the citation [JSG].


ModificationSetId: PSI-MOD
Name: 6x(13)C labeled L-arginine
DiffFormula: (12)C -6 (13)C 6
Formula: (13)C 6 H 12 N 4 O 1
AminoAcid: R
Definition:
A protein modification that effectively converts an L-arginine residue to 6x(13)C labeled L-arginine.


ModificationSetId: PSI-MOD
Name: 6x(13)C labeled L-isoleucine
DiffFormula: (12)C -6 (13)C 6
Formula: (13)C 6 H 11 N 1 O 1
AminoAcid: I
Definition:
A protein modification that effectively converts an L-isoleucine residue to 6x(13)C labeled L-isoleucine.


ModificationSetId: PSI-MOD
Name: deamidated 4-methyl esterified asparagine
DiffFormula: C 1 H 1 N -1 O 1
Formula: C 5 H 7 N 1 O 3
AminoAcid: N
Definition:
A protein modification that effectively converts an L-asparagine residue to L-aspartate 4-methyl ester.

Comment:
The deamidation and methylation of L-asparagine has not been reported as a natural modification. It is extremely unlikely that eukaryotes produce this modification, because a natural process that would form L-aspartic acid 4-methyl ester from either L-aspartic acid or L-asparagine would interfere with the D-aspartyl peptide repair mechanism [JSG].


ModificationSetId: PSI-MOD
Name: N6-ethyl-L-lysine
Definition: A protein modification that effectively converts an L-lysine residue to N6-ethyl-L-lysine.
DiffFormula: C 2 H 4
Formula: C 8 H 16 N 2 O 1
AminoAcid: K
Comment:
The UniMod citation refers to the formation of glutamate ethyl ester and not to either lysine or N-terminal alkylation [JSG].


ModificationSetId: PSI-MOD
Name: ethylated residue
Definition: A protein modification that effectively replaces a hydrogen atom with an ethyl group.
DiffFormula: C 2 H 4
Formula: none
Comment:
From DeltaMass: Average Mass: 28 with no citation. The UniMod citation refers to the formation of glutamate ethyl ester and not to either lysine or N-terminal alkylation [JSG].


ModificationSetId: PSI-MOD
Name: 2-amino-3-oxobutanoic acid
DiffFormula: H -2
Formula: C 4 H 5 N 1 O 2
AminoAcid: T
Definition:
A protein modification that effectively converts an L-threonine residue to 2-amino-3-oxobutanoic acid.

Comment:
There is no citation for this modification in the UniMod entry. Although mentioned in PubMed:9252331, there is no citation for it there [JSG].


ModificationSetId: PSI-MOD
Name: N4-hexosylated asparagine
DiffFormula: C 6 H 10 O 5
Formula: C 10 H 16 N 2 O 7
AminoAcid: N
Definition:
A protein modification that effectively converts an L-asparagine residue to an N4-hexosyl-L-asparagine.


ModificationSetId: PSI-MOD
Name: hexose glycated L-lysine
DiffFormula: C 6 H 10 O 5
Formula: C 12 H 22 N 2 O 6
AminoAcid: K
Definition:
A modification produced in a non-enzymatic reaction between a carbohydrate carbonyl group (C1 of aldohexose or C2 of fructose) and an L-lysine residue to form a Schiff-base or an Amadori ketosamine lysine adduct.


ModificationSetId: PSI-MOD
Name: O-hexosylated threonine
DiffFormula: C 6 H 10 O 5
Formula: C 10 H 17 N 1 O 7
AminoAcid: T
Definition:
A protein modification that effectively converts an L-threonine residue to an O-hexosyl-L-threonine.


ModificationSetId: PSI-MOD
Name: hydrolyzed N-ethylmaleimide cysteine adduct
Definition: modification from UniMod Chemical derivative -
DiffFormula: C 6 H 9 N 1 O 3
Formula: C 9 H 14 N 2 O 4 S 1
AminoAcid: C
Comment:
Hydolyzed N-ethylmaeimide adduct, a mixture of isobaric 2- and 3-(S-cysteinyl)-4-(ethylamino)-4-oxobutanoic acid [JSG].


ModificationSetId: PSI-MOD
Name: hydrolyzed N-ethylmaleimide lysine adduct
Definition: modification from UniMod Chemical derivative -
DiffFormula: C 6 H 9 N 1 O 3
Formula: C 12 H 21 N 3 O 4
AminoAcid: K
Comment:
Hydolyzed N-ethylmaeimide adduct, a mixture of isobaric 2- and 3-(N6-lysyl)-4-(ethylamino)-4-oxobutanoic acid [JSG].


ModificationSetId: PSI-MOD
Name: nitrated L-tryptophan
Comment: One or more isobaric isomers are produced by nitration with peroxynitrite reagent [JSG].
DiffFormula: H -1 N 1 O 2
Formula: C 11 H 9 N 3 O 3
AminoAcid: W
Definition:
A protein modification that effectively converts an L-tryptophan residue to a nitrated L-tryptophan.


ModificationSetId: PSI-MOD
Name: Hex1HexNAc1NeuAc1 N4-glycosylated asparagine
DiffFormula: C 25 H 41 N 2 O 18
Formula: C 29 H 47 N 4 O 20
AminoAcid: N
Definition:
A protein modification that effectively replaces an N4 hydrogen atom of an asparagine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc1 linked through a glycosidic bond.


ModificationSetId: PSI-MOD
Name: Hex1HexNAc1NeuAc1O-glycosylated threonine
DiffFormula: C 25 H 41 N 2 O 18
Formula: C 29 H 48 N 3 O 20
AminoAcid: T
Definition:
A protein modification that effectively replaces an O3 hydrogen atom of a threonine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc1 linked through a glycosidic bond.


ModificationSetId: PSI-MOD
Name: Hex1HexNAc1NeuAc1 O-glycosylated serine
DiffFormula: C 25 H 41 N 2 O 18
Formula: C 28 H 46 N 3 O 20
AminoAcid: S
Definition:
A protein modification that effectively replaces an O3 hydrogen atom of a serine residue with a carbohydrate-like group composed of Hex1HexNAc1NeuAc1 linked through a glycosidic bond.


ModificationSetId: PSI-MOD
Name: 2x(13)C,4x(2)H labeled dimethylated L-lysine
DiffFormula: (13)C 2 (2)H 4
Formula: (12)C 6 (13)C 2 (1)H 12 (2)H 4 N 2 O 1
AminoAcid: K
Definition:
A protein modification that effectively replaces two hydrogen atoms of an L-lysine residue containing common isotopes with two (13)C,3x(2)H labeled methyl groups to form a 2x(13)C,6x(2)H labeled dimethylated L-lysine.


ModificationSetId: PSI-MOD
Name: 4-sulfophenyl isothiocyanate N6-derivatized lysine
DiffFormula: C 7 H 5 N 1 O 3 S 2
Formula: C 13 H 17 N 3 O 4 S 2
AminoAcid: K
Definition:
A protein modification that effectively converts an L-lysine residue to the 4-sulfophenyl isothiocyanate adduct, N6-[(4-sulfophenyl)carbamothioyl]lysine.


ModificationSetId: PSI-MOD
Name: O-thiophospho-L-threonine
DiffFormula: H 1 O 2 P 1 S 1
Formula: C 4 H 8 N 1 O 4 P 1 S 1
AminoAcid: T
Definition:
A protein modification that effectively converts an L-threonine residue to O-thiophospho-L-threonine.


ModificationSetId: PSI-MOD
Name: O4'-thiophospho-L-tyrosine
DiffFormula: H 1 O 2 P 1 S 1
Formula: C 9 H 10 N 1 O 4 P 1 S 1
AminoAcid: Y
Definition:
A protein modification that effectively converts an L-tyrosine residue to O4'-thiophospho-L-tyrosine.


ModificationSetId: PSI-MOD
Name: deamidated and methyl esterified residue
DiffFormula: C 1 H 1 N -1 O 1
Formula: none
Definition:
A protein modification that effectively replaces a carboxamido group with a carboxyl methyl ester group.


ModificationSetId: PSI-MOD
Name: 6x(13)C,1x(15)N labeled residue
DiffFormula: (12)C -6 (13)C 6 (14)N -1 (15)N 1
Formula: none
Definition:
A protein modification that effectively converts a residue containing common isotopes to a 6x(13)C,1x(15)N labeled residue.


ModificationSetId: PSI-MOD
Name: (2S,4R)-5-hydroxyleucine
DiffFormula: C 0 H 0 N 0 O 1
Formula: C 6 H 11 N 1 O 2
AminoAcid: L
Definition:
A protein modification that effectively converts an L-leucine residue to a (2S,4R)-5-hydroxyleucine.


ModificationSetId: PSI-MOD
Name: (2S,4R)-5-oxoleucine
DiffFormula: C 0 H -2 N 0 O 1
Formula: C 6 H 9 N 1 O 2
AminoAcid: L
Definition:
A modification that effectively oxygenates C5 of an L-leucine residue to form a (2S,4R)-5-oxoleucine.


ModificationSetId: PSI-MOD
SwissprotTerm: (4R)-4,5-dihydroxyleucine
Name: (2S,4R)-4,5-dihydroxyleucine
DiffFormula: C 0 H 0 N 0 O 2
Formula: C 6 H 11 N 1 O 3
AminoAcid: L
Definition:
A protein modification that effectively converts an L-leucine residue to a (2S,4R)-4,5-dihydroxyleucine.


ModificationSetId: PSI-MOD
SwissprotTerm: (3S,4R)-3,4-dihydroxyisoleucine
Name: (2S,3S,4R)-3,4-dihydroxyisoleucine
DiffFormula: C 0 H 0 N 0 O 2
Formula: C 6 H 11 N 1 O 3
AminoAcid: I
Definition:
A protein modification that effectively converts an L-isoleucine residue to a (2S,3S,4R)-3,4-dihydroxyisoleucine.


ModificationSetId: PSI-MOD
SwissprotTerm: (3R,4S)-4-hydroxyisoleucine
Name: (2S,3R,4S)-4-hydroxyisoleucine
DiffFormula: C 0 H 0 N 0 O 1
Formula: C 6 H 11 N 1 O 2
AminoAcid: I
Definition:
A protein modification that effectively converts an L-isoleucine residue to a (2S,3R,4S)-4-hydroxyisoleucine.


ModificationSetId: PSI-MOD
SwissprotTerm: (3R,4R)-4,5-dihydroxyisoleucine
Name: (2S,3R,4R)-4,5-dihydroxyisoleucine
DiffFormula: C 0 H 0 N 0 O 2
Formula: C 6 H 11 N 1 O 3
AminoAcid: I
Definition:
A protein modification that effectively converts an L-isoleucine residue to a (2S,3R,4R)-4,5-dihydroxyisoleucine.


ModificationSetId: PSI-MOD
SwissprotTerm: 2'-methylsulfonyltryptophan
Name: 2'-methylsulfonyl-L-tryptophan
DiffFormula: C 1 H 2 N 0 O 2 S 1
Formula: C 12 H 12 N 2 O 3 S 1
AminoAcid: W
Definition:
A protein modification that effectively converts an L-tryptophan residue to 2'-methylsulfonyl-L-tryptophan.


ModificationSetId: PSI-MOD
Name: 2'-(S-L-cysteinyl)-6'-hydroxy-L-tryptophan sulfoxide
Comment: Cross-link 2.
DiffFormula: C 0 H -2 N 0 O 2 S 0
Formula: C 14 H 13 N 3 O 4 S 1
Definition:
A protein modification that effectively cross-links an L-cysteine residue and an L-tryptophan residue by a thioether bond to form 2'-(S-L-cysteinyl)-6'-hydroxy-L-tryptophan sulfoxide.


ModificationSetId: PSI-MOD
SwissprotTerm: N,N,N-trimethylmethionine
Name: N,N,N-trimethyl-L-methionine
DiffFormula: C 3 H 7 N 0 O 0 S 0
Formula: C 8 H 17 N 1 O 1 S 1
AminoAcid: M
Definition:
A protein modification that effectively converts an L-methionine residue to N,N,N-trimethyl-L-methionine.


ModificationSetId: PSI-MOD
Name: L-cystine S-oxide
Comment: Cross-link 2.
DiffFormula: C 0 H -2 N 0 O 1 S 0
Formula: C 6 H 8 N 2 O 3 S 2
Definition:
A protein modification that effectively cross-links two L-cysteine residues and oxidizes a sulfur to form L-cystine S-oxide.


ModificationSetId: PSI-MOD
SwissprotTerm: 3-hydroxyphenylalanine
Name: 3-hydroxy-L-phenylalanine
DiffFormula: C 0 H 0 N 0 O 1
Formula: C 9 H 9 N 1 O 2
AminoAcid: F
Definition:
A protein modification that effectively converts an L-phenylalanine residue to 3-hydroxy-L-phenylalanine.


ModificationSetId: PSI-MOD
Name: L-isoleucine thiazole-4-carboxylic acid
Comment: Cross-link 2.
DiffFormula: C 0 H -4 N 0 O -1 S 0
Formula: C 9 H 12 N 2 O 1 S 1
Definition:
A protein modification that effectively crosslinks an L-cysteine residue and an L-isoleucine residue to form L-isoleucine thiazole-4-carboxylic acid.


ModificationSetId: PSI-MOD
Name: L-valine thiazole-4-carboxylic acid
Comment: Cross-link 2.
DiffFormula: C 0 H -4 N 0 O -1 S 0
Formula: C 8 H 10 N 2 O 1 S 1
Definition:
A protein modification that effectively crosslinks an L-cysteine residue and an L-valine residue to form L-valine thiazole-4-carboxylic acid.


ModificationSetId: PSI-MOD
Name: L-valine 5-(methoxymethyl)thiazole-4-carboxylic acid
Comment: Cross-link 2.
DiffFormula: C 2 H 0 N 0 O 0 S 0
Formula: C 10 H 14 N 2 O 2 S 1
Definition:
A protein modification that effectively crosslinks an L-cysteine residue and an L-valine residue, and C-5 methoxymethylates to form L-valine 5-(methoxymethyl)thiazole-4-carboxylic acid.


ModificationSetId: PSI-MOD
Name: L-asparagine 5-methylthiazole-4-carboxylic acid
Comment: Cross-link 2.
DiffFormula: C 1 H -2 N 0 O -1 S 0
Formula: C 8 H 9 N 3 O 2 S 1
Definition:
A protein modification that effectively crosslinks an L-cysteine residue and an L-asparagine residue, and C-4 methylates to form L-asparagine 5-methylthiazole-4-carboxylic acid.


ModificationSetId: PSI-MOD
Name: L-cysteine pyridine-2,5-dicarboxylic acid
Comment: Cross-link 3.
DiffFormula: C 0 H -8 N -1 O -3 S 0
Formula: C 9 H 7 N 2 O 2 S 1
Definition:
A protein modification that crosslinks two serine residues and a cysteine residue by formation of a pyridine-2,5-dicarboxylic acid.


ModificationSetId: PSI-MOD
Name: L-cysteine 5-amino-3,4,5,6-tetrahydropyridine-2,5-dicarboxylic acid
Comment: Cross-link 3.
DiffFormula: C 0 H -5 N 0 O -3 S 0
Formula: C 9 H 11 N 3 O 2 S 1
Definition:
A protein modification that crosslinks two serine residues and a cysteine residue by formation of a 5-amino-3,4,5,6-tetrahydropyridine-2,5-dicarboxylic acid.


ModificationSetId: PSI-MOD
Name: 4-(1-hydroxyethyl)-7-isoleucino-2-(threonin-O3-ylcarbonyl)-7,8-dihydroquinolin-8-ol
Comment: Cross-link 2.
DiffFormula: C 12 H 9 N 1 O 3
Formula: C 22 H 28 N 3 O 6
Definition:
A protein modification that effectively results from forming an adduct between an isoleucine residue, a threonine residue and the quinaldate compound 2-carboxy-4-(1-hydroxyethyl)--7,8-dihydroquinolin-8-ol.


ModificationSetId: PSI-MOD
SwissprotTerm: 5-hydroxy-3-methylproline (Ile)
Name: 5-hydroxy-3-methyl-L-proline (Pro)
DiffFormula: C 1 H 2 N 0 O 1
Formula: C 6 H 9 N 1 O 2
AminoAcid: P
Definition:
A protein modification that effectively converts an L-proline residue to a 5-hydroxy-3-methyl-L-proline.

Comment:
This entry is for the hypothetical formation of 5-hydroxy-3-methyl-L-proline from proline. For the natural production from L-isoleucine, use MOD:01897 [JSG].


ModificationSetId: PSI-MOD
Name: L-serine 5-methyloxazole-4-carboxylic acid
Comment: Cross-link 2.
DiffFormula: C 0 H -4 N 0 O -1
Formula: C 7 H 8 N 2 O 3
Definition:
A protein modification that effectively crosslinks an L-serine residue and an L-threonine residue to form L-serine 5-methyloxazole-4-carboxylic acid.


ModificationSetId: PSI-MOD
Name: N6-propanoyl-L-lysine
Definition: A protein modification that effectively converts an L-lysine residue to N6-propanoyl-L-lysine.
DiffFormula: C 3 H 4 N 0 O 1
Formula: C 9 H 16 N 2 O 2
AminoAcid: K
Comment:
The binding of histone peptides with propanoylated lysine to nuclear bromodomain proteins is non-specific and weaker than binding to the corresponding acetylated lysine peptides [JSG].


ModificationSetId: PSI-MOD
SwissprotTerm: N6-(ADP-ribosyl)lysine
Name: N6-(ADP-ribosyl)-L-lysine
DiffFormula: C 15 H 21 N 5 O 13 P 2
Formula: C 21 H 33 N 7 O 14 P 2
AminoAcid: K
Definition:
A protein modification that effectively converts an L-lysine residue to an N6-(ADP-ribosyl)-L-lysine.


ModificationSetId: PSI-MOD
SwissprotTerm: Lysyl poly(ADP-ribose)
Name: L-lysyl-poly(ADP-ribose)
DiffFormula: C 15 H 21 N 5 O 13 P 2
Formula: C 21 H 34 N 7 O 15 P 2
AminoAcid: K
Definition:
A protein modification that effectively converts an L-lysine residue to an L-lysyl-poly(ADP-ribose).


ModificationSetId: PSI-MOD
SwissprotTerm: (3S)-3-hydroxyasparagine
Name: (2S,3S)-3-hydroxyasparagine
DiffFormula: C 0 H 0 N 0 O 1
Formula: C 4 H 6 N 2 O 3
AminoAcid: N
Definition:
A protein modification that effectively converts an L-asparagine residue to a (2S,3S)-3-hydroxyasparagine.


ModificationSetId: PSI-MOD
SwissprotTerm: (3R,4R)-3,4-dihydroxyproline
Name: (2S,3R,4R)-3,4-dihydroxyproline
DiffFormula: C 0 H 0 N 0 O 2
Formula: C 5 H 7 N 1 O 3
AminoAcid: P
Definition:
A protein modification that effectively converts an L-proline residue to a (2S,3R,4R)-3,4-dihydroxyproline.


ModificationSetId: PSI-MOD
SwissprotTerm: 4,5,4'-trihydroxyleucine
Name: (2S)-4,5,5'-trihydroxyleucine
DiffFormula: C 0 H 0 N 0 O 3
Formula: C 6 H 11 N 1 O 4
AminoAcid: L
Definition:
A protein modification that effectively converts an L-leucine residue to a (2S)-4,5,5'-trihydroxyleucine.


ModificationSetId: PSI-MOD
Name: L-asparagine thiazole-4-carboxylic acid
Comment: Cross-link 2.
DiffFormula: C 0 H -4 N 0 O -1 S 0
Formula: C 7 H 7 N 3 O 2 S 1
Definition:
A protein modification that effectively crosslinks an L-cysteine residue and an L-asparagine residue to form L-asparagine thiazole-4-carboxylic acid.


ModificationSetId: PSI-MOD
Name: L-proline thiazole-4-carboxylic acid
Comment: Cross-link 2.
DiffFormula: C 0 H -4 N 0 O -1 S 0
Formula: C 8 H 8 N 2 O 1 S 1
Definition:
A protein modification that effectively crosslinks an L-cysteine residue and an L-proline residue to form L-proline thiazole-4-carboxylic acid.


ModificationSetId: PSI-MOD
Name: L-threonine thiazole-4-carboxylic acid
Comment: Cross-link 2.
DiffFormula: C 0 H -4 N 0 O -1 S 0
Formula: C 7 H 8 N 2 O 2 S 1
Definition:
A protein modification that effectively crosslinks an L-cysteine residue and an L-threonine residue to form L-threonine thiazole-4-carboxylic acid.


ModificationSetId: PSI-MOD
Name: L-phenylalanine thiazoline-4-carboxylic acid
Comment: Cross-link 2.
DiffFormula: C 0 H -2 N 0 O -1 S 0
Formula: C 12 H 12 N 2 O 1 S 1
Definition:
A protein modification that effectively crosslinks an L-cysteine residue and an L-phenylalanine residue to form L-phenylalanine thiazoline-4-carboxylic acid.


ModificationSetId: PSI-MOD
Name: L-threonine thiazoline-4-carboxylic acid
Comment: Cross-link 2.
DiffFormula: C 0 H -2 N 0 O -1 S 0
Formula: C 7 H 10 N 2 O 2 S 1
Definition:
A protein modification that effectively crosslinks an L-cysteine residue and an L-threonine residue to form L-threonine thiazoline-4-carboxylic acid.


ModificationSetId: PSI-MOD
Name: monohydroxylated leucine
DiffFormula: C 0 H 0 N 0 O 1
Formula: C 6 H 11 N 1 O 2
AminoAcid: L
Definition:
A protein modification that effectively converts an L-leucine residue to a monohydroxylated leucine.


ModificationSetId: PSI-MOD
Name: hydroxylated isoleucine
DiffFormula: none
Formula: none
AminoAcid: I
Definition:
A protein modification that effectively converts an L-isoleucine residue to an hydroxylated isoleucine.


ModificationSetId: PSI-MOD
Name: monohydroxylated isoleucine
DiffFormula: C 0 H 0 N 0 O 1
Formula: C 6 H 11 N 1 O 2
AminoAcid: I
Definition:
A protein modification that effectively converts an L-isoleucine residue to a monohydroxylated isoleucine.


ModificationSetId: PSI-MOD
Name: dihydroxylated isoleucine
DiffFormula: C 0 H 0 N 0 O 2
Formula: C 6 H 11 N 1 O 3
AminoAcid: I
Definition:
A protein modification that effectively converts an L-isoleucine residue to a dihydroxylated isoleucine.


ModificationSetId: PSI-MOD
Name: methylated threonine
DiffFormula: none
Formula: none
AminoAcid: T
Definition:
A protein modification that effectively converts an L-threonine residue to a methylated threonine, such as O-methyl-L-threonine.


ModificationSetId: PSI-MOD
Name: oxazole/oxazoline ring crosslinked residues
Definition:
A protein modification that crosslinks two residues by condensation of a serine or threonine hydroxyl with the carbonyl of the preceding residue to form an oxazole or oxazoline ring, or by rearrangement and condensation of a cysteine with the carbonyl of the preceding residue to form a 1,3-oxazole-4-carbothionic acid.


ModificationSetId: PSI-MOD
Name: thiazole/thiazoline ring croslinked residues
DiffFormula: none
Formula: none
AminoAcid: C
Definition:
A protein modification that crosslinks two residues by condensation of a cysteine thiol with the carbonyl of the preceding residue to form a thiazole or thiazoline ring.


ModificationSetId: PSI-MOD
Name: oxazole/oxazoline ring crosslinked residues (Ser)
DiffFormula: none
Formula: none
AminoAcid: S
Definition:
A protein modification that crosslinks two residues by condensation of a serine hydroxyl with the carbonyl of the preceding residue to form an oxazole or oxazoline ring.


ModificationSetId: PSI-MOD
Name: oxazole/oxazoline ring crosslinked residues (Thr)
DiffFormula: none
Formula: none
AminoAcid: T
Definition:
A protein modification that crosslinks two residues by condensation of a threonine hydroxyl with the carbonyl of the preceding residue to form a 5-methyloxazole or 5-methyloxazoline ring.


ModificationSetId: PSI-MOD
Name: quinaldate modified residue
Definition:
A protein modification that effectively results from forming an adduct with a compound containing a quinaldate, kynurenate, or xanthurenate group.


ModificationSetId: PSI-MOD
Name: pyridinyl ring crosslinked residues
Comment: Cross-link 3.
DiffFormula: none
Formula: none
Definition:
A protein modification that crosslinks three residues by formation of a pyridinyl ring, such as pyridine-2,5-dicarboxylic acid or 5-aminopiperideine-2,5-dicarboxylic acid.


ModificationSetId: PSI-MOD
Name: isotope tagged reagent derivatized residue
Definition:
A protein modification that forms an adduct with a particular isotope labeled compound used as a reagent.


ModificationSetId: PSI-MOD
Name: (2S,4S)-4,5-dihydroxyleucine
DiffFormula: C 0 H 0 N 0 O 2
Formula: C 6 H 11 N 1 O 3
AminoAcid: L
Definition:
A protein modification that effectively converts an L-leucine residue to a (2S,4S)-4,5-dihydroxyleucine.


ModificationSetId: PSI-MOD
SwissprotTerm: 4-hydroxyglutamate
Name: 4-hydroxy-L-glutamic acid
DiffFormula: C 0 H 0 N 0 O 1
Formula: C 5 H 7 N 1 O 4
AminoAcid: E
Definition:
A protein modification that effectively converts an L-glutamic acid residue to a 4-hydroxy-L-glutamic acid.


ModificationSetId: PSI-MOD
Name: 2-(cystein-S-ylcarbonyl)-3-methyl-4-(glutam-5-yloxy)methylindole
Comment: Cross-link 2.
DiffFormula: C 11 H 7 N 1 O 1 S 0
Formula: C 19 H 19 N 3 O 5 S 1
Definition:
A protein modification that effectively results from forming an adduct between a cysteine residue, a glutamic acid residue and the indole compound 2-carboxy-3-methyl-4-hydroxymethyl--indole.


ModificationSetId: PSI-MOD
SwissprotTerm: Cyclo[(prolylserin)-O-yl] cysteinate
Name: cyclo[(prolylserin)-O-yl] cysteinate (Cys)
DiffFormula: C 8 H 10 N 2 O 2 S 0
Formula: C 11 H 16 N 3 O 4 S 1
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to cyclo[(prolylserin)-O-yl] cysteinate.


ModificationSetId: PSI-MOD
SwissprotTerm: Cyclo[(prolylserin)-O-yl] cysteinate
Name: cyclo[(prolylserin)-O-yl] cysteinate (Cys-Pro-Ser cross-link)
Comment: Cross-link 3.
DiffFormula: C 0 H -2 N 0 O -1 S 0
Formula: C 11 H 16 N 3 O 4 S 1
Definition:
A protein modification that effectively converts an L-cysteine residue, an L-proline residue, and an L-serine residue to cyclo[(prolylserin)-O-yl] cysteinate.


ModificationSetId: PSI-MOD
Name: S-[2-(pyridin-2-yl)ethyl]-L-cysteine
DiffFormula: C 7 H 7 N 1
Formula: C 10 H 12 N 2 O 1 S 1
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to S-[2-(pyridin-2-yl)ethyl]-L-cysteine.

Comment:
From DeltaMass: (name misspelled "Pyridylethyl Cystenyl", and formula incorrect, N and O reversed) Formula: C10H12O2N1S1 Monoisotopic Mass Change: 208.067 Average Mass Change: 208.286


ModificationSetId: PSI-MOD
Name: S-[2-(pyridin-4-yl)ethyl]-L-cysteine
DiffFormula: none
Formula: none
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to S-[2-(pyridin-4-yl)ethyl]-L-cysteine.


ModificationSetId: PSI-MOD
Name: glutamyl semialdehyde
DiffFormula: none
Formula: C 5 H 7 N 1 O 2
Definition:
A protein modification that effectively converts a source amino acid residue to an L-glutamyl semialdehyde.


ModificationSetId: PSI-MOD
Name: natural, standard, encoded residue
Definition:
A protein modification that inserts or replaces a residue with a natural, standard, encoded residue.


ModificationSetId: PSI-MOD
Name: 3-(O4'-L-tyrosyl)-L-valine
Comment: Cross-link 2.
DiffFormula: C 0 H -2 N 0 O 0
Formula: C 14 H 16 N 2 O 3
Definition:
A protein modification that effectively cross-links an L-valine residue and an L-tyrosine residue by an ether bond to form 3-(O4'-L-tyrosyl)-L-valine.


ModificationSetId: PSI-MOD
Name: tetrakis-L-glutamato bis-L-N1'-histidino lipid carboxylato manganese iron oxide
DiffFormula: C 14 Fe 1 H 23 Mn 1 N 0 O 3
Formula: C 46 Fe 1 H 65 Mn 1 N 10 O 17
Definition:
A protein modification that effectively converts four L-glutamic acid residues and two L-histidine residues to tetrakis-L-glutamato bis-L-N1'-histidino lipid carboxylato manganese iron oxide.

Comment:
Cross-link 6. It is not clear whether the lipid carboxylate is a cofactor or a substrate, and its identity is not certain. It was modeled as myristic acid [JSG].


ModificationSetId: PSI-MOD
Name: N-(dihydroxymethyl)-L-methionine (fMet)
DiffFormula: C 0 H 2 N 0 O 1 S 0
Formula: C 6 H 12 N 1 O 3 S 1
Definition:
A protein modification that effectively converts an N-formyl-Lmethionine residue to N-(dihydroxymethyl)-L-methionine.


ModificationSetId: PSI-MOD
Name: N-(dihydroxymethyl)-L-methionine (Met)
DiffFormula: C 1 H 2 N 0 O 2 S 0
Formula: C 6 H 12 N 1 O 3 S 1
AminoAcid: M
Definition:
A protein modification that effectively converts an L-methionine residue to N-(dihydroxymethyl)-L-methionine (not known as a natural, post-translational modification process).

Comment:
This entry is for the artifactual formation of N-(dihydroxymethyl)-L-methionine from methionine. For N-(dihydroxymethyl)-L-methionine derived from encoded N-formyl-L-methionine, use MOD:01446.


ModificationSetId: PSI-MOD
Name: L-3,3-dihydroxyoalanine
DiffFormula: none
Formula: C 3 H 5 N 1 O 3
Definition:
A protein modification that effectively converts a source amino acid residue to L-3,3-dihydroxyoalanine.


ModificationSetId: PSI-MOD
Name: L-3,3-dihydroxyoalanine (Oxoalanine)
DiffFormula: C 0 H 2 N 0 O 1
Formula: C 3 H 5 N 1 O 3
Definition:
A protein modification that effectively converts an L-3-oxoalanine residue to L-3,3-dihydroxyoalanine.


ModificationSetId: PSI-MOD
Name: O-phospho-L-serine arising from O-phosphopantetheine-L-serine after neutral loss of pantetheine
DiffFormula: C 0 H 1 N 0 O 3 P 1
Formula: C 3 H 6 N 1 O 5 P 1
AminoAcid: S
Definition:
A protein modification that converts an L-serine residue to O-phosphopantetheine-L-serine with secondary neutral loss of pantetheine resulting in O-phospho-L-serine.

Comment:
Phosphoserine is generated and detected after the facile elimination of pantetheine from the phosphopantetheine tertiary phosphodiester. See MOD:01452 for alternate origin.


ModificationSetId: PSI-MOD
Name: O-phosphopantetheine-L-serine with neutral loss of pantetheine
DiffFormula: C -11 H -20 N -2 O -3 P 0 S -1
Formula: C 3 H 6 N 1 O 5 P 1
Definition:
Covalent modification of a peptide or protein amino acid O-phosphopantetheine-L-serine with secondary neutral loss of pantetheine resulting in O-phospho-L-serine.

Comment:
Phosphoserine is generated and detected after the facile elimination of pantethiene from the phosphopantethiene tertiary phosphodiester. See MOD:01451 for alternate origin.


ModificationSetId: PSI-MOD
Name: L-glutamic acid 5-methyl ester
DiffFormula: none
Formula: C 6 H 9 N 1 O 3
Definition:
A protein modification that effectively converts a source amino acid residue to L-glutamate 5-methyl ester.


ModificationSetId: PSI-MOD
Name: N-(DNA-1',2'-dideoxyribos-1'-ylidene)-L-prolinium
Comment: This linkage is not a Schiff-base [JSG].
DiffFormula: C 5 H 8 N 0 O 5 P 1
Formula: C 10 H 16 N 1 O 6 P 1
AminoAcid: P
Definition:
A protein modification that effectively crosslinks an N-terminal L-proline residue and a strand of DNA at the C-1 of a ribose, freeing the nucleotide base and forming N-(DNA-1',2'-dideoxyribos-1'-ylidene)-L-prolinium.


ModificationSetId: PSI-MOD
Name: O-phosphorylated residue
DiffFormula: H 1 O 3 P 1
Formula: none
Definition:
A protein modification that effectively replaces a residue hydroxyl or carboxyl hydrogen with a phosphono group (H2PO3 or 'phosphate').


ModificationSetId: PSI-MOD
Name: N-phosphorylated residue
DiffFormula: H 1 O 3 P 1
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of a residue amino or imino group with a phosphono group (H2PO3 or 'phosphate').


ModificationSetId: PSI-MOD
Name: L-cysteine (Ser)
DiffFormula: C 0 H 0 N 0 O 1 S -1
Formula: C 3 H 5 N 1 O 1 S 1
AminoAcid: C
Definition:
A protein modification that effectively converts an L-serine residue to L-cysteine (not known as a natural, post-translational modification process).


ModificationSetId: PSI-MOD
Name: alpha-amino acetylated residue
DiffFormula: C 2 H 2 N 0 O 1
Formula: none
Definition:
A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an acetyl group.


ModificationSetId: PSI-MOD
Name: 4x(2)H labeled alpha-dimethylamino N-terminal residue
Comment: Supposed to be alpha-amino and Lys-N6 derivatized by C(2)H2O and reduction.
DiffFormula: C 2 (2)H 4
Formula: none
Definition:
A protein modification that effectively converts an N-terminal residue to an 4x(2)H labeled alpha-dimethylamino N-terminal residue.


ModificationSetId: PSI-MOD
Name: alpha-amino methylated residue
Definition:
A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a methyl group.


ModificationSetId: PSI-MOD
Name: N-methylated alanine
AminoAcid: A
Definition:
A protein modification that effectively replaces an L-alanine alpha amino hydrogen with a methyl group.


ModificationSetId: PSI-MOD
Name: N-methylated proline
AminoAcid: P
Definition:
A protein modification that effectively replaces an L-proline alpha imino hydrogen with a methyl group.


ModificationSetId: PSI-MOD
Name: N-methylated methionine
AminoAcid: M
Definition:
A protein modification that effectively replaces an L-methionine alpha amino hydrogen with a methyl group.


ModificationSetId: PSI-MOD
Name: protonated L-methionine (L-methioninium) residue
DiffFormula: C 0 H 1 N 0 O 0 S 0
Formula: C 5 H 11 N 1 O 1 S 1
AminoAcid: M
Definition:
A protein modification that effectively converts an L-methionine residue to an L-methioninium (protonated L-methionine).


ModificationSetId: PSI-MOD
Name: N,N,N-trimethyl-L-methionine (from L-methioninium)
DiffFormula: C 3 H 6 N 0 O 0 S 0
Formula: C 8 H 17 N 1 O 1 S 1
Definition:
A protein modification that effectively converts an L-methioninium (protonated L-methionine) residue to an N6,N6,N6-trimethyl-L-methionine.

Comment:
For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative N2Me3+Met process (MOD:01382) accounts for both protonation and trimethylation.


ModificationSetId: PSI-MOD
Name: L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide) (Cys)
DiffFormula: C 40 H 47 Mo 1 N 20 O 26 P 4 S 3 Se 1
Formula: C 43 H 52 Mo 1 N 21 O 27 P 4 S 4 Se 1
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide) (not known as a natural, post-translational modification process).

Comment:
This entry is for the artifactual formation of L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide) from cysteine. For natural formation from L-selenocysteine, use MOD:00253.


ModificationSetId: PSI-MOD
Name: L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide) (Cys)
DiffFormula: C 40 H 47 N 20 O 26 P 4 S 4 Se 1 W 1
Formula: C 43 H 52 N 21 O 27 P 4 S 5 Se 1 W 1
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide) (not known as a natural, post-translational modification process).

Comment:
This entry is for the artifactual formation of L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide) from cysteine. For natural formation from L-selenocysteine, use MOD:00381.


ModificationSetId: PSI-MOD
Name: reduced residue
Definition:
A protein modification that effectively either adds neutral hydrogen atoms (proton and electron), or removes oxygen atoms from a residue with or without the addition of hydrogen atoms.


ModificationSetId: PSI-MOD
Name: hydrogenated residue
Definition:
A protein modification that effectively adds neutral hydrogen atoms (proton and electron) to a residue.


ModificationSetId: PSI-MOD
Name: O-[S-(carboxymethyl)phosphopantetheine]-L-serine
DiffFormula: C 13 H 23 N 2 O 8 P 1 S 1
Formula: C 16 H 28 N 3 O 10 P 1 S 1
AminoAcid: S
Definition:
A protein modification that effectively converts an L-serine residue to O-[S-(carboxymethyl)phosphopantetheine]-L-serine.

Comment:
This modification results from the derivatization of the pantetheine sulfhydryl with iodoacetic acid [JSG].


ModificationSetId: PSI-MOD
Name: O-[S-(carboxamidomethyl)phosphopantetheine]-L-serine
DiffFormula: C 13 H 24 N 3 O 7 P 1 S 1
Formula: C 16 H 29 N 4 O 9 P 1 S 1
AminoAcid: S
Definition:
A protein modification that effectively converts an L-serine residue to O-[S-(carboxamidomethyl)phosphopantetheine]-L-serine.

Comment:
This modification results from the derivatization of the pantetheine sulfhydryl with iodoacetamide [JSG].


ModificationSetId: PSI-MOD
Name: 2'-fluoro-L-phenylalanine
DiffFormula: C 0 F 1 H -1 N 0 O 0
Formula: C 9 F 1 H 8 N 1 O 1
AminoAcid: F
Definition:
A protein modification that effectively converts an L-phenylalanine residue to an 2'-fluoro-L-fluorophenylalanine.


ModificationSetId: PSI-MOD
Name: 3'-fluoro-L-phenylalanine
DiffFormula: C 0 F 1 H -1 N 0 O 0
Formula: C 9 F 1 H 8 N 1 O 1
AminoAcid: F
Definition:
A protein modification that effectively converts an L-phenylalanine residue to an 3'-fluoro-L-fluorophenylalanine.


ModificationSetId: PSI-MOD
Name: 4'-fluoro-L-phenylalanine
DiffFormula: C 0 F 1 H -1 N 0 O 0
Formula: C 9 F 1 H 8 N 1 O 1
AminoAcid: F
Definition:
A protein modification that effectively converts an L-phenylalanine residue into an 4'-fluoro-L-fluorophenylalanine.


ModificationSetId: PSI-MOD
Name: 4'-fluoro-L-tryptophan
DiffFormula: F 1 H -1
Formula: C 11 F 1 H 9 N 2 O 1
AminoAcid: W
Definition:
A protein modification that effectively converts an L-tryptophan residue into an 4'-fluoro-L-tryptophan.


ModificationSetId: PSI-MOD
Name: 5'-fluoro-L-tryptophan
DiffFormula: F 1 H -1
Formula: C 11 F 1 H 9 N 2 O 1
AminoAcid: W
Definition:
A protein modification that effectively converts an L-tryptophan residue into an 5'-fluoro-L-tryptophan.


ModificationSetId: PSI-MOD
Name: 6'-fluoro-L-tryptophan
DiffFormula: F 1 H -1
Formula: C 11 F 1 H 9 N 2 O 1
AminoAcid: W
Definition:
A protein modification that effectively converts an L-tryptophan residue into an 6'-fluoro-L-tryptophan.


ModificationSetId: PSI-MOD
Name: calcium containing modified residue
Definition:
A protein modification that effectively substitutes a calcium atom or a cluster containing calcium for hydrogen atoms, or that coordinates a calcium ion.


ModificationSetId: PSI-MOD
Name: N6-(L-isoglutamyl)-L-lysine (Glu)
DiffFormula: C 0 H -2 N 0 O -1
Formula: C 11 H 17 N 3 O 3
Definition:
A protein modification that effectively crosslinks an L-glutamic acid residue and an L-lysine residue by an isopeptide bond to form N6-(L-isoglutamyl)-L-lysine and the release of water.

Comment:
Cross-link 2. This cross-link is usually made by glutamine and releases ammonia, rather than glutamic acid and requiring the consumption of ATP.


ModificationSetId: PSI-MOD
Name: iTRAQ4plex-114 reporter+balance reagent acylated residue
DiffFormula: (12)C 5 (13)C 2 H 12 N 2 (18)O 1
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group.

Comment:
The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.


ModificationSetId: PSI-MOD
Name: iTRAQ4plex-114 reporter+balance reagent acylated N-terminal
DiffFormula: (12)C 5 (13)C 2 H 12 N 2 (18)O 1
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ4plex-114 reporter+balance group.

Comment:
The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.


ModificationSetId: PSI-MOD
Name: iTRAQ4plex-114 reporter+balance reagent N6-acylated lysine
DiffFormula: (12)C 5 (13)C 2 H 12 N 2 (18)O 1
Formula: (12)C 11 (13)C 2 H 24 N 4 (16)O 1 (18)O 1
AminoAcid: K
Definition:
A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group.

Comment:
The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a carbonyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.


ModificationSetId: PSI-MOD
Name: iTRAQ4plex-114 reporter+balance reagent O4'-acylated tyrosine
DiffFormula: (12)C 5 (13)C 2 H 12 N 2 (18)O 1
Formula: (12)C 14 (13)C 2 H 21 N 3 (16)O 2 (18)O 1
AminoAcid: Y
Definition:
A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ4plex-114 reporter+balance reagent N'-acylated histidine
DiffFormula: (12)C 5 (13)C 2 H 12 N 2 (18)O 1
Formula: (12)C 11 (13)C 2 H 19 N 5 O 1 (18)O 1
AminoAcid: H
Definition:
A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ4plex-114 reporter+balance reagent O3-acylated serine
DiffFormula: (12)C 5 (13)C 2 H 12 N 2 (18)O 1
Formula: (12)C 8 (13)C 2 H 17 N 3 O 2 (18)O 1
AminoAcid: S
Definition:
A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ4plex-114 reporter+balance reagent O3-acylated threonine
DiffFormula: (12)C 5 (13)C 2 H 12 N 2 (18)O 1
Formula: (12)C 9 (13)C 2 H 19 N 3 O 2 (18)O 1
AminoAcid: T
Definition:
A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ4plex-114 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ4plex-115 reporter+balance reagent acylated residue
DiffFormula: (12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ4plex-115 reporter+balance reagent acylated N-terminal
DiffFormula: (12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ4plex-115 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ4plex-115 reporter+balance reagent N6-acylated lysine
DiffFormula: (12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1
Formula: (12)C 12 (13)C 1 H 24 (14)N 3 (15)N 1 (16)O 1 (18)O 1
AminoAcid: K
Definition:
A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ4plex-115 reporter+balance reagent O4'-acylated tyrosine
DiffFormula: (12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1
Formula: (12)C 15 (13)C 1 H 21 (14)N 2 (15)N 1 (16)O 2 (18)O 1
AminoAcid: Y
Definition:
A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ4plex-115 reporter+balance reagent N'-acylated histidine
DiffFormula: (12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1
Formula: (12)C 12 (13)C 1 H 19 (14)N 4 (15)N 1 (16)O 1 (18)O 1
AminoAcid: H
Definition:
A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ4plex-115 reporter+balance reagent O3-acylated serine
DiffFormula: (12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1
Formula: (12)C 9 (13)C 1 H 17 N 1 (14)N 1 (15)N 1 (16)O 2 (18)O 1
AminoAcid: S
Definition:
A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ4plex-115 reporter+balance reagent O3-acylated threonine
DiffFormula: (12)C 6 (13)C 1 H 12 (14)N 1 (15)N 1 (18)O 1
Formula: (12)C 10 (13)C 1 H 19 (14)N 2 (15)N 1 (16)O 2 (18)O 1
AminoAcid: T
Definition:
A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ4plex-115 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ4plex-116 reporter+balance reagent acylated residue
DiffFormula: (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ4plex-116 reporter+balance reagent acylated N-terminal
DiffFormula: (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ4plex-116 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ4plex-116 reporter+balance reagent N6-acylated lysine
DiffFormula: (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1
Formula: (12)C 10 (13)C 3 H 24 N 2 (14)N 1 (15)N 1 O 1 (16)O 1
AminoAcid: K
Definition:
A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ4plex-116 reporter+balance reagent O4'-acylated tyrosine
DiffFormula: (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1
Formula: (12)C 13 (13)C 3 H 21 N 1 (14)N 1 (15)N 1 O 2 (16)O 1
AminoAcid: Y
Definition:
A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ4plex-116 reporter+balance reagent N'-acylated histidine
DiffFormula: (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1
Formula: (12)C 10 (13)C 3 H 19 N 3 (14)N 1 (15)N 1 (16)O 2
AminoAcid: H
Definition:
A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ4plex-116 reporter+balance reagent O3-acylated serine
DiffFormula: (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1
Formula: (12)C 7 (13)C 3 H 17 (14)N 2 (15)N 1 (16)O 3
AminoAcid: S
Definition:
A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ4plex-116 reporter+balance reagent O3-acylated threonine
DiffFormula: (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1
Formula: (12)C 8 (13)C 3 H 19 (14)N 2 (15)N 1 (16)O 3
AminoAcid: T
Definition:
A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ4plex-116 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent acylated residue
DiffFormula: (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent acylated N-terminal
DiffFormula: (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ4plex-117 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent N6-acylated lysine
DiffFormula: (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1
Formula: (12)C 10 (13)C 3 H 24 N 2 (14)N 1 (15)N 1 O 1 (16)O 1
AminoAcid: K
Definition:
A protein modification that effectively replaces the N6-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ4plex-117, mTRAQ heavy, reporter+balance reagent O4'-acylated tyrosine
DiffFormula: (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1
Formula: (12)C 13 (13)C 3 H 21 N 1 (14)N 1 (15)N 1 O 2 (16)O 1
AminoAcid: Y
Definition:
A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ4plex-117 reporter+balance reagent N'-acylated histidine
DiffFormula: (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1
Formula: (12)C 10 (13)C 3 H 19 (14)N 4 (15)N 1 (16)O 2
AminoAcid: H
Definition:
A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ4plex-117 reporter+balance reagent O3-acylated serine
DiffFormula: (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1
Formula: (12)C 7 (13)C 3 H 17 (14)N 2 (15)N 1 (16)O 3
AminoAcid: S
Definition:
A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ4plex-117 reporter+balance reagent O3-acylated threonine
DiffFormula: (12)C 4 (13)C 3 H 12 (14)N 1 (15)N 1 (16)O 1
Formula: (12)C 8 (13)C 3 H 19 (14)N 2 (15)N 1 (16)O 3
AminoAcid: T
Definition:
A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ4plex-117 reporter+balance group.


ModificationSetId: PSI-MOD
Name:
modifications with monoisotopic mass differences that are nominally equal at a resolution below 0.1 Da

Definition:
Modifications that have monoisotopic mass differences from their respective origins that are nominally equal (sometimes called isobaric) at a resolution below 0.1 Da.


ModificationSetId: PSI-MOD
Name:
modifications with monoisotopic mass differences that are nominally equal at a resolution below 0.01 Da

Definition:
Modifications that have monoisotopic mass differences from their respective origins that are nominally equal (sometimes called isobaric) at a resolution below 0.01 Da.


ModificationSetId: PSI-MOD
Name:
modifications with monoisotopic mass differences that are nominally equal at a resolution below 0.000001 Da

Definition:
Modifications that have monoisotopic mass differences from their respective origins that are nominally equal (sometimes called isobaric) at a resolution below 0.000001 Da.


ModificationSetId: PSI-MOD
Name: modifications with monoisotopic mass diferences that are nominally equal at 144.099-144.106 Da.
Definition:
Modifications that have monoisotopic mass differences from their respective origins of 144.099-144.106 Da.


ModificationSetId: PSI-MOD
Name: modifications with monoisotopic mass differences that are nominally equal at 144.102062 Da
Definition:
Modifications that have monoisotopic mass differences from their respective origins of 144.102062 Da.


ModificationSetId: PSI-MOD
Name: iTRAQ4plex reporter+balance reagent acylated residue
DiffFormula: none
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of a residue with one of the Applied Biosystems iTRAQ4plex reagent reporter+balance groups.


ModificationSetId: PSI-MOD
Name: reporter fragment
Definition:
A distinct molecular entity produced from a protein or a protein modification as the result of a fragmentation process.

Comment:
The reporter fragment is either itself a modification consisting of atoms derived from the original amino acid residues, or its detection can be taken as evidence that particular modified residues had been present.


ModificationSetId: PSI-MOD
Name: modification reporter fragment
Definition:
A distinct molecular entity produced as the result of a fragmentation process performed on a particular modified residue.


ModificationSetId: PSI-MOD
Name: iTRAQ4plex reporter fragment
Definition:
A protein modification reporter fragment produced by an Applied Biosystems iTRAQ4plex reagent derivatized residue.


ModificationSetId: PSI-MOD
Name: iTRAQ4plex-114 reporter fragment
DiffFormula: none
Formula: (12)C 5 (13)C 1 H 13 (14)N 2
Definition:
The protein modification reporter fragment produced by an Applied Biosystems iTRAQ4plex 114 reagent derivatized residue.


ModificationSetId: PSI-MOD
Name: iTRAQ4plex-115 reporter fragment
DiffFormula: none
Formula: (12)C 5 (13)C 1 H 13 (14)N 1 (15)N 1
Definition:
The protein modification reporter fragment produced by an Applied Biosystems iTRAQ4plex 115 reagent derivatized residue.


ModificationSetId: PSI-MOD
Name: iTRAQ4plex-116 reporter fragment
DiffFormula: none
Formula: (12)C 4 (13)C 2 H 13 (14)N 1 (15)N 1
Definition:
The protein modification reporter fragment produced by an Applied Biosystems iTRAQ4plex 116 reagent derivatized residue.


ModificationSetId: PSI-MOD
Name: iTRAQ4plex-117, mTRAQ heavy, reporter fragment
DiffFormula: none
Formula: (12)C 3 (13)C 3 H 13 (14)N 1 (15)N 1
Definition:
The protein modification reporter fragment produced by an Applied Biosystems iTRAQ4plex 117 reagent derivatized residue.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex reporter+balance reagent acylated residue
DiffFormula: none
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of a residue with one of the Applied Biosystems iTRAQ8plex reagent reporter+balance groups.

Comment:
The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.


ModificationSetId: PSI-MOD
Name: residue reporter fragment
Definition:
A distinct molecular entity produced from a particular amino acid residue as the result of a fragmentation process.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-113 reporter+balance reagent acylated residue
DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group.

Comment:
The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-113 reporter+balance reagent acylated N-terminal
DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-113 reporter+balance group.

Comment:
The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a balance group that is isotopically labeled to produce a nominally isobaric combined modification.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-113 reporter+balance reagent N6-acylated lysine
DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3
Formula: (12)C 13 (13)C 7 H 36 (14)N 5 (15)N 1 (16)O 4
AminoAcid: K
Definition:
A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-113 reporter+balance reagent O4'-acylated tyrosine
DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3
Formula: (12)C 16 (13)C 7 H 33 (14)N 4 (15)N 1 (16)O 5
AminoAcid: Y
Definition:
A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-113 reporter+balance reagent N'-acylated histidine
DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3
Formula: (12)C 13 (13)C 7 H 31 (14)N 6 (15)N 1 (16)O 4
AminoAcid: H
Definition:
A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-113 reporter+balance reagent O3-acylated serine
DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3
Formula: (12)C 10 (13)C 7 H 29 (14)N 4 (15)N 1 (16)O 5
AminoAcid: S
Definition:
A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-113 reporter+balance reagent O3-acylated threonine
DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3
Formula: (12)C 11 (13)C 7 H 31 (14)N 4 (15)N 1 (16)O 5
AminoAcid: T
Definition:
A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-113 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-114 reporter+balance reagent acylated residue
DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group.

Comment:
The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a group that is isotopically labeled to produce a nominally isobaric combined modification.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-114 reporter+balance reagent acylated N-terminal
DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-114 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-114 reporter+balance reagent N6-acylated lysine
DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3
Formula: (12)C 13 (13)C 7 H 36 (14)N 5 (15)N 1 (16)O 4
AminoAcid: K
Definition:
A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-114 reporter+balance reagent O4'-acylated tyrosine
DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3
Formula: (12)C 16 (13)C 7 H 33 (14)N 4 (15)N 1 (16)O 5
AminoAcid: Y
Definition:
A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-114 reporter+balance reagent N'-acylated histidine
DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3
Formula: (12)C 13 (13)C 7 H 31 (14)N 6 (15)N 1 (16)O 4
AminoAcid: H
Definition:
A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-114 reporter+balance reagent O3-acylated serine
DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3
Formula: (12)C 10 (13)C 7 H 29 (14)N 4 (15)N 1 (16)O 5
AminoAcid: S
Definition:
A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-114 reporter+balance reagent O3-acylated threonine
DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3
Formula: (12)C 11 (13)C 7 H 31 (14)N 4 (15)N 1 (16)O 5
AminoAcid: T
Definition:
A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-114 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-115 reporter+balance reagent acylated residue
DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group.

Comment:
The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,4-dimethylpiperazine, is connected to a group that is isotopically labeled to produce a nominally isobaric combined modification.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-115 reporter+balance reagent acylated N-terminal
DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-115 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-115 reporter+balance reagent N6-acylated lysine
DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3
Formula: (12)C 14 (13)C 6 H 36 (14)N 4 (15)N 2 (16)O 4
AminoAcid: K
Definition:
A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-115 reporter+balance reagent O4'-acylated tyrosine
DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3
Formula: (12)C 17 (13)C 6 H 33 (14)N 3 (15)N 2 (16)O 5
AminoAcid: Y
Definition:
A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-115 reporter+balance reagent N'-derivatized histidine
DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3
Formula: (12)C 14 (13)C 6 H 31 (14)N 5 (15)N 2 (16)O 4
AminoAcid: H
Definition:
A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-115 reporter+balance reagent O3-acylated serine
DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3
Formula: (12)C 11 (13)C 6 H 29 (14)N 3 (15)N 2 (16)O 5
AminoAcid: S
Definition:
A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-115 reporter+balance reagent O3-acylated threonine
DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3
Formula: (12)C 12 (13)C 6 H 31 (14)N 3 (15)N 2 (16)O 5
AminoAcid: T
Definition:
A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-115 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-116 reporter+balance reagent acylated residue
DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-116 reporter+balance reagent acylated N-terminal
DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-116 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-116 reporter+balance reagent N6-acylated lysine
DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3
Formula: (12)C 13 (13)C 7 H 36 (14)N 5 (15)N 1 (16)O 4
AminoAcid: K
Definition:
A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-116 reporter+balance reagent O4'-acylated tyrosine
DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3
Formula: (12)C 16 (13)C 7 H 33 (14)N 4 (15)N 1 (16)O 5
AminoAcid: Y
Definition:
A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-116 reporter+balance reagent N'-acylated histidine
DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3
Formula: (12)C 13 (13)C 7 H 31 (14)N 6 (15)N 1 (16)O 4
AminoAcid: H
Definition:
A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-116 reporter+balance reagent O3-acylated serine
DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3
Formula: (12)C 10 (13)C 7 H 29 (14)N 4 (15)N 1 (16)O 5
AminoAcid: S
Definition:
A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-116 reporter+balance reagent O3-acylated threonine
DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3
Formula: (12)C 11 (13)C 7 H 31 (14)N 4 (15)N 1 (16)O 5
AminoAcid: T
Definition:
A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-116 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-117 reporter+balance reagent acylated residue
DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-117 reporter+balance reagent acylated N-terminal
DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-117 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-117 reporter+balance reagent N6-acylated lysine
DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3
Formula: (12)C 13 (13)C 7 H 36 (14)N 5 (15)N 1 (16)O 4
AminoAcid: K
Definition:
A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-117 reporter+balance reagent O4'-acylated tyrosine
DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3
Formula: (12)C 16 (13)C 7 H 33 (14)N 4 (15)N 1 (16)O 5
AminoAcid: Y
Definition:
A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-117 reporter+balance reagent N'-acylated histidine
DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3
Formula: (12)C 13 (13)C 7 H 31 (14)N 6 (15)N 1 (16)O 4
AminoAcid: H
Definition:
A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-117 reporter+balance reagent O3-acylated serine
DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3
Formula: (12)C 10 (13)C 7 H 29 (14)N 4 (15)N 1 (16)O 5
AminoAcid: S
Definition:
A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-117 reporter+balance reagent O3-acylated threonine
DiffFormula: (12)C 7 (13)C 7 H 24 (14)N 3 (15)N 1 (16)O 3
Formula: (12)C 11 (13)C 7 H 31 (14)N 4 (15)N 1 (16)O 5
AminoAcid: T
Definition:
A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-117 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-118 reporter+balance reagent acylated residue
DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-118 reporter+balance reagent acylated N-terminal
DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-118 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-118 reporter+balance reagent N6-acylated lysine
DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3
Formula: (12)C 14 (13)C 6 H 36 (14)N 4 (15)N 2 (16)O 4
AminoAcid: K
Definition:
A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-118 reporter+balance reagent O4'-acylated tyrosine
DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3
Formula: (12)C 17 (13)C 6 H 33 (14)N 3 (15)N 2 (16)O 5
AminoAcid: Y
Definition:
A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-118 reporter+balance reagent N'-acylated histidine
DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3
Formula: (12)C 14 (13)C 6 H 31 (14)N 5 (15)N 2 (16)O 4
AminoAcid: H
Definition:
A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-118 reporter+balance reagent O3-acylated serine
DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3
Formula: (12)C 11 (13)C 6 H 29 (14)N 3 (15)N 2 (16)O 5
AminoAcid: S
Definition:
A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-118 reporter+balance reagent O3-acylated threonine
DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3
Formula: (12)C 12 (13)C 6 H 31 (14)N 3 (15)N 2 (16)O 5
AminoAcid: T
Definition:
A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-118 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-119 reporter+balance reagent acylated residue
DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-119 reporter+balance reagent acylated N-terminal
DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-119 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-119 reporter+balance reagent N6-acylated lysine
DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3
Formula: (12)C 14 (13)C 6 H 36 (14)N 4 (15)N 2 (16)O 4
AminoAcid: K
Definition:
A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-119 reporter+balance reagent O4'-acylated tyrosine
DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3
Formula: (12)C 17 (13)C 6 H 33 (14)N 3 (15)N 2 (16)O 5
AminoAcid: Y
Definition:
A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-119 reporter+balance reagent N'-acylated histidine
DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3
Formula: (12)C 14 (13)C 6 H 31 (14)N 5 (15)N 2 (16)O 4
AminoAcid: H
Definition:
A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-119 reporter+balance reagent O3-acylated serine
DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3
Formula: (12)C 11 (13)C 6 H 29 (14)N 3 (15)N 2 (16)O 5
AminoAcid: S
Definition:
A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-119 reporter+balance reagent O3-acylated threonine
DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3
Formula: (12)C 12 (13)C 6 H 31 (14)N 3 (15)N 2 (16)O 5
AminoAcid: T
Definition:
A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-119 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-121 reporter+balance reagent acylated residue
DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of a residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-121 reporter+balance reagent acylated N-terminal
DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Applied Biosystems iTRAQ8plex-121 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-121 reporter+balance reagent N6-acylated lysine
DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3
Formula: (12)C 14 (13)C 6 H 36 (14)N 4 (15)N 2 (16)O 4
AminoAcid: K
Definition:
A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-121 reporter+balance reagent O4'-acylated tyrosine
DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3
Formula: (12)C 17 (13)C 6 H 33 (14)N 3 (15)N 2 (16)O 5
AminoAcid: Y
Definition:
A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-121 reporter+balance reagent N'-acylated histidine
DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3
Formula: (12)C 14 (13)C 6 H 31 (14)N 5 (15)N 2 (16)O 4
AminoAcid: H
Definition:
A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-121 reporter+balance reagent O3-acylated serine
DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3
Formula: (12)C 11 (13)C 6 H 29 (14)N 3 (15)N 2 (16)O 5
AminoAcid: S
Definition:
A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-121 reporter+balance reagent O3-acylated threonine
DiffFormula: (12)C 8 (13)C 6 H 24 (14)N 2 (15)N 2 (16)O 3
Formula: (12)C 12 (13)C 6 H 31 (14)N 3 (15)N 2 (16)O 5
AminoAcid: T
Definition:
A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Applied Biosystems iTRAQ8plex-121 reporter+balance group.


ModificationSetId: PSI-MOD
Name: modifications with monoisotopic mass differences that are nominally equal at 304.199039 Da
Definition:
Modifications that have monoisotopic mass differences from their respective origins of 304.199039 Da.


ModificationSetId: PSI-MOD
Name: O-glycyl-L-serine
Comment: Cross-link 2.
DiffFormula: C 0 H -2 N 0 O -1
Formula: C 5 H 7 N 2 O 3
Definition:
A protein modification that effectively crosslinks an L-serine residue and a glycine residue by an ester bond to form O-glycyl-L-serine.


ModificationSetId: PSI-MOD
Name: O-glycyl-L-threonine
Comment: Cross-link 2.
DiffFormula: C 0 H -2 N 0 O -1 S 0
Formula: C 6 H 9 N 2 O 3
Definition:
A protein modification that effectively crosslinks an L-threonine residue and a glycine residue by an ester bond to form O-glycyl-L-threonine.


ModificationSetId: PSI-MOD
SwissprotTerm: O-(2-aminoethylphosphoryl)serine
Name: O-(2-aminoethylphosphoryl)-L-serine
DiffFormula: C 2 H 6 N 1 O 3 P 1
Formula: C 5 H 11 N 2 O 5 P 1
AminoAcid: S
Definition:
A protein modification that effectively converts an L-serine residue to O-(2-aminoethylphosphoryl)-L-serine.


ModificationSetId: PSI-MOD
SwissprotTerm: O-(2-cholinephosphoryl)serine
Name: O-cholinephosphoryl-L-serine
DiffFormula: C 5 H 13 N 1 O 3 P 1
Formula: C 8 H 18 N 2 O 5 P 1
AminoAcid: S
Definition:
A protein modification that effectively converts an L-serine residue to O-cholinephosphoryl-L-serine.


ModificationSetId: PSI-MOD
Name: O-(2,4-diacetamido-2,4-dideoxyglucosyl)-L-serine
DiffFormula: C 10 H 16 N 2 O 5
Formula: C 13 H 21 N 3 O 7
AminoAcid: S
Definition:
A protein modification that effectively converts an L-serine residue to O-(2,4-diacetamido-2,4-dideoxyglucosyl)-L-serine.


ModificationSetId: PSI-MOD
Name: 3'-farnesyl-2',3'-dihydro-2',N2-cyclo-L-tryptophan
DiffFormula: C 15 H 24 N 0 O 0
Formula: C 26 H 34 N 2 O 1
AminoAcid: W
Definition:
A protein modification that effectively converts an L-tryptophan residue to 3'-farnesyl-2',3'-dihydro-2',N2-cyclo-L-tryptophan.


ModificationSetId: PSI-MOD
Name: modifications with monoisotopic mass differences that are nominally equal at 304.205359 Da
Definition:
Modifications that have monoisotopic mass differences from their respective origins of 304.205359 Da.


ModificationSetId: PSI-MOD
Name: modifications with monoisotopic mass differences that are nominally equal at 304.199-304.206 Da
Definition:
Modifications that have monoisotopic mass differences from their respective origins of 304.199-304.206 Da.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex reporter fragment
Definition:
A protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex reagent derivatized residue.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-113 reporter fragment
DiffFormula: none
Formula: (12)C 6 H 13 (14)N 2
Definition:
The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-113 reagent derivatized residue.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-114 reporter fragment
DiffFormula: none
Formula: (12)C 5 (13)C 1 H 13 (14)N 2
Definition:
The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-114 reagent derivatized residue.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-115 reporter fragment
DiffFormula: none
Formula: (12)C 5 (13)C 1 H 13 (14)N 1 (15)N 1
Definition:
The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-115 reagent derivatized residue.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-116 reporter fragment
DiffFormula: none
Formula: (12)C 4 (13)C 2 H 13 (14)N 1 (15)N 1
Definition:
The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-116 reagent derivatized residue.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-117 reporter fragment
DiffFormula: none
Formula: (12)C 3 (13)C 3 H 13 (14)N 1 (15)N 1
Definition:
The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-117 reagent derivatized residue.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-118 reporter fragment
DiffFormula: none
Formula: (12)C 3 (13)C 3 H 13 (15)N 2
Definition:
The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-118 reagent derivatized residue.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-119 reporter fragment
DiffFormula: none
Formula: (12)C 2 (13)C 4 H 13 (15)N 2
Definition:
The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-119 reagent derivatized residue.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex-121 reporter fragment
DiffFormula: none
Formula: (13)C 6 H 13 (15)N 2
Definition:
The protein modification reporter fragment produced by an Applied Biosystems iTRAQ8plex-121 reagent derivatized residue.


ModificationSetId: PSI-MOD
Name: S-(L-lysyl)-L-methionine sulfilimine
Comment: Cross-link 2.
DiffFormula: C 0 H -2 N 0 O 0 S 0
Formula: C 11 H 19 N 3 O 2 S 1
Definition:
A protein modification that effectively converts an L-lysine residue, and an L-methionine residue to S-(L-lysyl)-L-methionine sulfilimine.


ModificationSetId: PSI-MOD
Name: 4x(15)N labeled L-arginine
DiffFormula: (14)N -4 (15)N 4
Formula: C 6 H 12 (15)N 4 O 1
AminoAcid: R
Definition:
A protein modification that effectively converts an L-arginine residue to 4x(15)N labeled L-arginine.


ModificationSetId: PSI-MOD
SwissprotTerm: 5-glutamyl 2-aminoadipic acid
Name: 5-glutamyl 2-aminoadipic acid
DiffFormula: C 6 H 9 N 1 O 3
Formula: C 11 H 16 N 2 O 6
AminoAcid: E
Definition:
A protein modification that effectively converts an L-glutamic acid residue to 5-glutamyl 2-aminoadipic acid.


ModificationSetId: PSI-MOD
Name: 5-glutamyl 2-aminoadipic 6-phosphoric anhydride
DiffFormula: C 6 H 10 N 1 O 6 P 1
Formula: C 11 H 17 N 2 O 9 P 1
AminoAcid: E
Definition:
A protein modification that effectively converts an L-glutamic acid residue to 5-glutamyl 2-aminoadipic 6-phosphoric anhydride.


ModificationSetId: PSI-MOD
SwissprotTerm: 5-glutamyl N2-lysine
Name: N2-(L-isoglutamyl)-L-lysine
DiffFormula: C 6 H 12 N 2 O 1
Formula: C 11 H 19 N 3 O 4
AminoAcid: E
Definition:
A protein modification that effectively converts an L-glutamic acid residue to N2-(L-isoglutamyl)-L-lysine. This is not an isopeptide cross-link.


ModificationSetId: PSI-MOD
SwissprotTerm: 7'-hydroxytryptophan
Name: 7'-hydroxy-2'-alpha-mannosyl-L-tryptophan
DiffFormula: C 6 H 10 N 0 O 6
Formula: C 17 H 20 N 2 O 7
AminoAcid: W
Definition:
A protein modification that effectively converts an L-tryptophan residue to 7'-hydroxy-2'-alpha-mannosyl-L-tryptophan.


ModificationSetId: PSI-MOD
Name: L-threonine methyl ester
DiffFormula: C 1 H 2 N 0 O 0
Formula: C 5 H 10 N 1 O 3
AminoAcid: T
Definition:
A protein modification that effectively converts an L-threonine residue to L-threonine methyl ester.


ModificationSetId: PSI-MOD
Name: 6-(S-L-cysteinyl)-8alpha-(-3'-L-histidino)-FMN
Comment: Cross-link 2.
DiffFormula: C 17 H 17 N 4 O 9 P 1 S 0
Formula: C 26 H 29 N 8 O 11 P 1 S 1
Definition:
A protein modification that crosslinks a cysteine and a histidine residue by forming the adduct 6-(S-L-cysteinyl)-8alpha-(-3'-L-histidino)-FMN.


ModificationSetId: PSI-MOD
Name: glycyl cysteine dithioester
Comment: Cross-link 2.
DiffFormula: C 0 H -2 N 0 O -1 S 1
Formula: C 5 H 7 N 2 O 2 S 2
Definition:
A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a dithioester bond to form glycyl cysteine dithioester.


ModificationSetId: PSI-MOD
Name: trithiocystine
Comment: Cross-link 2.
DiffFormula: C 0 H -2 N 0 O 0 S 3
Formula: C 6 H 8 N 2 O 2 S 5
Definition:
A protein modification that effectively cross-links two L-cysteine residues and adds three sulfur atoms to form trithiocystine.


ModificationSetId: PSI-MOD
Name: O-(6-phosphomannosyl)-L-threonine
DiffFormula: C 6 H 11 N 0 O 8 P 1
Formula: C 10 H 18 N 1 O 10 P 1
AminoAcid: T
Definition:
A protein modification that effectively converts an L-threonine residue to O-(6-phosphomannosyl)-L-threonine.


ModificationSetId: PSI-MOD
Name: L-alanyl-L-isoaspartyl cyclopeptide
Comment: Cross-link 2.
DiffFormula: C 0 H -3 N -1 O 0
Formula: C 7 H 9 N 2 O 3
Definition:
A protein modification that effectively converts an L-alaine residue and an L-asparagine residue to L-alanyl-L-isoaspartyl cyclopeptide.


ModificationSetId: PSI-MOD
Name: multisulfide crosslinked residues
Definition:
A protein modification that crosslinks two cysteine residues by formation of a chain of two or more bonded sulfur atoms.


ModificationSetId: PSI-MOD
Name: polysulfide crosslinked residues
Definition:
A protein modification that crosslinks two cysteine residues by formation of a chain of three or more bonded sulfur atoms.


ModificationSetId: PSI-MOD
Name: flavin crosslinked residues
Definition:
A protein modification that crosslinks two or more amino acid residues by forming an adduct with a compound containing a flavin group.


ModificationSetId: PSI-MOD
Name: monohydroxylated tryptophan
DiffFormula: C 0 H 0 N 0 O 1
Formula: C 11 H 10 N 2 O 2
AminoAcid: W
Definition:
A protein modification that effectively converts an L-tryptophan residue to one of several monohydroxylated tryptophan residues, including 3-hydroxy-L-tryptophan and 7'-hydroxy-L-tryptophan.


ModificationSetId: PSI-MOD
Name: (2-aminosuccinimidyl)acetic acid (Asn)
Comment: Cross-link 2.
DiffFormula: C 0 H -3 N -1 O 0
Formula: C 6 H 6 N 2 O 3
Definition:
A protein modification that crosslinks an asparagine and the following glycine residue with the formation of (2-aminosuccinimidyl)acetic acid and the release of ammonia.


ModificationSetId: PSI-MOD
SwissprotTerm: 1-thioglycine
Name: 1-thioglycine
Definition: A protein modification that effectively converts a glycine residue to 1-thioglycine.
DiffFormula: C 0 H 0 N 0 O -1 S 1
Formula: none
AminoAcid: G
Comment:
This modification occurs naturally in two forms. At an interior peptide location (MOD:00270) it exists as aminoethanethionic acid, or aminoethanethioic O-acid. At the C-terminal (MOD:01623) it exists as aminoethanethiolic acid, or aminoethanethioic S-acid [JSG].


ModificationSetId: PSI-MOD
Name: L-cystine
DiffFormula: C 0 H -2 N 0 O 0 S 0
Formula: none
Definition:
A protein modification that forms L-cystine by forming a disulfide bond that either cross-links two peptidyl L-cysteine residues, or modifies a peptidyl cysteine with a free cysteine.

Comment:
This modification occurs naturally in two forms. It exists as a disulfide cross-link of two cysteine residues (MOD:00034), or as a disulfide cross-link of a cysteine residues and a free cysteine (MOD:00765).


ModificationSetId: PSI-MOD
Name: L-cysteinyl-L-selenocysteine
Comment: Cross-link 2.
DiffFormula: none
Formula: C 6 H 8 N 2 O 2 S 1 Se 1
Definition:
A protein modification that forms L-cysteinyl-L-selenocysteine either by the natural process of cross-linking an L-cysteine residue and an L-selenocysteine residue, or by the hypothetical process of substituting a selenium for a sulfur atom in cystine.


ModificationSetId: PSI-MOD
Name: (2-aminosuccinimidyl)acetic acid
DiffFormula: none
Formula: C 6 H 6 N 2 O 3
Definition:
A protein modification that forms (2-aminosuccinimidyl)acetic acid by crosslinking either an aspartic acid residue or an asparagine residue with the following glycine residue.

Comment:
Cross-link 2; this cross-link is formed by the condensation of an aspartic acid residue or an asparagine residue with the alpha-amido of the following residue.


ModificationSetId: PSI-MOD
SwissprotTerm: Cyclo[(prolylserin)-O-yl] cysteinate
Name: cyclo[(prolylserin)-O-yl] cysteinate
DiffFormula: none
Formula: C 11 H 16 N 3 O 4 S 1
Definition:
A protein modification that forms cyclo[(prolylserin)-O-yl] cysteinate by the natural process of cross-linking an L-cysteine residue an L-proline residue, and an L-serine residue, or by effectively modifying a cysteine residue.


ModificationSetId: PSI-MOD
Name: N6-(L-isoglutamyl)-L-lysine
Comment: Cross-link 2.
DiffFormula: none
Formula: C 11 H 17 N 3 O 3
Definition:
A protein modification that effectively crosslinks either an  L-glutamine residue or an L-glutamic acid residue with an L-lysine residue by an isopeptide bond to form  N6-(L-isoglutamyl)-L-lysine .


ModificationSetId: PSI-MOD
Name: L-alanine removal
Definition: A protein modification that effectively removes or replaces an L-alanine.
DiffFormula: C -3 H -5 N -1 O -1
Formula: none
AminoAcid: A
Comment:
This represents the loss or replacement of an L-alanine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution.


ModificationSetId: PSI-MOD
Name: L-arginine removal
Definition: A protein modification that effectively removes or replaces an L-arginine.
DiffFormula: C -6 H -12 N -4 O -1
Formula: none
AminoAcid: R
Comment:
This represents the loss or replacement of an L-arginine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution.


ModificationSetId: PSI-MOD
Name: L-asparagine removal
Definition: A protein modification that effectively removes or replaces an L-asparagine.
DiffFormula: C -4 H -6 N -2 O -2
Formula: none
AminoAcid: N
Comment:
This represents the loss or replacement of an L-asparagine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution.


ModificationSetId: PSI-MOD
Name: L-aspartic acid removal
Definition: A protein modification that effectively removes or replaces an L-aspartic acid.
DiffFormula: C -4 H -5 N -1 O -3
Formula: none
AminoAcid: D
Comment:
This represents the loss or replacement of an L-aspartic acid residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution.


ModificationSetId: PSI-MOD
Name: L-cysteine removal
Definition: A protein modification that effectively removes or replaces an L-cysteine.
DiffFormula: C -3 H -5 N -1 O -1 S -1
Formula: none
AminoAcid: C
Comment:
This represents the loss or replacement of an L-cysteine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution.


ModificationSetId: PSI-MOD
Name: L-glutamic acid removal
Definition: A protein modification that effectively removes or replaces an L-glutamic acid.
DiffFormula: C -5 H -7 N -1 O -3
Formula: none
AminoAcid: E
Comment:
This represents the loss or replacement of an L-glutamic acid residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution.


ModificationSetId: PSI-MOD
Name: L-glutamine removal
Definition: A protein modification that effectively removes or replaces an L-glutamine.
DiffFormula: C -5 H -8 N -2 O -2
Formula: none
AminoAcid: Q
Comment:
This represents the loss or replacement of an L-glutamine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution.


ModificationSetId: PSI-MOD
Name: glycine removal
Definition: A protein modification that effectively removes or replaces a glycine.
DiffFormula: C -2 H -3 N -1 O -1
Formula: none
AminoAcid: G
Comment:
This represents the loss or replacement of an glycine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution.


ModificationSetId: PSI-MOD
Name: L-histidine removal
Definition: A protein modification that effectively removes or replaces an L-histidine.
DiffFormula: C -6 H -7 N -3 O -1
Formula: none
AminoAcid: H
Comment:
This represents the loss or replacement of an L-histidine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution.


ModificationSetId: PSI-MOD
Name: L-isoleucine removal
Definition: A protein modification that effectively removes or replaces an L-isoleucine.
DiffFormula: C -6 H -11 N -1 O -1
Formula: none
AminoAcid: I
Comment:
This represents the loss or replacement of an L-isoleucine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution.


ModificationSetId: PSI-MOD
Name: L-leucine removal
Definition: A protein modification that effectively removes or replaces an L-leucine.
DiffFormula: C -6 H -11 N -1 O -1
Formula: none
AminoAcid: L
Comment:
This represents the loss or replacement of an L-leucine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution.


ModificationSetId: PSI-MOD
Name: L-lysine removal
Definition: A protein modification that effectively removes or replaces an L-lysine.
DiffFormula: C -6 H -12 N -2 O -1
Formula: none
AminoAcid: K
Comment:
This represents the loss or replacement of an L-lysine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution.


ModificationSetId: PSI-MOD
Name: L-methionine removal
Definition: A protein modification that effectively removes or replaces an L-methionine.
DiffFormula: C -5 H -9 N -1 O -1 S -1
Formula: none
AminoAcid: M
Comment:
This represents the loss or replacement of an L-methionine residue in a polypeptide, including initiator methionine removal in eukaryotes. It may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution [JSG].


ModificationSetId: PSI-MOD
Name: L-phenylalanine removal
Definition: A protein modification that effectively removes or replaces an L-phenylalanine.
DiffFormula: C -9 H -9 N -1 O -1
Formula: none
AminoAcid: F
Comment:
This represents the loss or replacement of an L-phenylalanine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution.


ModificationSetId: PSI-MOD
Name: L-proline removal
Definition: A protein modification that effectively removes or replaces an L-proline.
DiffFormula: C -5 H -7 N -1 O -1
Formula: none
AminoAcid: P
Comment:
This represents the loss or replacement of an L-proline residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution.


ModificationSetId: PSI-MOD
Name: L-serine removal
Definition: A protein modification that effectively removes or replaces an L-serine.
DiffFormula: C -3 H -5 N -1 O -2
Formula: none
AminoAcid: S
Comment:
This represents the loss or replacement of an L-serine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution.


ModificationSetId: PSI-MOD
Name: L-threonine removal
Definition: A protein modification that effectively removes or replaces an L-threonine.
DiffFormula: C -4 H -7 N -1 O -2
Formula: none
AminoAcid: T
Comment:
This represents the loss or replacement of an L-threonine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution.


ModificationSetId: PSI-MOD
Name: L-tryptophan removal
Definition: A protein modification that effectively removes or replaces an L-tryptophan.
DiffFormula: C -11 H -10 N -2 O -1
Formula: none
AminoAcid: W
Comment:
This represents the loss or replacement of an L-tryptophan residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution.


ModificationSetId: PSI-MOD
Name: L-tyrosine removal
Definition: A protein modification that effectively removes or replaces an L-tyrosine.
DiffFormula: C -9 H -9 N -1 O -2
Formula: none
AminoAcid: Y
Comment:
This represents the loss or replacement of an L-tyrosine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution.


ModificationSetId: PSI-MOD
Name: L-valine removal
Definition: A protein modification that effectively removes or replaces an L-valine.
DiffFormula: C -5 H -9 N -1 O -1
Formula: none
AminoAcid: V
Comment:
This represents the loss or replacement of an L-valine residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution.


ModificationSetId: PSI-MOD
Name: natural, standard, encoded residue removal
Definition: A protein modification that effectively removes or replaces a natural, standard, encoded residue.
Comment:
This represents the loss or replacement of an encoded residue in a polypeptide, and may be combined with the formula or mass of another entry that is the replacement residue to represent a mutation or substitution.


ModificationSetId: PSI-MOD
Name: sulfonyl halide reagent derivatized residue
Definition:
A protein modification that is produced by formation of an adduct with a sulfonyl halide compound used as a reagent.

Comment:
These reagents typically react with N6-amino group of lysine residues and a free alpha-amino group of a peptide.


ModificationSetId: PSI-MOD
Name: dansyl chloride derivatized residue
DiffFormula: C 12 H 11 N 1 O 2 S 1
Formula: none
Definition:
A protein modification that is produced by formation of an adduct with 5-dimethylaminonaphthalene-1-sulfonyl chloride, dansyl chloride.


ModificationSetId: PSI-MOD
Name: N6-Dansyl derivatized lysine
DiffFormula: C 12 H 11 N 1 O 2 S 1
Formula: C 18 H 23 N 3 O 3 S 1
AminoAcid: K
Definition:
A protein modification that is produced by reaction with 5-dimethylaminonaphthalene-1-sulfonyl chloride, dansyl chloride, to form N6-Dansyl-lysine.


ModificationSetId: PSI-MOD
Name: alpha-amino-Dansyl derivatized residue
DiffFormula: C 12 H 11 N 1 O 2 S 1
Formula: none
Definition:
A protein modification that is produced by reaction with 5-dimethylaminonaphthalene-1-sulfonyl chloride, dansyl chloride, to form an alpha-amino-Dansyl-derivatized residue.


ModificationSetId: PSI-MOD
Name: Dabsyl chloride derivatized residue
DiffFormula: C 14 H 13 N 3 O 2 S 1
Formula: none
Definition:
A protein modification that is produced by formation of an adduct with 4-(4-dimethylaminophenylazo)benzenesulfonyl chloride, Dabsyl chloride.


ModificationSetId: PSI-MOD
Name: N6-Dabsyl derivatized lysine
DiffFormula: C 14 H 13 N 3 O 2 S 1
Formula: C 20 H 25 N 5 O 3 S 1
AminoAcid: K
Definition:
A protein modification that is produced by reaction with 4-(4-dimethylaminophenylazo)benzenesulfonyl chloride, dabsyl chloride, to form N6-Dabsyl-lysine.


ModificationSetId: PSI-MOD
Name: alpha-amino-Dabsyl derivatized residue
DiffFormula: C 14 H 13 N 3 O 2 S 1
Formula: none
Definition:
A protein modification that is produced by reaction with 4-(4-dimethylaminophenylazo)benzenesulfonyl chloride, dabsyl chloride, to form an alpha-amino-Dabsyl-derivatized residue.


ModificationSetId: PSI-MOD
Name: Uniblue A derivatized residue
DiffFormula: C 22 H 16 N 2 O 7 S 2
Formula: none
Definition:
A protein modification that is produced by formation of an adduct with 1-amino-4-{[3-(ethenylsulfonyl)phenyl]amino}-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate, Uniblue A.

Comment:
This reagent has a reactive sulfonyl vinyl and typically reacts with the free thiol group of cysteine residues.


ModificationSetId: PSI-MOD
Name: Uniblue A derivatized cysteine
DiffFormula: C 22 H 16 N 2 O 7 S 2
Formula: C 25 H 21 N 3 O 8 S 3
AminoAcid: C
Definition:
A protein modification that is produced by reaction with 1-amino-4-{[3-(ethenylsulfonyl)phenyl]amino}-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate, Uniblue A, to form Uniblue A cysteine adduct.


ModificationSetId: PSI-MOD
Name: N5-(ADP-ribosyl)-L-glutamine
DiffFormula: C 15 H 21 N 5 O 13 P 2
Formula: C 20 H 29 N 7 O 15 P 2
AminoAcid: Q
Definition:
A protein modification that effectively converts an L-glutamine residue to N5-(ADP-ribosyl)-L-glutamine.


ModificationSetId: PSI-MOD
Name: O-(ADP-ribosyl)-L-threonine
DiffFormula: C 15 H 21 N 5 O 13 P 2
Formula: C 19 H 28 N 6 O 15 P 2
AminoAcid: T
Definition:
A protein modification that effectively converts an L-threonine residue to O-(ADP-ribosyl)-L-threonine.


ModificationSetId: PSI-MOD
Name: 7'-hydroxy-L-tryptophan
DiffFormula: C 0 H 0 N 0 O 1
Formula: C 11 H 10 N 2 O 2
AminoAcid: W
Definition:
A protein modification that effectively converts an L-tryptophan residue to a 7'-hydroxy-L-tryptophan.


ModificationSetId: PSI-MOD
Name: N-(DNA-1',2'-dideoxyribos-1'-ylidene)-L-valine
DiffFormula: C 5 H 7 N 0 O 5 P 1
Formula: C 10 H 17 N 1 O 6 P 1
AminoAcid: V
Definition:
A protein modification that effectively crosslinks an N-terminal L-valine residue and a strand of DNA at the C-1 of a ribose, freeing the nucleotide base and forming N-(DNA-1',2'-dideoxyribos-1'-ylidene)-L-valine.


ModificationSetId: PSI-MOD
Name: O4-(8alpha-FAD)-L-aspartate
DiffFormula: C 27 H 31 N 9 O 15 P 2
Formula: C 31 H 36 N 10 O 18 P 2
AminoAcid: D
Definition:
A protein modification that effectively converts an L-aspartic acid residue to O4-(8alpha-FAD)-L-aspartate.


ModificationSetId: PSI-MOD
Name: trimethyl-L-arginine
DiffFormula: C 3 H 6 N 0 O 0
Formula: C 9 H 18 N 4 O 1
AminoAcid: R
Definition:
A protein modification that effectively converts an L-arginine residue to N(omega),N(omega),N'(omega)-trimethyl-L-arginine.


ModificationSetId: PSI-MOD
Name: O-(L-isoaspartyl)-L-threonine (active site intermediate)
Comment: This is a threonine active intermediate and not an ester cross-link of peptides [JSG].
DiffFormula: C 4 H 5 N 1 O 3
Formula: C 8 H 12 N 2 O 5
AminoAcid: T
Definition:
A protein modification that effectively converts an L-threonine residue to O-(L-isoaspartyl)-L-threonine, using free L-asparagine and releasing ammonia.


ModificationSetId: PSI-MOD
Name: halogenated lysine
AminoAcid: K
Definition:
A protein modification that effectively substitutes a hydrogen atom of an L-lysine residue with a halogen atom.


ModificationSetId: PSI-MOD
Name: N-acetylaminohexosylated residue
DiffFormula: C 8 H 13 N 1 O 5
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom with an N-acetylaminohexose group through a glycosidic bond.


ModificationSetId: PSI-MOD
Name: N4-(N-acetylamino)hexosyl-L-asparagine
DiffFormula: C 8 H 13 N 1 O 5
Formula: C 12 H 19 N 3 O 7
AminoAcid: N
Definition:
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetaminohexosyl)-L-asparagine.


ModificationSetId: PSI-MOD
Name: O-(N-acetylamino)hexosyl-L-serine
DiffFormula: C 8 H 13 N 1 O 5
Formula: C 11 H 18 N 2 O 7
AminoAcid: S
Definition:
A protein modification that effectively converts an L-serine residue to O3-(N-acetylaminohexosyl)-L-serine.


ModificationSetId: PSI-MOD
Name: O-(N-acetylamino)hexosyl-L-threonine
DiffFormula: C 8 H 13 N 1 O 5
Formula: C 12 H 20 N 2 O 7
AminoAcid: T
Definition:
A protein modification that effectively converts an L-threonine residue to O3-(N-acetylaminohexosyl)-L-threonine.


ModificationSetId: PSI-MOD
Name: O4-(N-acetylamino)hexosyl-L-hydroxyproline
Comment: secondary to RESID:AA0030
DiffFormula: C 8 H 13 N 1 O 6
Formula: C 13 H 20 N 2 O 7
AminoAcid: P
Definition:
A protein modification that effectively converts an L-proline residue to O4-(N-acetylamino)hexosyl-L-hydroxyproline.


ModificationSetId: PSI-MOD
Name: N6-carbamoyl-L-lysine
Definition: A protein modification that effectively coverts L-lysine to N6-carbamoyl-L-lysine.
DiffFormula: C 1 H 1 N 1 O 1
Formula: C 7 H 13 N 3 O 2
AminoAcid: K
Comment:
This modification can be produced by hydrogen cyanate, either as a reagent or as released by urea degradation in solution [JSG].


ModificationSetId: PSI-MOD
Name: alpha-aminocarbamoylated residue
DiffFormula: C 1 H 1 N 1 O 1
Formula: none
Definition:
A protein modification that effectively replaces a residue alpha amino or imino hydrogen with a carbamoyl group.

Comment:
This modification can be produced by hydrogen cyanate, either as a reagent or as released by urea degradation. This modification effectively blocks Edman degradation, and because it can dehydrate to a cyanate group and react with another peptide N-terminal, it can effectively block two peptide molecules [JSG].


ModificationSetId: PSI-MOD
Name: alpha-amino monomethylated residue
DiffFormula: C 1 H 2 N 0 O 0
Formula: none
Definition:
A protein modification that effectively replaces one residue alpha amino or imino hydrogen with one methyl group.


ModificationSetId: PSI-MOD
Name: monomethylated L-aspartic acid
DiffFormula: C 1 H 2 N 0 O 0
Formula: C 5 H 7 N 1 O 3
AminoAcid: D
Definition:
A protein modification that effectively replaces one hydrogen atom of an L-aspartic acid residue with one methyl group.


ModificationSetId: PSI-MOD
Name: monomethylated L-cysteine
DiffFormula: C 1 H 2 N 0 O 0
Formula: C 4 H 7 N 1 O 1 S 1
AminoAcid: C
Definition:
A protein modification that effectively replaces one hydrogen atom of an L-cysteine residue with one methyl group.


ModificationSetId: PSI-MOD
Name: monomethylated L-lysine
DiffFormula: C 1 H 2 N 0 O 0
Formula: C 7 H 15 N 2 O 2
AminoAcid: K
Definition:
A protein modification that effectively replaces one hydrogen atom of an L-lysine residue with one methyl group.


ModificationSetId: PSI-MOD
Name: palmitoylated-L-cysteine
DiffFormula: C 16 H 30 N 0 O 1 S 0
Formula: C 19 H 35 N 1 O 2 S 1
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to a palmitoylated-L-cysteine, such as N-palmitoyl-L-cysteine or S-palmitoyl-L-cysteine.


ModificationSetId: PSI-MOD
Name: alpha-amino palmitoylated residue
DiffFormula: C 16 H 30 N 0 O 1 S 0
Formula: none
Definition:
A protein modification that effectively replaces a residue alpha-amino group with a alpha-palmitoylamino group.


ModificationSetId: PSI-MOD
Name: alpha-amino dimethylated residue
DiffFormula: C 2 H 4
Formula: none
Definition:
A protein modification that effectively replaces two alpha amino hydrogen atoms with two methyl group.

Comment:
For alpha-amino acids, both N-alpha-monomethylation and complete N-alpha protonation and trimethylation have been observed, but incomplete dimethylation has not been reported as a natural process. For N-terminal proline residues, dimethylation can only be effectively accomplished with a protonated imino group, whereas this process accounts only for dimethylation and not protonation. See MOD:00889.


ModificationSetId: PSI-MOD
Name: alpha-amino trimethylated residue
DiffFormula: C 3 H 6 N 0 O 0
Formula: none
Definition:
A protein modification that effectively replaces an alpha-aminium group with a trimethylaminium group.

Comment:
For amino acids residues, amine trimethylation can effectively only be accomplished with an aminium, protonated primary amino, group. This process accounts only for trimethylation and not protonation. The alternative N2Me3+Res process (MOD:01698) accounts for both protonation and trimethylation.


ModificationSetId: PSI-MOD
Name: 3-hydroxy-L-asparagine
DiffFormula: C 0 H 0 N 0 O 1
Formula: C 4 H 6 N 2 O 3
AminoAcid: N
Definition:
A protein modification that effectively converts an L-asparagine residue to one of the diastereomeric 3-hydroxy-L-asparagine residues.


ModificationSetId: PSI-MOD
Name: alpha-carboxyl methylated residue
DiffFormula: C 1 H 2 N 0 O 0 S 0
Formula: none
Definition:
A protein modification that effectively converts a carboxyl-terminal residue to an alpha-carboxyl (1-carboxyl) methyl ester.


ModificationSetId: PSI-MOD
Name: N-[(12R)-12-hydroxymyristoyl]-L-cysteine
DiffFormula: C 14 H 26 N 0 O 2 S 0
Formula: C 17 H 32 N 1 O 3 S 1
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to N-[(12R)-12-hydroxymyristoyl]-L-cysteine.


ModificationSetId: PSI-MOD
Name: N-(12-ketomyristoyl)-L-cysteine
DiffFormula: C 14 H 24 N 0 O 2 S 0
Formula: C 17 H 30 N 1 O 3 S 1
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to N-(12-ketomyristoyl)-L-cysteine.


ModificationSetId: PSI-MOD
Name: glutamyl semialdehyde (Glu)
DiffFormula: C 0 H 0 N 0 O -1
Formula: C 5 H 7 N 1 O 2
AminoAcid: E
Definition:
A protein modification that effectively converts an L-glutamic acid residue to L-glutamyl semialdehyde.


ModificationSetId: PSI-MOD
Name: alpha-amino pyridylacetylated residue
Comment: Produced by reaction with N-[(pyrid-3-yl)acetyl]oxy-succinimide [JSG].
DiffFormula: C 7 H 5 N 1 O 1
Formula: none
Definition:
A protein modification that effectively replaces a residue alpha amino or imino hydrogen with a (pyrid-3-yl)acetyl group.


ModificationSetId: PSI-MOD
SwissprotTerm: S-(coelenterazin-3a-yl)cysteine
Name: S-(coelenterazin-3a-yl)-L-cysteine
DiffFormula: C 26 H 19 N 3 O 3 S 0
Formula: C 29 H 24 N 4 O 4 S 1
AminoAcid: C
Definition:
A protein modification that effectively results from forming an adduct between an L-cysteine residue and the bioluminescent compound didehydrocoelenterazine to form S-(coelenterazin-3a-yl)-L-cysteine.


ModificationSetId: PSI-MOD
Name: alpha-amino 3-(carboxamidomethylthio)propanoylated residue
DiffFormula: C 5 H 7 N 1 O 2 S 1
Formula: none
Definition:
A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an 3-(carboxamidomethylthio)propanoyl group.


ModificationSetId: PSI-MOD
Name: alpha-amino 4-(2-aminoethyl)benzenesulfonylated residue
Comment: See the comment for MOD:00596 [JSG].
DiffFormula: C 8 H 9 N 1 O 2 S 1
Formula: none
Definition:
A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an 4-(2-aminoethyl)benzenesulfonyl group.


ModificationSetId: PSI-MOD
Name: protonated residue
DiffFormula: C 0 H 1 N 0 O 0
Formula: none
Definition:
A protein modification that effectively adds a hydrogen cation, a proton, forming a cationic residue.


ModificationSetId: PSI-MOD
Name: alpha-amino protonated residue
DiffFormula: C 0 H 1 N 0 O 0
Formula: none
Definition:
A protein modification that effectively adds a proton to a residue alpha-amnino or alpha-imino group forming an alpha-aminium or alpha-iminium group, respectively.


ModificationSetId: PSI-MOD
Name: deprotonated residue
DiffFormula: C 0 H -1 N 0 O 0
Formula: none
Definition:
A protein modification that effectively removes a hydrogen cation, a proton, forming an anionic residue.


ModificationSetId: PSI-MOD
Name: alpha-carboxyl deprotonated residue
DiffFormula: C 0 H -1 N 0 O 0
Formula: none
Definition:
A protein modification that effectively removes a proton from a residue 1-carboxyl group (referred to as the alpha-carboxyl), forming a carboxylate anion.


ModificationSetId: PSI-MOD
Name: dehydrobutyrine (Met)
Comment: It is expected that this neutral loss will produce a mix of (E)- and (Z)-isomers [JSG].
DiffFormula: C -1 H -4 N 0 O 0 S -1
Formula: C 4 H 5 N 1 O 1
AminoAcid: M
Definition:
A protein modification that effectively converts an L-methionine residue to dehydrobutyrine, by neutral loss of methyl sulfide.


ModificationSetId: PSI-MOD
Name: isotope tagged reagent acylated residue
Definition:
A protein modification that effectively replaces a residue hydrogen with an isotope tagged reagent acyl group.


ModificationSetId: PSI-MOD
Name: isotope tagged reagent N-acylated residue
Definition:
A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with an isotope tagged reagent acyl group.


ModificationSetId: PSI-MOD
Name: isotope tagged reagent O-acylated residue
Definition:
A protein modification that effectively replaces a residue hydroxyl group with an isotope tagged reagent acyloxy group.


ModificationSetId: PSI-MOD
Name: iTRAQ4plex reporter+balance reagent N-acylated residue
DiffFormula: none
Formula: none
Definition:
A protein modification that effectively replaces a residue amino- or imino-hydrogen with one of the Applied Biosystems iTRAQ4plex reagent reporter+balance groups.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex reporter+balance reagent N-acylated residue
DiffFormula: none
Formula: none
Definition:
A protein modification that effectively replaces a residue amino- or imino-hydrogen with one of the Applied Biosystems iTRAQ8plex reagent reporter+balance groups.


ModificationSetId: PSI-MOD
Name: iTRAQ4plex reporter+balance reagent acylated N-terminal
DiffFormula: none
Formula: none
Definition:
A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with one of the Applied Biosystems iTRAQ4plex reagent reporter+balance groups.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex reporter+balance reagent acylated N-terminal
DiffFormula: none
Formula: none
Definition:
A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with one of the Applied Biosystems iTRAQ8plex reagent reporter+balance groups.


ModificationSetId: PSI-MOD
Name: iTRAQ4plex reporter+balance reagent O-acylated residue
DiffFormula: none
Formula: none
Definition:
A protein modification that effectively replaces a residue hydroxyl with one of the Applied Biosystems iTRAQ4plex reagent reporter+balance acyloxy groups.


ModificationSetId: PSI-MOD
Name: iTRAQ8plex reporter+balance reagent O-acylated residue
DiffFormula: none
Formula: none
Definition:
A protein modification that effectively replaces a residue hydroxyl with one of the Applied Biosystems iTRAQ8plex reagent reporter+balance acyloxy groups.


ModificationSetId: PSI-MOD
Name: TMT6plex reporter+balance reagent acylated residue
DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of a residue with a Proteome Sciences TMT6plex reporter+balance group.

Comment:
The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.


ModificationSetId: PSI-MOD
Name: TMT6plex reporter fragment
Definition:
The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-126 reagent acylated residue.


ModificationSetId: PSI-MOD
Name: TMT6plex reporter+balance reagent N-acylated residue
DiffFormula: none
Formula: none
Definition:
A protein modification that effectively replaces a residue amino- or imino-hydrogen with a Proteome Sciences TMT6plex reporter+balance group.

Comment:
The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.


ModificationSetId: PSI-MOD
Name: TMT6plex reporter+balance reagent acylated N-terminal
DiffFormula: none
Formula: none
Definition:
A protein modification that effectively replaces a residue alpha-amino- or alpha-imino-hydrogen with a Proteome Sciences TMT6plex reporter+balance group.

Comment:
The reagent consists of a reporter group, a balance group and a protein reactive N-oxysuccinimide group. The reporter group, an isotopically labeled 1,2,6-trimethylpiperidine, is connected to a 3-(carbonylamino)propanoyl balance group that is isotopically labeled to produce a nominally isobaric combined modification.


ModificationSetId: PSI-MOD
Name: TMT6plex reporter+balance reagent O-acylated residue
DiffFormula: none
Formula: none
Definition:
A protein modification that effectively replaces a residue hydroxyl with one of the Proteome Sciences TMT6plex reagent reporter+balance acyloxy groups.


ModificationSetId: PSI-MOD
Name: TMT6plex-126 reporter+balance reagent acylated residue
DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-126 reporter+balance group.


ModificationSetId: PSI-MOD
Name: TMT6plex-126 reporter+balance reagent acylated N-terminal
DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-126 reporter+balance group.


ModificationSetId: PSI-MOD
Name: TMT6plex-126 reporter+balance reagent N6-acylated lysine
DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2
Formula: (12)C 14 (13)C 4 H 32 (14)N 3 (15)N 1 O 3
AminoAcid: K
Definition:
A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-126 reporter+balance group.


ModificationSetId: PSI-MOD
Name: TMT6plex-126 reporter+balance reagent O4'-acylated tyrosine
DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2
Formula: (12)C 17 (13)C 4 H 29 (14)N 2 (15)N 1 O 4
AminoAcid: Y
Definition:
A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-126 reporter+balance group.


ModificationSetId: PSI-MOD
Name: TMT6plex-126 reporter+balance reagent N'-acylated histidine
DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2
Formula: (12)C 14 (13)C 4 H 27 (14)N 4 (15)N 1 O 3
AminoAcid: H
Definition:
A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-126 reporter+balance group.


ModificationSetId: PSI-MOD
Name: TMT6plex-126 reporter+balance reagent O3-acylated serine
DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2
Formula: (12)C 11 (13)C 4 H 25 (14)N 2 (15)N 1 O 4
AminoAcid: S
Definition:
A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-126 reporter+balance group.


ModificationSetId: PSI-MOD
Name: TMT6plex-126 reporter+balance reagent O3-acylated threonine
DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2
Formula: (12)C 12 (13)C 4 H 27 (14)N 2 (15)N 1 O 4
AminoAcid: T
Definition:
A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-126 reporter+balance group.


ModificationSetId: PSI-MOD
Name: TMT6plex-127 reporter+balance reagent acylated residue
DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-127 reporter+balance group.


ModificationSetId: PSI-MOD
Name: TMT6plex-127 reporter+balance reagent acylated N-terminal
DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-127 reporter+balance group.


ModificationSetId: PSI-MOD
Name: TMT6plex-127 reporter+balance reagent N6-acylated lysine
DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2
Formula: (12)C 14 (13)C 4 H 32 (14)N 3 (15)N 1 O 3
AminoAcid: K
Definition:
A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-127 reporter+balance group.


ModificationSetId: PSI-MOD
Name: TMT6plex-127 reporter+balance reagent O4'-acylated tyrosine
DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2
Formula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2
AminoAcid: Y
Definition:
A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-127 reporter+balance group.


ModificationSetId: PSI-MOD
Name: TMT6plex-127 reporter+balance reagent N'-acylated histidine
DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2
Formula: (12)C 14 (13)C 4 H 27 (14)N 4 (15)N 1 O 3
AminoAcid: H
Definition:
A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-127 reporter+balance group.


ModificationSetId: PSI-MOD
Name: TMT6plex-127 reporter+balance reagent O3-acylated serine
DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2
Formula: (12)C 11 (13)C 4 H 25 (14)N 2 (15)N 1 O 4
AminoAcid: S
Definition:
A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-127 reporter+balance group.


ModificationSetId: PSI-MOD
Name: TMT6plex-127 reporter+balance reagent O3-acylated threonine
DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2
Formula: (12)C 12 (13)C 4 H 27 (14)N 2 (15)N 1 O 4
AminoAcid: T
Definition:
A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-127 reporter+balance group.


ModificationSetId: PSI-MOD
Name: TMT6plex-127 reporter fragment
DiffFormula: none
Formula: (12)C 7 (13)C 1 H 16 (14)N 1
Definition:
The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-127 reagent acylated residue.


ModificationSetId: PSI-MOD
Name: TMT6plex-128 reporter+balance reagent acylated residue
DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-128 reporter+balance group.


ModificationSetId: PSI-MOD
Name: TMT6plex-128 reporter+balance reagent acylated N-terminal
DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-128 reporter+balance group.


ModificationSetId: PSI-MOD
Name: TMT6plex-128 reporter+balance reagent N6-acylated lysine
DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2
Formula: (12)C 14 (13)C 4 H 32 (14)N 3 (15)N 1 O 3
AminoAcid: K
Definition:
A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-128 reporter+balance group.


ModificationSetId: PSI-MOD
Name: TMT6plex-128 reporter+balance reagent O4'-acylated tyrosine
DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2
Formula: (12)C 17 (13)C 4 H 29 (14)N 2 (15)N 1 O 4
AminoAcid: Y
Definition:
A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-128 reporter+balance group.


ModificationSetId: PSI-MOD
Name: TMT6plex-128 reporter+balance reagent N'-acylated histidine
DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2
Formula: (12)C 14 (13)C 4 H 27 (14)N 4 (15)N 1 O 3
AminoAcid: H
Definition:
A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-128 reporter+balance group.


ModificationSetId: PSI-MOD
Name: TMT6plex-128 reporter+balance reagent O3-acylated serine
DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2
Formula: (12)C 11 (13)C 4 H 25 (14)N 2 (15)N 1 O 4
AminoAcid: S
Definition:
A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-128 reporter+balance group.


ModificationSetId: PSI-MOD
Name: TMT6plex-128 reporter+balance reagent O3-acylated threonine
DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2
Formula: (12)C 12 (13)C 4 H 27 (14)N 2 (15)N 1 O 4
AminoAcid: T
Definition:
A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-128 reporter+balance group.


ModificationSetId: PSI-MOD
Name: TMT6plex-128 reporter fragment
DiffFormula: none
Formula: (12)C 6 (13)C 2 H 16 (14)N 1
Definition:
The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-128 reagent acylated residue.


ModificationSetId: PSI-MOD
Name: TMT6plex-129 reporter+balance reagent acylated residue
DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-129 reporter+balance group.


ModificationSetId: PSI-MOD
Name: TMT6plex-129 reporter+balance reagent acylated N-terminal
DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-129 reporter+balance group.


ModificationSetId: PSI-MOD
Name: TMT6plex-129 reporter+balance reagent N6-acylated lysine
DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2
Formula: (12)C 14 (13)C 4 H 32 (14)N 3 (15)N 1 O 3
AminoAcid: K
Definition:
A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-129 reporter+balance group.


ModificationSetId: PSI-MOD
Name: TMT6plex-129 reporter+balance reagent O4'-acylated tyrosine
DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2
Formula: (12)C 17 (13)C 4 H 29 (14)N 2 (15)N 1 O 4
AminoAcid: Y
Definition:
A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-129 reporter+balance group.


ModificationSetId: PSI-MOD
Name: TMT6plex-129 reporter+balance reagent N'-acylated histidine
DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2
Formula: (12)C 14 (13)C 4 H 27 (14)N 4 (15)N 1 O 3
AminoAcid: H
Definition:
A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-129 reporter+balance group.


ModificationSetId: PSI-MOD
Name: TMT6plex-129 reporter+balance reagent O3-acylated serine
DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2
Formula: (12)C 11 (13)C 4 H 25 (14)N 2 (15)N 1 O 4
AminoAcid: S
Definition:
A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-129 reporter+balance group.


ModificationSetId: PSI-MOD
Name: TMT6plex-129 reporter+balance reagent O3-acylated threonine
DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2
Formula: (12)C 12 (13)C 4 H 27 (14)N 2 (15)N 1 O 4
AminoAcid: T
Definition:
A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-129 reporter+balance group.


ModificationSetId: PSI-MOD
Name: TMT6plex-129 reporter fragment
DiffFormula: none
Formula: (12)C 5 (13)C 3 H 16 (14)N 1
Definition:
The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-129 reagent acylated residue.


ModificationSetId: PSI-MOD
Name: TMT6plex-130 reporter+balance reagent acylated residue
DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-130 reporter+balance group.


ModificationSetId: PSI-MOD
Name: TMT6plex-130 reporter+balance reagent acylated N-terminal
DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-130 reporter+balance group.


ModificationSetId: PSI-MOD
Name: TMT6plex-130 reporter+balance reagent N6-acylated lysine
DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2
Formula: (12)C 14 (13)C 4 H 32 (14)N 3 (15)N 1 O 3
AminoAcid: K
Definition:
A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-130 reporter+balance group.


ModificationSetId: PSI-MOD
Name: TMT6plex-130 reporter+balance reagent O4'-acylated tyrosine
DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2
Formula: (12)C 17 (13)C 4 H 29 (14)N 2 (15)N 1 O 4
AminoAcid: Y
Definition:
A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-130 reporter+balance group.


ModificationSetId: PSI-MOD
Name: TMT6plex-130 reporter+balance reagent N'-acylated histidine
DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2
Formula: (12)C 14 (13)C 4 H 27 (14)N 4 (15)N 1 O 3
AminoAcid: H
Definition:
A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-130 reporter+balance group.


ModificationSetId: PSI-MOD
Name: TMT6plex-130 reporter+balance reagent O3-acylated serine
DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2
Formula: (12)C 11 (13)C 4 H 25 (14)N 2 (15)N 1 O 4
AminoAcid: S
Definition:
A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-130 reporter+balance group.


ModificationSetId: PSI-MOD
Name: TMT6plex-130 reporter+balance reagent O3-acylated threonine
DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2
Formula: (12)C 12 (13)C 4 H 27 (14)N 2 (15)N 1 O 4
AminoAcid: T
Definition:
A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-130 reporter+balance group.


ModificationSetId: PSI-MOD
Name: TMT6plex-130 reporter fragment
DiffFormula: none
Formula: (12)C 4 (13)C 4 H 16 (14)N 1
Definition:
The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-130 reagent acylated residue.


ModificationSetId: PSI-MOD
Name: TMT6plex-131 reporter+balance reagent acylated residue
DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of a residue with the Proteome Sciences TMT6plex-131 reporter+balance group.


ModificationSetId: PSI-MOD
Name: TMT6plex-131 reporter+balance reagent acylated N-terminal
DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2
Formula: none
Definition:
A protein modification that effectively replaces a hydrogen atom of a protein N-terminal with the Proteome Sciences TMT6plex-131 reporter+balance group.


ModificationSetId: PSI-MOD
Name: TMT6plex-131 reporter+balance reagent N6-acylated lysine
DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2
Formula: (12)C 14 (13)C 4 H 32 (14)N 3 (15)N 1 O 3
AminoAcid: K
Definition:
A protein modification that effectively replaces the N6'-hydrogen atom of a lysine residue with the Proteome Sciences TMT6plex-131 reporter+balance group.


ModificationSetId: PSI-MOD
Name: TMT6plex-131 reporter+balance reagent O4'-acylated tyrosine
DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2
Formula: (12)C 17 (13)C 4 H 29 (14)N 2 (15)N 1 O 4
AminoAcid: Y
Definition:
A protein modification that effectively replaces the O4'-hydrogen atom of a tyrosine residue with the Proteome Sciences TMT6plex-131 reporter+balance group.


ModificationSetId: PSI-MOD
Name: TMT6plex-131 reporter+balance reagent N'-acylated histidine
DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2
Formula: (12)C 14 (13)C 4 H 27 (14)N 4 (15)N 1 O 3
AminoAcid: H
Definition:
A protein modification that effectively replaces an N'-hydrogen atom of a histidine residue with the Proteome Sciences TMT6plex-131 reporter+balance group.


ModificationSetId: PSI-MOD
Name: TMT6plex-131 reporter+balance reagent O3-acylated serine
DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2
Formula: (12)C 11 (13)C 4 H 25 (14)N 2 (15)N 1 O 4
AminoAcid: S
Definition:
A protein modification that effectively replaces an O3-hydrogen atom of a serine residue with the Proteome Sciences TMT6plex-131 reporter+balance group.


ModificationSetId: PSI-MOD
Name: TMT6plex-131 reporter+balance reagent O3-acylated threonine
DiffFormula: (12)C 8 (13)C 4 H 20 (14)N 1 (15)N 1 O 2
Formula: (12)C 12 (13)C 4 H 27 (14)N 2 (15)N 1 O 4
AminoAcid: T
Definition:
A protein modification that effectively replaces an O3-hydrogen atom of a threonine residue with the Proteome Sciences TMT6plex-131 reporter+balance group.


ModificationSetId: PSI-MOD
Name: TMT6plex-131 reporter fragment
DiffFormula: none
Formula: (12)C 4 (13)C 4 H 16 (15)N 1
Definition:
The protein modification reporter fragment produced by an Proteome Sciences TMT6plex-131 reagent acylated residue.


ModificationSetId: PSI-MOD
Name: O-palmitoleylated residue
DiffFormula: C 16 H 28 N 0 O 1
Formula: none
Definition:
A protein modification that effectively replaces a residue hydroxyl group with a palmitoleyloxy group.


ModificationSetId: PSI-MOD
Name: O-palmitoleyl-L-threonine
DiffFormula: C 16 H 28 N 0 O 1
Formula: C 20 H 35 N 1 O 3
AminoAcid: T
Definition:
A protein modification that effectively converts an L-threonine residue to O-palmitoleyl-L-threonine.


ModificationSetId: PSI-MOD
Name: O-palmitoyl-L-threonine amide
DiffFormula: C 16 H 32 N 1 O 1
Formula: C 20 H 39 N 2 O 3
AminoAcid: T
Definition:
A protein modification that effectively converts an L-threonine residue to O-palmitoyl-L-threonine amide.


ModificationSetId: PSI-MOD
Name: farnesyl reporter fragment
DiffFormula: none
Formula: C 15 H 25
Definition:
The farnesyl cation protein modification reporter fragment produced by fragmentation of some farnesyl modified residues.


ModificationSetId: PSI-MOD
Name: palmityl reporter fragment
DiffFormula: none
Formula: C 16 H 31 O 1
Definition:
The palmityl cation protein modification reporter fragment produced by fragmentation of some palmitoyl modified residues.


ModificationSetId: PSI-MOD
Name: N6,N6,N6-trimethyl-L-lysine with neutral loss of trimethylamine
DiffFormula: C -3 H -9 N -1 O 0
Formula: C 6 H 10 N 1 O 1
Definition:
Covalent modification of a trimethyllysine residue with secondary loss of a neutral trimethylamine molecular fragment.


ModificationSetId: PSI-MOD
Name: S-methylthiocarbonylaminoethylcysteine (Cys)
DiffFormula: C 4 H 7 N 1 O 1 S 1
Formula: C 7 H 12 N 2 O 2 S 2
AminoAcid: C
Definition:
A protein modification that effectively converts an L-cysteine residue to S-methylthiocarbonylaminoethylcysteine.

Comment:
This modified residue is a chemical analog of N6-acetyl-L-lysine produced from L-cysteine by methylthiocarbonylaziridine (MTCA, S-methyl aziridine-1-carbothioate).


ModificationSetId: PSI-MOD
SwissprotTerm: CysO-cysteine adduct
Name: S-(glycyl)-L-cysteine (Gly)
DiffFormula: C 3 H 5 N 1 O 1 S 1
Formula: C 5 H 9 N 2 O 3 S 1
AminoAcid: G
Definition:
A protein modification that effectively converts a C-terminal glycine residue to S-(glycyl)-L-cysteine by forming a thioester bond with a free L-cysteine.

Comment:
This is not the cross-linking of two peptides, but the modification of a C-terminal glycine by formation of an thioester bond with a free cysteine. For the cross-linking of two peptide see MOD:00211 [JSG].


ModificationSetId: PSI-MOD
SwissprotTerm: CysO-cysteine adduct
Name: N-(glycyl)-L-cysteine
DiffFormula: C 3 H 5 N 1 O 1 S 1
Formula: C 5 H 9 N 2 O 3 S 1
AminoAcid: G
Definition:
A protein modification that effectively converts a C-terminal glycine residue to N-(glycyl)-L-cysteine by forming a peptide bond with a free L-cysteine.


ModificationSetId: PSI-MOD
Name: N6-(L-lysyl)-L-lysine
DiffFormula: C 6 H 12 N 2 O 1
Formula: C 12 H 24 N 4 O 2
AminoAcid: K
Definition:
A protein modification that effectively converts an L-lysine residue to N6-(L-lysyl)-L-lysine by formation of an isopeptide bond between the carboxyl group of a free lysine and the N6-amino group of the peptidyl L-lysine.

Comment:
This is not the cross-linking of two peptides, but the modification of a peptidyl lysine by formation of an isopeptide bond with a free lysine [JSG].


ModificationSetId: PSI-MOD
SwissprotTerm: N6-(3,6-diaminohexanoyl)-5-hydroxylysine
Name: N6-(beta-lysyl)-L-5-hydroxylysine
DiffFormula: C 6 H 12 N 2 O 2
Formula: C 12 H 24 N 4 O 3
AminoAcid: K
Definition:
A protein modification that effectively converts an L-lysine residue to N6-(beta-lysyl)-L-5-hydroxylysine by formation of an isopeptide bond between the carboxyl group of a free beta-lysine and the N6-amino group of a peptidyl L-lysine.


ModificationSetId: PSI-MOD
Name: N6-butanoyl-L-lysine
Definition: A protein modification that effectively converts an L-lysine residue to N6-butanoyl-L-lysine.
DiffFormula: C 4 H 6 N 0 O 1
Formula: C 10 H 18 N 2 O 2
AminoAcid: K
Comment:
The binding of histone peptides with butanoylated lysine to nuclear bromodomain proteins is non-specific and weaker than binding to the corresponding acetylated lysine peptides [JSG].


